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[PMID]:28697872
[Au] Autor:Waters DJ; Kengeri SS; Maras AH; Suckow CL; Chiang EC
[Ad] Endereço:The Center for Exceptional Longevity Studies, Gerald P. Murphy Cancer Foundation, 3000 Kent Avenue, Suite E2-400, West Lafayette, IN 47906, USA. Electronic address: dwaters@gpmcf.org.
[Ti] Título:Life course analysis of the impact of mammary cancer and pyometra on age-anchored life expectancy in female Rottweilers: Implications for envisioning ovary conservation as a strategy to promote healthy longevity in pet dogs.
[So] Source:Vet J;224:25-37, 2017 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mammary cancer and pyometra are important health hazards associated with ovary conservation in pet dogs. Early ovariohysterectomy may reduce the incidence of these two diseases, but an estimate of the extent to which the development of mammary cancer or pyometra adversely influences overall longevity is missing. As a first step toward addressing this knowledge gap, the results of a historical cohort study of Rottweilers that lived in North America are reported. Questionnaires completed by owners and veterinarians were used to obtain lifetime health and medical information on 242 female Rottweilers, including years of lifetime ovary exposure, age at death, and cause of death. To determine the extent to which longevity was shortened in females that developed these ovary-associated diseases, age-anchored life expectancy-defined as the median number of remaining years until death for females alive at specified ages during the life course-and years of life lost, a measure of premature mortality, were estimated. Mammary carcinoma was diagnosed in 19 (7.9%) females; median age at diagnosis was 8.5 years; case fatality was 37%. Pyometra was diagnosed in 16 (6.6%) females; median age at diagnosis was 5.4 years; case fatality was 7%. Median lifetime ovary exposure for the study population was 4.3 years. Although risk for developing both diseases increased with longer ovary exposure, longer ovary exposure (≥4.3 years) was also associated with an overall longevity advantage-a 33% decrease in mortality, living 17 months longer than females with shorter ovary exposure (P=0.002). Analysis of age-anchored life expectancy showed that at no time points during the life course was the current or future diagnosis of mammary carcinoma or pyometra associated with shortened survival compared to females who never developed these conditions. This lack of longevity disadvantage is an expected result for diseases with late-onset, moderate (<50%) case fatality (mammary carcinoma) or low (<10%) case fatality (pyometra). These findings fail to support the notion that a strategy, such as elective ovariohysterectomy, implemented to reduce the incidence of mammary carcinoma and pyometra will beneficially impact overall longevity. It follows that future efforts to find and implement effective longevity-promoting interventions should look beyond reducing the incidence of a particular disease to considering trade-offs.
[Mh] Termos MeSH primário: Neoplasias da Mama/veterinária
Doenças do Cão/fisiopatologia
Doenças do Cão/cirurgia
Expectativa de Vida
Ovariectomia/veterinária
Piometra/veterinária
[Mh] Termos MeSH secundário: Animais
Neoplasias da Mama/fisiopatologia
Neoplasias da Mama/cirurgia
Cães
Feminino
Promoção da Saúde/métodos
Histerectomia/veterinária
Longevidade/fisiologia
Ovário/fisiopatologia
Piometra/fisiopatologia
Piometra/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28257873
[Au] Autor:Karstrup CC; Pedersen HG; Jensen TK; Agerholm JS
[Ad] Endereço:Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, DK-1870 Frederiksberg, Denmark.
[Ti] Título:Bacterial invasion of the uterus and oviducts in bovine pyometra.
[So] Source:Theriogenology;93:93-98, 2017 Apr 15.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pyometra is a common disease of cattle that causes infertility and thereby financial losses to the cattle industry. Bacteria involved in the development and progression of pyometra have been investigated by microbial culture but their tissue invading abilities, which is an important aspect of bacterial pathogenicity and development of lesions, have not been investigated. Bacterial invasion of the uterus and oviducts was studied in 21 cows diagnosed with pyometra at the time of slaughter by applying fluorescence in situ hybridization using probes targeting 16S ribosomal RNA of Fusobacterium necrophorum, Porphyromonas levii, Trueperella pyogenes and the overall bacterial domain Bacteria. Fusobacterium necrophorum and P. levii were found to invade the endometrium, especially if the endometrium was ulcerated, and penetrated deep into the lamina propria. These species co-localized within the tissue thus indicating a synergism. Trueperella pyogenes did not invade the uterine tissue. In addition to endometrial lesions, most cows with pyometra also had salpingitis but without significant bacterial invasion of the oviductal wall.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Doenças dos Bovinos/microbiologia
Tubas Uterinas/microbiologia
Piometra/veterinária
Útero/microbiologia
[Mh] Termos MeSH secundário: Actinomycetaceae/genética
Actinomycetaceae/isolamento & purificação
Animais
Bactérias/genética
Bovinos
Endométrio/microbiologia
Feminino
Fusobacterium necrophorum/genética
Fusobacterium necrophorum/isolamento & purificação
Hibridização in Situ Fluorescente/veterinária
Porphyromonas/genética
Porphyromonas/isolamento & purificação
Piometra/microbiologia
RNA Ribossômico 16S/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


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[PMID]:28108392
[Au] Autor:Bhaskar MM; Sistla S; Kumaravel S
[Ad] Endereço:Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER), Pondicherry, India.
[Ti] Título:A case of pyometrocolpos with Bifidobacterium species.
[So] Source:Anaerobe;44:48-50, 2017 Apr.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bifidobacterium species, a normal commensal of the human gastrointestinal tract, female genitourinary tract and vagina is usually considered non-pathogenic and is being used therapeutically as probiotic due to its beneficial effects. However, there are several case reports implicating Bifidobacteria as the causative agent in various infectious conditions. Infections with Bifidobacteria are often ignored or underreported as they are part of the normal gut microbiome. Here we discuss a case of pyometrocolpos with Bifidobacterium species. Clinical outcome of the patient was good after emergency drainage and antibiotic treatment with Cefoperazone sulbactam and Metronidazole.
[Mh] Termos MeSH primário: Infecções por Bifidobacteriales/diagnóstico
Infecções por Bifidobacteriales/microbiologia
Bifidobacterium/isolamento & purificação
Piometra/diagnóstico
Piometra/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Infecções por Bifidobacteriales/patologia
Infecções por Bifidobacteriales/terapia
Cefoperazona/administração & dosagem
Pré-Escolar
Drenagem
Feminino
Seres Humanos
Metronidazol/administração & dosagem
Piometra/patologia
Piometra/terapia
Sulbactam/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 140QMO216E (Metronidazole); 7U75I1278D (Cefoperazone); S4TF6I2330 (Sulbactam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE


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[PMID]:28100574
[Au] Autor:Ørum M; Fuglsang-Damgaard D; Nielsen HL
[Ad] Endereço:Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
[Ti] Título:Clostridium hastiforme bacteraemia secondary to pyometra in a 64-year-old woman.
[So] Source:BMJ Case Rep;2017, 2017 Jan 18.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Gram-negative, rod-shaped, anaerobe bacteria Tissierella praeacuta was first described in 1908 by Tissier. However, during the past decade, Clostridium hastiforme has been recognised as a later synonym of T. praeacuta. C. hastiforme/T. praeacuta has only rarely been described in previous literature as a cause of human infection. We present here a case report of C. hastiforme/T. praeacuta bacteraemia secondary to pyometra in a 64-year-old woman with a history of multiple sclerosis and an intrauterine device inserted three decades earlier. C. hastiforme/T. praeacuta was isolated from blood as well as pus from the site of infection. The patient was cured with a combination of drainage and antibiotic therapy.
[Mh] Termos MeSH primário: Bacteriemia/etiologia
Infecções por Clostridium/complicações
Dispositivos Intrauterinos
Infecções Relacionadas à Prótese/complicações
Piometra/complicações
[Mh] Termos MeSH secundário: Infecções por Clostridium/cirurgia
Remoção de Dispositivo
Drenagem
Feminino
Seres Humanos
Meia-Idade
Infecções Relacionadas à Prótese/cirurgia
Piometra/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE


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[PMID]:28056957
[Au] Autor:Jitpean S; Ambrosen A; Emanuelson U; Hagman R
[Ad] Endereço:Department of Surgery and Theriogenology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. supranee.jitpean@slu.se.
[Ti] Título:Closed cervix is associated with more severe illness in dogs with pyometra.
[So] Source:BMC Vet Res;13(1):11, 2017 Jan 05.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pyometra, a life-threatening bacterial infection of the uterus, is classified as open or closed depending on the functional patency of the cervix i.e. presence or absence of vaginal discharge. In closed cervix pyometra, pus and bacterial products accumulate in the uterus, which is thought to induce a more severe illness. The aim of this study was to investigate whether disease severity or outcome differed in dogs with open or closed cervix pyometra. RESULTS: Prospectively collected data from 111 female dogs diagnosed with pyometra at the University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, intermittently during 2005-2012 was analyzed. Seventy-two dogs (65%) had open cervix, whereas 39 dogs (35%) had closed cervix. Differences between the two groups were explored by Wilcoxon Two Sample Test for continuous variables and Chi-square or Fisher's exact test for categorical variables. P < 0.05 was considered significant. In dogs with open cervix the median age was 9.0 years and the median weight 26.0 kg. In dogs with closed cervix the median age was 9.6 years and the median weight 25.0 kg, with no significant differences between the groups (p = 0.69 and 0.24, respectively). Five dogs (4.5%) died, all with open cervix, and 16 dogs (14%) had complications. The general physical condition was moderately or severely depressed in 30% (21/71) of dogs with open cervix (severely depressed in 4 dogs, moderately depressed in 17 dogs) and in 56% (22/39) of dogs with closed cervix (severely depressed in 3 dogs, moderately depressed in 19 dogs). The general physical condition was mildly depressed in 41 dogs with open cervix and 16 dogs with closed cervix, whereas it was normal in nine dogs with open cervix and one dog with closed cervix. None of the included dogs had very severely depressed general physical condition or were non-responsive. Leukocytosis, neutrophilia, monocytosis and moderately to severely depressed general condition was more commonly found in dogs with closed cervix (p = 0.003, p = 0.008, p = 0.003 and p = 0.006, respectively). Sepsis was more commonly present in closed cervix pyometra (77%, 30/39 dogs) compared to open cervix pyometra (51%, 36/71 dogs) (p = 0.007). Presence of prolonged postoperative hospitalization did not differ significantly between the two groups. CONCLUSIONS: In dogs with closed cervix, sepsis was more common, the general physical condition more often moderately to severely depressed and leukocytosis, neutrophilia and monocytosis more frequently found. The results showed that closed cervix was associated with a more severe illness than open cervix at admission but not with poorer outcome as measured by postoperative hospitalization. These findings may be clinically valuable for optimizing monitoring and treatments in dogs with the disease.
[Mh] Termos MeSH primário: Colo do Útero/fisiologia
Doenças do Cão/patologia
Piometra/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/cirurgia
Cães
Feminino
Hospitalização
Piometra/mortalidade
Piometra/patologia
Piometra/cirurgia
Estudos Retrospectivos
Fatores de Risco
Sepse/veterinária
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-016-0924-0


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[PMID]:28043343
[Au] Autor:Prapaiwan N; Manee-In S; Olanratmanee E; Srisuwatanasagul S
[Ad] Endereço:Department of Anatomy, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
[Ti] Título:Expression of oxytocin, progesterone, and estrogen receptors in the reproductive tract of bitches with pyometra.
[So] Source:Theriogenology;89:131-139, 2017 Feb.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Canine pyometra is considered a serious and life-threatening condition. Due to the relationship among sex steroid hormones, oxytocin receptor (OTR) expression, and canine pyometra pathogenesis, this study aimed to investigate the expression of oxytocin, progesterone, and estrogen receptors in the reproductive tissues of canines with pyometra by real-time PCR and immunohistochemistry. A total of 27 pyometra bitches were classified into open- and closed-cervix pyometra groups based on the presence of vaginal discharge. Moreover, 15 normal bitches in the luteal phase served as a control group. The results showed that OTR gene expression in the ovary of pyometra bitches was higher than that of normal bitches, whereas the level of OTR gene expression in the cervix of pyometra bitches was less than that of normal bitches (P < 0.05). Conversely, a lower OTR H-score in ovarian follicles was observed in pyometra bitches compared with normal bitches, whereas a higher percentage of OTR-positive immunostaining in uteri and cervices were found in pyometra bitches compared with normal bitches (P < 0.05). Moreover, the H-scores of estrogen receptor alpha in uteri and cervices of pyometra bitches were less than that of normal bitches (P < 0.05). However, the localization of the OTR and sex steroid receptors between groups of pyometra bitches was not different. Our findings suggest that pyometra pathogenesis is associated with a change in expression of OTR and sex steroid receptors in the canine reproductive tract. However, cervical dilation in bitches with pyometra was not influenced by the expression of OTR and sex steroid receptors.
[Mh] Termos MeSH primário: Doenças do Cão/metabolismo
Piometra/veterinária
Receptores Estrogênicos/metabolismo
Receptores de Ocitocina/metabolismo
Receptores de Progesterona/metabolismo
[Mh] Termos MeSH secundário: Animais
Colo do Útero/metabolismo
Cães
Feminino
Regulação da Expressão Gênica
Imuno-Histoquímica
Ovário/metabolismo
Piometra/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Estrogen); 0 (Receptors, Oxytocin); 0 (Receptors, Progesterone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:27807901
[Au] Autor:Hagman R
[Ad] Endereço:Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Título:Canine pyometra: What is new?
[So] Source:Reprod Domest Anim;52 Suppl 2:288-292, 2017 Apr.
[Is] ISSN:1439-0531
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pyometra is a common disease in countries where elective spaying is not routinely performed. Hormonal and bacterial factors are fundamental in the pathogenesis of the disease, which manifests itself as a potentially life-threatening bacterial infection of the uterus. Surgical ovariohysterectomy is the safest and most effective treatment for pyometra, and it has recently been shown that laparoscopically assisted methods for surgical treatment are feasible to use in selected cases. New protocols for improved medical treatment alternatives have also been tested with promising results. To be able to predict outcome and presence of complications early would be valuable in clinical practice for optimizing therapy and increasing survival. Results of commonly investigated clinical and laboratory investigations have been shown to be useful as predictive markers, with leucopenia being associated with increased risk of peritonitis as well as prolonged post-operative hospitalization after surgical treatment. A cage-side rapid and cost-effective diagnostic test would be highly valuable in clinical practice, and detection of pyometra-specific upregulated genes in the uterus and the corresponding products is a potential start in identifying novel markers suitable for such as test. The focus of the present review is to highlight recent findings on pathogenesis, prediction of outcome, diagnosis and treatment. Additionally, central research questions and suggestions for future investigations about several aspects of canine pyometra will be addressed.
[Mh] Termos MeSH primário: Doenças do Cão/terapia
Piometra/veterinária
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/uso terapêutico
Infecções Bacterianas/terapia
Infecções Bacterianas/veterinária
Doenças do Cão/diagnóstico
Doenças do Cão/etiologia
Cães
Feminino
Histerectomia/métodos
Histerectomia/veterinária
Laparoscopia/veterinária
Ovariectomia/métodos
Ovariectomia/veterinária
Progesterona
Prognóstico
Piometra/diagnóstico
Piometra/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.1111/rda.12843


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[PMID]:27855712
[Au] Autor:Höglund OV; Lövebrant J; Olsson U; Höglund K
[Ad] Endereço:Department of Clinical Sciences, Box 7054, 750 07, Uppsala, Sweden. Odd.Hoglund@slu.se.
[Ti] Título:Blood pressure and heart rate during ovariohysterectomy in pyometra and control dogs: a preliminary investigation.
[So] Source:Acta Vet Scand;58(1):80, 2016 Nov 17.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surgery causes a stress response, a physiologic response to trauma. The intraoperative surgical stress response in dogs diagnosed with pyometra has not previously been described. The aim of this study was to investigate the intraoperative surgical stress response, assessed by blood pressure and heart rate measurements, in dogs diagnosed with pyometra and healthy controls. All dogs were premedicated with acepromazine and methadone, anaesthesia was induced with propofol and maintained with isoflurane, where after the dogs were subjected to ovariohysterectomy. RESULTS: Eight dogs diagnosed with pyometra and eight healthy controls were used. Systolic blood pressure and heart rate were measured to assess the surgical stress response. Additionally propofol dosage at induction of anaesthesia and the end-tidal isoflurane concentration were investigated. The surgery was split into four phases. Phase 0 was the period 10 min before the skin incision, phase 1 was skin incision and opening of abdomen, phase 2 was manipulation of uterine horns, lifting of the ovary with stretching of the mesovarium, ligation and transection of mesovarium and phase 3 was ligation and transection of cervix, removal of organs and closing of the abdomen. Dosage of propofol at induction of anaesthesia was 3.6 ± 1 mg/kg in dogs with pyometra and 4.1 ± 1 in healthy controls (P = 0.37). In both groups, systolic blood pressure increased between phase 1 and 2, from 87 ± 15 to 114 ± 19 mmHg in dogs with pyometra, and from 88 ± 18 to 106 ± 20 mmHg in healthy controls, (both P < 0.0001). Systolic blood pressure did not differ significantly between groups in any of the phases. Heart rate and end-tidal concentration of isoflurane did not differ significantly between phases or between groups. CONCLUSIONS: The increased blood pressure at removal of ovaries during ovariohysterectomy suggests a pronounced noxious stimulus at this part of the procedure. In principle, the study parameters and response to surgery did not differ significantly between dogs with pyometra and healthy controls.
[Mh] Termos MeSH primário: Pressão Sanguínea
Doenças do Cão/cirurgia
Frequência Cardíaca
Histerectomia/veterinária
Ovariectomia/veterinária
Piometra/veterinária
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Piometra/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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Carvalho, Sandra
[PMID]:27829462
[Au] Autor:Henriques S; Silva E; Silva MF; Carvalho S; Diniz P; Lopes-da-Costa L; Mateus L
[Ad] Endereço:Reproduction and Development Laboratory, CIISA, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
[Ti] Título:Immunomodulation in the canine endometrium by uteropathogenic Escherichia coli.
[So] Source:Vet Res;47(1):114, 2016 Nov 09.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was designed to evaluate the role of E. coli α-hemolysin (HlyA) in the pathogenesis of canine pyometra, and on the immune response of canine endometrial epithelial and stromal cells. In Experiment 1, the clinical, hematological, biochemical and uterine histological characteristics of ß-hemolytic and non-hemolytic E. coli pyometra bitches were compared. More (p < 0.05) metritis cases were observed in ß-hemolytic E. coli pyometra uteri than in non-hemolytic E. coli pyometra uteri. ß-hemolytic E. coli pyometra endometria had higher gene transcription of IL-1ß and IL-8 and lower gene transcription of IL-6 than non-hemolytic E. coli pyometra endometria (p < 0.01). In Experiment 2, the immune response of endometrial epithelial and stromal cells, to hemolytic (Pyo18) and non-hemolytic E. coli strains (Pyo18 with deleted hlya-Pyo18ΔhlyA- and Pyo14) were compared. Following 4 h of incubation, Pyo18 decreased epithelial cell numbers to 54% (p < 0.001), and induced death of all stromal cells (p < 0.0001), whereas Pyo18ΔhlyA and Pyo14 had no effect on cell numbers. Compared to Pyo18ΔhlyA and Pyo14, respectively, Pyo18 induced a lower transcription level of IL-1ß (0.99 vs 152.0 vs 50.9 fold increase, p < 0.001), TNFα (3.2 vs 49.9 vs 12.9 fold increase, p < 0.05) and IL-10 (0.4 vs 3.6 vs 2.6 fold increase, p < 0.001) in stromal cells, after 1 h of incubation. This may be seen as an attempt of hemolytic E. coli to delay the activation of the immune response. In conclusion, endometrial epithelial and stromal cell damage induced by HlyA is a potential relevant step of E. coli virulence in the pathogenesis of pyometra.
[Mh] Termos MeSH primário: Doenças do Cão/microbiologia
Infecções por Escherichia coli/veterinária
Piometra/veterinária
[Mh] Termos MeSH secundário: Animais
Citocinas/metabolismo
Doenças do Cão/imunologia
Cães
Endométrio/imunologia
Endométrio/microbiologia
Endométrio/patologia
Infecções por Escherichia coli/complicações
Infecções por Escherichia coli/imunologia
Infecções por Escherichia coli/microbiologia
Feminino
Imunofluorescência/veterinária
Imunomodulação/imunologia
Piometra/imunologia
Piometra/microbiologia
Piometra/patologia
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


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[PMID]:27435848
[Au] Autor:Kroon HM; Smolders RG
[Ad] Endereço:Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
[Ti] Título:Acute abdomen caused by spontaneous perforation of pyometra in a patient with cervical cancer.
[So] Source:BMJ Case Rep;2016, 2016 Jul 18.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Abdome Agudo/etiologia
Neoplasias de Células Escamosas/complicações
Piometra/complicações
Perfuração Espontânea/complicações
Neoplasias do Colo do Útero/complicações
Perfuração Uterina/complicações
[Mh] Termos MeSH secundário: Abdome Agudo/diagnóstico por imagem
Abdome Agudo/cirurgia
Idoso
Feminino
Seres Humanos
Neoplasias de Células Escamosas/diagnóstico por imagem
Neoplasias de Células Escamosas/cirurgia
Piometra/diagnóstico por imagem
Piometra/cirurgia
Perfuração Espontânea/diagnóstico por imagem
Perfuração Espontânea/cirurgia
Tomografia Computadorizada por Raios X
Neoplasias do Colo do Útero/diagnóstico por imagem
Neoplasias do Colo do Útero/cirurgia
Perfuração Uterina/diagnóstico por imagem
Perfuração Uterina/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE



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