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[PMID]:28370332
[Au] Autor:Pelander L; Häggström J; Ley CJ; Ljungvall I
[Ad] Endereço:Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Título:Cardiac Troponin I and Amino-Terminal Pro B-Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease.
[So] Source:J Vet Intern Med;31(3):805-813, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Increased concentrations of N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) in dogs with azotemia have been documented. Knowledge of mechanisms behind increased concentrations of cardiac biomarkers in dogs with azotemia is warranted for correct interpretation of test results. OBJECTIVES: The aim of the article was to investigate possible associations between plasma concentrations of cTnI and NT-proBNP, respectively, and patient characteristics, glomerular filtration rate (GFR), a plasma volume factor (PVF) derived from scintigraphic examination (PVf), systolic blood pressure (SBP), selected hematologic and biochemical variables, and echocardiographic measurements in dogs with stable chronic kidney disease (CKD) and in healthy dogs. ANIMALS: Fifty student-, staff-, and client-owned dogs were included. Twenty-three of the dogs were healthy and 27 were diagnosed with CKD. METHODS: In this cross-sectional observational study, dogs with a previous diagnosis of CKD and healthy control dogs were included. At inclusion, all dogs were characterized by physical examination, repeated blood pressure measurements, complete urinalysis, hematology and biochemistry panel, echocardiography, abdominal ultrasound examination of the entire urinary tract, and scintigraphic examination for measurement of GFR. RESULTS: Plasma volume factor and PCV were independently associated with NT-proBNP (Radj2 = 0.42; P < .0001). Age, body weight (BW), and SBP were independently associated with cTnI (Radj2 = 0.50; P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: Neither NT-proBNP nor cTnI concentrations were independently associated with measured GFR. Thus, findings were not suggestive of passive accumulation of either marker, suggesting that increased circulating concentrations of cTnI and NT-proBNP can be interpreted similarly in dogs with stable CKD as in dogs without CKD.
[Mh] Termos MeSH primário: Doenças do Cão/sangue
Peptídeo Natriurético Encefálico/sangue
Fragmentos de Peptídeos/sangue
Insuficiência Renal Crônica/veterinária
Troponina I/sangue
[Mh] Termos MeSH secundário: Animais
Azotemia/sangue
Azotemia/veterinária
Pressão Sanguínea
Estudos de Casos e Controles
Estudos Transversais
Cães
Feminino
Taxa de Filtração Glomerular/veterinária
Masculino
Volume Plasmático/veterinária
Insuficiência Renal Crônica/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Peptide Fragments); 0 (Troponin I); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14703


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[PMID]:28248187
[Au] Autor:Breuer W; Nickeleit V; Metzner M; Knubben-Schweizer G; Hafner-Marx A
[Ad] Endereço:Bavarian Health and Food Safety Authority, Section of Pathology, Oberschleißheim, Germany.
[Ti] Título:Fatal proteinuric kidney disease in a 30-month-old German Fleckvieh heifer caused by unilateral focal segmental glomerulosclerosis subsequent to a non-functional counterpart kidney.
[Ti] Título:Unilaterale fokale segmentale Glomerulosklerose mit fatalem renalem Proteinverlust- Syndrom als Folge eines kontralateralen chronischen Nierenversagens bei einer 30 Monate alten Deutsches Fleckvieh Färse..
[So] Source:Schweiz Arch Tierheilkd;159(3):179-184, 2017 Mar.
[Is] ISSN:0036-7281
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: A case of secondary focal segmental glomerulosclerosis (FSGS) in a heifer is presented. A 30-month-old female German Fleckvieh heifer showed deterioration of the general condition, a poor nutritional status, proteinuria, hypoalbuminemia, and renal azotemia. Pathologically, it was diagnosed with unilateral hydronephrosis, and contralateral renal fibrosis with numerous cysts. Histologically, the fibrotic kidney showed FSGS, hyaline reabsorption droplets in proximal tubular epithelial cells, interstitial fibrosis, and tubulointerstitial inflammation. Apart from that, thrombotic microangiopathy (TMA) was seen in few renal arteries and meningeal arterioles. Pathogenesis of FSGS secondary to unilateral renal parenchymal loss (hydronephrosis) and TMA is discussed.
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Glomerulosclerose Segmentar e Focal/veterinária
Proteinúria/veterinária
[Mh] Termos MeSH secundário: Animais
Azotemia/diagnóstico
Azotemia/etiologia
Azotemia/fisiopatologia
Azotemia/veterinária
Bovinos
Doenças dos Bovinos/fisiopatologia
Evolução Fatal
Feminino
Glomerulosclerose Segmentar e Focal/complicações
Glomerulosclerose Segmentar e Focal/diagnóstico
Glomerulosclerose Segmentar e Focal/fisiopatologia
Hipoalbuminemia/diagnóstico
Hipoalbuminemia/etiologia
Hipoalbuminemia/fisiopatologia
Hipoalbuminemia/veterinária
Rim/fisiopatologia
Proteinúria/diagnóstico
Proteinúria/etiologia
Proteinúria/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.17236/sat00110


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[PMID]:28240785
[Au] Autor:Legendre KP; Leissinger M; Le Donne V; Grasperge BJ; Gaunt SD
[Ad] Endereço:Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
[Ti] Título:The effect of urea on refractometric total protein measurement in dogs and cats with azotemia.
[So] Source:Vet Clin Pathol;46(1):138-142, 2017 Mar.
[Is] ISSN:1939-165X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While protein is the predominant solute measured in plasma or serum by a refractometer, nonprotein substances also contribute to the angle of refraction. There is debate in the current literature regarding which nonprotein substances cause factitiously high refractometric total protein measurements, as compared to the biuret assay. OBJECTIVES: The purpose of the study was to determine if the blood of azotemic animals, specifically with increased blood urea concentration, will have significantly higher refractometric total protein concentrations compared to the total protein concentrations measured by biuret assay. METHODS: A prospective case series was conducted by collecting data from azotemic (n = 26) and nonazotemic (n = 34) dogs and cats. In addition, an in vitro study was performed where urea was added to an enhanced electrolyte solution at increasing concentrations, and total protein was assessed by both the refractometer and spectrophotometer. Statistical analysis was performed to determine the effect of urea. RESULTS: The refractometric total protein measurement showed a positive bias when compared to the biuret protein measurement in both groups, but the bias was higher in the azotemic group vs the nonazotemic group. The mean difference in total protein measurements of the nonazotemic group (0.59 g/dL) was significantly less (P < .01) than the mean difference of the azotemic group (0.95 g/dL). The in vitro experiment revealed a positive bias with a proportional error. CONCLUSIONS: This study demonstrated that increasing concentrations of urea significantly increased the total protein concentration measured by the refractometer as compared to the biuret assay, both in vivo and in vitro.
[Mh] Termos MeSH primário: Azotemia/veterinária
Doenças do Gato/sangue
Doenças do Cão/sangue
Ureia/sangue
[Mh] Termos MeSH secundário: Animais
Azotemia/sangue
Bilirrubina/sangue
Biureto
Proteínas Sanguíneas/análise
Gatos
Cães
Estudos Prospectivos
Refratometria/veterinária
Espectrofotometria/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 89LJ369D1H (Biuret); 8W8T17847W (Urea); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1111/vcp.12464


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[PMID]:28220028
[Au] Autor:Parikh CR; Mansour SG
[Ad] Endereço:Program of Applied Translational Research, Department of Medicine, and chirag.parikh@yale.edu.
[Ti] Título:Perspective on Clinical Application of Biomarkers in AKI.
[So] Source:J Am Soc Nephrol;28(6):1677-1685, 2017 Jun.
[Is] ISSN:1533-3450
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several biomarkers of renal injury have been identified but the utility of these biomarkers is largely confined to research studies, whereas widespread clinical applicability is limited. This is partly because the use of serum creatinine as the comparator has several limitations and restricts the full interpretation of biomarker performance. To highlight the potential for clinical application of biomarkers, the most pertinent biomarker data are summarized here, using clinically relevant scenarios in which biomarkers could assist with diagnostic and management dilemmas. The paradigms proposed in this review aim to enhance the clinical diagnosis, management, and prognosis of AKI through the combined use of available clinical markers and novel inflammatory, injury, and repair biomarkers.
[Mh] Termos MeSH primário: Lesão Renal Aguda/diagnóstico
Biomarcadores/análise
[Mh] Termos MeSH secundário: Azotemia/diagnóstico
Síndrome Cardiorrenal/diagnóstico
Diagnóstico Diferencial
Fibrose/diagnóstico
Seres Humanos
Nefropatias/diagnóstico
Transplante de Rim
Obtenção de Tecidos e Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1681/ASN.2016101127


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[PMID]:28218918
[Au] Autor:Beckerman P; Bi-Karchin J; Park AS; Qiu C; Dummer PD; Soomro I; Boustany-Kari CM; Pullen SS; Miner JH; Hu CA; Rohacs T; Inoue K; Ishibe S; Saleem MA; Palmer MB; Cuervo AM; Kopp JB; Susztak K
[Ad] Endereço:Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
[Ti] Título:Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.
[So] Source:Nat Med;23(4):429-438, 2017 Apr.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:African Americans have a heightened risk of developing chronic and end-stage kidney disease, an association that is largely attributed to two common genetic variants, termed G1 and G2, in the APOL1 gene. Direct evidence demonstrating that these APOL1 risk alleles are pathogenic is still lacking because the APOL1 gene is present in only some primates and humans; thus it has been challenging to demonstrate experimental proof of causality of these risk alleles for renal disease. Here we generated mice with podocyte-specific inducible expression of the APOL1 reference allele (termed G0) or each of the risk-conferring alleles (G1 or G2). We show that mice with podocyte-specific expression of either APOL1 risk allele, but not of the G0 allele, develop functional (albuminuria and azotemia), structural (foot-process effacement and glomerulosclerosis) and molecular (gene-expression) changes that closely resemble human kidney disease. Disease development was cell-type specific and likely reversible, and the severity correlated with the level of expression of the risk allele. We further found that expression of the risk-variant APOL1 alleles interferes with endosomal trafficking and blocks autophagic flux, which ultimately leads to inflammatory-mediated podocyte death and glomerular scarring. In summary, this is the first demonstration that the expression of APOL1 risk alleles is causal for altered podocyte function and glomerular disease in vivo.
[Mh] Termos MeSH primário: Apolipoproteínas/genética
Glomérulos Renais/metabolismo
Lipoproteínas HDL/genética
Podócitos/metabolismo
Insuficiência Renal Crônica/genética
[Mh] Termos MeSH secundário: Albuminúria/genética
Alelos
Animais
Apolipoproteína L1
Autofagia/genética
Azotemia/genética
Western Blotting
Endocitose/genética
Endossomos/metabolismo
Imunofluorescência
Predisposição Genética para Doença
Variação Genética
Glomerulosclerose Segmentar e Focal/genética
Glomerulosclerose Segmentar e Focal/patologia
Células HEK293
Células HeLa
Seres Humanos
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Glomérulos Renais/patologia
Glomérulos Renais/ultraestrutura
Camundongos
Camundongos Transgênicos
Microscopia Eletrônica
Podócitos/ultraestrutura
Insuficiência Renal Crônica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (APOL1 protein, human); 0 (Apolipoprotein L1); 0 (Apolipoproteins); 0 (Lipoproteins, HDL)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4287


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[PMID]:27560016
[Au] Autor:Knipp D; Lane BF; Mitchell JW; Daly BD
[Ad] Endereço:From the *Department of Radiology, Massachusetts General Hospital, Boston, MA; and †Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
[Ti] Título:Computed Tomographic Angiography of the Abdomen and Pelvis in Azotemic Patients Utilizing 80-kV(p) Technique and Reduced Dose Iodinated Contrast: Comparison With Routine 120-kV(p) Technique.
[So] Source:J Comput Assist Tomogr;41(1):141-147, 2017 Jan.
[Is] ISSN:1532-3145
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate image quality (IQ) of a reduced contrast volume, low kilovolt (peak) [kV(p)] abdominopelvic computed tomographic angiography (AP-CTA) protocol compared to a standard 120-kV(p) AP-CTA protocol. METHODS: A retrospective image analysis was performed on 103 patients with end-stage renal disease who underwent AP-CTA. Forty-nine patients were scanned at 80 kV(p) with a mean of 48 mL of contrast, and 54 patients were scanned at 120 kV(p) with a mean of 98 mL of contrast. Objective comparison of arterial attenuation, noise, and contrast-to-noise ratio was obtained, in addition to radiation dose. Subjective assessment of IQ, enhancement intensity, and image noise (IN) was scored on a 3-point scale. RESULTS: The 6-level aggregate contrast-to-noise ratio for the 80-kV(p) group was 11.8 ± 7.0, compared to 12.4 ± 4.6 in the 120-kV(p) group (P = 0.210). Radiation exposure was significantly lower in the 80-kV(p) group versus the 120-kV(p) group, as measured by average CT dose index (mGy) of 9.0 ± 3.1 and 15.8 ± 5.8 (P < 0.0001), respectively; and average dose length product (mGy × cm) of 490.0 ± 214.1 and 863.1 ± 344.4 (P < 0.0001), respectively. The 120-kV(p) technique scored better for subjective IQ (P = 0.042) and IN (P = 0.004) but not for enhancement intensity (P = 0.205). CONCLUSIONS: A 50% reduced iodinated contrast dose coupled with 80-kV(p) technique with iterative reconstruction allows for satisfactory AP-CTA studies at a 43% mean radiation dose reduction compared to a standard protocol. Negative but potentially reversible sequelae of this drop in radiation dose include increased IN and reduced subjective IQ.
[Mh] Termos MeSH primário: Azotemia/diagnóstico por imagem
Angiografia por Tomografia Computadorizada/métodos
Iodo/administração & dosagem
Nefropatias/diagnóstico por imagem
Pelve/diagnóstico por imagem
Exposição à Radiação/prevenção & controle
[Mh] Termos MeSH secundário: Meios de Contraste/administração & dosagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Pelve/irrigação sanguínea
Dose de Radiação
Exposição à Radiação/análise
Radiografia Abdominal/métodos
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.1097/RCT.0000000000000478


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[PMID]:27903994
[Au] Autor:Dehghani H; Heidari F; Mozaffari-Khosravi H; Nouri-Majelan N; Dehghani A
[Ad] Endereço:Department of Nursing, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
[Ti] Título:Synbiotic Supplementations for Azotemia in Patients With Chronic Kidney Disease: a Randomized Controlled Trial.
[So] Source:Iran J Kidney Dis;10(6):351-357, 2016 11.
[Is] ISSN:1735-8604
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Chronic kidney disease (CKD) is a progressive and irreversible impairment of kidney function; if it progresses to the end-stage of CKD, dialysis or kidney transplant is needed. In general, there are no definitive treatment to slow the progression of CKD. This study aimed to determine the effect of synbiotic supplementations on azotemia in patients with CKD. MATERIALS AND METHODS: A randomized controlled trial was conducted on 66 patients with CKD (stages 3 and 4). The participants were randomly divided into 2 groups to receive synbiotic supplement, 1000 mg/d, and placebo (2 capsules a day) for 6 weeks. At the beginning and end of the study, blood parameters and kidney function were evaluated. RESULTS: Of the 66 patients studied, 16 patients (24.2%) were women and 50 (75.8%) were men. The mean age and body mass index of the participants were 61 ± 7.65 years and 28.52 ± 4.06 kg/m2, respectively. The level of blood urea nitrogen showed a significant reduction following the intake of synbiotic supplement (from 40.80 ± 22.11 mg/dL to 36.14 ± 20.52 mg/dL, P = .01). Serum creatinine, uric acid, and other indicators of kidney function showed no significant change. CONCLUSIONS: The intake of synbiotic supplement could reduce blood urea nitrogen in patients with CKD in stages 3 and 4; however, it had no effect on the other markers of kidney function.
[Mh] Termos MeSH primário: Azotemia/tratamento farmacológico
Prebióticos
Probióticos/uso terapêutico
Insuficiência Renal Crônica/tratamento farmacológico
Simbióticos
[Mh] Termos MeSH secundário: Idoso
Azotemia/sangue
Azotemia/etiologia
Nitrogênio da Ureia Sanguínea
Creatinina/sangue
Suplementos Nutricionais
Método Duplo-Cego
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Masculino
Meia-Idade
Insuficiência Renal Crônica/sangue
Insuficiência Renal Crônica/complicações
Índice de Gravidade de Doença
Ácido Úrico/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Prebiotics); 268B43MJ25 (Uric Acid); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


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[PMID]:27661025
[Au] Autor:Filomia R; Maimone S; Caccamo G; Saitta C; Visconti L; Alibrandi A; Caloggero S; Bottari A; Franzè MS; Gambino CG; Lembo T; Oliva G; Cacciola I; Raimondo G; Squadrito G
[Ad] Endereço:aDepartment of Internal Medicine bDivision of Clinical and Molecular Hepatology cDepartment of Clinical and Experimental Medicine, University Hospital of Messina dDepartment of Economics, University of Messina eDepartment of Diagnostic Imaging and Radiotherapy fDepartment of Biomedical Sciences and Morphological and Functional Imaging gDepartment of Human Pathology of Adult and Evolutive Age, University Hospital of Messina, Messina, Italy.
[Ti] Título:Acute kidney injury in cirrhotic patients undergoing contrast-enhanced computed tomography.
[So] Source:Medicine (Baltimore);95(38):e4836, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contrast medium administration is one of the leading causes of acute kidney injury (AKI) in different clinical settings. The aim of the study was to investigate occurrence and predisposing factors of AKI in cirrhotic patients undergoing contrast-enhanced computed tomography (CECT).Datasets of 1279 consecutively hospitalized cirrhotic patients were retrospectively analyzed. Two hundred forty-nine of 1279 patients (mean age 64 ±â€Š11 years, 165 male) who had undergone CECT were selected on the basis of the availability of serum creatinine (sCr) values evaluated before and after CECT (CECT group). In analogy, 203/1279 cases (mean age 66 ±â€Š10 years, 132 male) who had not undergone CECT and had been tested twice for sCr in 7 days were also included as controls (Control group). AKI network criteria were employed to assess contrast-induced AKI (CI-AKI) development. Apart from lack of narrowed double sCr measurements, additional exclusion criteria were active bacterial infections, nephrotoxic drugs intake, and estimated glomerular filtration rate <30 mL/min.AKI developed in 22/249 (8.8%) and in 6/203 (3%) of the CECT and the Control groups, respectively (P = 0.01). The multivariate logistic regression analysis showed that AKI was significantly associated with contrast medium administration (odds ratio [OR]: 3.242, 95% confidence interval [CI]: 1.255-8.375; P = 0.015), female sex (OR: 0.339, 95% CI: 0.139-0.827; P = 0.017), and sCr values (OR: 0.124, 95% CI: 0.016-0.975; P = 0.047). In the CECT group, presence of ascites (OR: 2.796, 95% CI: 1.109-7.052; P = 0.029), female sex (OR: 0.192, 95% CI: 0.073-0.510; P = 0.001), and hyperazotemia (OR: 1.018, 95% CI: 1.001-1.037; P = 0.043) correlated with CI-AKI development at multivariate analysis.CI-AKI is a quite frequent occurrence in cirrhotic patients with female sex, presence of ascites, and hyperazotemia being the predisposing factors.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Meios de Contraste/efeitos adversos
Cirrose Hepática/diagnóstico por imagem
Tomografia Computadorizada por Raios X/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/epidemiologia
Idoso
Ascite/etiologia
Azotemia/etiologia
Meios de Contraste/administração & dosagem
Creatinina/sangue
Feminino
Seres Humanos
Testes de Função Renal
Cirrose Hepática/sangue
Cirrose Hepática/complicações
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Razão de Chances
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Fatores Sexuais
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004836


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[PMID]:27483570
[Au] Autor:Milosevski-Lomic G; Markovic-Lipkovski J; Kostic M; Dusan Paripovic; Spasojevic-Dimitrijeva B; Peco-Antic A
[Ti] Título:Granulomatous interstitial nephritis associated with influenza A: H1N1 infection--A case report.
[So] Source:Srp Arh Celok Lek;144(3-4):215-8, 2016 Mar-Apr.
[Is] ISSN:0370-8179
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The causes of acute tubulointerstitial nephritis can be grouped into four broad categories: medications, infections, immunologic diseases, or idiopathic processes. Here we report a 17-year-old female who developed acute kidney injury (AKI) due to granulomatous interstitial nephritis (GIN) associated with influenza A: H1N1 infection. CASE OUTLINE: The illness presented after two weeks of respiratory tract infection, skin rash and hypermenorrhea. On admission the patient was febrile, with bilateral pedal edema, macular skin rash, and auscultatory finding that suggested pneumonia. Laboratory investigations showed normocytic anemia, azotemia, hematuria and proteinuria. Renal ultrasound was normal. Antinuclear antibodies, antineutrophil cytoplasmic antibodies, lupus anticoagulant, antiphospholipid antibodies were negative with normal complement. Urine cultures including analysis for Mycobacterium tuberculosis were negative. The diagnosis of influenza A: H1N1 infection was made by positive serology. A kidney biopsy showed interstitial nephritis with peritubular granulomas. Glomeruli were normal. Staining for immunoglobulins A, M, G, and F was negative. The girl was treated with oseltamivir phosphate (Tamiflu; Genentech, Inc., South San Francisco, CA, USA) for five days, as well as with tapered prednisone after a starting dose of 2 mg/kg. The treatment resulted in a complete remission during two years of follow-up. CONCLUSION: We present a severe but reversible case of GIN and AKI associated with influenza A: H1N1 infection. Although a causal effect cannot be confirmed, this case suggests that influenza A: H1N1 should be considered in the differential diagnosis of GIN manifested with AKI in children.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Influenza Humana/complicações
Nefrite Intersticial/complicações
[Mh] Termos MeSH secundário: Lesão Renal Aguda/tratamento farmacológico
Lesão Renal Aguda/patologia
Adolescente
Anti-Inflamatórios/uso terapêutico
Antivirais/uso terapêutico
Azotemia/etiologia
Feminino
Hematúria/etiologia
Seres Humanos
Vírus da Influenza A Subtipo H1N1
Influenza Humana/tratamento farmacológico
Nefrite Intersticial/tratamento farmacológico
Nefrite Intersticial/patologia
Oseltamivir/uso terapêutico
Prednisona/uso terapêutico
Proteinúria/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antiviral Agents); 20O93L6F9H (Oseltamivir); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160803
[Lr] Data última revisão:
160803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


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[PMID]:27429464
[Au] Autor:Devine L; Polzin DJ
[Ad] Endereço:North Carolina State Veterinary Hospital - Internal Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA (Devine); University of Minnesota - Internal Medicine, St. Paul, Minnesota, 55108, USA (Polzin).
[Ti] Título:Presumed masitinib-induced nephrotic syndrome and azotemia in a dog.
[So] Source:Can Vet J;57(7):752-6, 2016 Jul.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Masitinib mesylate is a tyrosine-kinase inhibitor approved for the treatment of nonresectable or recurrent, Grade 2 or 3 mast cell tumors in dogs. This report describes nephrotic syndrome and acute kidney injury attributed to masitinib and illustrates the need for regular monitoring of serum creatinine concentration, urinalysis, and urine protein:creatinine ratio during its use.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Azotemia/veterinária
Doenças do Cão/induzido quimicamente
Síndrome Nefrótica/veterinária
Proteínas Tirosina Quinases/antagonistas & inibidores
Tiazóis/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Azotemia/induzido quimicamente
Cães
Feminino
Mastocitoma/tratamento farmacológico
Mastocitoma/veterinária
Síndrome Nefrótica/induzido quimicamente
Tiazóis/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Thiazoles); EC 2.7.10.1 (Protein-Tyrosine Kinases); M59NC4E26P (masitinib)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE



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