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[PMID]:28264669
[Au] Autor:Lek SM; Ku CW; Allen JC; Malhotra R; Tan NS; Østbye T; Tan TC
[Ad] Endereço:Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore. lekszemin@gmail.com.
[Ti] Título:Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage.
[So] Source:BMC Pregnancy Childbirth;17(1):78, 2017 Mar 06.
[Is] ISSN:1471-2393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our recent paper, based on a pilot cohort of 119 women, showed that serum progesterone <35 nmol/L was prognostic of spontaneous miscarriage by 16 weeks in women with threatened miscarriage in early pregnancy. Using a larger cohort of women from the same setting (validation cohort), we aim to assess the validity of serum progesterone <35 nmol/L with the outcome of spontaneous miscarriage by 16 weeks. METHODS: In a prospective cohort study, 360 pregnant women presenting with threatened miscarriage between gestation weeks 6-10 at a tertiary hospital emergency unit for women in Singapore were recruited for this study. The main outcome measure measured is spontaneous miscarriage prior to week 16 of gestation. Area under the ROC curve (AUC) and test characteristics (sensitivity, specificity, positive and negative predictive value) at a serum progesterone cutpoint of <35 nmol/L for predicting high and low risk of spontaneous miscarriage by 16 weeks were compared between the Pilot and Validation cohorts. RESULTS: Test characteristics and AUC values using serum progesterone <35 nmol/L in the validation cohort were not significantly different from those in the Pilot cohort, demonstrating excellent accuracy and reproducibility of the proposed serum progesterone cut-off level. CONCLUSIONS: The cut-off value for serum progesterone (35 nmol/L) demonstrated clinical relevance and allow clinicians to stratify patients into high and low risk groups for spontaneous miscarriage.
[Mh] Termos MeSH primário: Aborto Espontâneo/sangue
Ameaça de Aborto/sangue
Progesterona/sangue
[Mh] Termos MeSH secundário: Aborto Espontâneo/diagnóstico
Adulto
Área Sob a Curva
Estudos de Coortes
Técnicas de Apoio para a Decisão
Feminino
Seres Humanos
Proteínas do Tecido Nervoso
Gravidez
Primeiro Trimestre da Gravidez
Prognóstico
Estudos Prospectivos
Curva ROC
Reprodutibilidade dos Testes
Medição de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (Singar1 protein, rat); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1186/s12884-017-1261-4


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[PMID]:27760481
[Au] Autor:Boza A; Api M; Kayatas S; Ceyhan M; Boza B
[Ad] Endereço:a Department of Obstetrics and Gynecology , Goztepe Training and Research Hospital , Kadikoy , Istanbul , Turkey.
[Ti] Título:Is progestogen supplementation necessary to prevent abortion?
[So] Source:J Obstet Gynaecol;36(8):1076-1079, 2016 Nov.
[Is] ISSN:1364-6893
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A prospective study was conducted to evaluate the effect of progestogens on the pregnancy outcome of threatened abortion (TA). A total of 251 pregnant women less than 20 weeks of gestational age (GA) were included. Group 1 consisted of women with vaginal bleeding who had already been under treatment with progestogens and Group 2 was composed of women with vaginal bleeding who were only followed without progestogen therapy, whereas Group 3 was the control group without any vaginal bleeding or progestogen therapy. The pregnancy outcomes and serum progesterone levels were compared among the groups. The mean serum progesterone concentrations were statistically significantly higher in Group 1 in comparison to Group 2 and 3 (p < 0.001). Abortion rates were similar among the study groups. Although progestogen supplementation leads to increased level of serum progesterone, this finding does not translate to its beneficial effect on the pregnancy outcomes in cases of TAs.
[Mh] Termos MeSH primário: Ameaça de Aborto/prevenção & controle
Progestinas/uso terapêutico
[Mh] Termos MeSH secundário: Aborto Induzido/estatística & dados numéricos
Ameaça de Aborto/sangue
Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Gravidez
Resultado da Gravidez
Progesterona/sangue
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Progestins); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27719779
[Au] Autor:Roth CK; Syed LJ
[Ti] Título:von Willebrand disease in pregnancy.
[So] Source:Nurs Womens Health;20(5):501-505, 2016 Oct - Nov.
[Is] ISSN:1751-486X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:von Willebrand disease is the most prevalent inherited bleeding disorder, affecting up to 1.3% of the population. It is caused by a defect or deficiency of the von Willebrand factor. Women with the condition may not be aware of their condition at the time of childbirth, but they are at high risk of postpartum hemorrhage even days after birth. In this article we briefly review the condition and specific considerations for the antepartum, intrapartum, and postpartum phases. It is important for nurses who care for women during childbirth to have a keen understanding of this condition.
[Mh] Termos MeSH primário: Enfermagem Obstétrica/métodos
Complicações Hematológicas na Gravidez/enfermagem
Cuidado Pré-Natal/métodos
Doenças de von Willebrand/enfermagem
[Mh] Termos MeSH secundário: Ameaça de Aborto/etiologia
Feminino
Seres Humanos
Relações Enfermeiro-Paciente
Hemorragia Pós-Parto/etiologia
Gravidez
Hemorragia Uterina/etiologia
Doenças de von Willebrand/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27717319
[Au] Autor:Betts D; Smith CA; Dahlen HG
[Ad] Endereço:National Institute of Complementary Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia. Debra.betts@nzsao.com.
[Ti] Título:Does acupuncture have a role in the treatment of threatened miscarriage? Findings from a feasibility randomised trial and semi-structured participant interviews.
[So] Source:BMC Pregnancy Childbirth;16(1):298, 2016 Oct 07.
[Is] ISSN:1471-2393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Threatened miscarriage is a common complication of early pregnancy increasing the risk of miscarriage or premature labour. Currently there is limited evidence to recommend any biomedical pharmacological or self-care management, resulting in a 'watchful waiting' approach. The objective of this study was to examine the feasibility of offering acupuncture as a therapeutic treatment for women presenting with threatened miscarriage. METHODS: A mixed methods study involving a randomised controlled trial and semi structured interviews. A pragmatic acupuncture protocol including medical self-care advice was compared to an active control receiving touch intervention and medical self-care advice. Descriptive statistics were used to examine the demographic and baseline characteristics. Endpoints were analysed between groups using a mean t-test and chi-square tests with P < 0.05 considered statistically significant. Dichotomous data was expressed as Risk Ratio with 95 % confidence intervals. Eleven participants were purposively interviewed about their experiences on exiting the trial with interviews analysed using thematic analysis. RESULTS: Forty women were successfully randomised. For women receiving acupuncture there was a statically significant reduction with threatened miscarriage symptoms including bleeding, cramping and back pain compared with the control (p = 0.04). Thematic analysis revealed women were dissatisfied with the medical support and advice received. An overarching theme emerged from the data of 'finding something you can do.' This encompassed the themes: 'they said there was nothing they could do,' 'feeling the benefits' and 'managing while marking time.' CONCLUSION: Acupuncture was a feasible intervention and reduced threatened miscarriage symptoms when compared to a touch intervention. Further research is required to further explore acupuncture use for this common complication and whether it can reduce the incidence of miscarriage. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12610000850077 . Date of registration 12/10/2010. Retrospectively registered, with first participant enrolled 11/10/2012.
[Mh] Termos MeSH primário: Aborto Espontâneo/prevenção & controle
Ameaça de Aborto/terapia
Terapia por Acupuntura/métodos
Aceitação pelo Paciente de Cuidados de Saúde/psicologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/psicologia
Ameaça de Aborto/psicologia
Terapia por Acupuntura/psicologia
Adulto
Estudos de Viabilidade
Feminino
Seres Humanos
Gravidez
Projetos de Pesquisa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:27180760
[Au] Autor:Li Q; Zhu J; Hua K
[Ad] Endereço:Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China.
[Ti] Título:[Effects of subchorionic hematoma on pregnancy outcome: a meta analysis].
[So] Source:Zhonghua Yi Xue Za Zhi;96(17):1383-5, 2016 May 10.
[Is] ISSN:0376-2491
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the effects of subchorionic hematoma (SCH) on pregnancy outcome. METHODS: We searched publications from January 2000 to July 2015 for cohort and case-control studies evaluating subchorionic hematoma and perinatal outcomes, including spontaneous abortion, premature delivery and delivery mode. RESULTS: Data of 6 articles analyzed by meta-analysis showed that SCH group had higher rate of spontaneous abortion, while no difference in premature delivery and delivery mode, compared with threatened abortion group. CONCLUSION: Subchorionic hematoma increases the risk of spontaneous abortion, while premature delivery rate and delivery mode are not affected if the pregnant women can continue the pregnancy.
[Mh] Termos MeSH primário: Hematoma
Complicações na Gravidez
[Mh] Termos MeSH secundário: Aborto Espontâneo
Ameaça de Aborto
Estudos de Casos e Controles
Feminino
Seres Humanos
Gravidez
Resultado da Gravidez
Nascimento Prematuro
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160517
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0376-2491.2016.17.017


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Registro de Ensaios Clínicos
[PMID]:27160142
[Au] Autor:Costantino M; Guaraldi C; Costantino D
[Ad] Endereço:Department of Chemistry and Pharmaceutical Technologies, University of Ferrara, Ferrara, Italy. kostin5893@yahoo.it.
[Ti] Título:Resolution of subchorionic hematoma and symptoms of threatened miscarriage using vaginal alpha lipoic acid or progesterone: clinical evidences.
[So] Source:Eur Rev Med Pharmacol Sci;20(8):1656-63, 2016 Apr.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Alpha Lipoic Acid (ALA) is a safe natural molecule that exerts a selective immunomodulating activity with antioxidant and anti-inflammatory properties. This randomized controlled clinical trial (RCT) tested the effect of the vaginal administration with ALA or Progesterone, in subchorionic hematoma resorption in women with threatened miscarriage. PATIENTS AND METHODS: 400 mg of vaginal Progesterone or 10 mg of vaginal ALA were administered to sixty-two pregnant women, in the first trimester of gestation with threatened miscarriage and subchorionic hematoma. Controls were patients who chose not to receive any treatment. RESULTS: In the ALA group the subchorionic hematoma was reabsorbed more quickly in comparison with the progression detected in Progesterone group (p ≤ 0.05). The other parameters checked (pelvic pain and vaginal bleeding) did not show any significant difference and a smaller number of miscarriages was recorded in the ALA group, compared to Progesterone group. CONCLUSIONS: Our data provides the first evidence of the efficacy of ALA, administered by vaginal route, in the healing process of patients with threatened miscarriage, thus supporting the normal course of pregnancy. CLINICAL TRIAL REGISTRATION NUMBER: NCT02601898 (ClinicalTrials.gov registry).
[Mh] Termos MeSH primário: Ameaça de Aborto/prevenção & controle
Hematoma
Progesterona/uso terapêutico
Ácido Tióctico/uso terapêutico
[Mh] Termos MeSH secundário: Aborto Espontâneo
Feminino
Seres Humanos
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 73Y7P0K73Y (Thioctic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:26663220
[Au] Autor:Pillai RN; Konje JC; Tincello DG; Potdar N
[Ad] Endereço:Womens and Children CMG, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK University of Leicester, Leicester LE1 7RH, UK.
[Ti] Título:Role of serum biomarkers in the prediction of outcome in women with threatened miscarriage: a systematic review and diagnostic accuracy meta-analysis.
[So] Source:Hum Reprod Update;22(2):228-39, 2016 Mar-Apr.
[Is] ISSN:1460-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Threatened miscarriage affects one in five women and is associated with significant emotional distress. The uncertainty around the prognosis of threatened miscarriage makes it equally challenging to the healthcare professionals. Various biochemical markers have been investigated in the past to predict the outcome of threatened miscarriage; however, the results have been conflicting. Therefore, we have conducted a systematic review and meta-analysis to determine the diagnostic accuracy of biochemical markers in predicting the outcome in women presenting with threatened miscarriage. METHODS: This is a systematic review and meta-analysis of prospective studies that investigated biochemical markers to determine outcomes for women with threatened miscarriage at 5-23 weeks gestational age. Electronic databases were searched up to June 2015 and study quality assessment was performed using QUADAS-2 (Quality Assessment for Diagnostic Accuracy Studies-2: A Revised Tool) for evaluating the diagnostic accuracy studies. Statistical analysis was performed using the Cochrane systematic review software. RESULTS: A total of 19 studies were included in the qualitative data synthesis of which 15 (including 1263 women) were eligible for the meta-analysis. The review highlights the role of biochemical markers serum progesterone, hCG, pregnancy associated plasma protein A, estradiol and cancer antigen 125 (CA 125) in the prediction of outcome in women with threatened miscarriage. Interestingly, serum CA 125 appears to be the most promising marker (n = 648 women in seven studies), whereas serum progesterone and hCG are less useful once fetal viability is established. The summary receiver operating characteristics for CA 125 showed a sensitivity of 90% (95% confidence interval (CI) 83-94%), specificity of 88% (95% CI 79-93%), positive likelihood ratio of 7.86 (95% CI 4.23-14.60) and negative likelihood ratio of 0.10 (95% CI 0.06-0.20). The inverse of negative likelihood ratio was 9.31 (95% CI 5-17.1) indicating that a negative test is likely to identify those who are likely to continue with the pregnancy. Serum estradiol was the next best marker with a sensitivity of 45% (95% CI 6-90%), a specificity of 87% (95% CI 81-92%), a positive likelihood ratio of 3.72 (95% CI 1.01-13.71) and a negative likelihood ratio of 0.62 (95% CI 0.20-1.84). CONCLUSIONS: In women with threatened miscarriage, serum CA 125 has high predictive value in identifying pregnancies that are 'likely to continue', whereas the most commonly used biomarkers of serum hCG and progesterone are not useful in predicting outcome of a pregnancy with a viable fetus. Other markers such as inhibin A and a combination of markers need to be investigated to hopefully improve the prediction of outcome in women with threatened miscarriage.
[Mh] Termos MeSH primário: Ameaça de Aborto/diagnóstico
Biomarcadores/sangue
[Mh] Termos MeSH secundário: Ameaça de Aborto/sangue
Estradiol/sangue
Feminino
Seres Humanos
Inibinas/sangue
Valor Preditivo dos Testes
Gravidez
Progesterona/sangue
Prognóstico
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (inhibin A); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 57285-09-3 (Inhibins)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1093/humupd/dmv054


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[PMID]:26259744
[Au] Autor:Arias-Cabello B; Arroyo-Yllanes ME; Pérez-Pérez JF; Fonte-Vázquez A
[Ad] Endereço:Servicio de Oftalmología, Clínica de Estrabismo, Hospital General de México Dr. Eduardo Liceaga, Secretaria de Salud, México D. F., México. Electronic address: beloca83@yahoo.com.mx.
[Ti] Título:[Clinical features of strabismus in psychomotor retardation].
[Ti] Título:Características clínicas del estrabismo en retraso psicomotor..
[So] Source:Cir Cir;84(1):9-14, 2016 Jan-Feb.
[Is] ISSN:0009-7411
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:BACKGROUND: In psychomotor retardation there is an abnormal development of mental, sensory and motor skills associated with ocular manifestations. There are biological and psychosocial risk factors that predispose an individual to neurological damage. From 50% to 80% of patients with strabismus retardation have special features that differentiate it from the rest of strabismus in healthy patients. OBJECTIVE: To determine the most common type of strabismus in patients with psychomotor retardation and their clinical features. MATERIAL AND METHODS: Patients with psychomotor retardation and strabismus were included. An ophthalmological examination was performed, as well as an evaluation of the characteristics of strabismus, including perinatal and post-natal history. RESULTS: Esotropia was the most frequent squint with 65.3%, followed by exotropia with 32.7%. The variability in the squint magnitude was 60% in both types, and 6 patients had dissociated vertical deviation. Most of the patients started to present strabismus since they were born. The most frequent perinatal risk factors were threatened miscarriage, pre-eclampsia, foetal distress, and hypoxia. CONCLUSIONS: Esotropia is the most common type of strabismus in psychomotor retardation. The variability of squint magnitude is a characteristic in these patients. The moderate variability is the most frequent in both esotropia and exotropia. The most common refractive error is hyperopic astigmatism in esotropia and the myopic kind in exotropia.
[Mh] Termos MeSH primário: Esotropia/complicações
Exotropia/complicações
Deficiência Intelectual/complicações
Transtornos Psicomotores/complicações
[Mh] Termos MeSH secundário: Ameaça de Aborto/epidemiologia
Adolescente
Asfixia Neonatal/epidemiologia
Astigmatismo/complicações
Causalidade
Paralisia Cerebral/complicações
Criança
Pré-Escolar
Feminino
Sofrimento Fetal/epidemiologia
Seres Humanos
Lactente
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Prematuro
Masculino
Idade Materna
Nistagmo Patológico/complicações
Pré-Eclâmpsia/epidemiologia
Gravidez
Gravidez na Adolescência
Efeitos Tardios da Exposição Pré-Natal
Estudos Prospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE


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[PMID]:26509178
[Au] Autor:Shobeiri SS; Rahmani Z; Hossein Nataj H; Ranjbaran H; Mohammadi M; Abediankenari S
[Ad] Endereço:Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48169 78741, Iran.
[Ti] Título:Uterine Natural Killer Cell and Human Leukocyte Antigen-G1 and Human Leukocyte Antigen-G5 Expression in Vaginal Discharge of Threatened-Abortion Women: A Case-Control Study.
[So] Source:J Immunol Res;2015:692198, 2015.
[Is] ISSN:2314-7156
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:The immunotolerant human leukocyte antigen-G (HLA-G) molecules have a major role in fetal-maternal tolerance during pregnancy. Interaction between these molecules and uterine natural killer (uNK) cells inhibitory receptors prevents NK cell invasion against fetus trophoblast cells. The aim of this study was to evaluate the percentages of uNK cells and HLA-G1 and HLA-G5 isoforms expression in vaginal discharge of threatened-abortion women in comparison with control. In a case-control study, we investigated 30 threatened-abortion women with bleeding or spotting less than 20 weeks of pregnancy as compared to 30 normal pregnant women. uNK cells percentage was assessed by flow cytometry. Furthermore, we evaluated HLA-G1 and HLA-G5 isoforms expression by Real-Time PCR in these groups. The results of this study showed that threatened-abortion women had increased uNK cells and decreased T cells percentage in vaginal discharge in comparison with normal pregnant women (p = 0.01, p = 0.003, resp.). In addition, HLA-G1 isoform had lower expression in threatened-abortion women in comparison with control group (p = 0.0001). The increase of uNK cells level with the decrease of HLA-G expression in vaginal discharge of threatened-abortion pregnant women is an indicator of mother's immune dysregulation. It is concluded that HLA-G expression level with uNK cells percentage can be determined as a diagnostic marker for threatened-abortion women.
[Mh] Termos MeSH primário: Ameaça de Aborto/imunologia
Antígenos HLA-G/genética
Células Matadoras Naturais/imunologia
Útero/imunologia
Descarga Vaginal/imunologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Citometria de Fluxo
Seres Humanos
Tolerância Imunológica
Interleucina-10/imunologia
Gravidez
Reação em Cadeia da Polimerase em Tempo Real
Trofoblastos
Útero/citologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HLA-G Antigens); 0 (IL10 protein, human); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1155/2015/692198


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[PMID]:26439038
[Au] Autor:Porcaro G; Brillo E; Giardina I; Di Iorio R
[Ad] Endereço:Department of Obstetrics and Gynecology, University of Perugia, Perugia, Italy. giusy.porcaro@gmail.com.
[Ti] Título:Alpha Lipoic Acid (ALA) effects on subchorionic hematoma: preliminary clinical results.
[So] Source:Eur Rev Med Pharmacol Sci;19(18):3426-32, 2015 Sep.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The clinic use of alpha Lipoic Acid (ALA) is linked to its capability to exert antioxidant effects and, more interestingly, to counteract the pathologic changes of complex networks of cytokines, chemokines and growth factors, restoring their physiological state. The aim of this randomized controlled clinical trial was to test the contribution of oral supplementation of ALA to the standard treatment with Progesterone vaginal suppositories, in healing subchorionic hematomas in patients with threatened miscarriage. Controls were administered only Progesterone suppositories. PATIENTS AND METHODS: Nineteen pregnant women in the first trimester of gestation, with threatened miscarriage and ultrasound evidence of subchorionic hematoma, were included in the trial and randomly divided in two groups: controls, treated with 400 mg Progesterone (200 mg 2 times per day), given by vaginal suppositories, and case study treated with the same Progesterone dosage, plus ALA, given orally at the dose of 600 mg (300 mg 2 times per day, DAV®, Lo.Li. Pharma srl, Italy). Sixteen patients completed the trial. Treatment was performed until complete resolution of the clinical picture. RESULTS: In both groups, the subjects improved significantly but, in general, a better and faster evolution in the major signs of threatened miscarriage was observed in the subjects treated with ALA and Progesterone. In these patients, the speed of resorption of subchorionic hematoma was significantly (p ≤ 0.05) superior compared to controls. The ALA and Progesterone group showed a faster decrease or disappearance of all symptoms than that observed in the control group, however the difference was not significant. CONCLUSIONS: These preliminary results suggest that ALA supplementation significantly contributes to speed up the process of restoration of physiological conditions in threatened miscarriage and ameliorates the medical conditions of both the mothers and the foetus, probably modulating the networks of cytokines, growth factors and other molecules.
[Mh] Termos MeSH primário: Ameaça de Aborto/prevenção & controle
Córion/patologia
Hematoma/tratamento farmacológico
Complicações na Gravidez/tratamento farmacológico
Ácido Tióctico/administração & dosagem
Hemorragia Uterina/tratamento farmacológico
[Mh] Termos MeSH secundário: Ameaça de Aborto/etiologia
Adulto
Feminino
Seres Humanos
Gravidez
Progesterona/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 73Y7P0K73Y (Thioctic Acid)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151007
[Lr] Data última revisão:
151007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE



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