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[PMID]:29394247
[Au] Autor:Sacoor C; Payne B; Augusto O; Vilanculo F; Nhacolo A; Vidler M; Makanga PT; Munguambe K; Lee T; Macete E; von Dadelszen P; Sevene E; CLIP Working Group
[Ad] Endereço:Centro de Investigação em Saúde da Manhiça (CISM), Manhiça, Mozambique.
[Ti] Título:Health and socio-demographic profile of women of reproductive age in rural communities of southern Mozambique.
[So] Source:PLoS One;13(2):e0184249, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reliable statistics on maternal morbidity and mortality are scarce in low and middle-income countries, especially in rural areas. This is the case in Mozambique where many births happen at home. Furthermore, a sizeable number of facility births have inadequate registration. Such information is crucial for developing effective national and global health policies for maternal and child health. The aim of this study was to generate reliable baseline socio-demographic information on women of reproductive age as well as to establish a demographic surveillance platform to support the planning and implementation of the Community Level Intervention for Pre-eclampsia (CLIP) study, a cluster randomized controlled trial. This study represents a census of all women of reproductive age (12-49 years) in twelve rural communities in Maputo and Gaza provinces of Mozambique. The data were collected through electronic forms implemented in Open Data Kit (ODK) (an app for android based tablets) and household and individual characteristics. Verbal autopsies were conducted on all reported maternal deaths to determine the underlying cause of death. Between March and October 2014, 50,493 households and 80,483 women of reproductive age (mean age 26.9 years) were surveyed. A total of 14,617 pregnancies were reported in the twelve months prior to the census, resulting in 9,029 completed pregnancies. Of completed pregnancies, 8,796 resulted in live births, 466 resulted in stillbirths and 288 resulted in miscarriages. The remaining pregnancies had not yet been completed during the time of the survey (5,588 pregnancies). The age specific fertility indicates that highest rate (188 live births per 1,000 women) occurs in the age 20-24 years old. The estimated stillbirth rate was 50.3/1,000 live and stillbirths; neonatal mortality rate was 13.3/1,000 live births and maternal mortality ratio was 204.6/100,000 live births. The most common direct cause of maternal death was eclampsia and tuberculosis was the most common indirect cause of death. This study found that fertility rate is high at age 20-24 years old. Pregnancy in the advanced age (>35 years of age) in this study was associated with higher poor outcomes such as miscarriage and stillbirth. The study also found high stillbirth rate indicating a need for increased attention to maternal health in southern Mozambique. Tuberculosis and HIV/AIDS are prominent indirect causes of maternal death, while eclampsia represents the number one direct obstetric cause of maternal deaths in these communities. Additional efforts to promote safe motherhood and improve child survival are crucial in these communities.
[Mh] Termos MeSH primário: Demografia
Nível de Saúde
População Rural
Classe Social
[Mh] Termos MeSH secundário: Aborto Espontâneo
Adolescente
Adulto
Criança
Feminino
Seres Humanos
Lactente
Mortalidade Infantil
Recém-Nascido
Mortalidade Materna
Meia-Idade
Moçambique/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184249


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[PMID]:29320815
[Au] Autor:Matin S; Shahbazi G; Namin ST; Moradpour R; Feizi F; Piri-Dogahe H
[Ad] Endereço:Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
[Ti] Título:Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, Iran.
[So] Source:Korean J Parasitol;55(6):607-611, 2017 Dec.
[Is] ISSN:1738-0006
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. This study was conducted to test the utility of PCR assay to detect recent infections with Toxoplasma in aborted women at various gestational ages who referred to Obstetrics and Gynecology Department of Alavi Hospital in Ardabil during 2014 and 2016. Two hundred women with a history of single or repeated abortion were investigated in this study. Blood samples were tested for specific anti-Toxoplasma IgM and IgG antibodies by ELISA. According to the results, 53.5% of the women under study were positive for anti-Toxoplasma antibodies: 4.0% of them had IgM, 43.0% had IgG, and 6.5% had both IgM and IgG. Subsequently, Nested-PCR analysis was used to detect T. gondii DNA in the placenta of subjects. In 10.5% of the women, the results were positive for 529 bp element of T. gondii. Among them, 5 (23.8%) cases were IgM positive, 1 (4.8%) case was IgG positive, and 11 (52.4%) were both IgM and IgG positive. In 4 (19.0%) patients, none of the antibodies were found to be positive. In total, 16 patients had positive results in both ELISA and PCR methods, and 174 cases had negative results for new infection. The findings of this study revealed that T. gondii might be one of the significant factors leading to abortion, and that the analysis of placenta can be important in order to achieve increased detection sensitivity.
[Mh] Termos MeSH primário: Aborto Habitual/etiologia
Aborto Espontâneo/etiologia
Anticorpos Antiprotozoários/sangue
Reação em Cadeia da Polimerase/métodos
Complicações Parasitárias na Gravidez/diagnóstico
Testes Sorológicos/métodos
Toxoplasma/imunologia
Toxoplasmose/diagnóstico
Toxoplasmose/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biomarcadores/sangue
DNA de Protozoário/sangue
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Irã (Geográfico)/epidemiologia
Gravidez
Complicações Parasitárias na Gravidez/epidemiologia
Complicações Parasitárias na Gravidez/parasitologia
Toxoplasma/genética
Toxoplasmose/complicações
Toxoplasmose/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Biomarkers); 0 (DNA, Protozoan); 0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2017.55.6.607


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[PMID]:29215421
[Au] Autor:Merrigan JL
[Ad] Endereço:Joyce L. Merrigan is a Resolve Through Sharing® National Faculty member, Clinton, New Jersey. The author can be reached via e-mail at joyce.merrigan@yahoo.com.
[Ti] Título:Educating Emergency Department Nurses About Miscarriage.
[So] Source:MCN Am J Matern Child Nurs;43(1):26-31, 2018 Jan/Feb.
[Is] ISSN:1539-0683
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Miscarriage is the unwanted ending of a pregnancy before 20 weeks gestation. Women experiencing miscarriage require specialized care from nurses and other healthcare professionals. Many women are dissatisfied with emergency care related to miscarriage and desire honest communication, validation of urgency, and more robust information at discharge. Perinatal bereavement education offers an opportunity for emergency department nurses to acquire specific knowledge and communication skills that assist with understanding the individualized experience of early pregnancy loss. For many women, a miscarriage is devastating, whereas for some, a part of life. Therefore, assessing the meaning of miscarriage is an essential step to providing sensitive, supportive care. Education was offered to emergency department nurses based on a 4-hour Resolve Through Sharing curriculum. Education focused on knowledge of policy and practice, medical aspects of pregnancy loss, information on how to assess the meaning of the miscarriage, respectful handling and disposition of the remains, and communication strategies to initiate and sustain a meaningful relationship with the woman and her family, within the barriers to care that are exclusive to the emergency department. Participants embraced the information and actively participated in dialogue of an evaluation process to identify needed revisions in current policies and practices for caring for this patient population. Recommendations and guidance for emergency room nurses who care for women experiencing miscarriage are offered.
[Mh] Termos MeSH primário: Aborto Espontâneo/enfermagem
Luto
Enfermagem em Emergência/educação
Gestantes/psicologia
[Mh] Termos MeSH secundário: Serviço Hospitalar de Emergência/organização & administração
Feminino
Pessoal de Saúde/psicologia
Seres Humanos
Gravidez
Revelação da Verdade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/NMC.0000000000000391


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[PMID]:29215420
[Au] Autor:Catlin A
[Ad] Endereço:Anita Catlin is Manager, Research and Redesign, Kaiser Santa Rosa, and Consultant, Ethics Committee, Santa Rosa, CA. The author can be reached via e-mail at acatlin@napanet.net.
[Ti] Título:Interdisciplinary Guidelines for Care of Women Presenting to the Emergency Department With Pregnancy Loss.
[So] Source:MCN Am J Matern Child Nurs;43(1):13-18, 2018 Jan/Feb.
[Is] ISSN:1539-0683
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In April 2016, the National Perinatal Association and Kaiser Permanente Northern California Nursing Research Community Benefits Grant sponsored an interdisciplinary summit to explore the needs of women who present with actual or potential pregnancy loss to the emergency department (ED). Thirty-two experts in the field of pregnancy loss, 17 of whom represented their professional organizations, participated. These experts, which included nurses, physicians, social workers, counselors, authors, and parents, worked together to create guidelines for care of women with a pregnancy loss in the ED. Recommendations for ED healthcare providers are included. Emergency department personnel agreed that improvements in care could be offered and were willing to endorse education for their staff. The guidelines delineate how to better provide physical, emotional, and bereavement support at any stage of gestational loss. Administrative support for policies in the ED is essential to ensure the delivery of family-centered, culturally sensitive practices when a pregnancy ends.
[Mh] Termos MeSH primário: Aborto Espontâneo/psicologia
Aborto Espontâneo/terapia
Guias como Assunto
Gestantes/psicologia
[Mh] Termos MeSH secundário: Adulto
Serviço Hospitalar de Emergência/organização & administração
Feminino
Pessoal de Saúde/educação
Seres Humanos
Comunicação Interdisciplinar
Gravidez
Inquéritos e Questionários
Texas
Revelação da Verdade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/NMC.0000000000000399


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[PMID]:28461175
[Au] Autor:Cohen SB; Bouaziz J; Bar-On A; Schiff E; Goldenberg M; Mashiach R
[Ad] Endereço:Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Herzliya Medical Center, Herzliya, Israel.
[Ti] Título:In-office Hysteroscopic Extraction of Intrauterine Devices in Pregnant Patients Who Underwent Prior Ultrasound-guided Extraction Failure.
[So] Source:J Minim Invasive Gynecol;24(5):833-836, 2017 Jul - Aug.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVE: To determine an effective method of intrauterine device (IUD) retrieval from pregnant women who had previous unsuccessful ultrasound-guided IUD extraction failure. DESIGN: A retrospective cohort study (Canadian task force classification II-1). SETTING: A gynecology department of an outpatient clinic. PATIENTS: Pregnant patients in their first trimester with IUD in situ who underwent prior unsuccessful ultrasound-guided IUD extraction. INTERVENTIONS: Hysteroscopic IUD extraction guided by transabdominal ultrasound. MEASUREMENTS AND MAIN RESULTS: Between 2011 and 2014, 7 of 8 pregnant patients who had undergone previous failed attempts at IUD retrieval via ultrasound guidance underwent successful removal via ultrasound-guided hysteroscopy performed without anesthesia. The sole patient with extraction failure was in her 12th week of pregnancy, and the procedure was concluded to avoid risk to the fetus. Minimal vaginal bleeding was experienced by 2 patients after the procedure. Seven of 8 patients delivered at term without any obstetric complications. One patient had a miscarriage in her 8th week of pregnancy, 2 weeks after successful IUD removal. CONCLUSION: A novel, easy outpatient hysteroscopic technique without anesthesia is presented in case of failure of previous ultrasound-guided IUD removal in early pregnancy. Results are encouraging in this difficult context.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios/métodos
Remoção de Dispositivo/métodos
Histeroscopia/métodos
Dispositivos Intrauterinos
Complicações na Gravidez/cirurgia
Reoperação/métodos
Ultrassonografia de Intervenção/métodos
[Mh] Termos MeSH secundário: Aborto Espontâneo/epidemiologia
Aborto Espontâneo/etiologia
Adulto
Procedimentos Cirúrgicos Ambulatórios/efeitos adversos
Eficácia de Contraceptivos
Remoção de Dispositivo/efeitos adversos
Falha de Equipamento
Feminino
Seres Humanos
Histeroscopia/efeitos adversos
Migração de Dispositivo Intrauterino
Gravidez
Primeiro Trimestre da Gravidez
Reoperação/efeitos adversos
Estudos Retrospectivos
Ultrassonografia de Intervenção/efeitos adversos
Ultrassonografia Pré-Natal/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29374881
[Au] Autor:Wei DM; Zhang ZZ; Wang Z; Li P; Wang JF; Liu YJ; Zhang JT; Shi YH
[Ad] Endereço:Reproductive Endocrinology Department, The Center for Reproductive Medicine, Shandong University, Jinan 250021, China.
[Ti] Título:[Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;53(1):18-22, 2018 Jan 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); 3.94, 95% 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery ( 3.67, 95% 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all 0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all 0.05). In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.
[Mh] Termos MeSH primário: Peso ao Nascer
Hiperandrogenismo/epidemiologia
Síndrome do Ovário Policístico/epidemiologia
Nascimento Prematuro/epidemiologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/epidemiologia
Índice de Massa Corporal
Diabetes Gestacional/epidemiologia
Feminino
Fertilização In Vitro
Idade Gestacional
Seres Humanos
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Pré-Eclâmpsia/epidemiologia
Gravidez
Complicações na Gravidez/epidemiologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2018.01.005


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[PMID]:29390469
[Au] Autor:Zeng XX; Tang YL; Hu KX; Wang J; Zhu LY; Liu JY; Xu J
[Ad] Endereço:Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
[Ti] Título:Insulin autoimmune syndrome in a pregnant female: A rare case report.
[So] Source:Medicine (Baltimore);96(51):e9213, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS. PATIENT CONCERNS: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. The patient exhibited recurrent spontaneous hypoglycemia. DIAGNOSES: On evaluation, laboratory findings detected both high fasting insulin (>1000 mIU/L) and insulin autoantibodies. An oral glucose tolerance test showed elevated insulin concentrations with disproportionately elevated C-peptide levels. The imaging study showed nomasslesionsinthepancreas,and the patient was clinically diagnosed with IAS. INTERVENTIONS: The patient had an abortion, discontinued methimazole and switched to oral prednisone (30 mg once daily) and propylth- iouracil (100 mg 3 times daily) for 3 months. OUTCOMES: At the 3-month follow-up visit, hypoglycemic episodes had disappeared and insulin antibody levels were no longer detectable. LESSONS: We have described this case and reviewed the relevant literature concerning diagnosis and treatment of IAS. Importantly, this case indicates that clinicians should view pregnancy as another factor of hypoglycemia in IAS.
[Mh] Termos MeSH primário: Doenças Autoimunes/diagnóstico
Hipoglicemia/induzido quimicamente
Insulina/sangue
Metimazol/efeitos adversos
Complicações na Gravidez/diagnóstico
[Mh] Termos MeSH secundário: Aborto Espontâneo
Adulto
Feminino
Seguimentos
Idade Gestacional
Doença de Graves/diagnóstico
Doença de Graves/tratamento farmacológico
Seres Humanos
Hipoglicemia/imunologia
Hipoglicemia/fisiopatologia
Insulina/imunologia
Anticorpos Anti-Insulina/sangue
Metimazol/uso terapêutico
Prednisona/uso terapêutico
Gravidez
Doenças Raras
Medição de Risco
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insulin); 0 (Insulin Antibodies); 554Z48XN5E (Methimazole); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009213


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[PMID]:29328643
[Au] Autor:Grujic Z; Grujic I; Bogavac M; Nikolic A; Mitic R; Stajic Z
[Ti] Título:Disturbance of oxidative balance in the first trimester of spontaneous abortions.
[So] Source:Vojnosanit Pregl;73(11):1038-43, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Pregnancy is defined as a condition of increased oxidative stress. The aim of this research was to determine the intensity of pro-oxidative processes and the content of GSH, as well as antioxidative enzymes: superoxide dismutase (SOD), catalase (CAT), gluthatione peroxidase (GSH-Px), and the total antioxidative status (TAS) in patients with spontaneous abortions. Methods: A total of 120 patients were involved in the research (70 spontaneous abortions and 50 healthy pregnancies). The patients were divided into groups: 35 patients with incomplete and complete spontaneous abortion (group S), 35 patients with missed abortion (group M) and a control group of 50 healthy pregnancies (group N), all of them being in the first trimester of pregnancy. The intensity of lipid proxidation (LPx) was determined with a modified thyobarbituric acid method. The GSH content in erythrocytes was determined by the method ba-sed on the amount of non-protein sulfhydryl residues using the Ellman's reagens. The following antioxidative parameters in the blood were measured: SOD ­ by the method with xanthine oxidase-using commercial RANSOD sets; CAT ­ by the method of Aebi (the enzyme activity was measured by monitoring the decomposition of H2O2 at 240 nm); GSH-Px was determined using hydrogen peroxide as a substrate. The TAS was determined using the ferric reducing autioxidant potential (FRAP) met-hod. Results: The highest average value of LPx was recorded in the spontaneous abortion group (48.03 pmoL/mg Hgb), and the lowest value was recorded in the control group (26.06 pmoL/mg Hgb). A statistically significant positive correlation between LPx and CAT in the group of patients with missed abortion was also noted (p < 0.05, r = 0.37). There was a statistically highly significant difference (p < 0.001) in SOD and in CAT activitices be-tween the examined patients (groups S and N) and the control group (Student's t-test and ANOVA). The highest average value of TAS was recorded in the group S (710.39 µmol/L), while the value in the group M was 277.66 µmol/L. The average value of TAS in the control group was 452.12 µmol/L. Student's t-test showed a statistically highly significant difference in the values of TAS between the examined patients (groups S and M) and the control group. Conclusion: Determination of the value of pro-oxidative and antioxidative parameters in patients with sponta-neous abortion can be the indicator of condition of fetoplacental unit and these analyses can be included in the protocol of the rutine perinatal diagnostics.
[Mh] Termos MeSH primário: Aborto Espontâneo/sangue
Estresse Oxidativo
Primeiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Aborto Espontâneo/fisiopatologia
Adulto
Antioxidantes/metabolismo
Biomarcadores/sangue
Estudos de Casos e Controles
Catalase/sangue
Feminino
Glutationa/sangue
Glutationa Peroxidase/sangue
Seres Humanos
Peroxidação de Lipídeos
Gravidez
Estudos Prospectivos
Superóxido Dismutase/sangue
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Thiobarbituric Acid Reactive Substances); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150321123G


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[PMID]:29369548
[Au] Autor:Mashkina EV; Kovalenko KA; Marakhovskaya TA; Saraev KN; Belanova AA; Shkurat TP
[Ti] Título:[Association of gene polymorphisms of matrix metalloproteinases with reproductive losses in the first trimester of pregnancy].
[So] Source:Genetika;52(8):958-65, 2016 Aug.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the present study, the frequencies of genotypes and alleles of candidate genes with respect to polymorphisms associated with increased pregnancy loss in the first trimester of pregnancy, including MMP1­1607insG, MMP9 A­8202G, and TIMP1 С536T, were reported. The frequency of homozygotes for allele MMP9 A­8202 was increased by a factor of two among women with miscarriage in the first trimester compared to the control. Significant models of interaction of genes MMPs and TIMP1 were revealed. The genotypes of genes MMP1 (rs1799750), MMP9 (rs11697325), and TIMP1 (rs11551797) increasing the risk of pregnancy loss in the first trimester were determined.
[Mh] Termos MeSH primário: Aborto Espontâneo/genética
Alelos
Frequência do Gene
Metaloproteinase 1 da Matriz/genética
Metaloproteinase 9 da Matriz/genética
Polimorfismo Genético
Primeiro Trimestre da Gravidez/genética
[Mh] Termos MeSH secundário: Aborto Espontâneo/enzimologia
Adulto
Feminino
Seres Humanos
Metaloproteinase 1 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Gravidez
Primeiro Trimestre da Gravidez/metabolismo
Inibidor Tecidual de Metaloproteinase-1/genética
Inibidor Tecidual de Metaloproteinase-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TIMP1 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:27773758
[Au] Autor:Reid F; Oakeshott P; Kerry SR; Hay PE; Jensen JS
[Ad] Endereço:Department of Primary Care and Public Health Sciences, King's College London, London, UK.
[Ti] Título:Chlamydia related bacteria (Chlamydiales) in early pregnancy: community-based cohort study.
[So] Source:Clin Microbiol Infect;23(2):119.e9-119.e14, 2017 Feb.
[Is] ISSN:1469-0691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Serological case-control studies suggest that certain chlamydia-related bacteria (Chlamydiales) which cause cows to abort may do the same in humans. Chlamydiales include Waddlia chondrophila, Chlamydia abortus and Chlamydia trachomatis. Data on prevalence of Chlamydiales in pregnancy are sparse. Using stored urine samples from a carefully characterised cohort of 847 newly pregnant women recruited from 37 general practices in London, UK, we aimed to investigate the prevalence and types of Chlamydiales infections. We also explored possible associations with miscarriage or spontaneous preterm birth. METHODS: Samples were tested using W. chondrophila and pan-Chlamydiales specific real-time PCRs targeting the 16S rRNA gene. Samples positive on either PCR were subjected to DNA sequencing and C. trachomatis PCR. RESULTS: The overall prevalence of Chlamydiales was 4.3% (36/847, 95% CI 3.0% to 5.8%). The prevalence of W. chondrophila was 0.6% (n = 5), C. trachomatis 1.7% (n = 14), and other Chlamydiales species 2.0% (n = 17). Infection with C. trachomatis was more common in women aged <25, of black ethnicity or with bacterial vaginosis, but this did not apply to W. chondrophila or other Chlamydiales. Follow up was 99.9% at 16 weeks gestation and 90% at term. No infection was significantly associated with miscarriage at ≤12 weeks (prevalence 10%, 81/827) or preterm birth <37 weeks (prevalence 4%, 23/628). Of 25 samples sequenced, seven (28%) were positive for Chlamydiales bacterium sequences associated with respiratory tract infections in children. CONCLUSION: In the first study to use the pan-Chlamydiales assay on female urine samples, 4% of pregnant women tested positive for Chlamydiales, including species known to be pathogenic in mothers and neonates.
[Mh] Termos MeSH primário: Chlamydia
Infecções por Chlamydiaceae/epidemiologia
Infecções por Chlamydiaceae/microbiologia
Complicações Infecciosas na Gravidez/epidemiologia
Complicações Infecciosas na Gravidez/microbiologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/etiologia
Adolescente
Adulto
Estudos de Casos e Controles
Chlamydia/classificação
Chlamydia/genética
Estudos de Coortes
Feminino
Seres Humanos
Meia-Idade
Gravidez
Nascimento Prematuro
Prevalência
RNA Ribossômico 16S/genética
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE



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