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  1 / 6528 MEDLINE  
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[PMID]:29390453
[Au] Autor:Zhang X; Zhang G; Zhang L; Sun C; Liu N; Chen M
[Ad] Endereço:School of Medicine, Southeast University.
[Ti] Título:Spontaneous rupture of the urinary bladder caused by eosinophilic cystitis in a male after binge drinking: A case report.
[So] Source:Medicine (Baltimore);96(51):e9170, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Spontaneous rupture of the urinary bladder is a rare, difficult to diagnose surgical emergency with a high mortality, there are many causes for spontaneous rupture of the urinary bladder, but we only found 2 reports on this condition in our literature search. A 36-year-old male patient was admitted with "whole abdominal pain associated with hematuria for 5 hours." Our patient did not have a history of definite allergy, but a long-term history of alcohol abuse. This patient was followed up for 1 year, and the cystoscopy recheck showed that the bladder lesion had healed. CONCLUSIONS: Since eosinophilic cystitis is associated with long-term alcohol consumption, we recommended that the patient should stop drinking and taking antihistamines.
[Mh] Termos MeSH primário: Bebedeira/complicações
Cistite/complicações
Eosinofilia/complicações
Bexiga Urinária/lesões
[Mh] Termos MeSH secundário: Adulto
Cistografia
Seres Humanos
Masculino
Ruptura Espontânea/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009170


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[PMID]:28952689
[Au] Autor:Spivak LG; Enikeev DV; Platonova DV
[Ad] Endereço:I.M. Sechenov First MSMU of Minzdrav of Russia, Moscow, Russia.
[Ti] Título:[Experience of using phytolysin in combination therapy of chronic cystitis in patients with urate nephrolythisis].
[So] Source:Urologiia;(4):32-36, 2017 Sep.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate the effectiveness of the herbal preparation Phytolysin in the comprehensive management of urate nephrolithiasis against the background of chronic cystitis exacerbation. MATERIALS AND METHODS: The study comprised 21 patients aged 19 to 57; 11 of them (the study group) received ciprofloxacin 500 mg once daily for 7 days, Phytolysin (for 1 month) and Blemaren (for 3 months), while 10 patients of control group were treated with antibacterial therapy and Blemaren. The clinical evaluation of the patients included laboratory testing and ultrasound imaging. RESULTS: The combination therapy resulted in a decrease in leukocyturia and bacteriuria. There was no tendency to relapse. The occurrence of relapse was identified by dysuria, urgent and frequent urination, suprapubic pain and results of laboratory testing (leukocyturia, bacteriuria >103) on days 15, 29, 57, 85 and 112 of the study. CONCLUSIONS: The findings suggest that the use of Phytolysin can be an effective and safe way to prevent exacerbation of chronic cystitis in patients with urate nephrolithiasis.
[Mh] Termos MeSH primário: Cistite/tratamento farmacológico
Nefrolitíase/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Doença Crônica
Cistite/complicações
Feminino
Seres Humanos
Meia-Idade
Nefrolitíase/complicações
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  3 / 6528 MEDLINE  
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[PMID]:28845934
[Au] Autor:Saenko VS; Kapsargin FP; Pesegov SV; M V
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia, Department of Urology, University Clinic of Urology 2, R.M. Fronshteyn Urology Clinic, Moscow, Russia.
[Ti] Título:[Troyakov. Experience in using hytolysin in the integrated management of urinary tract infections and methapylactics of nephrolithiasis].
[So] Source:Urologiia;(3):16-21, 2017 Jul.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:RELEVANCE: Urinary tract infection (UTI) are a risk factor for diseases leading to impairment of renal function and kidney stone disease (KSD). Growing resistance of uropathogens to antibacterial agents is a challenging issue in most countries of the world. Urolithiasis is the second most prevalent urologic condition following urinary tract infections and has a pronounced tendency to recur. Rational stone metaphylaxis leads to a significant reduction in the incidence of recurrent stones. In recent decades, there has been a markedly increasing interest in plant-based therapies in managing urologic diseases. AIM: To evaluate the effectiveness of phytotherapeutic medication Phytolysin in the integrated management of UTI and metaphylaxis of urolithiasis. MATERIALS AND METHODS: Comprehensive evaluation of the effectiveness of Phytolysin was conducted at the Department of Urology, I.M. Sechenov First MSMU and Department of Urology, Andrology and Sexology, Voino-Yasenetsky Krasnoyarsk SMU in 40 women with episodes of exacerbation of chronic cystitis and 30 patients of both sexes during the postoperative metaphylaxis of the KSD. The age of the patients ranged from 20 to 68 years (mean age 40+/-2,8 years). RESULTS: Adding Phytolysin to the integrated management results in the improvement in general clinical signs and laboratory parameters of blood and urine, leads to a decrease in the level of leukocyturia, bacteriuria and an increase in diuresis and urinary alkalinization, reduces the number relapses of UTI and stone formation. CONCLUSION: Phytolysin is an effective and safe medication.
[Mh] Termos MeSH primário: Cistite/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Infecções Urinárias/tratamento farmacológico
Urolitíase/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Cistite/complicações
Quimioterapia Combinada
Feminino
Seres Humanos
Meia-Idade
Fitoterapia
Infecções Urinárias/complicações
Urolitíase/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28826558
[Au] Autor:Lee YL; Lin KL; Chuang SM; Lee YC; Lu MC; Wu BN; Wu WJ; Yuan SF; Ho WT; Juan YS
[Ad] Endereço:Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Urology, Sinying Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
[Ti] Título:Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model.
[So] Source:Am J Pathol;187(9):1945-1959, 2017 Sep.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ketamine-induced ulcerative cystitis (KIC) initially damaged the bladder mucosa and induced contracted bladder thereafter. Hyaluronan (hyaluronic acid; HA) instillation to the bladder has been used to treat KIC. The present study investigated bladder injury by urothelial defect and HA degeneration and bladder repair by urothelium proliferation and differentiation. This work was based on the hypothesis that HA treatment altered the bladder urothelial layer and the expression of hyaluronan-metabolizing enzymes and/or HA receptors in KIC. Cystometrogram study and tracing analysis of voiding behavior revealed that the ketamine-treated rats exhibited significant bladder hyperactivity with an increase in micturition frequency and a decrease in bladder capacity. The expression of inflammatory and fibrosis markers was also increased in the ketamine-treated group. Moreover, ketamine administration decreased the expression of urothelial barrier-associated protein, altered HA production, and induced abnormal urothelial differentiation, which might attribute to urothelial lining defects. However, HA instillation ameliorated bladder hyperactivity, lessened bladder mucosa damage, and decreased interstitial fibrosis. HA instillation also improved the level of HA receptors (CD44, Toll-like receptor-4, and receptor for HA-mediated motility) and HA synthases 1 to 3 and decreased the expression of hyaluronidases in the urothelial layer of bladder, resulting in enhanced mucosal regeneration. These findings suggested that HA could modulate inflammatory responses, enhance mucosal regeneration, and improve urothelial lining defects in KIC.
[Mh] Termos MeSH primário: Cistite/fisiopatologia
Ácido Hialurônico/uso terapêutico
Bexiga Urinária/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cistite/induzido quimicamente
Cistite/metabolismo
Modelos Animais de Doenças
Feminino
Receptores de Hialuronatos/metabolismo
Ácido Hialurônico/metabolismo
Ácido Hialurônico/farmacologia
Inflamação/induzido quimicamente
Inflamação/metabolismo
Inflamação/fisiopatologia
Ketamina
Ratos
Ratos Sprague-Dawley
Receptor 4 Toll-Like/metabolismo
Bexiga Urinária/metabolismo
Bexiga Urinária/fisiopatologia
Urotélio/metabolismo
Urotélio/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hyaluronan Receptors); 0 (Toll-Like Receptor 4); 690G0D6V8H (Ketamine); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28783162
[Au] Autor:Wang K; Gaitsch H; Poon H; Cox NJ; Rzhetsky A
[Ad] Endereço:Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, Illinois, USA.
[Ti] Título:Classification of common human diseases derived from shared genetic and environmental determinants.
[So] Source:Nat Genet;49(9):1319-1325, 2017 Sep.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we used insurance claims for over one-third of the entire US population to create a subset of 128,989 families (481,657 unique individuals). We then used these data to (i) estimate the heritability and familial environmental patterns of 149 diseases and (ii) infer the genetic and environmental correlations for disease pairs from a set of 29 complex diseases. The majority (52 of 65) of our study's heritability estimates matched earlier reports, and 84 of our estimates appear to have been obtained for the first time. We used correlation matrices to compute environmental and genetic disease classifications and corresponding reliability measures. Among unexpected observations, we found that migraine, typically classified as a disease of the central nervous system, appeared to be most genetically similar to irritable bowel syndrome and most environmentally similar to cystitis and urethritis, all of which are inflammatory diseases.
[Mh] Termos MeSH primário: Doença/genética
Meio Ambiente
Predisposição Genética para Doença/genética
Formulário de Reclamação de Seguro/estatística & dados numéricos
[Mh] Termos MeSH secundário: Cistite/classificação
Cistite/genética
Doença/classificação
Feminino
Seres Humanos
Inflamação/classificação
Inflamação/genética
Padrões de Herança/genética
Síndrome do Intestino Irritável/classificação
Síndrome do Intestino Irritável/genética
Modelos Lineares
Masculino
Transtornos de Enxaqueca/classificação
Transtornos de Enxaqueca/genética
Análise Multivariada
Linhagem
Fatores de Risco
Estados Unidos
Uretrite/classificação
Uretrite/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3931


  6 / 6528 MEDLINE  
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[PMID]:28631908
[Au] Autor:Kuzmenko AV; Kuzmenko VV; Gyaurgiev TA
[Ad] Endereço:Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.
[Ti] Título:[Chronobiological approach to managing an exacerbation of chronic recurrent bacterial cystite].
[So] Source:Urologiia;(2):60-65, 2017 Jun.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To investigate the effects of complex therapy with and without phototherapy for an exacerbation of chronic recurrent bacterial cystitis in women at the peaks of chronobiological activity. MATERIALS AND METHODS: The study comprised 60 patients (mean age 30.1+/-5.5 years) with exacerbations of chronic recurrent bacterial cystitis. Patients in the comparison group (n=30) were managed with standard therapy, in the study group (n=30) standard therapy was used concurrently with phototherapy by low-intensity light radiation carried out at the maximum peaks of chronobiological activity. An assessment of the results included estimation of clinical and laboratory outcomes and the chronobiological status of patients in both groups. RESULTS: The study findings showed that phototherapy at the peaks of patients chronobiological activity icombined with standard treatment resulted in a faster reduction of clinical signs of the disease and desynchronosis.
[Mh] Termos MeSH primário: Infecções Bacterianas/terapia
Cronoterapia
Cistite/terapia
Fototerapia
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Infecções Bacterianas/tratamento farmacológico
Terapia Combinada
Cistite/tratamento farmacológico
Cistite/microbiologia
Progressão da Doença
Feminino
Seres Humanos
Meia-Idade
Recidiva
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


  7 / 6528 MEDLINE  
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[PMID]:28625025
[Au] Autor:Owari T; Yamamoto T; Mizobuchi S; Itami Y; Nakahama T; Matsumoto Y; Yamada K; Momose H
[Ad] Endereço:The Department of Urology, Japan Community Health-care Organization Hoshigaoka Medical Center.
[Ti] Título:[Causative Bacterial Strains and Sensitivityto Antimicrobial Agents in Female Acute Uncomplicated Cystitis].
[So] Source:Hinyokika Kiyo;63(5):189-193, 2017 May.
[Is] ISSN:0018-1994
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Recently, wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection. To investigate the causative bacterial strains of female acute uncomplicated cystitis (AUC) in the community and their sensitivity to antimicrobial agents, we retrospectively reviewed the medical records of 215 female AUC patients treated at our clinics from April 2014 to June 2015. Two hundred and nineteen strains were isolated as the causative bacteria from the patients'urine samples, including E. coli of 179 strains (82%) followed by Klebsiella pneumoniae (5.5%). One hundred and forty five strains (81%) of the isolated E. coli were sensitive to levofloxacin, whereas 32 strains (17.9%) were levofloxacin-resistant. To fosfomycin, the isolated E. coli showed the highest sensitivity (93.9%) among all antimicrobial agents tested. In univariate analysis, factors associated with levofloxacinresistant E. coli included two or more episodes of cystitis within the past year and levofloxacin use at the latest episode of cystitis. Inmultivariate analysis, two or more episodes of cystitis withinthe past year were found to be associated with levofloxacinresistan ce (p=0.004). To prevent the increasing prevalence of infections caused by antibiotic-resistant bacteria, it is important to confirm the sensitivity of the causative agents for optimal antimicrobial therapy. The community-based surveillance data should be collected and considered when selecting empirical antimicrobial agents.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Cistite/tratamento farmacológico
Cistite/microbiologia
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Farmacorresistência Bacteriana
Escherichia coli/isolamento & purificação
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/microbiologia
Feminino
Seres Humanos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE
[do] DOI:10.14989/ActaUrolJap_63_5_189


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[PMID]:28594717
[Au] Autor:Kwaan MR; Fan Y; Jarosek S; Elliott SP
[Ad] Endereço:1Department of Surgery, University of Minnesota, Minneapolis, Minnesota 2Department of Urology, University of Minnesota, Minneapolis, Minnesota.
[Ti] Título:Long-term Risk of Urinary Adverse Events in Curatively Treated Patients With Rectal Cancer: A Population-Based Analysis.
[So] Source:Dis Colon Rectum;60(7):682-690, 2017 Jul.
[Is] ISSN:1530-0358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Treatment modalities for rectal cancer, including radiation, are associated with urinary adverse effects. OBJECTIVE: The purpose of this study was to determine the influence of surgery and radiation therapy for rectal cancer on long-term urinary complications. DESIGN: Using the Surveillance Epidemiology and End Results-Medicare data set from the United States, patients with rectal cancer older than 66 years of age who underwent rectal resection between 1992 and 2007 were stratified into treatment groups that accounted for surgical resection and the timing of radiation therapy, if used. A control group of patients who did not have rectal cancer were matched by age, sex, demographics, and comorbidities. The primary outcome was a urinary adverse event defined as a relevant urinary diagnosis with an associated procedure. Patients with rectal cancer in different treatment groups were compared with control patients using a propensity-adjusted, multivariable Cox regression analysis. SETTINGS: The study was conducted with the Surveillance Epidemiology and End Results-Medicare data set from the United States at our institution. RESULTS: Of the 11,068 patients with rectal cancer, 56.2% had surgical resection alone, 21.7% received preoperative radiation, and 22.1% received postoperative radiation. The median follow-up for all of the groups of patients was >2 years. All of the groups of patients with rectal cancer were more likely to develop a urinary adverse event compared with control subjects. Adjusted HRs were 2.28 (95% CI, 2.02-2.57) for abdominoperineal resection alone, 2.24 (95% CI, 1.79-2.80) for preoperative radiation and surgical resection, 2.04 (95% CI, 1.70-2.44) for surgical resection and postoperative radiation, and 1.69 (95% CI, 1.52-1.89) for low anterior resection alone. LIMITATIONS: Treatment patterns are somewhat outdated, with a large proportion of patients receiving postoperative radiation. The data did not allow for accurate assessment of urinary tract infections or mild urinary retention that is not managed with a procedure. CONCLUSIONS: Rectal cancer surgery with or without radiation is associated with a higher risk of urinary complications requiring procedures. Patients who undergo low anterior resection without radiation tend toward the lowest risk for a urinary adverse event.
[Mh] Termos MeSH primário: Adenocarcinoma/terapia
Procedimentos Cirúrgicos do Sistema Digestório
Terapia Neoadjuvante
Radioterapia Adjuvante
Radioterapia
Neoplasias Retais/terapia
Doenças Urológicas/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Cistite/epidemiologia
Feminino
Seguimentos
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Análise Multivariada
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Programa de SEER
Obstrução Ureteral/epidemiologia
Fístula Urinária/epidemiologia
Incontinência Urinária/epidemiologia
Retenção Urinária/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1097/DCR.0000000000000788


  9 / 6528 MEDLINE  
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[PMID]:28592040
[Au] Autor:Tang FF; Zhang XH; Chen H; Chen YY; Han W; Wang JZ; Wang FR; Chen Y; Huang XJ; Xu LP
[Ad] Endereço:Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
[Ti] Título:[Surgical treatment of severe, refractory hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: a report of 17 patients].
[So] Source:Zhonghua Nei Ke Za Zhi;56(6):414-418, 2017 Jun 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinical effect and safety of surgical treatment for severe, refractory hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients with severe HC, who were admitted to Peking University Institute of Hematology from January 2010 to December 2015, were enrolled in this study.All patients were refractory to medical managements and received bladder surgery including mucous electrocoagulation and/or selective transcatheter arterial embolization. A total of 17 patients with severe HC (grade Ⅲ, =5; grade Ⅳ, =12) received surgical treatment, including 11 embolization and 18 mucous electrocoagulation.The median time from allo-HSCT to surgery was 107 d (46-179 d) and 75 d after HC.Eight patients only received embolization.Four patients only received mucous electrocoagulation.Five patients were given combined embolization and electrocoagulation.HC was cured in 11 patients, improved in 1 patient, which corresponded to a response rate of 70.6% and complete remission rate of 64.7%.Five patients didn't respond to these methods.In patients with response, macroscopic hematuria disappeared 3 to 10 days after treatments whereas microscopic hematuria vanished after 25 to 32 days.Both procedures were well tolerated and no severe adverse effects were observed. Surgery of bladder mucous electrocoagulation and/or selective arterial embolization are safe and effective for severe HC.
[Mh] Termos MeSH primário: Cistite/cirurgia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Hematúria/virologia
[Mh] Termos MeSH secundário: Adulto
Cistite/virologia
Feminino
Hemorragia
Seres Humanos
Masculino
Transplante Homólogo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2017.06.006


  10 / 6528 MEDLINE  
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[PMID]:28591758
[Au] Autor:Schneidewind L; Neumann T; Knoll F; Zimmermann K; Smola S; Schmidt CA; Krüger W
[Ad] Endereço:Institute of Virology, Saarland University Medical Center, Saarland University, Homburg/Saar, Germany.
[Ti] Título:Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?
[So] Source:Acta Haematol;138(1):3-9, 2017.
[Is] ISSN:1421-9662
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. METHODS: We conducted a retrospective study of 64 adult patients who received their first allogeneic stem cell transplantation between March 2010 and December 2014; the follow-up time was 2 years. RESULTS: Acute leukemia was the most frequent underlying disease (45.3%), and conditioning included myeloablative (67.2%) and nonmyeloablative protocols (32.8%). All patients received 10 mg of alemtuzumab on day -2 (20 mg in case of mismatch) as GvHD prophylaxis. Twenty-seven patients (41.5%) developed cytomegalovirus (CMV) reactivation. BKPyV-associated hemorrhagic cystitis was diagnosed in 10 patients (15.6%). Other opportunistic infections caused by viruses or protozoa occurred rarely (<10%). There was no association of BKPyV or JCPyV with CMV reactivation, Epstein-Barr virus reactivation, human herpes virus 6, or parvovirus B19 infection requiring treatment. There was a significant correlation of BKPyV-associated hemorrhagic cystitis with toxoplasmosis (p = 0.013). Additionally, there was a significant link of simultaneous BKPyV and JCPyV viruria with toxoplasmosis (p = 0.047). BKPyV and JCPyV were not associated with GvHD, relapse, or death. CONCLUSION: We found no association of BKPyV or JCPyV with viral infections or GvHD. Only the correlation of both polyomaviruses with toxoplasmosis was significant. This is a novel and interesting finding.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/uso terapêutico
Antineoplásicos/uso terapêutico
Doença Enxerto-Hospedeiro/etiologia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Leucemia/terapia
Infecções Oportunistas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Alemtuzumab
Vírus BK/fisiologia
Cistite/diagnóstico
Cistite/etiologia
Feminino
Seguimentos
Seres Humanos
Vírus JC/fisiologia
Leucemia/complicações
Leucemia/mortalidade
Leucemia Mieloide Aguda/complicações
Leucemia Mieloide Aguda/terapia
Masculino
Meia-Idade
Infecções Oportunistas/complicações
Infecções Oportunistas/patologia
Infecções Oportunistas/virologia
Infecções por Polyomavirus/complicações
Infecções por Polyomavirus/virologia
Estudos Retrospectivos
Toxoplasma/isolamento & purificação
Transplante Homólogo
Infecções Tumorais por Vírus/complicações
Infecções Tumorais por Vírus/virologia
Infecções Urinárias/complicações
Infecções Urinárias/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (Antineoplastic Agents); 3A189DH42V (Alemtuzumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1159/000468972



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