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[PMID]:28450253
[Au] Autor:Ladenhauf HN; Brandtner MG; Ardelean MA; Schimke C; Metzger R
[Ad] Endereço:Department of Pediatric and Adolescent Surgery, Paracelsus Medical University, Salzburg, Austria. Electronic address: h.ladenhauf@salk.at.
[Ti] Título:Laparoscopic Management of Autoamputated Ovary in Newborns: A Report of 2 Cases.
[So] Source:J Minim Invasive Gynecol;24(5):859-862, 2017 Jul - Aug.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intrauterine autoamputation of the ovary is an extremely rare diagnosis in the pediatric population. The current literature is limited to contradictory recommendations, while a standard management protocol for autoamputated adnexa secondary to intrauterine ovarian torsion is yet to be established. We report 2 cases of auto-amputation of the ovary, leading to a free-floating intra-abdominal cyst in the newborn. Laparoscopic management was successful in both cases.
[Mh] Termos MeSH primário: Doenças dos Anexos/cirurgia
Cistos/cirurgia
Laparoscopia/métodos
Doenças Ovarianas/cirurgia
Ovário/cirurgia
Anormalidade Torcional/cirurgia
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Lactente
Recém-Nascido
Ovário/anormalidades
Ovário/lesões
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29174658
[Au] Autor:Chauvet P; Roman H; Gremeau AS; Canis M; Bourdel N
[Ad] Endereço:CHU de Clermont-Ferrand, CHU Estaing, service de gynécologie obstétrique et reproduction humaine, gynécologie A, 1, place Lucie-Aubrac, 63100 Clermont-Ferrand, France; Faculté de médecine, centre international de chirurgie endoscopique (CICE), bâtiment 3C, 28, place Henri-Dunant, 63000 Clermont-Ferr
[Ti] Título:[Management of endometrioma].
[Ti] Título:Prise en charge des endométriomes..
[So] Source:Presse Med;46(12 Pt 1):1173-1183, 2017 Dec.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Preoperative evaluation: clinical examination, and research for associated lesions. Laparoscopic approach. Cystectomy: gold standard, conformed to the endometrioma pathophysiology (3 zones). Laser CO Plasmajet vaporisation: important data lead to legitimate utilisation. Haemostasis: be patient! Use of bipolar energy sparingly. Look for other endometriotic lesions, and systematic treatment. Preoperative medical treatment not always useful. Postoperative treatment: decrease recurrence. Especially for patients with no immediate pregnancy desire.
[Mh] Termos MeSH primário: Endometriose/cirurgia
Doenças Ovarianas/cirurgia
[Mh] Termos MeSH secundário: Feminino
Procedimentos Cirúrgicos em Ginecologia/métodos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29069000
[Au] Autor:Bolli P; Schädelin S; Holland-Cunz S; Zimmermann P
[Ad] Endereço:aPediatric Surgery, University Children's Hospital Basel bClinical Trial Unit, University Hospital Basel, Basel, Switzerland cPediatric Surgery, University of Leipzig, Leipzig, Germany.
[Ti] Título:Ovarian torsion in children: Development of a predictive score.
[So] Source:Medicine (Baltimore);96(43):e8299, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to identify clinical signs and symptoms of ovarian torsion (OT) in children and to develop a simple predictive score.A chart review of patients with acute adnexal pathologies treated at the University Children's Hospital Basel, Switzerland, between March 2006 and June 2015 was performed. Medical records were screened for demographic and clinical data. These included clinical symptoms, laboratory studies, imaging, and type of treatment. The diagnosis OT was defined as intraoperative visualization of the torsed ovary around its pedicle at least 360 degrees. Variables predictive for OT were identified and the following score for the likelihood of having OT was developed: age (points = number of years) minus 3 points (if vomitus = "yes") and plus 1 point (if "pain duration >12 hours").A total of 80 patients with acute adnexal pathologies were identified. OT was recorded in 17 (21%) cases and ovarian cysts (OC) only in 63 (79%) cases. Patients who presented with OT were significantly younger than patients with OC only (P = .001). Correspondingly, 11 (65%) of the patients with OT had no menarche compared to 3 (5%) patients with OC only (P = .001). Vomiting (P = .001), a shorter pain duration (P = .01), and an elevated C-reactive protein (CRP) (P = .01) were observed significantly more often in patients with OT. The sensitivity of a positive OT score was 0.81 and increased to 1.00 if restricted to girls between 2 to 12 years of age.The presence of vomiting, short duration of abdominal pain, and elevated CRP level have a predictive value for the diagnosis of OT. In these patients, an exploratory laparoscopy should be conducted without delay. The presented OT score appears to be a helpful tool in diagnosing OT in children.
[Mh] Termos MeSH primário: Proteína C-Reativa/análise
Laparoscopia/métodos
Doenças Ovarianas
Ovário/diagnóstico por imagem
Medição de Risco/métodos
Anormalidade Torcional
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico
Dor Abdominal/etiologia
Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Doenças Ovarianas/diagnóstico
Doenças Ovarianas/epidemiologia
Doenças Ovarianas/fisiopatologia
Doenças Ovarianas/cirurgia
Valor Preditivo dos Testes
Projetos de Pesquisa
Fatores de Risco
Sensibilidade e Especificidade
Suíça/epidemiologia
Avaliação de Sintomas/métodos
Avaliação de Sintomas/estatística & dados numéricos
Anormalidade Torcional/diagnóstico
Anormalidade Torcional/epidemiologia
Anormalidade Torcional/fisiopatologia
Anormalidade Torcional/cirurgia
Vômito/diagnóstico
Vômito/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008299


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[PMID]:29016487
[Au] Autor:Lenz CJ; Wysokinski WE; Henkin S; Cohoon KP; Casanegra A; Simmons BS; Saadiq RA; Daniels PR; Wysokinska EM; Bjarnason H; McBane RD
[Ad] Endereço:Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota; and Duke Medical Center, Durham, North Carolina.
[Ti] Título:Ovarian Vein Thrombosis: Incidence of Recurrent Venous Thromboembolism and Survival.
[So] Source:Obstet Gynecol;130(5):1127-1135, 2017 Nov.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To identify the risk of venous thromboembolism recurrence, major bleeding, and mortality in patients with ovarian vein thrombosis so as to better define optimal treatment strategies. METHODS: Patients with ovarian vein thrombosis (1990-2015) and age- and gender-matched patients with contemporary leg deep vein thrombosis (DVT) were assessed for differences in etiology, venous thromboembolism recurrence, and survival in a case-control study. RESULTS: Over the timeframe of this study, only 219 ovarian vein thrombosis cases were identified compared with 13,417 leg DVTs. Median duration of follow-up was 1.23 years (interquartile range 0.25-4.14). Pulmonary embolism was identified at presentation in 6% of patients with ovarian vein thrombosis and 16% of those with DVT (P=.001). Frequent causes of ovarian vein thrombosis included cancer, hormonal stimulation, surgery, and hospitalization. Cancer was twofold more frequent in patients with ovarian vein thrombosis (44% compared with 21%; P<.01). Despite being less frequently treated with anticoagulation (ovarian vein thrombosis 54% compared with DVT 98%, P<.001), venous thromboembolism recurrence rates were similar between groups (ovarian vein thrombosis 2.3 compared with DVT 1.8 per 100 patient-years, P=.49). A personal history of venous thromboembolism and preceding surgery was found to be an independent risk factor for venous thromboembolism recurrence among those treated with anticoagulation (hazard ratio 6.7, P=.04 and hazard ratio 13.6, P=.03, respectively). There was no significant difference in overall survival. CONCLUSION: Ovarian vein thrombosis is a rare thrombotic condition with an incidence 60-fold lower compared with leg DVT in our institution. The striking association with cancer adversely affects overall survival rates in patients with ovarian vein thrombosis. Venous thromboembolism recurrence rates argue for anticoagulation with a direct oral anticoagulant or vitamin K antagonist, particularly in those with a history of venous thromboembolism.
[Mh] Termos MeSH primário: Doenças Ovarianas/complicações
Ovário/irrigação sanguínea
Tromboembolia Venosa/epidemiologia
Trombose Venosa/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticoagulantes/uso terapêutico
Estudos de Casos e Controles
Feminino
Seres Humanos
Incidência
Meia-Idade
Neoplasias/epidemiologia
Neoplasias/etiologia
Doenças Ovarianas/tratamento farmacológico
Modelos de Riscos Proporcionais
Recidiva
Fatores de Risco
Tromboembolia Venosa/tratamento farmacológico
Tromboembolia Venosa/etiologia
Trombose Venosa/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002319


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[PMID]:28904722
[Au] Autor:Guennoun A; Krimou Y; Mamouni N; Errarhay S; Bouchikhi C; Banani A
[Ad] Endereço:Departement de Gynécologie ObstétriqueI, Hôpital Univiersitaire Hassan II, Fez, Maroc.
[Ti] Título:[Normal adnexal torsion and pregnancy: about a case].
[Ti] Título:Torsion d'annexe saine et grossesse: à propos d'un cas..
[So] Source:Pan Afr Med J;27:197, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Normal adnexal torsion is rare during pregnancy. We here report the case of a 22-year old patient presenting with acute lateropelvic pain associated with a 2-month history amenorrhea. Exploratory laparotomy showed severe ischemia due to torsion in a normal ovary. The patient underwent adnexal detorsion without ovarian pexy. The postoperative course was uneventful. Ultrasound examination after 3 weeks showed normal pregnancy. Ovarian torsion is an emergency that should not be ignored in pregnant women with acute pelvic pain. Conservative treatment is the gold standard and proper management is necessary to avoid possible maternal and fetal complications.
[Mh] Termos MeSH primário: Doenças Ovarianas/diagnóstico
Dor Pélvica/etiologia
Complicações na Gravidez/diagnóstico
Anormalidade Torcional/diagnóstico
[Mh] Termos MeSH secundário: Dor Aguda/etiologia
Doenças dos Anexos/diagnóstico
Doenças dos Anexos/cirurgia
Feminino
Seres Humanos
Isquemia/etiologia
Laparotomia/métodos
Doenças Ovarianas/cirurgia
Gravidez
Complicações na Gravidez/cirurgia
Anormalidade Torcional/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.197.12250


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[PMID]:28902871
[Au] Autor:Sbracia M; McKinnon B; Scarpellini F; Marconi D; Rossi G; Simmilion C; Mueller MD; Barnea ER; Mueller M
[Ad] Endereço:Hungaria Center for Endocrinology and Reproductive Medicine, Rome, Italy.
[Ti] Título:PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium.
[So] Source:PLoS One;12(9):e0184399, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson's theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, with T regulatory FoxP3+ expressing T cells (Tregs) being a significant factor. PreImplantation Factor (PIF) is a peptide essential for pregnancy recognition and development. An immune modulatory function of the synthetic PIF analog (sPIF) has been successfully confirmed in multiple animal models. We report that PIF is expressed in the epithelial ectopic cells in close proximity to FoxP3+ stromal cells. We provide evidence that PIF interacts with FoxP3+ cells and modulates cell viability, dependent on cell source and presence of inflammatory mediators. Our finding represent a novel PIF-based mechanism in endometriosis that has potential for novel therapeutics.
[Mh] Termos MeSH primário: Endometriose/imunologia
Endométrio/imunologia
Endométrio/metabolismo
Imunidade Inata/genética
Proteínas da Gravidez/fisiologia
[Mh] Termos MeSH secundário: Células Cultivadas
Coristoma/genética
Coristoma/metabolismo
Coristoma/patologia
Endometriose/genética
Endometriose/patologia
Endométrio/patologia
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Imunidade Inata/efeitos dos fármacos
Doenças Ovarianas/genética
Doenças Ovarianas/imunologia
Doenças Ovarianas/patologia
Doenças Peritoneais/genética
Doenças Peritoneais/imunologia
Doenças Peritoneais/patologia
Gravidez
Complicações na Gravidez/genética
Complicações na Gravidez/imunologia
Complicações na Gravidez/patologia
Proteínas da Gravidez/genética
Proteínas da Gravidez/metabolismo
Proteínas da Gravidez/farmacologia
Células Estromais/efeitos dos fármacos
Células Estromais/metabolismo
Células Estromais/patologia
Transcriptoma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pregnancy Proteins); 0 (preimplantation factor, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184399


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[PMID]:28886344
[Au] Autor:Chen T; Bian Y; Liu X; Zhao S; Wu K; Yan L; Li M; Yang Z; Liu H; Zhao H; Chen ZJ
[Ad] Endereço:Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250001, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan 250001, China; The Key Laboratory for Reproductive Endocrinology, Shandong University,
[Ti] Título:A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.
[So] Source:Am J Hum Genet;101(3):459-465, 2017 Sep 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Empty follicle syndrome (EFS) is defined as the failure to aspirate oocytes from mature ovarian follicles during in vitro fertilization. Except for some cases caused by pharmacological or iatrogenic problems, the etiology of EFS remains enigmatic. In the present study, we describe a large family with a dominant inheritance pattern of female infertility characterized by recurrent EFS. Genome-wide linkage analyses and whole-exome sequencing revealed a paternally transmitted heterozygous missense mutation of c.400 G>A (p.Ala134Thr) in zona pellucida glycoprotein 3 (ZP3). The same mutation was identified in an unrelated EFS pedigree. Haplotype analysis revealed that the disease allele of these two families came from different origins. Furthermore, in a cohort of 21 cases of EFS, two were also found to have the ZP3 c.400 G>A mutation. Immunofluorescence and histological analysis indicated that the oocytes of the EFS female had degenerated and lacked the zona pellucida (ZP). ZP3 is a major component of the ZP filament. When mutant ZP3 was co-expressed with wild-type ZP3, the interaction between wild-type ZP3 and ZP2 was markedly decreased as a result of the binding of wild-type ZP3 and mutant ZP3, via dominant negative inhibition. As a result, the assembly of ZP was impeded and the communication between cumulus cells and the oocyte was prevented, resulting in oocyte degeneration. These results identified a genetic basis for EFS and oocyte degeneration and, moreover, might pave the way for genetic diagnosis of infertile females with this phenotype.
[Mh] Termos MeSH primário: Infertilidade Feminina/genética
Mutação de Sentido Incorreto
Oócitos/patologia
Doenças Ovarianas/genética
Glicoproteínas da Zona Pelúcida/genética
Zona Pelúcida/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Genótipo
Heterozigoto
Seres Humanos
Infertilidade Feminina/patologia
Masculino
Oócitos/metabolismo
Doenças Ovarianas/patologia
Indução da Ovulação/métodos
Linhagem
Zona Pelúcida/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ZP3 protein, human); 0 (Zona Pellucida Glycoproteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


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[PMID]:28681369
[Au] Autor:Hirabayashi T; Ueno S; Hirakawa H; Tei E; Mori M
[Ti] Título:Surgical Treatment of Inguinal Hernia with Prolapsed Ovary in Young Girls: Emergency Surgery or Elective Surgery.
[So] Source:Tokai J Exp Clin Med;42(2):89-95, 2017 Jul 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Inguinal ovarian hernias are common in young girls. Many articles in medical literature recommend early surgery for inguinal ovarian hernia because of the risk of torsion of the prolapsed ovary. However, since many irreducible herniated ovaries in newborn infants and during early infancy undergo spontaneous reduction by the age of 9 months, the policy at our institute is to obtain informed consent from the patient's family and then wait to perform surgery until after 9 months of age. In the present study, we assessed the indications for surgery for inguinal ovarian hernia in newborn infants and during early infancy. METHODS: Between 2003 and 2011, a total of 673 girls with inguinal hernias (age at the time of onset of symptoms: mean, 42.5 months; median, 39 months) were brought to our outpatient clinic for consultation. We reviewed their age at the time of the onset of hernia symptoms and their age at the time of surgery, their history of surgery, and their history of inguinal ovarian hernia using information obtained from their medical records. RESULTS: Among the 673 outpatients, 71 patients (mean/median age at the time of onset of symptoms: 11.2/1.5 months) were diagnosed as having an inguinal ovarian hernia at the time of diagnosis. Among these patients, surgery was performed for 58 patients (mean/median age at the time of surgery: 21.3/11 months). Of these patients, the ovary had already spontaneously reduced into the abdomen in 35 cases (mean/median age at the time of surgery: 24.1/12months), whereas the ovaries were on the wall of the hernia sac in 22 cases (mean/median age at the time of surgery: 17.3/10 months). In one case, a testis instead of an ovary was observed in the hernia sac at the time of surgery. Surgeries were performed in 611 of the 673 patients (mean/median age at the time of surgery: 54/50 months). In 35 cases (mean/median age at the time of surgery: 21.6/10 months), the ovary was still on the hernia sac wall at the time of surgery, but an inguinal ovarian hernia had not been diagnosed before surgery in 13 of these cases. A severe complication occurred in only one case, in which a hernia sac that contained a fallopian tube and ovary was ligated. None of the cases exhibited torsion of the ovary within the inguinal canal. CONCLUSION: Since the ovary can be expected to undergo spontaneous reduction into the abdomen by late infancy in many young patients with inguinal ovarian hernias, patients with inguinal ovarian hernias can be treated by elective surgery at the most convenient age, after 9 months of age.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Eletivos
Hérnia Inguinal/cirurgia
Doenças Ovarianas/cirurgia
Ovário/cirurgia
Prolapso de Órgão Pélvico/cirurgia
Procedimentos Cirúrgicos Urogenitais/métodos
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Criança
Pré-Escolar
Emergências
Feminino
Seres Humanos
Lactente
Recém-Nascido
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28597474
[Au] Autor:Furuya M; Masuda H; Hara K; Uchida H; Sato K; Sato S; Asada H; Maruyama T; Yoshimura Y; Katabuchi H; Tanaka M; Saya H
[Ad] Endereço:Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:ZEB1 expression is a potential indicator of invasive endometriosis.
[So] Source:Acta Obstet Gynecol Scand;96(9):1128-1135, 2017 Sep.
[Is] ISSN:1600-0412
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Although endometriosis is a benign disease, it shares some features with cancers, such as invasiveness and the potential to metastasize. This study sought to investigate the epithelial-mesenchymal transition status in human endometriotic lesions. MATERIAL AND METHODS: Thirteen endometriosis patients and 10 control women without endometriosis undergoing surgery for benign indications were recruited. We examined the expression of E-cadherin, vimentin, and epithelial-mesenchymal transition-induced transcriptional factors, such as Snail and ZEB1, by immunohistochemistry. We evaluated the expression of each marker in epithelial cells of both endometriotic lesions (ovarian endometrioma, deep infiltrating endometriosis, adenomyosis) and normal endometria. The correlation between ZEB1 expression and serum level of CA125 was also investigated. RESULTS: Immunohistochemical analysis revealed that although E-cadherin, vimentin, and Snail were expressed in epithelia of normal endometria and endometriotic lesions, ZEB1 expression was only expressed in epithelia of endometriotic lesions. Additionally, ZEB1 was most frequently observed in epithelial cells of invasive endometriosis. The endometriosis patients with high serum CA125 level were more likely to have ZEB1-positive lesions. CONCLUSIONS: This is the first observation of ZEB1 expression in epithelial cells of benign disease. The preferential expression of ZEB1 in epithelial cells of endometriotic lesions suggests that these cells may have, at least in part, a higher level of mesenchymal features possibly via ZEB1-driven epithelial-mesenchymal transition than normal endometria and that ZEB1 can be a potential indicator of invasiveness or severity of endometriosis.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Endometriose/diagnóstico
Homeobox 1 de Ligação a E-box em Dedo de Zinco/metabolismo
[Mh] Termos MeSH secundário: Adenomiose/diagnóstico
Adenomiose/metabolismo
Adenomiose/patologia
Adenomiose/cirurgia
Adulto
Endometriose/metabolismo
Endometriose/patologia
Endometriose/cirurgia
Feminino
Seres Humanos
Imuno-Histoquímica
Ligamentos/patologia
Invasividade Neoplásica
Doenças Ovarianas/diagnóstico
Doenças Ovarianas/metabolismo
Doenças Ovarianas/patologia
Doenças Ovarianas/cirurgia
Valor Preditivo dos Testes
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (ZEB1 protein, human); 0 (Zinc Finger E-box-Binding Homeobox 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1111/aogs.13179


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[PMID]:28579409
[Au] Autor:Cohen A; Almog B; Tulandi T
[Ad] Endereço:Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. Electronic address: co.aviad@gmail.com.
[Ti] Título:Sclerotherapy in the management of ovarian endometrioma: systematic review and meta-analysis.
[So] Source:Fertil Steril;108(1):117-124.e5, 2017 Jul.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the efficacy of sclerotherapy for ovarian endometrioma on the risk of recurrence, clinical symptoms, and reproductive function. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Patients who underwent sclerotherapy of ovarian endometrioma. INTERVENTION(S): An electronic-based search with the use of Pubmed, Embase, Ovid Medline, Google Scholar, Clinicaltrials.gov, and the Cochrane Central Register of Controlled Trials. MAIN OUTCOME MEASURE(S): Recurrence rate, symptoms relief, fertility outcome, and adverse events. RESULT(S): Eighteen studies were included in our review. The overall recurrence rates of endometrioma after sclerotherapy ranged from 0 to 62.5%. The risk of recurrence was significantly higher in women who were treated by means of ethanol washing than by means of ethanol retention. The number of oocytes retrieved was higher after endometrioma sclerotherapy compared with laparoscopic cystectomy, but clinical pregnancy rates were similar. There was no difference in the number of oocytes retrieved and the clinical pregnancy rates between the sclerotherapy-treated group with and the untreated group. CONCLUSION(S): Sclerotherapy for ovarian endometrioma may be considered in symptomatic women who plan to conceive.
[Mh] Termos MeSH primário: Endometriose/epidemiologia
Endometriose/terapia
Infertilidade Feminina/epidemiologia
Infertilidade Feminina/prevenção & controle
Resultado da Gravidez/epidemiologia
Escleroterapia/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Meia-Idade
Doenças Ovarianas/etnologia
Doenças Ovarianas/terapia
Gravidez
Prevalência
Recidiva
Fatores de Risco
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE



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