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[PMID]:29394255
[Au] Autor:Hsiao PJ; Lin HC; Chang ST; Hsu JT; Lin WS; Chung CM; Chang JJ; Hung KC; Shih YW; Chen FC; Hu FK; Wu YS; Chang CW; Su SL; Chu CM
[Ad] Endereço:Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
[Ti] Título:Albuminuria and neck circumference are determinate factors of successful accurate estimation of glomerular filtration rate in high cardiovascular risk patients.
[So] Source:PLoS One;13(2):e0185693, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Estimated glomerular filtration rate (eGFR) is used for diagnosis of chronic kidney disease (CKD). The eGFR models based on serum creatinine or cystatin C are used more in clinical practice. Albuminuria and neck circumference are associated with CKD and may have correlations with eGFR. AIM: We explored the correlations and modelling formulates among various indicators such as serum creatinine, cystatin C, albuminuria, and neck circumference for eGFR. DESIGN: Cross-sectional study. METHODS: We reviewed the records of patients with high cardiovascular risk from 2010 to 2011 in Taiwan. 24-hour urine creatinine clearance was used as the standard. We utilized a decision tree to select for variables and adopted a stepwise regression method to generate five models. Model 1 was based on only serum creatinine and was adjusted for age and gender. Model 2 added serum cystatin C, models 3 and 4 added albuminuria and neck circumference, respectively. Model 5 simultaneously added both albuminuria and neck circumference. RESULTS: Total 177 patients were recruited in this study. In model 1, the bias was 2.01 and its precision was 14.04. In model 2, the bias was reduced to 1.86 with a precision of 13.48. The bias of model 3 was 1.49 with a precision of 12.89, and the bias for model 4 was 1.74 with a precision of 12.97. In model 5, the bias could be lower to 1.40 with a precision of 12.53. CONCLUSIONS: In this study, the predicting ability of eGFR was improved after the addition of serum cystatin C compared to serum creatinine alone. The bias was more significantly reduced by the calculation of albuminuria. Furthermore, the model generated by combined albuminuria and neck circumference could provide the best eGFR predictions among these five eGFR models. Neck circumference can be investigated potentially in the further studies.
[Mh] Termos MeSH primário: Albuminúria/fisiopatologia
Antropometria
Doenças Cardiovasculares/epidemiologia
Taxa de Filtração Glomerular
Pescoço/anatomia & histologia
[Mh] Termos MeSH secundário: Idoso
Doenças Cardiovasculares/diagnóstico
Creatinina/sangue
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185693


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[PMID]:27776839
[Au] Autor:Haley WE; Enders FT; Vaughan LE; Mehta RA; Thoman ME; Vrtiska TJ; Krambeck AE; Lieske JC; Rule AD
[Ad] Endereço:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
[Ti] Título:Kidney Function After the First Kidney Stone Event.
[So] Source:Mayo Clin Proc;91(12):1744-1752, 2016 Dec.
[Is] ISSN:1942-5546
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether there is a persistent decline in kidney function after the first kidney stone event. PATIENT AND METHODS: Incident symptomatic stone formers and age- and sex-matched controls underwent 2 study visits 90 days apart to assess kidney function, complete a survey, and have their medical records reviewed. Kidney function was compared between stone formers and controls adjusting for clinical, blood, and urine risk factors. RESULTS: There were 384 stone formers and 457 controls. At visit 1, a median of 104 days after the stone event, stone formers compared with controls had similar serum creatinine (0.86 vs 0.84 mg/dL; P=.23), higher serum cystatin C (0.83 vs 0.72 mg/L; P<.001), higher urine protein (34.2 vs 19.7 mg/24 h; P<.001) levels, and were more likely to have albuminuria (24 h urine albumin >30 mg: 5.4% vs 2.2%; P=.02). Findings were similar after adjustment for risk factors and at visit 2, a median of 92 days after visit 1. In the 173 stone formers with serum creatinine levels from care before study participation, the mean serum creatinine level was 0.84 mg/dL before the stone event, increased to 0.97 mg/dL (P<.001) at the stone event, but returned to 0.85 mg/dL (P=.38) after the stone event (visit 1). CONCLUSIONS: Incident symptomatic stone formers have a rise in serum creatinine levels that resolves. However, stone formers have sustained higher cystatin C levels and proteinuria that may affect long-term risk of chronic kidney disease.
[Mh] Termos MeSH primário: Cálculos Renais/metabolismo
Cálculos Renais/fisiopatologia
Rim/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Albuminúria/metabolismo
Estudos de Casos e Controles
Creatinina/sangue
Cistatina C/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cystatin C); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


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[PMID]:28450414
[Au] Autor:Bohlouli B; Jackson TJ; Tonelli M; Hemmelgarn B; Klarenbach S
[Ad] Endereço:Department of Medicine, University of Alberta, Edmonton, Alberta.
[Ti] Título:Adverse Outcomes Associated with Preventable Complications in Hospitalized Patients with CKD.
[So] Source:Clin J Am Soc Nephrol;12(5):799-806, 2017 May 08.
[Is] ISSN:1555-905X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with CKD are at risk of hospital-acquired complications (HACs). We sought to determine the association of preventable HACs with mortality, length of stay (LOS), and readmission. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All adults hospitalized from April of 2003 to March of 2008 in Alberta were characterized by kidney function and occurrence of preventable HACs. CKD was defined by eGFR<60 ml/min per 1.73 m and/or albumin-to-creatinine ratio >3-30 mg/mmol for >3 months in the time frame from 365 to 90 days before admission. Regression models examined the association of HACs with outcomes. RESULTS: Of 536,549 hospitalizations, 8.5% ( =45,733) had CKD and 9.8% of patients with CKD had one or more potentially preventable HAC. In patients with potentially preventable HACs, proportions of death within index hospitalization and from discharge to 90 days were 17.7% and 6.8%, respectively. In patients with CKD, comparing with those hospitalizations without potentially preventable HACs, the adjusted odds ratio (OR) of mortality during index hospitalization and from hospital discharge to 90 days in patients with one or more preventable HAC was 4.67 (95% confidence interval [95% CI], 4.17 to 5.22) and 1.08 (95% CI, 0.94 to 1.25), respectively. Median incremental LOS in patients with one or more preventable HAC was 9.86 days (95% CI, 9.25 to 10.48). The OR for readmission with preventable HAC was 1.24 (95% CI, 1.15 to 1.34). In a cohort with and without CKD, the adjusted ORs of mortality during index hospitalization in patients with CKD and no preventable HACs, patients without CKD and with preventable HACs, and patients with CKD and preventable HACs were 2.22 (95% CI, 1.69 to 2.94), 5.26 (95% CI, 4.98 to 5.55), and 9.56 (95% CI, 7.23 to 12.56), respectively (referenced to patients without CKD or preventable HACs). CONCLUSIONS: Preventable HACs are associated with higher mortality, incremental LOS, and greater risk of readmission, especially in people with CKD. Targeted strategies to reduce complications should be a high priority.
[Mh] Termos MeSH primário: Doença Iatrogênica
Admissão do Paciente
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Alberta
Albuminúria/etiologia
Biomarcadores/urina
Creatinina/urina
Feminino
Taxa de Filtração Glomerular
Mortalidade Hospitalar
Seres Humanos
Doença Iatrogênica/prevenção & controle
Rim/fisiopatologia
Tempo de Internação
Masculino
Meia-Idade
Readmissão do Paciente
Serviços Preventivos de Saúde
Insuficiência Renal Crônica/diagnóstico
Insuficiência Renal Crônica/mortalidade
Insuficiência Renal Crônica/terapia
Medição de Risco
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.2215/CJN.09410916


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[PMID]:29254317
[Au] Autor:Wang J; Ren LJ; Chen XL; Ma L; Chen BJ; Ran SJ; Lu S
[Ad] Endereço:Department of General Surgery, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
[Ti] Título:Quick rehabilitation nursing improves the recovery of colon cancer patients after laparoscopy.
[So] Source:J Biol Regul Homeost Agents;31(4):1073-1079, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Colon cancer is a common malignant tumor with particularly high morbidity and mortality. The aim of this study was to compare the effect of quick rehabilitation nursing and routine nursing in postoperative recovery of patients with colon cancer after laparoscopic surgery. Two hundred forty patients with colon cancer were classified into four random groups (A, B, C and D, with 60 patients in each group). All patients underwent surgery to remove the colon tumor by laparoscopy under general anesthesia. Patients in groups A and B received quick rehabilitation nursing for post-surgery recovery. In group C patients, local anesthesia associated with quick rehabilitation nursing for post-surgery recovery was used. Group D was used as control group and the patients were treated based on routine nursing. Time to get out of bed, first bowel movement time and the average time of hospitalisation in group A was lower than group D (p less than 0.05), postoperative leukocyte level as well as the occurrence rate of nausea and vomiting, ankylenteron and pelvic adhesion was decreased in group A compared to group D (p less than 0.05), but the postoperative albumin and total protein level was higher than group D (p less than 0.05). The serum level of C-Reactive Protein (CRP) and interleukin 6 (IL-6) in group A was decreased compared to group D several days after surgery (p less than 0.05); group B had 4 cases of intestinal obstruction after surgery that could be cured through conservative treatment, while group D had 10 cases of intestinal obstruction, 8 of which could be cured through conservative treatment and two needed surgery (p less than 0.05); VAS for pain degree of group C in active state was clearly lower at 1h, 5h, 7h, 15h, 30h and 42h after surgery, and side effects of postoperative analgesia were clearly reduced. Time to get out of bed was obviously decreased, while there was no evident effect on postoperative dosage, chronic pain and complications. Adopting quick rehabilitation nursing can effectively reduce occurrence of complications and postoperative pain, speed up the recovery of gastrointestinal function, shorten the length of stay, and improve patients’ satisfaction.
[Mh] Termos MeSH primário: Neoplasias do Colo/reabilitação
Obstrução Intestinal/diagnóstico
Laparoscopia/reabilitação
Dor Pós-Operatória/prevenção & controle
Náusea e Vômito Pós-Operatório/prevenção & controle
Enfermagem em Reabilitação/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Albuminúria/sangue
Albuminúria/diagnóstico
Albuminúria/fisiopatologia
Anestesia Geral/métodos
Anestesia Local/métodos
Proteína C-Reativa/metabolismo
Neoplasias do Colo/sangue
Neoplasias do Colo/patologia
Neoplasias do Colo/cirurgia
Feminino
Seres Humanos
Interleucina-6/sangue
Obstrução Intestinal/sangue
Obstrução Intestinal/patologia
Obstrução Intestinal/cirurgia
Tempo de Internação
Masculino
Meia-Idade
Dor Pós-Operatória/sangue
Dor Pós-Operatória/diagnóstico
Dor Pós-Operatória/fisiopatologia
Satisfação do Paciente/estatística & dados numéricos
Náusea e Vômito Pós-Operatório/sangue
Náusea e Vômito Pós-Operatório/diagnóstico
Náusea e Vômito Pós-Operatório/fisiopatologia
Período Pós-Operatório
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL6 protein, human); 0 (Interleukin-6); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29182834
[Au] Autor:Tsuruya K
[Ti] Título:[Cerebrovascular disease in chronic kidney disease.]
[So] Source:Nihon Naika Gakkai Zasshi;105(5):825-833, 2016 May.
[Is] ISSN:0021-5384
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Transtornos Cerebrovasculares/complicações
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Albuminúria/complicações
Seres Humanos
Hiperlipidemias/complicações
Prognóstico
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29182831
[Au] Autor:Tamura K
[Ti] Título:[Pathophysiology of atherosclerosis in chronic kidney disease.]
[So] Source:Nihon Naika Gakkai Zasshi;105(5):802-810, 2016 May.
[Is] ISSN:0021-5384
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Aterosclerose/fisiopatologia
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Albuminúria/complicações
Aterosclerose/complicações
Células Endoteliais
Seres Humanos
Estresse Oxidativo
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29317203
[Au] Autor:Liu T; Duan W; Nizigiyimana P; Gao L; Liao Z; Xu B; Liu L; Lei M
[Ad] Endereço:Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Department of Endocrinology, Haikou People's Hospital, Haikou, Hainan, 570208, China.
[Ti] Título:Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress.
[So] Source:Biochem Biophys Res Commun;496(2):394-400, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Diabetic nephropathy is a common complication of diabetes, but there are currently few treatment options. The aim of this study was to gain insight into the effect of alpha-mangostin on diabetic nephropathy and possible related mechanisms. METHODS: Goto-Kakizaki rats were used as a diabetic model and received alpha-mangostin or desipramine treatment with normal saline as a control. Ten age-matched Sprague Dawley rats were used as normal controls and treated with normal saline. At week 12, blood glucose, albuminuria, apoptosis and renal pathologic changes were assessed. Protein levels for acid sphingomyelinase, glucose-regulated protein 78, phosphorylated PKR-like ER-resident kinase, activated transcription factor 4, CCAAT/enhancer-binding protein, homologous protein), and cleaved-caspase12 were measured. RESULTS: The level of acid sphingomyelinase was significantly increased, and ER stress was activated in diabetic rat kidneys when compared to the control animals. When acid sphingomyelinase was inhibited by alpha-mangostin, the expression of ER stress-related proteins was down-regulated in association with decreased levels of diabetic kidney injury. CONCLUSIONS: Alpha-mangostin, an acid sphingomyelinase inhibitor plays a protective role in diabetic neuropathy by relieving ER stress induced-renal cell apoptosis.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Nefropatias Diabéticas/tratamento farmacológico
Inibidores Enzimáticos/farmacologia
Substâncias Protetoras/farmacologia
Esfingomielina Fosfodiesterase/antagonistas & inibidores
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Fator 4 Ativador da Transcrição/genética
Fator 4 Ativador da Transcrição/metabolismo
Albuminúria/genética
Albuminúria/metabolismo
Albuminúria/patologia
Albuminúria/prevenção & controle
Animais
Apoptose/efeitos dos fármacos
Glicemia/metabolismo
Caspase 12/genética
Caspase 12/metabolismo
Desipramina/farmacologia
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/genética
Diabetes Mellitus Experimental/patologia
Nefropatias Diabéticas/induzido quimicamente
Nefropatias Diabéticas/genética
Nefropatias Diabéticas/patologia
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Regulação da Expressão Gênica
Proteínas de Choque Térmico/genética
Proteínas de Choque Térmico/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Masculino
Ratos
Ratos Sprague-Dawley
Esfingomielina Fosfodiesterase/genética
Esfingomielina Fosfodiesterase/metabolismo
Estreptozocina
eIF-2 Quinase/genética
eIF-2 Quinase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Atf4 protein, rat); 0 (Blood Glucose); 0 (Enzyme Inhibitors); 0 (Heat-Shock Proteins); 0 (Hspa5 protein, rat); 0 (Protective Agents); 0 (Xanthones); 145891-90-3 (Activating Transcription Factor 4); 5W494URQ81 (Streptozocin); EC 2.7.11.1 (PERK kinase); EC 2.7.11.1 (eIF-2 Kinase); EC 3.1.4.- (acid sphingomyelinase-1); EC 3.1.4.12 (Sphingomyelin Phosphodiesterase); EC 3.4.22.- (Casp12 protein, rat); EC 3.4.22.- (Caspase 12); TG537D343B (Desipramine); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:28466968
[Au] Autor:Geard A; Pule GD; Chetcha Chemegni B; Ngo Bitoungui VJ; Kengne AP; Chimusa ER; Wonkam A
[Ad] Endereço:Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
[Ti] Título:Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon.
[So] Source:Br J Haematol;178(4):629-639, 2017 08.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Micro-albuminuria and glomerular hyperfiltration are primary indicators of renal dysfunctions in Sickle Cell Disease (SCD), with more severe manifestations previously associated with variants in APOL1 and HMOX1 among African Americans. We have investigated 413 SCD patients from Cameroon. Anthropometric variables, haematological indices, crude albuminuria, albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. Patients were genotyped for 3·7 kb alpha-globin gene (HBA1/HBA2) deletion, and for variants in APOL1 (G1/G2; rs60910145, rs73885319, rs71785313) and HMOX1 (rs3074372, rs743811). The median age was 15 years; the majority presented with micro-albuminuria (60·9%; n = 248), and approximately half with glomerular hyperfiltration (49·5%; n = 200). Age, male sex, haemoglobin level, leucocyte count, mean corpuscular volume, blood pressure, body mass index and creatinine levels significantly affected albuminuria and/or eGFR. Co-inheritance of alpha-thalassaemia was protective against macro-albuminuria (P = 0·03). APOL1 G1/G2 risk variants were significantly associated with the ACR (P = 0·01) and borderline with eGFR (P = 0·07). HMOX1 - rs743811 was borderline associated with micro-albuminuria (P = 0·07) and macro-albuminuria (P = 0·06). The results revealed a high proportion of micro-albuminuria and glomerular hyperfiltration among Cameroonian SCD patients, and support the possible use of targeted genetic biomarkers for risks assessment.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Insuficiência Renal/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Albuminúria/epidemiologia
Albuminúria/etiologia
Albuminúria/genética
Anemia Falciforme/epidemiologia
Anemia Falciforme/genética
Antropometria/métodos
Apolipoproteína L1
Apolipoproteínas/genética
Camarões/epidemiologia
Criança
Pré-Escolar
Feminino
Deleção de Genes
Predisposição Genética para Doença
Variação Genética
Taxa de Filtração Glomerular/genética
Hemoglobina A Glicada/genética
Heme Oxigenase-1/genética
Seres Humanos
Lipoproteínas HDL/genética
Masculino
Meia-Idade
Estudos Prospectivos
Insuficiência Renal/epidemiologia
Insuficiência Renal/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (APOL1 protein, human); 0 (Apolipoprotein L1); 0 (Apolipoproteins); 0 (Glycated Hemoglobin A); 0 (Lipoproteins, HDL); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14724


  9 / 13197 MEDLINE  
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[PMID]:29227600
[Au] Autor:Sahu A; Gupta T; Kavishwar A; Singh RK
[Ti] Título:Cardiovascular disease among patients with type 2 diabetes: Role of Homocysteine as an inflammatory marker.
[So] Source:Ukr Biochem J;88(2):35-44, 2016 Mar-Apr.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:It is known that inflammation has a role in the pathogenesis of cardiovascular diseases; measurement of inflammatory markers improves the risk prediction of cardiovascular diseases. Hyperhomocysteinemia has been correlated with the occurrence of blood clots, heart attacks and strokes; though it is unclear whether hyperhomocysteinemia is an independent risk factor for these conditions. In the present study, we aimed to evaluate the role of homocysteine in type 2 diabetes patients with cardiovascular disease in a population of Madhya Pradesh India. Total 100 type 2 diabetes patients were included in the study, of these 50 had angiographically proven cardiovascular disease and 50 had no evidence of it. High sensitivity C-reactive protein, fibrinogen, and lipoprotein (a) were measured in serum. Homocysteine, blood glucose in plasma, erythrocyte sedimentation rate, glycated haemoglobin were measured in whole blood. A albumin excretion rate, creatinine clearance rate were measured in the urine sample for renal function. It was shown that, levels of homocysteine and other inflammatory markers were elevated significantly in the group II (n = 50). A correlation between hyperhomocysteinemia and inflammatory markers in patients with impaired renal function was observed. It was concluded that impairment of renal function is a key factor that affects homocysteine level.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Doenças Cardiovasculares/sangue
Diabetes Mellitus Tipo 2/sangue
Homocisteína/sangue
Hiper-Homocisteinemia/sangue
[Mh] Termos MeSH secundário: Adulto
Albuminúria/urina
Angiografia
Biomarcadores/sangue
Sedimentação Sanguínea
Proteína C-Reativa/metabolismo
Doenças Cardiovasculares/complicações
Doenças Cardiovasculares/diagnóstico por imagem
Estudos de Casos e Controles
Creatinina/urina
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/diagnóstico por imagem
Feminino
Fibrinogênio/metabolismo
Hemoglobina A Glicada/metabolismo
Seres Humanos
Hiper-Homocisteinemia/complicações
Hiper-Homocisteinemia/diagnóstico por imagem
Testes de Função Renal
Lipoproteína(a)/sangue
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Lipoprotein(a)); 0 (hemoglobin A1c protein, human); 0LVT1QZ0BA (Homocysteine); 9001-32-5 (Fibrinogen); 9007-41-4 (C-Reactive Protein); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.02.035


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[PMID]:29261715
[Au] Autor:Park JB; Kim SA; Sung KC; Kim JY
[Ad] Endereço:JB lab and clinic, Seoul, South Korea.
[Ti] Título:Gender-specific differences in the incidence of microalbuminuria in metabolic syndrome patients after treatment with fimasartan: The K-MetS study.
[So] Source:PLoS One;12(12):e0189342, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The effect of resolving metabolic syndrome on target organ damage in hypertensive patients is not well described. We evaluated whether treating metabolic syndrome (MetS) with an angiotensin receptor blocker subsequently reduced microalbuminuria in the K-MetS cohort. METHODS: Among 10,601 total metabolic syndrome patients, 3,250 (52.2% male, 56.2±10.0 years) with sufficient data on five specific metabolic components were included in this study. Patients were divided into four groups based on MetS status at baseline and 3 months. All patients received an angiotensin receptor blocker, fimasartan, for these 3 months; thereafter, treatment was modified at the discretion of each patient's physician. Microalbuminuria and the albumin/creatine ratio were evaluated as a proxy of organ damage. RESULTS: Blood pressure and waist circumference decreased from baseline to 3 months and 1 year. The average albumin/creatinine ratio significantly improved during the first three months of the study from 36.0±147.4 to 21.0±74.9 mg/g (p<0.05) and was persistently high in patients with MetS at baseline and 3 months versus other groups. Women in comparison with men showed significantly lower ACR among patients with newly developed MetS at 3-month. CONCLUSIONS: Treatment of hypertensive patients for one year with the angiotensin receptor blocker fimasartan significantly reduced the albumin/creatine ratio, irrespective of whether the patient had MetS; however, the albumin/creatinine ratio was significantly higher in patents with persistent or newly developed MetS compared to patients without MetS. Additionally, these findings were more prominent in women than in men.
[Mh] Termos MeSH primário: Albuminúria/tratamento farmacológico
Albuminúria/epidemiologia
Compostos de Bifenilo/uso terapêutico
Síndrome Metabólica/tratamento farmacológico
Síndrome Metabólica/epidemiologia
Pirimidinas/uso terapêutico
Caracteres Sexuais
Tetrazóis/uso terapêutico
[Mh] Termos MeSH secundário: Albuminas/metabolismo
Albuminúria/fisiopatologia
Pressão Sanguínea
Creatinina/metabolismo
Feminino
Seres Humanos
Incidência
Masculino
Síndrome Metabólica/fisiopatologia
Meia-Idade
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Biphenyl Compounds); 0 (Pyrimidines); 0 (Tetrazoles); AYI8EX34EU (Creatinine); P58222188P (fimasartan)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189342



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