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[PMID]:28935536
[Au] Autor:Elwakil HS; Tawfik RA; Alam-Eldin YH; Nassar DA
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
[Ti] Título:The effect of iron on metronidazole activity against Trichomonas vaginalis in vitro.
[So] Source:Exp Parasitol;182:34-36, 2017 Nov.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Metronidazole is administered in an inactive form then activated to its cytotoxic form within the hydrogenosome of trichomonads. Two hydrogenosomal proteins, pyruvate ferredoxin oxidoreductase (PFOR) and ferredoxin, play a critical role in the reductive activation of metronidazole. The expression of these proteins and other hydrogenosomal proteins are likewise positively regulated by iron. In the present study, the effect of iron on minimal lethal concentration (MLC) of metronidazole on in vitro cultured Trichomonas vaginalis(T. vaginalis) isolates was investigated. Interestingly, Addition of Ferrous ammonium sulphate (FAS) to T. vaginalis culture led to decrease in the MLC of metronidazole. On using aerobic assay, MLC of metronidazole on untreated T. vaginalis of both isolates was 12.5 µg/ml that decreased to 0.38 µg/ml on FAS treated trichomonads. Also anaerobic assay revealed that MLC on untreated parasites was 3.12 µg/ml that decreased to 0.097 µg/ml and 0.19 µg/ml for isolate 1 and isolate 2 respectively after iron addition. It was concluded that, addition of iron to in vitro cultured T. vaginalis decreases metronidazole MLC that was detected by both aerobic and anaerobic assays.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Ferro/farmacologia
Metronidazol/farmacologia
Vaginite por Trichomonas/parasitologia
Trichomonas vaginalis/efeitos dos fármacos
Descarga Vaginal/parasitologia
[Mh] Termos MeSH secundário: Adulto
Aerobiose
Anaerobiose
Antiprotozoários/metabolismo
Interações Medicamentosas
Feminino
Ferredoxinas/metabolismo
Compostos Ferrosos/farmacologia
Seres Humanos
Dose Letal Mediana
Metronidazol/metabolismo
Oxirredução
Piruvato Sintase/metabolismo
Compostos de Amônio Quaternário/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Ferredoxins); 0 (Ferrous Compounds); 0 (Quaternary Ammonium Compounds); 140QMO216E (Metronidazole); 9Q764AYJ9G (ammonium ferrous sulfate); E1UOL152H7 (Iron); EC 1.2.7.1 (Pyruvate Synthase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


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[PMID]:28612378
[Au] Autor:Serwin AB; Bulhak-Koziol V; Sokolowska M; Golparian D; Unemo M
[Ad] Endereço:Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
[Ti] Título:Trichomonas vaginalis is very rare among women with vaginal discharge in Podlaskie province, Poland.
[So] Source:APMIS;125(9):840-843, 2017 Sep.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Trichomonas vaginalis is the most common curable sexually transmitted pathogen globally. However, in the European Union (EU), trichomoniasis appears to be a rare condition. The aim of this study was to examine the prevalence of T. vaginalis among females attending an STI centre in Bialystok, Poland, using the highly sensitive and specific APTIMA T. vaginalis assay. Consecutive females, referred by gynaecologists mainly because of abnormal vaginal discharge, were diagnosed using wet mount microscopy, culture and APTIMA T. vaginalis assay. Among 272 women studied, 82% were pre- and 18% postmenopausal. The average age was 36.0 ± 13.9 (range: 18-86) years. Abnormal discharge (alone or accompanied by itch or vulvovaginal burning) was the most frequent complain in both groups (66.2% and 48.0%). Erythema and discharge were the most frequent abnormal signs (58.6% and 56.0%). Not a single T. vaginalis-positive sample was detected using wet mount microscopy, culture or APTIMA T. vaginalis assay. Despite using the highly sensitive APTIMA T. vaginalis assay for detection, the pathogen could not be identified in females in the studied setting, similar to results from other EU settings. The need for general screening using NAAT for this pathogen while diagnosing vulvovaginal symptoms in females in Poland appears to be low.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Doenças Sexualmente Transmissíveis/diagnóstico
Vaginite por Trichomonas/diagnóstico
Vaginite por Trichomonas/epidemiologia
Trichomonas vaginalis/genética
Descarga Vaginal/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Microscopia/métodos
Meia-Idade
Polônia/epidemiologia
Doenças Sexualmente Transmissíveis/epidemiologia
Doenças Sexualmente Transmissíveis/parasitologia
Trichomonas vaginalis/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12713


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[PMID]:28318582
[Au] Autor:Giuliodori MJ; Magnasco M; Magnasco RP; Lacau-Mengido IM; de la Sota RL
[Ad] Endereço:Cátedra de Fisiología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata (FCV-UNLP), Calle 60 y 118, La Plata, B1900AVW, Argentina.
[Ti] Título:Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F treatment.
[So] Source:J Dairy Sci;100(5):3805-3815, 2017 May.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objectives of this study were to assess the association of a 4-point scale of vaginal discharge score (VDS) with time to pregnancy to define criteria for a practical case of purulent vaginal discharge (PVD) in dairy cows, to test the risk factors for PVD, and, finally, the effect of a dose of PGF on cure and reproductive performance. In experiment 1, grazing Holstein cows (n = 2,414) had their vaginal discharge scored at ∼32 d in milk (DIM) on a 4-point scale, the effect of VDS on the hazard of pregnancy by 300 DIM was then assessed to derive a case definition of PVD. Risk factors for PVD and self-cure were also assessed. In experiment 2, grazing Holstein cows (n = 6,326) from 5 herds were checked for PVD at ∼30 DIM. Cows with PVD were assigned to receive one dose of 500 µg of PGF analog (Cloprostenol; Ciclase, Syntex SA, Buenos Aires, Argentina) per cow (odd ear tag number) or to remain untreated (even tag number). Cure was declared if cows presented clear normal vaginal discharge (VDS-0) at visit 2 (∼62 DIM). Data were analyzed with Cox's regression and mixed logistic models. In experiment 1, cows with VDS ≥1 had lower hazard of pregnancy and longer calving to pregnancy interval than cows with VDS-0. This finding was not affected by the time at which the diagnosis was performed. Therefore, a cow ≥21 DIM and having VDS ≥1 was used to define a case of PVD. The odds of PVD were greater in primiparous cows compared with multiparous, in cows with abnormal calving compared with those with normal calving, and in those losing BCS peripartum. In experiment 2, PGF treatment tended to slightly increase the hazard of pregnancy (adjusted hazard ratio = 1.13). Conversely, PGF had no effect on the odds of cure of PVD [adjusted odds ratio (AOR) = 1.19], pregnancy at first service (AOR = 1.03), or pregnancy by 100 DIM (AOR = 0.89) or 200 DIM (AOR = 1.27). In conclusion, cows with VDS ≥1 can be considered to have PVD because of their lower hazard of pregnancy and longer calving to pregnancy interval (up to 48 d). Important risk factors are parity, calving, and body condition score loss peripartum. Optimal time of diagnosis is ≥28 to 35 DIM because cows experience a high self-cure rate. Self-cure is also affected by parity, prepartum BCS, and VDS. Finally, as treatment with one dose of PGF had a small effect on the hazard of pregnancy and no effect on clinical cure, its therapeutic use in grazing dairy cows with PVD is not recommended.
[Mh] Termos MeSH primário: Dinoprosta/uso terapêutico
Endometrite/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/diagnóstico
Feminino
Fatores de Risco
Descarga Vaginal/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
B7IN85G1HY (Dinoprost)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28259411
[Au] Autor:Bicalho MLS; Lima S; Higgins CH; Machado VS; Lima FS; Bicalho RC
[Ad] Endereço:Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
[Ti] Título:Genetic and functional analysis of the bovine uterine microbiota. Part II: Purulent vaginal discharge versus healthy cows.
[So] Source:J Dairy Sci;100(5):3863-3874, 2017 May.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to characterize, using metagenomic shotgun DNA sequencing, the intrauterine microbial population and its predicted functional diversity within healthy cows and cows presenting purulent vaginal discharge (PVD). Twenty Holstein dairy cows from a single farm were enrolled in the study at 25 to 35 d postpartum. Purulent vaginal discharge was diagnosed by retrieving and scoring vaginal discharge using the Metricheck device (Simcro, Hamilton, New Zealand). Intrauterine samples for metagenomic analysis were collected by the cytobrush technique from 8 cows diagnosed with PVD and 12 healthy cows. Pair-end sequencing was performed using the Illumina MiSeq platform (Illumina Inc., San Diego, CA). Metagenomic sequences were analyzed using the MG-RAST server (metagenomic rapid annotations using subsystems technology; http://metagenomics.anl.gov/), and the STAMP software (http://kiwi.cs.dal.ca/Software/STAMP) was used to study statistically significant differential abundance of taxonomic and functional features between the 2 metagenomes. Additionally, the total number of bacterial 16S rDNA copies was estimated by real-time PCR. Taxonomic analysis revealed that Bacteroidetes was the most abundant phylum in the uterine microbiota from cows with PVD, and Fusobacteria was almost completely absent in the healthy uterine microbiota. Moreover, species belonging to the genus Trueperella were present only in the uterine microbiota of PVD cows. The increased abundance of Fusobacteria and the unique presence of Trueperella in the PVD cows highlight the important role of these bacteria in the pathogenesis of PVD. Genes encoding cytolethal distending toxin were exclusive to the microbiota of PVD cows. Similarly, genes associated with lipid A modification were present only in samples from PVD cows; such modification is associated with greater resistance to cationic antimicrobial peptides. Conversely, genes encoding bacteriocins and ribosomally antibacterial peptide were exclusively found in the healthy uterine microbiota and dominated by tolerance to colicin E2. No difference was observed in total bacterial load between the 2 microbiotas. This study provides deep insight into the uterine microbial community in health and disease. The observations that the healthy microbiota is tolerant to colicin E2, whereas the uterine microbiota of PVD cows produces cytolethal distending toxins and modifies its lipopolysaccharides suggest that species-intrinsic factors may be more relevant than bacterial abundance to the development of disease or maintenance of health in the dairy cow postpartum uterus.
[Mh] Termos MeSH primário: Doenças dos Bovinos/microbiologia
Endometrite/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Microbiota
Período Pós-Parto
Descarga Vaginal/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


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[PMID]:28237589
[Au] Autor:Madoz LV; Prunner I; Jaureguiberry M; Gelfert CC; de la Sota RL; Giuliodori MJ; Drillich M
[Ad] Endereço:Cátedra y Servicio de Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad de La Plata (FCV-UNLP), La Plata, B1900AVW, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, C1033AAJ, Argentina.
[Ti] Título:Application of a bacteriological on-farm test to reduce antimicrobial usage in dairy cows with purulent vaginal discharge.
[So] Source:J Dairy Sci;100(5):3875-3882, 2017 May.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the effect of a selective antibiotic treatment strategy based on a quick bacteriological on-farm test (Petrifilm, 3M Corp., St. Paul, MN) compared with the conventional antibiotic treatment of all cows having clinical endometritis (CE) defined by the presence of purulent vaginal discharge on both clinical cure rate and reproductive performance. The study was simultaneously conducted with dairy cows reared under a highly supplemented rotational grazing system in Argentina and in a freestall system in Slovakia. Cows having an abnormal vaginal discharge (VD, indicative of clinical endometritis) on 21 to 35 d in milk (DIM) were randomly allocated to 1 of 2 study groups: selective treatment (ST) or conventional treatment (CT). All cows in the CT group (n = 174) received a single intrauterine administration of 500 mg of cephapirin. In the ST group (n = 178), treatment decision was made according to the results of the bacteriological on-farm test. For this test, we collected intrauterine samples with the cytobrush technique and stroke the brushes onto 2 different Petrifilm plates, one for aerobic count and another for Enterobacteriaceae count, incubated the plates, and counted the number of colonies after 24 h. Positive cows (≥5 colonies in one or both plates) received a single intrauterine treatment with 500 mg of cephapirin, whereas negative cows (<5 colonies) remained untreated. Clinical cure rate was assessed by direct vaginal inspection at 14 d after treatment (VD-0). The odds for conception at first artificial insemination, artificial insemination by 80 DIM, pregnancy by 100 DIM, and for nonpregnancy by 200 DIM were estimated with mixed logistic regression models. The hazard of conception was also assessed with proportional hazard regression model. The selective antibiotic treatment strategy based on the outcome of Petrifilm test reduced the number of required treatments (57%) and maintained similar efficacy in terms of clinical cure and reproductive performance as the conventional antibiotic treatment of all endometritic cows.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Lactação
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Endometrite/veterinária
Fazendas
Feminino
Reprodução/efeitos dos fármacos
Descarga Vaginal/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28070590
[Au] Autor:Dippon M; Petzl W; Lange D; Zerbe H
[Ti] Título:[Automated parturition control in primi- and multiparous cows of a Simmental and Holstein crossbred herd].
[Ti] Título:Automatische Geburtsüberwachung bei primi- und pluriparen Rindern einer Kreuzungsherde aus Holstein Friesian und Fleckvieh..
[So] Source:Tierarztl Prax Ausg G Grosstiere Nutztiere;45(1):18-23, 2017 Feb 09.
[Is] ISSN:1434-1220
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Perinatal calf mortality is a current problem in dairy farming with regards to ethics and economic losses. Optimizing calving management by frequent monitoring helps increasing the survival rate. The objective of this study was to evaluate the breed and parity dependent applicability of a recently introduced automated parturition control system with regards to its reliability in the field. MATERIAL AND METHODS: Seven days prior to the calculated calving date the automated parturition control system was applied intravaginally in 23 primiparous and 31 multiparous cows in a Holstein-Friesian (HF) and Simmental (FV) crossbred herd. In the case of three consecutive false alarms the animal was removed from the study and was rated as false positive (FP). The statistical significant interdependence of FP alarms and the genetic proportion of HF was calculated using the Mann-Whitney-U test. RESULTS: The automated parturition control system could successfully be applied in all animals with a genetic HF proportion > 66%. Animals with a predominant FV proportion (> 66%) frequently showed FP alarms (31.6%). Furthermore, multiparous cows lost the intravaginal sender more frequently than primiparous cows (29.0% vs. 8.7%). In 72.2% heavily pregnant cows purulent vaginal discharge was observed. CONCLUSION AND CLINICAL RELEVANCE: The automated parturition control system can successfully be applied in HF cows. Due to frequent losses of the intravaginal sender we cannot recommend its use in cows with a genetic FV proportion > 66%. Future developments of intravaginal automated parturition control systems should incorporate the influence of different breeds on its applicability.
[Mh] Termos MeSH primário: Processamento Automatizado de Dados/instrumentação
Doenças dos Bovinos/diagnóstico
Bovinos/fisiologia
Paridade/fisiologia
Parto
Descarga Vaginal/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos/classificação
Bovinos/genética
Cruzamentos Genéticos
Indústria de Laticínios
Feminino
Parto/fisiologia
Gravidez
Descarga Vaginal/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.15653/TPG-160812


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[PMID]:28043367
[Au] Autor:Tison N; Bouchard E; DesCôteaux L; Lefebvre RC
[Ad] Endereço:Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
[Ti] Título:Effectiveness of intrauterine treatment with cephapirin in dairy cows with purulent vaginal discharge.
[So] Source:Theriogenology;89:305-317, 2017 Feb.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the efficacy of cephapirin intrauterine treatment preceding a timed artificial insemination protocol in lactating dairy cows with purulent vaginal discharges (PVDs). Holstein dairy cows (n = 1247) from 18 herds were enrolled in a controlled randomized clinical trial. At 34 days in milk (DIM; ±7 days), cows had a genital examination (transrectal palpation, vaginoscopy, and uterine bacteriology). They were randomly assigned to either the control group (CONT, no treatment) or the treatment group (CEPH) consisting of 1 intrauterine infusion of 500-mg cephapirin benzathine (RCL) (Metricure, Merck Animal Health, Montreal, Canada) regardless of the uterine health status. All cows were systematically enrolled in a presynch-ovsynch protocol for the first insemination. A second genital examination was made 2 weeks later. Cows that received any systemic or local antibiotics 10 days prior sampling to the end of the synchronization protocol were excluded from the study. Reproductive data of cows were collected for at least 300 DIM, entered in a databank, and validated (health record management software, DSAHR). Pregnancy diagnosis was done by transrectal palpation at the routinely scheduled veterinarian visits. On the basis of the highest sum of sensibility and specificity for pregnancy status at 120 DIM, the optimal cutoff for vaginal discharge score was determined as the presence of cloudy discharge with or without purulent material (PVD+, score 2). With a prevalence of 21.6% at 34 DIM, PVD+ was detrimental to the first-service conception rate (FSCR; PVD+: 26 ± 5%; PVD-: 40 ± 3%; P = 0.02). The negative effect of PVD+ was indicated by a hazard ratio of 0.72 (chi-square = 8.58; P < 0.01; 95% confidence interval = 0.56-0.91). Treatment with cephapirin was associated with a significant improvement of the FSCR in PVD+ cows (PVD+ CEPH: 36 ± 5%, PVD+ CONT: 23 ± 5%; P < 0.05), although it did not produce a considerable clinical cure based on the second examination. Thus, a longer period of time following treatment may be needed to properly assess the efficacy of intrauterine treatment in PVD+ cows. In conclusion, cephapirin intrauterine treatment in PVD+ cows at 34 DIM considerably improves reproductive performance compared with untreated PVD+ cows.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Doenças dos Bovinos/tratamento farmacológico
Cefapirina/uso terapêutico
Doenças Uterinas/veterinária
Descarga Vaginal/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Doenças Uterinas/tratamento farmacológico
Útero/microbiologia
Descarga Vaginal/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 89B59H32VN (Cephapirin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:27845064
[Au] Autor:Abdel-Moein KA; Hamza DA
[Ad] Endereço:Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt. Electronic address: khal_105@cu.edu.eg.
[Ti] Título:The burden of Coxiella burnetii among aborted dairy animals in Egypt and its public health implications.
[So] Source:Acta Trop;166:92-95, 2017 Feb.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Q fever is a zoonotic disease of mounting public health implications. Dairy animals are major reservoir for such disease whereas abortion is the main clinical outcome. The current study was conducted to investigate the burden of C. burnetii abortions among dairy animals in Egypt to provide more knowledge for better control of such disease. For this purpose, placental cotyledons and vaginal discharges from 108 aborted dairy animals (27 sheep, 29 goats, 26 cattle, 26 buffaloes) were examined for the presence of C. burnetii by nested PCR. Serum samples from 58 human contacts were examined for the presence of C. burnetii IgG antibodies using ELISA. Out of the 108 examined animals only one goat yielded positive result in both placental tissue and vaginal discharges with an overall prevalence 0.9% while that among goats is 3.4%. Moreover, the seroprevalence of C. burnetii IgG antibodies among the examined individuals was 19% whereas the prevalence in farmers is significantly higher than that among veterinarians and veterinary assistants. In conclusion, C. burnetii may play a role in dairy goat abortions rather than other dairy animals in Egypt while its public health implications cannot be ruled out.
[Mh] Termos MeSH primário: Feto Abortado/microbiologia
Coxiella burnetii
Doenças das Cabras/epidemiologia
Febre Q/veterinária
[Mh] Termos MeSH secundário: Técnicos em Manejo de Animais
Animais
Anticorpos Antibacterianos/sangue
Bovinos
Doenças dos Bovinos/epidemiologia
Doenças dos Bovinos/microbiologia
Transmissão de Doença Infecciosa/veterinária
Egito/epidemiologia
Ensaio de Imunoadsorção Enzimática/veterinária
Fazendeiros
Feminino
Doenças das Cabras/microbiologia
Cabras
Seres Humanos
Masculino
Placenta/microbiologia
Reação em Cadeia da Polimerase/veterinária
Gravidez
Prevalência
Febre Q/epidemiologia
Febre Q/microbiologia
Febre Q/transmissão
Estudos Soroepidemiológicos
Ovinos
Doenças dos Ovinos/epidemiologia
Doenças dos Ovinos/microbiologia
Descarga Vaginal/microbiologia
Médicos Veterinários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27614288
[Au] Autor:Nakib G; Calcaterra V; Pelizzo G
[Ad] Endereço:Department of Pediatric Surgery, Mediclinic Middle East, Mediclinic City Hospital Dubai, Dubai, United Arab Emirates.
[Ti] Título:Longstanding Presence of a Vaginal Foreign Body (Battery): Severe Stenosis in a 13-Year-Old Girl.
[So] Source:J Pediatr Adolesc Gynecol;30(1):e15-e18, 2017 Feb.
[Is] ISSN:1873-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In recurrent/unresponsive vaginal discharge a vaginal foreign body should be considered. CASE: We present the case of a 13-year-old girl who suffered from a foul-smelling dark brownish and malodorous vaginal discharge since the age of 7 years. When the girl was 11 years old, a foreign body was discovered on ultrasound imaging; removal by colposcopy failed, because of the complete battery inclusion in the posterior vaginal wall. Two years later, at our institution, radiological images yielded the general position of the foreign body; colposcopy showed complete vaginal stenosis. Forced dilatation allowed surgical removal of the battery which was embedded in the vaginal fundal wall. SUMMARY AND CONCLUSION: Early removal of foreign objects prevents ulceration, necrosis, stenosis, perforations, and late serious sequelae such as pelvic inflammation and infertility.
[Mh] Termos MeSH primário: Fontes de Energia Elétrica/efeitos adversos
Corpos Estranhos/complicações
Vagina
Descarga Vaginal/etiologia
Doenças Vaginais/etiologia
[Mh] Termos MeSH secundário: Adolescente
Constrição Patológica/etiologia
Feminino
Corpos Estranhos/diagnóstico por imagem
Seres Humanos
Fatores de Tempo
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE


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[PMID]:28124960
[Au] Autor:Ertabaklar H; Yaman Karadam S; Malatyali E; Ertug S
[Ti] Título:[Investigation of in vitro metronidazole resistance in the clinical isolates of Trichomonas vaginalis].
[Ti] Título:Trichomonas vaginalis klinik izolatlarinda in vitro metronidazol direncinin arastirilmasi..
[So] Source:Mikrobiyol Bul;50(4):552-558, 2016 Oct.
[Is] ISSN:0374-9096
[Cp] País de publicação:Turkey
[La] Idioma:tur
[Ab] Resumo:Trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. Although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. Many studies from Turkey mostly dealing with the in vitro effects of compounds and natural products against T.vaginalis have been reported, however, only one study has been encountered searching the metronidazole resistance in a single T.vaginalis isolate. The aim of this study was to determine the in vitro metronidazole resistance and minimum lethal concentrations (MLCs) of the isolates from symptomatic cases. T.vaginalis strains isolated from vaginal discharge samples of symptomatic women that were sent to Adnan Menderes University Faculty of Medicine, Research and Training Hospital Parasitology Laboratory, between 2009-2014 period, were included in the study. The strains were isolated by the inoculation of samples into trypticase-yeast-maltose medium supplemented with 10% fetal calf serum. A total of 40 T.vaginalis isolates stored by cryopreservation were revived before the experiments. T.vaginalis trophozoites were incubated with different concentrations of metronidazole (200, 100, 50, 25, 12.5, 6.25, 3.12, 1.56 µg/ml) and the viability of cells were examined in both aerobic and anaerobic conditions under phase contrast microscope. Additionally, non-motile isolates were further inoculated into fresh media and viability was checked. The wells containing motile trophozoites after 48 hours of incubation with 15 µg/ml and/or higher metronidazole concentration in anaerobic condition and 75 µg/ml and/or higher metronidazole concentration in aerobic conditions were determined as resistant isolates. Of the 40 T.vaginalis isolates three (7.5%) were resistant to metronidazole. MLC mean values of metronidazole-sensitive isolates were 27.17 µg/ml in aerobic and 7.75 µg/ml in anaerobic conditions. The rate of metronidazole resistance detected in this study was higher than most of reports from different countries. Despite being limited to the isolates from Aydin province (located at Agean region of Turkey), the present study has a value as it presented the existence of metronidazole-resistant isolates in Turkey for the first time. More research from other parts of Turkey is needed to better understand the metronidazole resistance at a national scale and to investigate novel strategies for the treatment. Moreover, further studies need to be carried out in order to clarify the relationship between clinical treatment response and in vitro metronidazole resistance in trichomoniasis.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Metronidazol/farmacologia
Vaginite por Trichomonas/parasitologia
Trichomonas vaginalis/efeitos dos fármacos
Descarga Vaginal/parasitologia
[Mh] Termos MeSH secundário: Anaerobiose
Resistência a Medicamentos
Feminino
Seres Humanos
Testes de Sensibilidade Microbiana
Vaginite por Trichomonas/tratamento farmacológico
Turquia
Descarga Vaginal/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 140QMO216E (Metronidazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE



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