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  1 / 17945 MEDLINE  
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[PMID]:29442029
[Au] Autor:Mu P; Zhou J; Ma X; Zhang G; Li Y
[Ti] Título:Expression, regulation and function of MicroRNAs in endometriosis.
[So] Source:Pharmazie;71(8):434-438, 2016 Aug 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Endometriosis (EMS), characterized by the presence and growth of functional en do met rial-like tissues outside the uterine cavity, is a common and benign gyneco logical disorder with a poorly understood and somewhat enigmatic etiopathogenesis and pathophysiology. MicroRNAs (miRNAs) are single-stranded 19-25 nucleotide-long RNAs and have an important role in post-transcriptional gene silencing by base pairing with target mRNAs. Recent research has shown that miRNAs and their target mRNAs are differentially expressed in endometriosis and other disorders of the female reproductive system. In this paper, we review the recent progress in understanding the roles of miRNAs in endometriosis, and specific miRNAs as biomarkers and therapeutic targets for endometriosis.
[Mh] Termos MeSH primário: Endometriose/genética
MicroRNAs/biossíntese
[Mh] Termos MeSH secundário: Biomarcadores
Endometriose/diagnóstico
Feminino
Regulação da Expressão Gênica
Seres Humanos
MicroRNAs/análise
MicroRNAs/genética
Interferência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (MicroRNAs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.5904


  2 / 17945 MEDLINE  
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[PMID]:27778641
[Au] Autor:Joshi NR; Miyadahira EH; Afshar Y; Jeong JW; Young SL; Lessey BA; Serafini PC; Fazleabas AT
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan 49503.
[Ti] Título:Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.
[So] Source:J Clin Endocrinol Metab;102(1):141-149, 2017 Jan 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Endometriosis results in aberrant gene expression in the eutopic endometrium (EuE) and subsequent progesterone resistance. MicroRNA (miR) microarray data in a baboon model of endometriosis showed an increased expression of miR-29c. Objectives: To explore the role of miR-29c in progesterone resistance in a subset of women with endometriosis. Design: MiR-29c expression was analyzed in the endometrium of baboons and women with or without endometriosis. The role in progesterone resistance and decidualization was analyzed by transfecting human uterine fibroblast cells with miR-29c. Patients: Subjects diagnosed with deep infiltrative endometriosis (DIE) by transvaginal ultrasound with bowel preparation underwent surgical excision of endometriosis. Eutopic secretory endometrium was collected pre- and postoperatively. Women with normal EuE and without DIE served as controls. Results: Quantitative reverse transcription polymerase chain reaction demonstrated that miR-29c expression increased, while the transcript levels of its target, FK506-binding protein 4 (FKBP4), decreased in the EuE of baboons following the induction of endometriosis. FKBP4 messenger RNA and decidual markers were statistically significantly decreased in decidualized human uterine fibroblast cells transfected with a miR-29c mimic compared with controls. Human data corroborated our baboon data and demonstrated higher expression of miR-29c in endometriosis EuE compared with normal EuE. MiR-29c was significantly decreased in endometriosis EuE postoperatively compared with preoperative tissues, and FKBP4 showed an inverse trend following radical laparoscopic resection surgery. Conclusions: We demonstrate that miR-29c expression is increased in EuE of baboons and women with endometriosis, which might contribute to a compromised progesterone response by diminishing the levels of FKBP4. Resection of DIE is likely to reverse the progesterone resistance associated with endometriosis in women.
[Mh] Termos MeSH primário: Biomarcadores/análise
Endometriose/genética
Endométrio/anormalidades
MicroRNAs/genética
Progesterona/farmacologia
Proteínas de Ligação a Tacrolimo/metabolismo
Doenças Uterinas/genética
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Modelos Animais de Doenças
Endometriose/tratamento farmacológico
Endometriose/patologia
Feminino
Seres Humanos
Papio
Prognóstico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (MIRN29 microRNA, human); 0 (MicroRNAs); 4G7DS2Q64Y (Progesterone); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.- (tacrolimus binding protein 4)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-2076


  3 / 17945 MEDLINE  
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[PMID]:29184406
[Au] Autor:Yuan M; Ding S; Meng T; Lu B; Shao S; Zhang X; Yuan H; Hu F
[Ad] Endereço:Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan.
[Ti] Título:Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain.
[So] Source:Int J Nanomedicine;12:8171-8183, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Endometriosis is a common gynecological disease with a lack of effective clinical treatment. Current therapy often results in endometriosis pain recurrence and serious side effects. P2X receptor, an adenosine triphosphate (ATP)-gated ion channel, might be implicated in endometriosis pain. In this study, chitosan oligosaccharide-g-stearic acid (CSOSA) polymer micelles-coated nanostructured lipid carriers (NLCs) were developed as a novel delivery system for A-317491, a selective P2X receptor antagonist for endometriosis pain therapy. A-317491-loaded NLC (NLC/A-317491) could be coated by CSOSA micelles to form CSOSA/NLC/A-317491 nanoparticles. Pheochromocytoma PC12 cells, which highly expressed P2X receptors, were used as a cell model, and the CSOSA/NLC/A-317491 partly blocked the Ca influx induced by ATP stimulation. In nude mouse and rat endometriotic models, CSOSA/NLC could accumulate into endometriotic lesions after vein injection. In endometriotic rats, CSOSA/NLC/A-317491 reversed mechanical and heat hyperalgesia with long-term efficacy, which might be attributed to the massive CSOSA/NLC/A-317491 distribution in the endometriotic lesions. In conclusion, A-317491 delivered by CSOSA/NLC nanoparticles attenuated endometriosis pain in rats, and CSOSA/NLC/A-317491 could be used as an effective treatment strategy for P2X -targeted therapy in endometriosis pain.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos
Endometriose/tratamento farmacológico
Nanopartículas/administração & dosagem
Dor/tratamento farmacológico
Fenóis/administração & dosagem
Compostos Policíclicos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Feminino
Glicolipídeos/química
Seres Humanos
Camundongos Nus
Micelas
Nanopartículas/química
Oligossacarídeos/química
Células PC12
Fenóis/química
Fenóis/farmacologia
Compostos Policíclicos/química
Compostos Policíclicos/farmacologia
Polímeros/química
Antagonistas do Receptor Purinérgico P2X/farmacologia
Ratos
Receptores Purinérgicos P2X3
Ácidos Esteáricos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (A-317491); 0 (Glycolipids); 0 (Micelles); 0 (Oligosaccharides); 0 (Phenols); 0 (Polycyclic Compounds); 0 (Polymers); 0 (Purinergic P2X Receptor Antagonists); 0 (Receptors, Purinergic P2X3); 0 (Stearic Acids); 4ELV7Z65AP (stearic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S146569


  4 / 17945 MEDLINE  
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[PMID]:28470452
[Au] Autor:de Oliveira Francisco D; de Paula Andres M; Gueuvoghlanian-Silva BY; Podgaec S; Fridman C
[Ad] Endereço:Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, n°115, Cerqueira Cesar, Sao Paulo, SP, CEP: 05405-000, Brazil.
[Ti] Título:CCDC22 gene polymorphism is associated with advanced stages of endometriosis in a sample of Brazilian women.
[So] Source:J Assist Reprod Genet;34(7):939-944, 2017 Jul.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Based on the assumption that genetic factors are involved in the etiology of endometriosis, this study aimed to investigate the possibility of rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), and rs2294021 (CCDC22 gene) polymorphisms being associated with the occurrence of this disease in a sample of Brazilian women. METHODS: We conducted a case-control study with 100 women with histological confirmation of endometriosis (endometriosis group) and 100 women submitted to laparoscopy for benign disorders, in which the absence of endometriosis was confirmed (control group). All samples were genotyped by real-time PCR technique for rs498679, rs1799964, rs3024496, and rs2294021 polymorphisms. RESULTS: No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV). On the other hand, significant difference between stages I-II and III-IV of the disease was found in genotypic and allelic frequencies for the rs2294021 (CCDC22 gene) SNP (p = 0.048 and p = 0.017, respectively). CONCLUSION: Our results suggest that the rs2294021 (CCDC22 gene) polymorphism could be associated with increased susceptibility to endometriosis in Brazilian women when the allele C is present. In order to clarify this result, further studies should be conducted on a larger population.
[Mh] Termos MeSH primário: Endometriose/genética
Polimorfismo de Nucleotídeo Único
Proteínas/genética
[Mh] Termos MeSH secundário: Brasil
Estudos de Casos e Controles
Feminino
Genótipo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCDC22 protein, human); 0 (Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-0936-0


  5 / 17945 MEDLINE  
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[PMID]:29465552
[Au] Autor:Alborzi S; Rasekhi A; Shomali Z; Madadi G; Alborzi M; Kazemi M; Hosseini Nohandani A
[Ad] Endereço:Laparoscopy Research Center, Department of Obstetrics and Gynecology.
[Ti] Título:Diagnostic accuracy of magnetic resonance imaging, transvaginal, and transrectal ultrasonography in deep infiltrating endometriosis.
[So] Source:Medicine (Baltimore);97(8):e9536, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine the diagnostic accuracy of pelvic magnetic resonance imaging (MRI), transvaginal sonography (TVS), and transrectal sonography (TRS) in diagnosis of deep infiltrating endometriosis (DIE).This diagnostic accuracy study was conducted during a 2-year period including a total number of 317 patients with signs and symptoms of endometriosis. All the patients were evaluated by pelvic MRI, TVS, and TRS in the same center. The criterion standard was considered to be the laparoscopy and histopathologic examination.Of 317 patients being included in the present study, 252 tested positive for DIE. The sensitivity, specificity, positive predictive value, and negative predictive value of TVS was found to be 83.3%, 46.1%, 85.7%, and 41.6%, respectively. These variables were 80.5%, 18.6%, 79.3%, and 19.7% for TRS and 90.4%, 66.1%, 91.2%, and 64.1% for MRI, respectively. MRI had the highest accuracy (85.4%) when compared to TVS (75.7%) and TRS (67.8%). The sensitivity of TRS, TVS, and MRI in uterosacral ligament DIE was 82.8%, 70.9%, and 63.6%, respectively. On the contrary, specificity had a reverse trend, favoring MRI (93.9%, 92.8%, and 89.8% for TVS and TRS, respectively).The results of the present study demonstrated that TVS and TRS have appropriate diagnostic accuracy in diagnosis of DIE comparable to MRI.
[Mh] Termos MeSH primário: Endometriose/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Adulto
Endometriose/patologia
Feminino
Seres Humanos
Laparoscopia/métodos
Estudos Longitudinais
Pelve/diagnóstico por imagem
Valor Preditivo dos Testes
Estudos Prospectivos
Reto/diagnóstico por imagem
Sensibilidade e Especificidade
Vagina/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009536


  6 / 17945 MEDLINE  
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Rizzo, Luiz Vicente
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[PMID]:28463710
[Au] Autor:de Barros IBL; Malvezzi H; Gueuvoghlanian-Silva BY; Piccinato CA; Rizzo LV; Podgaec S
[Ad] Endereço:Hospital Israelita Albert Einstein, Av. Albert Einstein 627, Morumbi, CEP: 05652-900, Sao Paulo, Brazil. Electronic address: isabela.bottura@einstein.br.
[Ti] Título:"What do we know about regulatory T cells and endometriosis? A systematic review".
[So] Source:J Reprod Immunol;120:48-55, 2017 Apr.
[Is] ISSN:1872-7603
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Endometriosis is a benign, chronic inflammatory disease that presents alterations in immune response that can be detected in eutopic endometrium, peritoneal fluid and peripheral blood of affected women. Regulatory T (T ) cells are a subpopulation of T lymphocytes specialized in immune regulation that seem to participate in the development of endometriosis, by suppressing the immune response and favoring the establishment of lesions. Our aim was to review the scientific literature that evaluates T cell phenotypes in the context of endometriosis. PRISMA statement for systematic reviews was applied, using "regulatory T cells" and "endometriosis" as keywords in the following databases: PubMed, Cochrane, EMBASE and Lilacs. The initial search and abstract review yielded 41 papers relating to the subject. At the end, 12 studies, published between 2009 and 2016, were included. Most studies that analyzed T cells did not characterize these cells with current Bona Fide markers. In peritoneal fluid and endometriotic lesions, there was a higher concentration of T cell phenotype and/or T cell expression markers in patients with endometriosis when compared with controls. However, there is still not a consensus about T cells concentration in eutopic endometrium and peripheral blood between the revised studies. Taken together, this data collection suggests that endometriosis is related to T cells alterations, although further studies are necessary to reach more precise conclusions, especially regarding the percentage of these cells in eutopic endometrium and peripheral blood. This systematic review attempted to provide instructive and up-to-date collection of data that may help better design future studies.
[Mh] Termos MeSH primário: Coristoma/imunologia
Endometriose/imunologia
Endométrio/imunologia
Subpopulações de Linfócitos T/imunologia
Linfócitos T Reguladores/imunologia
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Imunomodulação
Contagem de Linfócitos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  7 / 17945 MEDLINE  
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[PMID]:29304094
[Au] Autor:Wang HS; Tsai CL; Chang PY; Chao A; Wu RC; Chen SH; Wang CJ; Yen CF; Lee YS; Wang TH
[Ad] Endereço:Department of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis.
[So] Source:PLoS One;13(1):e0190573, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis.
[Mh] Termos MeSH primário: Endometriose/enzimologia
Proteínas de Choque Térmico/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Regulação para Cima
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Linhagem Celular Tumoral
Ensaio de Imunoadsorção Enzimática
Feminino
Proteínas de Choque Térmico/sangue
Proteínas de Choque Térmico/genética
Seres Humanos
Imuno-Histoquímica
Metaloproteinase 9 da Matriz/genética
Regiões Promotoras Genéticas
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Heat-Shock Proteins); 0 (STIP1 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190573


  8 / 17945 MEDLINE  
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[PMID]:29262869
[Au] Autor:Okoshi K; Mizumoto M; Kinoshita K
[Ad] Endereço:Department of Surgery, The Japan Baptist Hospital, 47 Yamanomoto-cho, Kitashirakawa, Sakyo-ku, Kyoto, 606-8273, Japan. kae_md@kuhp.kyoto-u.ac.jp.
[Ti] Título:Endometriosis-associated hydrocele of the canal of Nuck with immunohistochemical confirmation: a case report.
[So] Source:J Med Case Rep;11(1):354, 2017 Dec 21.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The canal of Nuck is an embryological vestige of the processus vaginalis, and presents a potential site for endometriosis seeding. Hydroceles in this region are a rare cause of inguinal swelling in females. In addition, endometriosis localized to the canal of Nuck is exceedingly rare. CASE PRESENTATION: A 44-year-old Japanese woman presented with a painful mass overlying her right pubis. She underwent surgery to completely excise the mass. During surgery, division of the external oblique aponeurosis revealed a cyst that occupied the inguinal canal and it adhered to the transverse fascia, inguinal ligament, and pubic bone. The cyst was dissected from the round ligament, and the defect in the internal inguinal ring was repaired and reinforced with mesh. On macroscopic examination, the cyst had a heterogeneous fibrous aspect with dark brown inclusions. Microscopic examination revealed that the cyst was tortuous, lined by mesothelial-like cells, and accompanied by partial subcapsular hemorrhage. Endometrium-like tissue was observed in the cystic wall. Immunohistochemical staining for podoplanin confirmed the mesothelial origin of the cyst-lining cells. The epithelial cells and stromal cells were positive for estrogen receptors. CONCLUSIONS: In this case of an endometriosis-associated hydrocele of the canal of Nuck, the mesothelial origin of the cyst-lining cells and endometriosis were confirmed by positive immunohistochemical staining for podoplanin and estrogen receptors, respectively. We determined that hydrocele resection and reinforcement of the anterior inguinal canal wall (if necessary) are appropriate treatments for this condition.
[Mh] Termos MeSH primário: Cistos/diagnóstico por imagem
Endometriose/diagnóstico por imagem
Doenças Peritoneais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Cistos/metabolismo
Cistos/patologia
Cistos/cirurgia
Endometriose/metabolismo
Endometriose/patologia
Endometriose/cirurgia
Feminino
Seres Humanos
Imuno-Histoquímica
Canal Inguinal
Doenças Peritoneais/metabolismo
Doenças Peritoneais/patologia
Doenças Peritoneais/cirurgia
Receptores Estrogênicos/metabolismo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Estrogen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1522-x


  9 / 17945 MEDLINE  
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[PMID]:29233171
[Au] Autor:Lee HJ; Lee YS
[Ad] Endereço:Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, 130, Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea.
[Ti] Título:Deep infiltrating ureteral endometriosis with catamenial hydroureteronephrosis: a case report.
[So] Source:J Med Case Rep;11(1):346, 2017 Dec 13.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This aim of this case report is to raise awareness of ureteral endometriosis in women of reproductive age with hydronephrosis in the absence of urolithiasis to enable early diagnosis and prevent loss of renal function. CASE PRESENTATION: A 44-year-old Asian woman presented with a 4-year history of cyclic right flank pain and right hydronephrosis during menstruation. Despite several evaluations by physicians, including gynecologists, the cause of her symptoms was not diagnosed. On transvaginal ultrasonography, the uterus was observed deviated to the right, with a nodular lesion at the right uterosacral ligament, and the right ovary was attached to the uterus with no apparent cystic lesion. Magnetic resonance imaging showed a mass in the right uterine wall and mild wall thickening with delayed enhancement of the right distal ureter. Right ureteral endometriosis was suspected. Diagnostic laparoscopy revealed narrowing of the distal right ureter between the right uterosacral ligament and the right ovary with adhesions caused by deep infiltrating endometriosis. The adhesion bands and infiltrating endometriosis around the right ureter were dissected. CONCLUSIONS: The nonspecific symptoms of ureteral endometriosis can result in incorrect diagnosis, with renal damage as a result of prolonged hydronephrosis. A high index of suspicion and use of imaging modalities enable earlier diagnosis and preservation of renal function.
[Mh] Termos MeSH primário: Endometriose/cirurgia
Hidronefrose/cirurgia
Doenças Ureterais/cirurgia
[Mh] Termos MeSH secundário: Adulto
Constrição Patológica/complicações
Constrição Patológica/diagnóstico por imagem
Constrição Patológica/cirurgia
Dilatação
Endometriose/complicações
Endometriose/diagnóstico por imagem
Feminino
Seres Humanos
Hidronefrose/diagnóstico por imagem
Hidronefrose/etiologia
Laparoscopia
Imagem por Ressonância Magnética
Radiografia Abdominal
Tomografia Computadorizada por Raios X
Ultrassonografia
Doenças Ureterais/complicações
Doenças Ureterais/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1518-6


  10 / 17945 MEDLINE  
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[PMID]:28456617
[Au] Autor:Pundir J; Omanwa K; Kovoor E; Pundir V; Lancaster G; Barton-Smith P
[Ad] Endereço:Centre for Reproductive Medicine, St Bartholomew's Hospital, West Smithfield, London, United Kingdom. Electronic address: jyotsnapundir@yahoo.com.
[Ti] Título:Laparoscopic Excision Versus Ablation for Endometriosis-associated Pain: An Updated Systematic Review and Meta-analysis.
[So] Source:J Minim Invasive Gynecol;24(5):747-756, 2017 Jul - Aug.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to update the evidence on the surgical management of endometriosis-associated pain. Does laparoscopic excision offer any benefits over laparoscopic ablation? This is a systematic review and meta-analysis in which we searched MEDLINE, Embase, Institute for Scientific Information conference proceedings, the International Standard Randomised Controlled Trial Number registry, the Register and Meta-register for randomized controlled trials, the World Health Organization trials search portal, the Cochrane Library, and the British Library of electronic theses. Three randomized controlled trials were included, which enrolled 335 participants with a sample size per study ranging from 24 to 178 participants. Of these 3 studies, data from 2 could be pooled for meta-analysis. The primary outcome measure was the reduction in the visual analog scale score for dysmenorrhea. The secondary outcome measures included the reduction in the visual analog scale score for dyspareunia, dyschezia, and chronic pelvic pain and the reduction in Endometriosis Health Profile-30 core pain scores. The meta-analysis showed that the excision group had a significantly greater reduction in symptoms of dysmenorrhea (mean difference [MD] = 0.99; 95% confidence interval [CI], -0.02 to 2.00; p = .05) and dyschezia (MD = 1.31; 95% CI, 0.33-2.29; p = .009) compared with ablation. The symptoms of dyspareunia showed a nonsignificant benefit with excision (MD = 0.96; 95% CI, -0.07 to 1.99; p = .07). Data from 1 study showed a significant reduction in chronic pelvic pain (MD = 2.57; 95% CI, 1.27-3.87; p = .0001) and Endometriosis Health Profile-30 core pain scores (MD = 13.20; 95% CI, 3.70-22.70; p = .006) with the excision group compared with the ablation group. The limited available evidence shows that at 12 months postsurgery, symptoms of dysmenorrhea, dyschezia, and chronic pelvic pain secondary to endometriosis showed a significantly greater improvement with laparoscopic excision compared with ablation.
[Mh] Termos MeSH primário: Técnicas de Ablação Endometrial/métodos
Endometriose/cirurgia
Laparoscopia/métodos
Distúrbios do Assoalho Pélvico/cirurgia
Dor Pélvica/cirurgia
[Mh] Termos MeSH secundário: Dor Crônica/etiologia
Dor Crônica/cirurgia
Dismenorreia/etiologia
Dismenorreia/cirurgia
Dispareunia/etiologia
Dispareunia/cirurgia
Técnicas de Ablação Endometrial/efeitos adversos
Endometriose/complicações
Feminino
Seres Humanos
Laparoscopia/efeitos adversos
Terapia a Laser/efeitos adversos
Terapia a Laser/métodos
Distúrbios do Assoalho Pélvico/complicações
Dor Pélvica/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE



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