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[PMID]: 28954299 [Au] Autor: Safaeian M; Sampson JN; Pan Y; Porras C; Kemp TJ; Herrero R; Quint W; van Doorn LJ; Schussler J; Lowy DR; Schiller J; Schiffman MT; Rodriguez AC; Gail MH; Hildesheim A; Gonzalez P; Pinto LA; Kreimer AR; Costa Rica HPV Vaccine Trial (CVT) Group [Ad] Endereço: Roche Molecular Diagnostics, Pleasanton, CA; National Cancer Institute, National Institutes of Health, Bethesda, MD; HPV Immunology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD; Agencia Costarricense de Investigaciones Biomédicas (ACI [Ti] Título: Durability of Protection Afforded by Fewer Doses of the HPV16/18 Vaccine: The CVT Trial. [So] Source: J Natl Cancer Inst;110(2), 2018 Feb 01. [Is] ISSN: 1460-2105 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Previously, we demonstrated similar human papillomavirus (HPV)16/18 vaccine efficacy estimates and stable HPV16/18 antibody levels four years postvaccination in a nonrandomized analysis of women who received a varying number of doses of the bivalent HPV16/18 vaccine. Here we extend data to seven years following initial vaccination. Methods: We evaluated HPV16/18-vaccinated women who received one (n = 134), two (n 0/1 = 193, n 0/6 = 79), or three doses (n = 2043) to a median of 6.9 years postvaccination. Cervical HPV DNA was measured with the SPF10- DEIA-LiPA PCR system; HPV16/18-specific antibody levels were measured using enzyme-linked immunosorbent assays (n = 486). Infection and immunological measures were compared across vaccine dose groups. Prevalent HPV infection at year 7 was also compared with an unvaccinated control group (UCG). All statistical tests were two-sided. Results: Among women in the three-dose, two-dose 0/6 , two-dose 0/1 , and one-dose groups, cumulative incident HPV16/18 infection rates (No. of events/No. of individuals) were 4.3% (88/2036, 95% confidence interval [CI] = 3.5% to 5.3%), 3.8% (3/78, 95% CI = 1.0% to 10.1%), 3.6% (7/192, 95% CI = 1.6% to 7.1%), and 1.5% (2/133, 95% CI = 0.3% to 4.9%; P = 1.00, .85, .17 comparing the two-dose 0/6 , two-dose 0/1 , and one-dose groups to the three-dose group, respectively). The prevalence of other carcinogenic and noncarcinogenic HPV types, excluding HPV16/18/31/33/45, were high and not statistically different among all dose groups, indicating that the low incidence of HPV16/18 in the one- and two-dose groups was not due to lack of exposure. At seven years, 100% of participants in all dose groups remained HPV16 and HPV18 seropositive. A non-statistically significant decrease in the geometric mean of the HPV16 antibody levels between years 4 and 7 was observed among women in the three-dose group: -10.8% (95% CI = -25.3% to 6.6%); two-dose (0/6 months) group: -17.3% (95% CI = -39.3% to 12.8%), two-dose (0/1 month) group: -6.9% (95% CI = -22.1% to 11.2%), and one-dose group: -5.5% (95% CI = -29.7% to 27.0%); results were similar for HPV18. Conclusions: At an average of seven years of follow-up, we observed similar low rates of HPV16/18 infections and slight, if any, decreases in HPV16/18 antibody levels by dose group. [Mh] Termos MeSH primário: Papillomavirus Humano 16/imunologia Papillomavirus Humano 18/imunologia Vacinas contra Papillomavirus/administração & dosagem Vacinas contra Papillomavirus/imunologia [Mh] Termos MeSH secundário: Adolescente Adulto Anticorpos Antivirais/sangue Anticorpos Antivirais/imunologia Colo do Útero/virologia DNA Viral/genética Feminino Papillomavirus Humano 16/genética Papillomavirus Humano 18/genética Seres Humanos Infecções por Papillomavirus/imunologia Infecções por Papillomavirus/prevenção & controle Infecções por Papillomavirus/virologia Doenças do Colo do Útero/imunologia Doenças do Colo do Útero/prevenção & controle Doenças do Colo do Útero/virologia Adulto Jovem [Pt] Tipo de publicação: CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Antibodies, Viral); 0 (DNA, Viral); 0 (Papillomavirus Vaccines); 0 (human papillomavirus vaccine, L1 type 16, 18) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE [do] DOI: 10.1093/jnci/djx158

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[PMID]: 29424508 [Au] Autor: Beltrán-Montoya J; Escudero-Gontes S; Martínez-Huerta NE; Ávila-Vergara MA; Morales-Hernández V; Canchola-Sotelo C; Palacios-González B; Vadillo-Ortega F [Ti] Título: [Pilot tests using molecular diagnostic assay cervicovaginal infection during pregnancy]. [Ti] Título: Ensayo piloto del uso de pruebas moleculares para el diagnóstico de infecciones cervicovaginales en pacientes embarazadas.. [So] Source: Ginecol Obstet Mex;84(8):475-83, 2016 08. [Is] ISSN: 0300-9041 [Cp] País de publicação: Mexico [La] Idioma: spa [Ab] Resumo: Background: The prevalence of cervicovaginal infections during pregnancy has been associated with adverse perinatal outcomes however, the actual approach used for diagnosis is not effective. The aim of this study was to compare the diagnosis of vaginal infections in pregnant women using clinical, molecular diagnostic and traditional microbiological culture in a pilot study, to determine the prevalence and association with the development of preterm labor. Materials and methods: We performed a nested cross-sectional study composed by 54 women in a cohort of pregnant women in Mexico City. Cervicovaginal infections were evaluated by clinical methods, microbiology culture and a commercially available molecular biology test. Results: Prevalence of cervicovaginal infections during pregnancy was estimated between 28% and 50% according to methodologies. Considering the clinical diagnosis of preterm labor as the gold standard, all diagnostic tests were poor as predictors of preterm labor. Conclusion: Traditional approaches to establish the significance of cervicovaginal infection in pregnancy are exhausted, so be sought new ways to understand this complex relationship. Meanwhile it is recommended to continue to use traditional methods to identify infections during pregnancy in both knowledge of new methods aimed at understanding these relationships are sophisticated. [Mh] Termos MeSH primário: Técnicas de Diagnóstico Molecular/métodos Complicações Infecciosas na Gravidez/diagnóstico Doenças do Colo do Útero/diagnóstico Doenças Vaginais/diagnóstico [Mh] Termos MeSH secundário: Adolescente Adulto Estudos de Coortes Estudos Transversais Feminino Seres Humanos México Trabalho de Parto Prematuro/epidemiologia Projetos Piloto Gravidez Complicações Infecciosas na Gravidez/microbiologia Resultado da Gravidez Doenças do Colo do Útero/microbiologia Doenças Vaginais/microbiologia Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180210 [St] Status: MEDLINE

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[PMID]: 29310409 [Au] Autor: Zhang R; Gu P; Liu Q; Li B; Bai W [Ad] Endereço: Department of Obstetrics and Gynecology, Beijing Shijitan Hospital of Capital Medical University. [Ti] Título: Analysis of diagnosis and treatment of complicated cervical severe adhesion atresia after removal of endometrial stromal nodule: A case report. [So] Source: Medicine (Baltimore);96(48):e8979, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Endometrial stromal nodule (ESN) is a rare benign endometrial stroma tumor.Experiences are helpful for avoiding and treating similar postoperative complications (cervical adhesions and atresia). PATIENT CONCERNS: When appearing in the cervical, this tumor can easily lead to complications after the surgical resection. The diagnosis and postsurgery complication of a young woman's ESN was reported here. DIAGNOSES: The postoperative pathological diagnosis was ESN. INTERVENTIONS: A 29-year-old young woman was diagnosed and treated for ESN in cervical parts with postsurgery complications of cervical complex adhesion atresia. OUTCOMES: The complication was complex cervix adhesion atresia with very special imaging performance-the cervix and the palace imaged as "Twisted and Angled Staircase." This particular cervix adhesion was challenging for operation. We achieved a successful treatment through the carefully designed surgical procedure including the application of hysteroscopy and laparoscopy. LESSONS: The lower uterine segment and cervix should be paid attention during suturing in this situation. Close and positive follow-ups should be planned after the endometrial stromal resection. The reconstruction of the tunnel is a solution for the problem of menstruation. [Mh] Termos MeSH primário: Neoplasias do Endométrio/cirurgia Tumores do Estroma Endometrial/cirurgia Complicações Pós-Operatórias Doenças do Colo do Útero/diagnóstico Doenças do Colo do Útero/cirurgia [Mh] Termos MeSH secundário: Adulto Diagnóstico Diferencial Neoplasias do Endométrio/diagnóstico Neoplasias do Endométrio/patologia Tumores do Estroma Endometrial/diagnóstico Tumores do Estroma Endometrial/patologia Feminino Seres Humanos Aderências Teciduais/diagnóstico Aderências Teciduais/etiologia Aderências Teciduais/cirurgia Doenças do Colo do Útero/etiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180110 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008979

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[PMID]: 28954002 [Au] Autor: Oliveira GR; Siqueira JD; Finger-Jardim F; Vieira VC; Silva RL; Gonçalves CV; Soares EA; Martinez AMB; Soares MA [Ad] Endereço: Universidade Federal do Rio Grande, Escola de Medicina, Laboratório de Biologia Molecular, Rio Grande, RS, Brasil. [Ti] Título: Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil. [So] Source: Mem Inst Oswaldo Cruz;112(10):728-731, 2017 Oct. [Is] ISSN: 1678-8060 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil. [Mh] Termos MeSH primário: Genoma Viral Papillomaviridae/genética Infecções por Papillomavirus/virologia Doenças do Colo do Útero/virologia [Mh] Termos MeSH secundário: Adulto Brasil DNA Viral Feminino Seres Humanos Papillomaviridae/isolamento & purificação Filogenia Fatores de Risco Esfregaço Vaginal [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Viral) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE

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[PMID]: 28697117 [Au] Autor: Hilal Z; Alici F; Tempfer CB; Seebacher V; Rezniczek GA [Ad] Endereço: Department of Obstetrics and Gynecology, Ruhr-Universität Bochum, Bochum, Germany; and the Department of Gynecology and Gynecologic Oncology, Gynecologic Cancer Unit, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria. [Ti] Título: Video Colposcopy for Reducing Patient Anxiety During Colposcopy: A Randomized Controlled Trial. [So] Source: Obstet Gynecol;130(2):411-419, 2017 Aug. [Is] ISSN: 1873-233X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To test whether video colposcopy reduces anxiety among patients undergoing colposcopy. METHODS: In a prospective, randomized multicenter trial, we compared video colposcopy and no video colposcopy in a one-to-one ratio. Situation-specific anxiety was measured before (S1) and after (S2) colposcopy using the State-Trait Anxiety Inventory. The primary endpoint was the reduction of the situation-specific anxiety scores (ΔS=S2-S1). Secondary endpoints were pain during and 10 minutes after colposcopy, general unpleasantness, anxiety during colposcopy, satisfaction with the information about the procedure, and overall satisfaction (11-item visual analog scales). Analysis was by intention to treat. A sample size of 104 per group (n=208) was planned to achieve 80% power to detect a difference of 4.8 with a SD of 12.3 in the primary outcome. RESULTS: Between August 2016 and March 2017, 225 women were randomized. The mean ΔS was -10.3±11.3 SD in 111 women in the video colposcopy group and -10.3±11.0 SD in 105 women without video colposcopy (P=.50). The secondary endpoints pain during examination (median 2 [interquartile range 1-3] compared with 2 [1-4]; P=.91), pain 10 minutes after examination (1 [0-3] compared with 1 [0-2.5]; P=.24), general unpleasantness (3 [1-5] compared with 3 [1-5]; P=.90), anxiety during examination (3 [1-5] compared with 3 [1-5]; P=.61), satisfaction with the information about the procedure (10 [9-10] compared with 10 [9-10]; P=.88), and overall satisfaction (10 [9-10] compared with 10 [9-10]; P=.54) were also not different between the two study groups. In a multivariate linear regression analysis, study center (P=.028), body mass index (P=.033), and smoking status (P=.025) independently affected the reduction of anxiety. CONCLUSION: Video colposcopy does not reduce anxiety in women undergoing colposcopy. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02697175. [Mh] Termos MeSH primário: Ansiedade/prevenção & controle Colposcopia/psicologia Cirurgia Vídeoassistida/psicologia [Mh] Termos MeSH secundário: Adulto Índice de Massa Corporal Colposcopia/efeitos adversos Colposcopia/métodos Feminino Seres Humanos Meia-Idade Medição da Dor Estudos Prospectivos Fumar/epidemiologia Doenças do Colo do Útero/diagnóstico [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170821 [Lr] Data última revisão: 170821 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170712 [St] Status: MEDLINE [do] DOI: 10.1097/AOG.0000000000002127

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[PMID]: 28577618 [Au] Autor: Suen MWH; Bougie O; Singh SS [Ad] Endereço: Department of Obstetrics, Gynecology and Newborn Care, University of Ottawa, Ottawa, Ontario, Canada. [Ti] Título: Hysteroscopic management of a stenotic cervix. [So] Source: Fertil Steril;107(6):e19, 2017 Jun. [Is] ISSN: 1556-5653 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To demonstrate an approach to the hysteroscopic management of a stenotic cervix. DESIGN: Step-by-step explanation of the techniques using video and animation (educational video). SETTING: Academic tertiary level referral center. PATIENT(S): Patients with cervical stenosis, inclusive of both reproductive age and postmenopausal women. Gynecologists require intrauterine access for many procedures, but a stenotic cervix can obstruct surgery. Blind dilation of a stenotic cervix can lead to a cervical laceration or uterine perforation, with concomitant complications. INTERVENTION(S): The hysteroscopic management of a stenotic cervix includes optimizing the surgical environment, performing vaginoscopy and "no-touch" hysteroscopy, and revision of the cervical canal. Revision can be performed using microscissors, micrograspers, or a cutting loop electrode. Partial cervical canal excision to aid in hysteroscopy access should be reserved in women who are not interested in future pregnancy or those who are postmenopausal. Outpatient hysteroscopy uses smaller instruments and shows operative success with patient satisfaction. Although these techniques are demonstrated in an outpatient hysteroscopy setting, they can be adapted for use in an operating theater. MAIN OUTCOME MEASURE(S): The individual steps and approach are emphasized. RESULT(S): Intrauterine access can be achieved with various techniques. CONCLUSION(S): The "see-and-treat" approach demonstrated in this video can allow access into the uterine cavity despite a stenotic cervix. [Mh] Termos MeSH primário: Colo do Útero/patologia Colo do Útero/cirurgia Histeroscopia/métodos Procedimentos Cirúrgicos Minimamente Invasivos/métodos Doenças do Colo do Útero/patologia Doenças do Colo do Útero/cirurgia [Mh] Termos MeSH secundário: Adulto Constrição Patológica Feminino Seres Humanos Microcirurgia/métodos Meia-Idade [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170818 [Lr] Data última revisão: 170818 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170605 [St] Status: MEDLINE

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[PMID]: 28277359 [Au] Autor: Lachica R; Chan Y; Uquillas KR; Lee RH [Ad] Endereço: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Southern California, Los Angeles, California. [Ti] Título: Vaginal Delivery After Dührssen Incisions in a Patient With Bladder Exstrophy and Uterine Prolapse. [So] Source: Obstet Gynecol;129(4):689-692, 2017 Apr. [Is] ISSN: 1873-233X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Bladder exstrophy is a rare congenital anomaly affecting the lower abdominal wall, pelvis, and genitourinary structures. Pregnant women with bladder exstrophy present a unique challenge to the obstetrician. CASE: The patient is a 35-year old pregnant woman with bladder exstrophy, an extensive surgical history, and uterine prolapse with an abnormal, rubbery consistency to her cervix. Prenatally, she was counseled on the potential use of Dührssen incisions to facilitate vaginal delivery. Labor was induced at 36 4/7 weeks of gestation after her pregnancy was complicated by recurrent pyelonephritis. Vaginal delivery was achieved 8 minutes after the creation of Dührssen incisions. CONCLUSION: The care of pregnant women with bladder exstrophy requires multidisciplinary management and careful delivery planning. Successful vaginal delivery can be attained in these patients. [Mh] Termos MeSH primário: Extrofia Vesical Colo do Útero/cirurgia Parto Obstétrico/métodos Complicações na Gravidez Doenças do Colo do Útero Prolapso Uterino [Mh] Termos MeSH secundário: Adulto Extrofia Vesical/complicações Extrofia Vesical/fisiopatologia Colo do Útero/fisiopatologia Feminino Seres Humanos Planejamento de Assistência ao Paciente Gravidez Complicações na Gravidez/etiologia Complicações na Gravidez/fisiopatologia Complicações na Gravidez/cirurgia Resultado da Gravidez Procedimentos Cirúrgicos Reconstrutivos/métodos Risco Ajustado Doenças do Colo do Útero/etiologia Doenças do Colo do Útero/fisiopatologia Doenças do Colo do Útero/cirurgia Prolapso Uterino/etiologia Prolapso Uterino/fisiopatologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170621 [Lr] Data última revisão: 170621 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170310 [St] Status: MEDLINE [do] DOI: 10.1097/AOG.0000000000001938

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[PMID]: 28249017 [Au] Autor: Davies BM; McHugh M; Elgheriani A; Kolias AG; Tetreault L; Hutchinson PJ; Fehlings MG; Kotter MR [Ad] Endereço: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. [Ti] Título: The reporting of study and population characteristics in degenerative cervical myelopathy: A systematic review. [So] Source: PLoS One;12(3):e0172564, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECT: Degenerative cervical myelopathy [DCM] is a disabling and increasingly prevalent condition. Variable reporting in interventional trials of study design and sample characteristics limits the interpretation of pooled outcomes. This is pertinent in DCM where baseline characteristics are known to influence outcome. The present study aims to assess the reporting of the study design and baseline characteristics in DCM as the premise for the development of a standardised reporting set. METHODS: A systematic review of MEDLINE and EMBASE databases, registered with PROSPERO (CRD42015025497) was conducted in accordance with PRISMA guidelines. Full text articles in English, with >50 patients (prospective) or >200 patients (retrospective), reporting outcomes of DCM were deemed to be eligible. RESULTS: A total of 108 studies involving 23,876 patients, conducted world-wide, were identified. 33 (31%) specified a clear primary objective. Study populations often included radiculopathy (51, 47%) but excluded patients who had undergone previous surgery (42, 39%). Diagnositic criteria for myelopathy were often uncertain; MRI assessment was specified in only 67 (62%) of studies. Patient comorbidities were referenced by 37 (34%) studies. Symptom duration was reported by 46 (43%) studies. Multivariate analysis was used to control for baseline characteristics in 33 (31%) of studies. CONCLUSIONS: The reporting of study design and sample characteristics is variable. The development of a consensus minimum dataset for (CODE-DCM) will facilitate future research synthesis in the future. [Mh] Termos MeSH primário: Doenças da Medula Espinal Doenças do Colo do Útero [Mh] Termos MeSH secundário: Feminino Seres Humanos Prevalência Doenças da Medula Espinal/diagnóstico Doenças da Medula Espinal/epidemiologia Doenças da Medula Espinal/patologia Doenças da Medula Espinal/fisiopatologia Doenças do Colo do Útero/diagnóstico Doenças do Colo do Útero/epidemiologia Doenças do Colo do Útero/patologia Doenças do Colo do Útero/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170302 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0172564

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[PMID]: 28246983 [Au] Autor: Liu HL; Chen CM; Pai LW; Hwu YJ; Lee HM; Chung YC [Ad] Endereço: Department of Nursing, Central Taiwan University of Science and Technology, No. 666, Buzih Road, Beitun District, Taichung, 40601, Taiwan, Republic of China. [Ti] Título: Comorbidity profiles among women with postcoital bleeding: a nationwide health insurance database. [So] Source: Arch Gynecol Obstet;295(4):935-941, 2017 Apr. [Is] ISSN: 1432-0711 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: PURPOSE: Most of the existing studies on postcoital bleeding (PCB) in Western countries. To date, no study has focused on the various PCB-related comorbidities in Taiwan women. This work aims to analyze and compare the presence or absence of PCB among Taiwanese women with gynecological comorbidity. METHODS: This study is a population-based retrospective cohort investigation. Outpatients with PCB after the index date were considered. A total of 2377 female patients with PCB (ICD-9 626.7) were identified using a nationwide outpatient sample from 2001 to 2010. For comparison, 7131 cases were randomly matched with the study group in terms of gender and age. RESULTS: The PCB incidence rate was 39-59 cases/100,000 Taiwanese women, with mean age (±SD) of 36.74 ± 10.79 years, median age of 36 years, and mode age of 29 years. Women with PCB exhibited 1.47-fold risk of cervical dysplasia and 1.59-fold risk for malignant neoplasm of cervix. Young women with PCB showed high risk of cervical cancer. The most common benign diseases among PCB- related comorbidities were cervical erosion and ectropion (20.66%), followed by vaginitis and vulvovaginitis (19.18%). Comparison between PCB and non-PCB groups indicated several significant high-risk comorbidities including cervical polyps, cervical erosion, leukoplakia of cervix, intrauterine contraceptive device, cervicitis, vaginitis, menopause, dyspareunia, and vulvodynia. CONCLUSIONS: This study provides evidence that PCB-related comorbidities manifested benign diseases (51.58%), lower genital tract infection (46.11%), and cervical cancer (2.31%). Thus, healthcare providers must ensure that appropriate routine screening tests and counseling are given to women with PCB. [Mh] Termos MeSH primário: Disfunções Sexuais Fisiológicas/epidemiologia [Mh] Termos MeSH secundário: Adulto Idoso Neoplasia Intraepitelial Cervical/epidemiologia Neoplasia Intraepitelial Cervical/patologia Comorbidade Feminino Seres Humanos Seguro Saúde Dispositivos Intrauterinos/efeitos adversos Menopausa Meia-Idade Pólipos/epidemiologia Pólipos/patologia Infecções do Sistema Genital/epidemiologia Infecções do Sistema Genital/patologia Estudos Retrospectivos Taiwan Doenças do Colo do Útero/epidemiologia Doenças do Colo do Útero/patologia Displasia do Colo do Útero/epidemiologia Displasia do Colo do Útero/patologia Neoplasias do Colo do Útero/epidemiologia Neoplasias do Colo do Útero/patologia Cervicite Uterina/epidemiologia Cervicite Uterina/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170911 [Lr] Data última revisão: 170911 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170302 [St] Status: MEDLINE [do] DOI: 10.1007/s00404-017-4327-7

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[PMID]: 28170039 [Au] Autor: Kottaridi C; Kyrgiou M; Pouliakis A; Magkana M; Aga E; Spathis A; Mitra A; Makris G; Chrelias C; Mpakou V; Paraskevaidis E; Panayiotides JG; Karakitsos P [Ad] Endereço: Department of Cytopathology, National and Kapodistrian University of Athens Medical School, "ATTIKON" University Hospital, Athens, Greece. [Ti] Título: Quantitative Measurement of L1 Human Papillomavirus Type 16 Methylation for the Prediction of Preinvasive and Invasive Cervical Disease. [So] Source: J Infect Dis;215(5):764-771, 2017 03 01. [Is] ISSN: 1537-6613 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Methylation of the human papillomavirus (HPV) DNA has been proposed as a novel biomarker. Here, we correlated the mean methylation level of 12 CpG sites within the L1 gene, to the histological grade of cervical precancer and cancer. We assessed whether HPV L1 gene methylation can predict the presence of high-grade disease at histology in women testing positive for HPV16 genotype. Methods: Pyrosequencing was used for DNA methylation quantification and 145 women were recruited. Results: We found that the L1 HPV16 mean methylation (±SD) significantly increased with disease severity (cervical intraepithelial neoplasia [CIN] 3, 17.9% [±7.2] vs CIN2, 11.6% [±6.5], P < .001 or vs CIN1, 9.0% [±3.5], P < .001). Mean methylation was a good predictor of CIN3+ cases; the area under the curve was higher for sites 5611 in the prediction of CIN2+ and higher for position 7145 for CIN3+. The evaluation of different methylation thresholds for the prediction of CIN3+ showed that the optimal balance of sensitivity and specificity (75.7% and 77.5%, respectively) and positive and negative predictive values (74.7% and 78.5%, respectively) was achieved for a methylation of 14.0% with overall accuracy of 76.7%. Conclusions: Elevated methylation level is associated with increased disease severity and has good ability to discriminate HPV16-positive women that have high-grade disease or worse. [Mh] Termos MeSH primário: Proteínas do Capsídeo/genética Metilação de DNA Proteínas Oncogênicas Virais/genética Infecções por Papillomavirus/diagnóstico Doenças do Colo do Útero/diagnóstico [Mh] Termos MeSH secundário: Adulto Idoso Neoplasia Intraepitelial Cervical/diagnóstico Neoplasia Intraepitelial Cervical/virologia Ilhas de CpG DNA Viral/química Feminino Genótipo Grécia Papillomavirus Humano 16 Seres Humanos Modelos Lineares Meia-Idade Estudos Prospectivos Sensibilidade e Especificidade Reino Unido Doenças do Colo do Útero/virologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY [Nm] Nome de substância: 0 (Capsid Proteins); 0 (DNA, Viral); 0 (HPV L1 protein, Human papillomavirus); 0 (Oncogene Proteins, Viral) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170715 [Lr] Data última revisão: 170715 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170208 [St] Status: MEDLINE [do] DOI: 10.1093/infdis/jiw645

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