Base de dados : MEDLINE
Pesquisa : C13.351.500 [Categoria DeCS]
Referências encontradas : 14623 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1463 ir para página                         

  1 / 14623 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27779566
[Au] Autor:Lai JC; Chen HH; Chu KH; Wang KL; Huang N; Hu HY; Chou YJ
[Ad] Endereço:1Institute of Public Health and Department of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan 2Department of Nursing, Ching Kuo Institute of Management and Health, Keelung, Taiwan 3Department of Nursing, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan 4Department of Obstetrics and Gynecology, Taitung Mackay Memorial Hospital, Taitung, Taiwan 5Department of Obstetrics and Gynecology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan 6Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan 7Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.
[Ti] Título:In-hospital complications of bilateral salpingo-oophorectomy at benign hysterectomy: a population-based cohort study.
[So] Source:Menopause;24(2):187-195, 2017 Feb.
[Is] ISSN:1530-0374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The study compared the in-hospital complications and related outcomes between women who underwent bilateral salpingo-oophorectomy at hysterectomy for benign diseases and those who had hysterectomy only. METHODS: We conducted a population-based, retrospective cohort study using data from Taiwan's National Health Insurance program. Women who underwent concurrent bilateral salpingo-oophorectomy at hysterectomy for benign indications (n = 34,509) were compared with those who had hysterectomy only (n = 176,305). Separate models were estimated to account for the effect of baseline comorbid condition, age, and hysterectomy approach on the relationship between bilateral salpingo-oophorectomy and study outcomes. A secondary analysis was also performed to evaluate the association of inpatient readmission within 30 days and complications among women who underwent bilateral salpingo-oophorectomy. RESULTS: The addition of a bilateral salpingo-oophorectomy to hysterectomy was associated with a lower risk of surgical complications, a longer length of hospital stay, and an increased risk of inpatient readmission within 30 days. Among women who underwent bilateral salpingo-oophorectomy, women with complications were also more likely to require inpatient readmission within 30 days than those without complications. Our data also suggested that bilateral salpingo-oophorectomy was not associated with an overall risk of medical complications, with the exception of urethral obstruction. The relationships remained even after adjustments by age, surgical indications, hysterectomy approach, and health-related risk factors, such as baseline comorbid condition and status of any prior catastrophic illness. CONCLUSIONS: Bilateral salpingo-oophorectomy at hysterectomy for benign conditions is not associated with an increased risk of in-hospital complications.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/cirurgia
Hospitalização/estatística & dados numéricos
Histerectomia/efeitos adversos
Complicações Pós-Operatórias/epidemiologia
Salpingo-Ooforectomía/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Terapia Combinada
Feminino
Seres Humanos
Histerectomia/métodos
Meia-Idade
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
Fatores de Risco
Salpingo-Ooforectomía/métodos
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1097/GME.0000000000000746


  2 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29406058
[Au] Autor:Yura E; Flury S
[Ad] Endereço:Department of Urology, Northwestern University, Tarry Building Room 16-703, 300 East Superior Street, Chicago, IL 60611, USA.
[Ti] Título:Cutaneous Lesions of the External Genitalia.
[So] Source:Med Clin North Am;102(2):279-300, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals with cutaneous diseases of the external genitalia often initially present to their primary care provider. When present, these conditions may be associated with considerable physical symptoms and psychological distress. Dermatoses affecting the genitals may be of infectious, inflammatory, or neoplastic cause, and can be processes confined to the genitalia or a manifestation of a more widespread dermatologic condition. This article provides a guide to recognizing and managing common genital dermatoses and when to refer for specialist opinion.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/diagnóstico
Doenças dos Genitais Masculinos/diagnóstico
Genitália/patologia
Dermatopatias/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Doenças dos Genitais Femininos/etiologia
Doenças dos Genitais Masculinos/etiologia
Seres Humanos
Masculino
Pênis/patologia
Escroto/patologia
Dermatopatias/etiologia
Vulva/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  3 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29215524
[Au] Autor:Wong JMK; Bortoletto P; Tolentino J; Jung MJ; Milad MP
[Ad] Endereço:Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and the Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.
[Ti] Título:Urinary Tract Injury in Gynecologic Laparoscopy for Benign Indication: A Systematic Review.
[So] Source:Obstet Gynecol;131(1):100-108, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To perform a comprehensive literature review of the incidence, location, etiology, timing, management, and long-term sequelae of urinary tract injury in gynecologic laparoscopy for benign indication. DATA SOURCES: A systematic review of PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov was conducted. METHODS OF STUDY SELECTION: Four hundred thirty-three studies were screened for inclusion with 136 full-text articles reviewed. Ninety studies published between 1975 and 2015 met inclusion criteria, representing 140,444 surgeries. Articles reporting the incidence of urinary tract injury in gynecologic laparoscopy for benign indication were included. Exclusion criteria comprised malignancy, surgery by urogynecologists, research not in English, and insufficient data. TABULATION, INTEGRATION, AND RESULTS: A total of 458 lower urinary tract injuries were reported with an incidence of 0.33% (95% CI 0.30-0.36). Bladder injury (0.24%, 95% CI 0.22-0.27) was overall three times more frequent than ureteral injury (0.08%, 95% CI 0.07-0.10). Laparoscopic hysterectomy not otherwise specified (1.8%, 95% CI 1.2-2.6) and laparoscopically assisted vaginal hysterectomy (1.0%, 95% CI 0.9-1.2) had the highest rates of injury. Most ureteral injuries resulted from electrosurgery (33.3%, 95% CI 24.3-45.8), whereas most bladder injuries resulted from lysis of adhesions (23.3%, 95% CI 18.7-29.0). Ureteral injuries were most often recognized postoperatively (60%, 95% CI 47-76) and were repaired by open ureteral anastomosis (47.4%, 95% CI 36.3-61.9). In contrast, bladder injuries were most often recognized intraoperatively (85%, 95% CI 75-95) and were repaired by laparoscopic suturing (34.9%, 95% CI 29.2-41.7). CONCLUSION: The incidence of lower urinary tract injury in gynecologic laparoscopy for benign indication remains low at 0.33%. Bladder injury was three times more common than ureteral injury, although ureteral injuries were more often unrecognized intraoperatively and underwent open surgical repair. These risk estimates can assist gynecologic surgeons in effectively counseling their patients preoperatively concerning the risks of lower urinary tract injury.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/patologia
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos
Doença Iatrogênica
Complicações Intraoperatórias/epidemiologia
Laparoscopia/efeitos adversos
Sistema Urinário/lesões
[Mh] Termos MeSH secundário: Feminino
Doenças dos Genitais Femininos/cirurgia
Procedimentos Cirúrgicos em Ginecologia/métodos
Seres Humanos
Incidência
Complicações Intraoperatórias/fisiopatologia
Laparoscopia/métodos
Medição de Risco
Sistema Urinário/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002414


  4 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29074629
[Au] Autor:Kalliala I; Markozannes G; Gunter MJ; Paraskevaidis E; Gabra H; Mitra A; Terzidou V; Bennett P; Martin-Hirsch P; Tsilidis KK; Kyrgiou M
[Ad] Endereço:Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London W12 0NN, UK.
[Ti] Título:Obesity and gynaecological and obstetric conditions: umbrella review of the literature.
[So] Source:BMJ;359:j4511, 2017 Oct 26.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To study the strength and validity of associations between adiposity and risk of any type of obstetric or gynaecological conditions. An umbrella review of meta-analyses. PubMed, Cochrane database of systematic reviews, manual screening of references for systematic reviews or meta-analyses of observational and interventional studies evaluating the association between adiposity and risk of any obstetrical or gynaecological outcome. Meta-analyses of cohort studies on associations between indices of adiposity and obstetric and gynaecological outcomes. Evidence from observational studies was graded into strong, highly suggestive, suggestive, or weak based on the significance of the random effects summary estimate and the largest study in the included meta-analysis, the number of cases, heterogeneity between studies, 95% prediction intervals, small study effects, excess significance bias, and sensitivity analysis with credibility ceilings. Interventional meta-analyses were assessed separately. 156 meta-analyses of observational studies were included, investigating associations between adiposity and risk of 84 obstetric or gynaecological outcomes. Of the 144 meta-analyses that included cohort studies, only 11 (8%) had strong evidence for eight outcomes: adiposity was associated with a higher risk of endometrial cancer, ovarian cancer, antenatal depression, total and emergency caesarean section, pre-eclampsia, fetal macrosomia, and low Apgar score. The summary effect estimates ranged from 1.21 (95% confidence interval 1.13 to 1.29) for an association between a 0.1 unit increase in waist to hip ratio and risk endometrial cancer up to 4.14 (3.61 to 4.75) for risk of pre-eclampsia for BMI >35 compared with <25. Only three out of these eight outcomes were also assessed in meta-analyses of trials evaluating weight loss interventions. These interventions significantly reduced the risk of caesarean section and pre-eclampsia, whereas there was no evidence of association with fetal macrosomia. Although the associations between adiposity and obstetric and gynaecological outcomes have been extensively studied, only a minority were considered strong and without hints of bias.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/complicações
Obesidade/complicações
Complicações na Gravidez
[Mh] Termos MeSH secundário: Índice de Apgar
Cesárea
Depressão/complicações
Neoplasias do Endométrio/complicações
Feminino
Macrossomia Fetal/complicações
Seres Humanos
Neoplasias Ovarianas/complicações
Pré-Eclâmpsia
Gravidez
Complicações na Gravidez/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4511


  5 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29065798
[Au] Autor:Young AN; Moyle-Heyrman G; Kim JJ; Burdette JE
[Ad] Endereço:1 College of Pharmacy, University of Illinois, Chicago, IL 60607, USA.
[Ti] Título:Microphysiologic systems in female reproductive biology.
[So] Source:Exp Biol Med (Maywood);242(17):1690-1700, 2017 Nov.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a tissue-tissue interface or physical forces like fluid sheer stress. The female reproductive system is a series of interconnected organs that are necessary to produce eggs, support embryo development and female health, and impact the functioning of non-reproductive tissues throughout the body. Despite its importance, the human reproductive tract has received less attention than other organ systems, such as the liver and kidney, in terms of modeling with MPS. In this review, we discuss current gaps in the field and areas for technological advancement through the application of MPS. We explore current MPS research in female reproductive biology, including fertilization, pregnancy, and female reproductive tract diseases, with a focus on their clinical applications. Impact statement This review discusses existing microphysiologic systems technology that may be applied to study of the female reproductive tract, and those currently in development to specifically investigate gametes, fertilization, embryo development, pregnancy, and diseases of the female reproductive tract. We focus on the clinical applicability of these new technologies in fields such as assisted reproductive technologies, drug testing, disease diagnostics, and personalized medicine.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário/fisiologia
Doenças dos Genitais Femininos/patologia
Genitália Feminina/fisiopatologia
Microfluídica/métodos
[Mh] Termos MeSH secundário: Técnicas de Cultura de Células
Feminino
Seres Humanos
Gravidez
Técnicas de Reprodução Assistida
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217697386


  6 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28968732
[Au] Autor:Ishido T; Horita N; Takeuchi M; Kawagoe T; Shibuya E; Yamane T; Hayashi T; Meguro A; Ishido M; Minegishi K; Yoshimi R; Kirino Y; Kato S; Arimoto J; Ishigatsubo Y; Takeno M; Kurosawa M; Kaneko T; Mizuki N
[Ad] Endereço:Department of Ophthalmology and Visual Science.
[Ti] Título:Clinical manifestations of Behçet's disease depending on sex and age: results from Japanese nationwide registration.
[So] Source:Rheumatology (Oxford);56(11):1918-1927, 2017 Nov 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: This report aimed to scrutinize the prevalence of Behçet's disease (BD)-related clinical manifestations based on age- and sex-specific subgroups using a Japanese nationwide registration database. Methods: The database of newly registered BD was obtained from the Japanese Ministry of Health, Labour and Welfare. Patients who met the International Criteria for Behçet's Disease were selected and analysed. Results: Among 6627 International Criteria for Behçet's Disease cases, 2651 (40.0%) were men and 3976 (60.0%) were women with a median age of 39 years (interquartile range: 31-50 years). Ocular lesion was more common in male [odds ratio (male: female) 2.64 (95% CI: 2.35, 2.95, P < 0.001)] and genital ulceration was more common in female (odds ratio = 0.29, 95% CI: 0.25, 0.32, P < 0.001). Ocular lesion (P < 0.001), arthritis (P < 0.001) and vascular lesions (P < 0.001) were more frequently observed in elderly registered patients. Contrarily, genital ulceration (P < 0.001), epididymitis of males (P = 0.023) and oral ulceration (P = 0.003) were more common in younger patients. Simultaneous assessment of sex and age revealed that male predominance of ocular involvement was found in the young adult generation, but not in patients over 70 year of age. A female predominance of genital ulcer was prominently observed in patients 20-59 year of age; however, the sex difference was not found in patients over 60 years of age. Sensitivity analysis using International Study Group criteria replicated the results. Conclusion: We showed that clinical phenotype in early phase of BD was different depending on onset age and sex.
[Mh] Termos MeSH primário: Síndrome de Behçet/fisiopatologia
Sistema de Registros
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Artrite/etiologia
Artrite/fisiopatologia
Síndrome de Behçet/complicações
Síndrome de Behçet/genética
Criança
Bases de Dados Factuais
Epididimite/etiologia
Epididimite/fisiopatologia
Oftalmopatias/etiologia
Oftalmopatias/fisiopatologia
Feminino
Gastroenteropatias/etiologia
Gastroenteropatias/fisiopatologia
Doenças dos Genitais Femininos/etiologia
Doenças dos Genitais Femininos/fisiopatologia
Doenças dos Genitais Masculinos/etiologia
Doenças dos Genitais Masculinos/fisiopatologia
Antígeno HLA-B51/genética
Seres Humanos
Japão
Masculino
Meia-Idade
Doenças do Sistema Nervoso/etiologia
Doenças do Sistema Nervoso/fisiopatologia
Razão de Chances
Úlceras Orais/etiologia
Úlceras Orais/fisiopatologia
Fenótipo
Fatores Sexuais
Úlcera Cutânea/etiologia
Úlcera Cutânea/fisiopatologia
Doenças Vasculares/etiologia
Doenças Vasculares/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-B51 Antigen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex285


  7 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28802473
[Au] Autor:Chiaramonte D; Ring M; Locke AB
[Ad] Endereço:Department of Family and Community Medicine, Center for Integrative Medicine, University of Maryland School of Medicine, 520 West Lombard Street, East Hall, Baltimore, MD 21201, USA; Department of Epidemiology and Public Health, Center for Integrative Medicine, University of Maryland School of Medicine, 520 West Lombard Street, East Hall, Baltimore, MD 21201, USA. Electronic address: dchiaramonte@som.umaryland.edu.
[Ti] Título:Integrative Women's Health.
[So] Source:Med Clin North Am;101(5):955-975, 2017 Sep.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article addresses the common women's health concerns of menopause-related symptoms, premenstrual syndrome, and chronic pelvic pain. Each can be effectively addressed with an integrative approach that incorporates interventions such as pharmaceuticals, nutraceuticals, mind-body approaches, acupuncture, and lifestyle modification.
[Mh] Termos MeSH primário: Terapias Complementares/métodos
Doenças dos Genitais Femininos/terapia
Medicina Integrativa/métodos
Menopausa
Síndrome Pré-Menstrual/terapia
[Mh] Termos MeSH secundário: Peso Corporal
Doença Crônica
Cistite Intersticial/terapia
Dieta
Terapia de Reposição de Estrogênios/métodos
Feminino
Comportamentos Relacionados com a Saúde
Seres Humanos
Estilo de Vida
Terapias Mente-Corpo/métodos
Dor Pélvica/terapia
Fitoterapia/métodos
Transtorno Disfórico Pré-Menstrual/terapia
Vulvodinia/terapia
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


  8 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28739831
[Au] Autor:Naglak EK; Morrison SG; Morrison RP
[Ad] Endereço:Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
[Ti] Título:Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia.
[So] Source:Infect Immun;85(10), 2017 Oct.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Determining the effector populations involved in humoral protection against genital chlamydia infection is crucial to development of an effective chlamydial vaccine. Antibody has been implicated in protection studies in multiple animal models, and we previously showed that the passive transfer of immune serum alone does not confer immunity in the mouse. Using the model of genital infection, we demonstrate a protective role for both -specific immunoglobulin G (IgG) and polymorphonuclear neutrophils and show the importance of an antibody/effector cell interaction in mediating humoral immunity. While neutrophils were found to contribute significantly to antibody-mediated protection , natural killer (NK) cells were dispensable for protective immunity. Furthermore, gamma interferon (IFN-γ)-stimulated primary peritoneal neutrophils (PPNs) killed chlamydiae in an antibody-dependent manner. The results from this study support the view that an IFN-γ-activated effector cell population cooperates with antibody to protect against genital chlamydia and establish neutrophils as a key effector cell in this response.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/imunologia
Infecções por Chlamydia/imunologia
Chlamydia muridarum/imunologia
Doenças dos Genitais Femininos/imunologia
Genitália/imunologia
Imunidade Humoral
Neutrófilos/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Linfócitos T CD4-Positivos/imunologia
Infecções por Chlamydia/prevenção & controle
Feminino
Doenças dos Genitais Femininos/prevenção & controle
Genitália/microbiologia
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Interferon gama/imunologia
Interferon gama/farmacologia
Células Matadoras Naturais/imunologia
Camundongos
Neutrófilos/efeitos dos fármacos
Doenças Sexualmente Transmissíveis/imunologia
Doenças Sexualmente Transmissíveis/microbiologia
Doenças Sexualmente Transmissíveis/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Immunoglobulin G); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  9 / 14623 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28737591
[Au] Autor:Joseph Davey DL; Wall KM; Kilembe W; Naw HK; Brill I; Vwalika B; Chomba E; Mulenga J; Tichacek A; Javanbakt M; Gorbach PM; Allen SA
[Ad] Endereço:*Rwanda Zambia HIV Research Group, Department of Pathology and Laboratory Medicine, School of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA; †Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA; ‡Department of Epidemiology, Rollins School of Public Health, Laney Graduate School, Emory University, Atlanta, GA; §Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL; ‖Department of Gynecology and Obstetrics, School of Medicine, University of Zambia, Lusaka, Zambia; and ¶Ministry of Community Development, Mother and Child Health, Lusaka, Zambia.
[Ti] Título:HIV Incidence and Predictors of HIV Acquisition From an Outside Partner in Serodiscordant Couples in Lusaka, Zambia.
[So] Source:J Acquir Immune Defic Syndr;76(2):123-131, 2017 Oct 01.
[Is] ISSN:1944-7884
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Evaluate the incidence and predictors of HIV acquisition from outside partners in serodiscordant couples. METHODS: Demographic, behavioral, and clinical exposures were measured quarterly in a cohort of serodiscordant cohabiting couples in Zambia from 1995 to 2012 (n = 3049). Genetic analysis classified incident infections as those acquired from the study partner (linked) or acquired from an outside partner (unlinked). Factors associated with time to unlinked HIV infection were evaluated using multivariable Cox proportional hazards regression stratified by sex. RESULTS: There were 100 unlinked infections in couples followed for a median of 806 days. Forty-five infections occurred in women [1.85/100 couple-years; 95% confidence interval (CI): 1.35 to 2.47]. Risk of female unlinked infection (vs. nonseroconverting females) was associated with reporting being drunk weekly/daily vs. moderate/nondrinkers at baseline [adjusted hazard ratio (aHR) = 5.44; 95% CI: 1.03 to 28.73], genital ulcers (aHR = 6.09; 95% CI: 2.72 to 13.64), or genital inflammation (aHR = 11.92; 95% CI: 5.60 to 25.37) during follow-up adjusting for age, years cohabiting, income, contraceptive use, previous pregnancies, history of sexually transmitted infections, and condomless sex with study partner. Fifty-five infections occurred in men (1.82/100 couple-years; 95% CI: 1.37 to 2.37). Risk of male unlinked infection was associated with genital inflammation (aHR = 8.52; 95% CI: 3.82 to 19.03) or genital ulceration (aHR = 2.31; 95% CI: 2.05 to 8.89), reporting ≥1 outside sexual partner (aHR = 3.86; 95% CI: 0.98 to 15.17) during follow-up, and reporting being drunk weekly/daily vs. moderate/nondrinkers at baseline (aHR = 3.84; 95% CI: 1.28 to 11.55), controlling for age, income, circumcision status, and history of sexually transmitted infection. CONCLUSIONS: Predictors of unlinked infection in serodiscordant relationships were alcohol use, genital inflammation, and ulceration. Causes of genital inflammation and ulceration should be screened for and treated in HIV-negative individuals. Counseling on risk of alcohol use and sex with outside partners should be discussed with couples where 1 or both are HIV-negative, including in counseling on use of pre-exposure prophylaxis to prevent HIV acquisition in the HIV-negative partner (when feasible and affordable).
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
Infecções por HIV/transmissão
[Mh] Termos MeSH secundário: Adulto
Consumo de Bebidas Alcoólicas
Feminino
Seguimentos
Doenças dos Genitais Femininos/epidemiologia
Doenças dos Genitais Masculinos/epidemiologia
Seres Humanos
Incidência
Estudos Longitudinais
Masculino
Profilaxia Pré-Exposição
Estudos Prospectivos
Fatores de Risco
Parceiros Sexuais
Doenças Sexualmente Transmissíveis/epidemiologia
Adulto Jovem
Zâmbia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1097/QAI.0000000000001494


  10 / 14623 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28731868
[Au] Autor:Pickett JL; Chou A; Andrici JA; Clarkson A; Sioson L; Sheen A; Reagh J; Najdawi F; Kim Y; Riley D; Maidens J; Nevell D; McIlroy K; Valmadre S; Gard G; Hogg R; Turchini J; Robertson G; Friedlander M; Gill AJ
[Ad] Endereço:*Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research ¶Gynaecological Oncology, Royal North Shore Hospital, St Leonards †Department of Anatomical Pathology, Royal North Shore Hospital ∥University of Sydney #Department of Obstetrics and Gynecology, St George Hospital **University of NSW ‡‡Prince of Wales Clinical School, University of New South Wales, Sydney ††Department of Medical Oncology, Prince of Wales Hospital and Royal Hospital for Women, Randwick ‡Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital §The Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
[Ti] Título:Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized: A Low Threshold for ALK Immunohistochemistry Is Required.
[So] Source:Am J Surg Pathol;41(10):1433-1442, 2017 Oct.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory myofibroblastic tumor (IMT) of the female genital tract is under-recognized. We investigated the prevalence of ALK-positive IMT in lesions previously diagnosed as gynecologic smooth muscle tumors. Immunohistochemistry (IHC) for ALK was performed on tissue microarrays of unselected tumors resected from 2009 to 2013. Three of 1176 (0.26%) "leiomyomas" and 1 of 44 (2.3%) "leiomyosarcomas" were ALK IHC positive, confirmed translocated by fluorescence in situ hybridization (FISH) and therefore more appropriately classified as IMT. On review significant areas of all 4 tumors closely mimicked smooth muscle tumors morphologically, but all showed at least subtle/focal features suggesting IMT. Recognizing that the distinction between IMT and leiomyoma/leiomyosarcoma can be subtle, we then reviewed 1 hematoxylin and eosin slide from each patient undergoing surgery for "leiomyoma" from 2014 to 2017 and selected cases for ALK IHC with a low threshold. Of these, 30 of 571 (5.3%) underwent IHC. Two were confirmed to be IHC positive and FISH rearranged. Of the 6 IMTs, only 1 tumor with a previous diagnosis of leiomyosarcoma, an infiltrative margin and equivocal necrosis, metastasized. Of note it demonstrated a less aggressive clinical course compared with most metastatic leiomyosarcomas (alive with disease at 6 y). The patient was subsequently offered crizotinib to which she responded rapidly. In conclusion, IMTs may closely mimic gynecologic smooth muscle tumors. IMTs account for at least 5 of 1747 (0.3%) tumors previously diagnosed as leiomyoma and 1 of 44 (2.3%) as leiomyosarcoma. These tumors may be recognized prospectively with awareness of subtle/focal histologic clues, coupled with a low threshold for ALK IHC.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/patologia
Granuloma de Células Plasmáticas/patologia
Receptores Proteína Tirosina Quinases/análise
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Doenças dos Genitais Femininos/metabolismo
Granuloma de Células Plasmáticas/metabolismo
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Receptores Proteína Tirosina Quinases/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (anaplastic lymphoma kinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000909



página 1 de 1463 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde