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[PMID]:28460636
[Au] Autor:Saugier-Veber P; Marguet F; Lecoquierre F; Adle-Biassette H; Guimiot F; Cipriani S; Patrier S; Brasseur-Daudruy M; Goldenberg A; Layet V; Capri Y; Gérard M; Frébourg T; Laquerrière A
[Ad] Endereço:Department of Genetics, Normandie Univ, UNIROUEN, INSERM U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, F76000, Rouen, France.
[Ti] Título:Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
[So] Source:Acta Neuropathol Commun;5(1):36, 2017 05 01.
[Is] ISSN:2051-5960
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Congenital hydrocephalus is considered as either acquired due to haemorrhage, infection or neoplasia or as of developmental nature and is divided into two subgroups, communicating and obstructive. Congenital hydrocephalus is either syndromic or non-syndromic, and in the latter no cause is found in more than half of the patients. In patients with isolated hydrocephalus, L1CAM mutations represent the most common aetiology. More recently, a founder mutation has also been reported in the MPDZ gene in foetuses presenting massive hydrocephalus, but the neuropathology remains unknown. We describe here three novel homozygous null mutations in the MPDZ gene in foetuses whose post-mortem examination has revealed a homogeneous phenotype characterized by multiple ependymal malformations along the aqueduct of Sylvius, the third and fourth ventricles as well as the central canal of the medulla, consisting in multifocal rosettes with immature cell accumulation in the vicinity of ependymal lining early detached from the ventricular zone. MPDZ also named MUPP1 is an essential component of tight junctions which are expressed from early brain development in the choroid plexuses and ependyma. Alterations in the formation of tight junctions within the ependyma very likely account for the lesions observed and highlight for the first time that primary multifocal ependymal malformations of the ventricular system is genetically determined in humans. Therefore, MPDZ sequencing should be performed when neuropathological examination reveals multifocal ependymal rosette formation within the aqueduct of Sylvius, of the third and fourth ventricles and of the central canal of the medulla.
[Mh] Termos MeSH primário: Proteínas de Transporte/genética
Epêndima/anormalidades
Doenças Fetais/genética
Hidrocefalia/genética
Mutação com Perda de Função
[Mh] Termos MeSH secundário: Adulto
Epêndima/diagnóstico por imagem
Família
Feminino
Doenças Fetais/diagnóstico por imagem
Doenças Fetais/etiologia
Doenças Fetais/patologia
Homozigoto
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Hidrocefalia/etiologia
Hidrocefalia/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (MPDZ protein, human)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s40478-017-0438-4


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[PMID]:29390381
[Au] Autor:Ek S; Rosenborg S
[Ad] Endereço:Department of Obstetrics and Gynecology, Center of Fetal Medicine, Karolinska University Hospital.
[Ti] Título:Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report.
[So] Source:Medicine (Baltimore);96(50):e9277, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Mesalazine and its prodrug sulfasalazine are both used for inflammatory bowel disease. Sulfasalazine has been associated with hematological side-effects such as aplastic and hemolytic anemia in patients, but also in fetuses after intrauterine exposure. To our knowledge, we describe the first case of a fetus with severe anemia, and subsequent hydrops, where this drug was found at concentrations in the fetus corresponding to those in the mother and most likely responsible for the fetal condition. PATIENT CONCERNS: A uniparous woman was referred at 31 weeks of gestation due to a hydropic fetus with massive ascites and cardiomegaly. DIAGNOSES: The patient had Crohn's disease and was thus treated with 4 g mesalazine daily. The fetus had severe anemia with an initial hemoglobin level of 51 g/L. INTERVENTIONS: The maternal medication was discontinued and four intrauterine erythrocyte transfusions were given during three weeks. Plasma samples were drawn from mother and fetus during cordocentesis for later analysis of mesalazine. OUTCOMES: A healthy baby was born after 37 full weeks of gestation. Plasma levels of mesalazine were non-conspicuous in neither mother nor fetus. The mesalazine half-life in the fetus (37 h) was half that of the mother (80 h), both considerably longer than previously reported (about 19 h). LESSONS: A causal relationship must be suspected between the fetal anemia and the maternal use of mesalazine. This fetal side-effect should be considered in pregnant women on mesalazine (and its prodrug sulfasalazine).
[Mh] Termos MeSH primário: Anemia/induzido quimicamente
Anti-Inflamatórios não Esteroides/efeitos adversos
Doenças Fetais/induzido quimicamente
Hidropisia Fetal/induzido quimicamente
Mesalamina/efeitos adversos
[Mh] Termos MeSH secundário: Anemia/terapia
Transfusão de Eritrócitos
Feminino
Doenças Fetais/terapia
Seres Humanos
Hidropisia Fetal/terapia
Gravidez
Resultado da Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 4Q81I59GXC (Mesalamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009277


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[PMID]:29320537
[Au] Autor:Garabedian C; Clermont-Hama Y; Sharma D; Aubry E; Butruille L; Deruelle P; Storme L; De Jonckheere J; Houfflin-Debarge V
[Ad] Endereço:Univ. Lille, EA 4489 -Perinatal Environment and Health, Lille, France.
[Ti] Título:Correlation of a new index reflecting the fluctuation of parasympathetic tone and fetal acidosis in an experimental study in a sheep model.
[So] Source:PLoS One;13(1):e0190463, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The autonomic nervous system plays a leading role in the control of fetal homeostasis. Fetal heart rate variability (HRV) analysis is a reflection of its activity. We developed a new index (the Fetal Stress Index, FSI) reflecting parasympathetic tone. The objective of this study was to evaluate this index as a predictor of fetal acid-base status. This was an experimental study on chronically instrumented fetal lambs (n = 11, surgery at 128 +/- 2 days gestational age, term = 145 days). The model was based on 75% occlusion of the umbilical cord for a maximum of 120 minutes or until an arterial pH ≤ 7.20 was reached. Hemodynamic, gasometric and FSI parameters were recorded throughout the experimentation. We studied the FSI during the 10 minutes prior to pH samplings and compared values for pH>7.20 and pH≤ 7.20. In order to analyze the FSI evolution during the 10 minutes periods, we analyzed the minimum, maximum and mean values of the FSI (respectively FSImin, FSImax and FSImean) over the periods. 11 experimentations were performed. During occlusion, the heart rate dropped with an increase in blood pressure (respectively 160(155-182) vs 106(101-120) bpm and 42(41-45) vs 58(55-62) mmHg after occlusion). The FSImin was 38.6 (35.2-43.3) in the group pH>7.20 and was higher in the group pH less than 7.20 (46.5 (43.3-52.0), p = 0.012). The correlation of FSImin was significant for arterial pH (coefficient of -0.671; p = 0.004) and for base excess (coefficient of -0.632; p = 0.009). The correlations were not significant for the other parameters. In conclusion, our new index seems well correlated with the fetal acid-base status. Other studies must be carried out in a situation close to the physiology of labor by sequential occlusion of the cord.
[Mh] Termos MeSH primário: Acidose/fisiopatologia
Doenças Fetais/fisiopatologia
Sistema Nervoso Parassimpático/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190463


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[PMID]:29215523
[Au] Autor:Sugarman J; Anderson J; Baschat AA; Herrera Beutler J; Bienstock JL; Bunchman TE; Desai NM; Gates E; Goldberg A; Grimm PC; Henry LM; Jelin EB; Johnson E; Hertenstein CB; Mastroianni AC; Mercurio MR; Neu A; Nogee LM; Polzin WJ; Ralston SJ; Ramus RM; Singleton MK; Somers MJG; Wang KC; Boss R
[Ad] Endereço:Berman Institute of Bioethics, the Department of Gynecology and Obstetrics, the Center for Fetal Therapy, the Department of Surgery, Pediatric Palliative Care, the Division of Pediatric Nephrology, the Division of Neonatology, and the Human Research Protection Program, Johns Hopkins School of Medicine and University, Baltimore, Maryland; U.S. House of Representatives, Southwest Washington 3rd District, Washington, DC; the Department of Pediatric Nephrology, Transplantation and Rheumatology, Children's Hospital of Richmond, the Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia; the Department of Obstetrics, Gynecology and Reproductive Services, University of California, San Francisco, San Francisco, California; the Department of Pediatrics-Nephrology, Max Rady College of Medicine, Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada; Francis King Carey School of Law, University of Maryland, Baltimore, Maryland; the Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California; the University of Washington School of Law and Institute for Public Health Genetics, Seattle, Washington; the Division of Neonatal-Perinatal Medicine and Program for Biomedical Ethics, Yale University School of Medicine, New Haven, Connecticut; Cincinnati Fetal Center, TriHealth Good Samaritan Hospital, Cincinnati, Ohio; the Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia, Pennsylvania; and the Division of Nephrology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
[Ti] Título:Ethical Considerations Concerning Amnioinfusions for Treating Fetal Bilateral Renal Agenesis.
[So] Source:Obstet Gynecol;131(1):130-134, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital bilateral renal agenesis has been considered a uniformly fatal condition. However, the report of using serial amnioinfusions followed by the live birth in 2012 and ongoing survival of a child with bilateral renal agenesis has generated hope, but also considerable controversy over an array of complex clinical and ethical concerns. To assess the ethical concerns associated with using serial amnioinfusions for bilateral renal agenesis, we assembled a multidisciplinary group to map the ethical issues relevant to this novel intervention. The key ethical issues identified were related to 1) potential risks and benefits, 2) clinical care compared with innovation compared with research, 3) counseling of expectant parents, 4) consent, 5) outcome measures, 6) access and justice, 7) conflicts of interest, 8) effects on clinicians, 9) effects on institutions, and 10) long-term societal implications. These ethical issues should be addressed in conjunction with systematic efforts to examine whether this intervention is safe and effective. Future work should capture the experiences of expectant parents, women who undergo serial amnioinfusions, those born with bilateral renal agenesis and their families as well as clinicians confronted with making difficult choices related to it.
[Mh] Termos MeSH primário: Âmnio
Anormalidades Congênitas/diagnóstico por imagem
Anormalidades Congênitas/terapia
Infusões Intralesionais/ética
Nefropatias/congênito
Rim/anormalidades
Oligo-Hidrâmnio/terapia
Resultado da Gravidez
[Mh] Termos MeSH secundário: Feminino
Doenças Fetais/diagnóstico por imagem
Doenças Fetais/terapia
Seres Humanos
Consentimento Livre e Esclarecido
Rim/diagnóstico por imagem
Nefropatias/diagnóstico por imagem
Nefropatias/terapia
Saúde Materna
Oligo-Hidrâmnio/diagnóstico por imagem
Gravidez
Medição de Risco
Ultrassonografia Pré-Natal/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002416


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[PMID]:28076981
[Au] Autor:Zhang H; Yang H; Sun Y; Fan L; Zhang X
[Ad] Endereço:a Department of Obstetrics and Gynecology , Peking University First Hospital , Beijing , China.
[Ti] Título:Prenatal drainage of fetal urinoma with polyhydramnios: a case report and literature review.
[So] Source:J Matern Fetal Neonatal Med;31(2):264-266, 2018 Jan.
[Is] ISSN:1476-4954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The appearance of fetal urinoma is rare in prenatal care, especially when associated with polyhydramnions. Many previous reports have concluded that the visualization of a prenatal urinoma is probably a sign of underlying renal dysplasia or poor function. Thus, the management of the reported cases, conservative treatment or uniroma drainage, has not been unified. In this paper, we present two cases of prenatally detected urinoma with prenatal drainage to improve the prognosis.
[Mh] Termos MeSH primário: Drenagem/métodos
Doenças Fetais
Poli-Hidrâmnios
Urinoma
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Gravidez
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1080/14767058.2017.1281242


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[PMID]:27777190
[Au] Autor:Deng XJ; Chen CH; Qiu YW; Xiao SF; Liao SX; Zhong M; Yang F
[Ad] Endereço:Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: dengxujie@126.com.
[Ti] Título:[Correlation analysis of fetal middle cerebral artery peak systolic velocity, cardiothoracic ratio and crown-rump length in early pregnancy].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1312-1315, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the pattern of variations in middle cerebral artery peak systolic velocity (MCA PSV) and cardiothoracic ratio (CTR) during early pregnancy, establish their reference ranges and explore their correlation with the crown-rump length (CRL). METHODS: A total of 522 pregnant women with normal findings in antenatal examinations underwent routine color Doppler ultrasound examination to collect the data of MCA PSV, CTR and CRL. The reference ranges of MCA PSV and CTR for different CRL levels were established, and the correlation of MCA PSV and CTR with CRL was analyzed. RESULTS: During the first trimester, MCA PSV and CRL showed a moderate positive correlation with a correlation coefficient of 0.426 (P<0.001), while CTR and CRL showed no significant correlation (0.168, P<0.001). The reference range of MCA PSV was 14.35 (14.08-14.62) cm/s and that of CTR was 0.34 (0.33-0.34) during early pregnancy. CONCLUSION: Color Doppler ultrasound is a safe and feasible modality to assess fetal MCA PSV and CTR for detecting fetal growth abnormalities in early pregnancy. The established reference ranges of MCA PSV and CTR offer a clinical theoretical basis for detecting α-thalassemia in early pregnancy.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo
Estatura Cabeça-Cóccix
Artéria Cerebral Média/fisiologia
Ultrassonografia Pré-Natal
[Mh] Termos MeSH secundário: Feminino
Doenças Fetais/diagnóstico por imagem
Seres Humanos
Gravidez
Primeiro Trimestre da Gravidez
Valores de Referência
Sístole
Ultrassonografia Doppler em Cores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29072954
[Au] Autor:Heider A
[Ad] Endereço:From the Department of Pathology Michigan Medicine, University of Michigan, Ann Arbor.
[Ti] Título:Fetal Vascular Malperfusion.
[So] Source:Arch Pathol Lab Med;141(11):1484-1489, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Fetal vascular malperfusion, also known as fetal thrombotic vasculopathy, remains an underrecognized pathologic finding and should be noted during placental evaluation. OBJECTIVE: - To review histologic findings, gain familiarity with the updated terminology, and to recognize important clinical associations with this entity. DATA SOURCES: - University of Michigan cases, PubMed search, multiple review articles including recent placental workshop group consensus statement, and selected book chapters. CONCLUSIONS: - Multiple histologic patterns of fetal vascular malperfusion have been described including thrombosis, avascular villi, villous stromal-vascular karyorrhexis, intramural fibrin thrombi, and stem villous vascular obliteration. Various underlying etiologies can be involved in fetal vascular malperfusion. Cord lesions including abnormal insertion, length, and coiling are important causes. Maternal vascular malperfusion such as preeclampsia, hypercoagulable states, lupus anticoagulant, and sometimes diabetes have been associated with this condition. Fetal cardiac dysfunction/malformations and severe fetal inflammatory response in the setting of ascending intrauterine infection have also been attributed to this important finding. Fetal vascular malperfusion has been implicated in several significant and sometimes devastating clinical associations; these include intrauterine growth restriction, poor perinatal outcome, fetal demise, and neurodevelopmental sequelae. A diagnostic challenge may be encountered in cases with prior intrauterine fetal death, since degenerative changes post demise result in a similar histomorphologic picture. The diffuse versus the focal nature of the lesions may help in the distinction.
[Mh] Termos MeSH primário: Doenças Fetais/patologia
Doenças Placentárias/patologia
Circulação Placentária
Trombose/etiologia
Doenças Vasculares/patologia
[Mh] Termos MeSH secundário: Autopsia
Anormalidades Cardiovasculares/patologia
Anormalidades Cardiovasculares/fisiopatologia
Feminino
Morte Fetal/etiologia
Doenças Fetais/etiologia
Doenças Fetais/fisiopatologia
Seres Humanos
Doenças Placentárias/etiologia
Doenças Placentárias/fisiopatologia
Gravidez
Complicações Infecciosas na Gravidez/fisiopatologia
Terminologia como Assunto
Cordão Umbilical/anormalidades
Cordão Umbilical/irrigação sanguínea
Cordão Umbilical/patologia
Doenças Vasculares/etiologia
Doenças Vasculares/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0212-RA


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[PMID]:29060963
[Au] Autor:Jiang YL; Qi QW; Zhou XY; Geng FF; Bai JJ; Hao N; Liu JT
[Ad] Endereço:Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Título:[Prenatal diagnosis of 17q12 microdeletion syndrome in fetal renal abnormalities].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;52(10):662-668, 2017 Oct 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze 3 cases of 17q12 microdeletion syndrome diagnosed prenatally, and to demonstrate clinical phenotype of the syndrome in prenatal setting. From January 2013 to July 2017, 1 370 women received invasive prenatal diagnosis and chromosome microarray analysis (CMA) in Peking Union Medical College Hospital. Among them, 3 fetuses were diagnosed as 17q12 microdeletion syndrome. All 3 cases were low-risk pregnancies. Abnormal structures in fetal kidney were found in all 3 cases, including 1 case of multiple renal cysts, 2 cases of bilateral hyperechogenic kidneys. These women accepted invasive prenatal diagnosis followed by karyotyping, parental fluorescence in situ hybridization or CMA validation. The second and third trimester ultrasound showed that all 3 fetuses had bilateral renal structural abnormalities, including hyperechogenic kidney, multiple cysts and renal pelvis dilatation. The karyotyping of the 3 fetuses were normal. CMA examination showed that each case had 1.4-1.6 Mb deletion in 17q12 region. Two cases were de novo deletion and 1 case was inherited from the mother who had mild symptoms. The 3 women decided to terminate pregnancies after genetic counseling. 17q12 microdeletion syndrome is a recurrent chromosome microdeletion syndrome, and the unique phenotype in prenatal setting is the abnormal structure of bilateral kidneys. A few cases of 17q12 microdeletion syndrome even inherited normally phenotypical parents, and prenatal genetic counseling of 17q12 microdeletion syndrome is relatively difficult.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/diagnóstico por imagem
Doenças Fetais/genética
Deficiência Intelectual/diagnóstico por imagem
Rim/diagnóstico por imagem
Diagnóstico Pré-Natal
Ultrassonografia Pré-Natal
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/genética
Deleção Cromossômica
Cromossomos Humanos Par 17/genética
Feminino
Doenças Fetais/diagnóstico por imagem
Seres Humanos
Hibridização in Situ Fluorescente
Deficiência Intelectual/genética
Cariotipagem
Análise em Microsséries
Fenótipo
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2017.10.004


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[PMID]:28931792
[Au] Autor:Sakamoto M; Itai T; Murata K
[Ad] Endereço:Department of International Affairs and Environmental Research, National Institute for Minamata Disease.
[Ti] Título:Effects of Prenatal Methylmercury Exposure: From Minamata Disease to Environmental Health Studies.
[So] Source:Nihon Eiseigaku Zasshi;72(3):140-148, 2017.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Methylmercury, the causative agent of Minamata disease, can easily penetrate the brain, and adult-type Minamata disease patients showed neurological symptoms according to the brain regions where the neurons, mainly in the cerebrum and cerebellum, were damaged. In addition, fetuses are exposed to methylmercury via the placenta from maternal fish consumption, and high-level exposure to methylmercury causes damage to the brains of infants. Typical patients with fetal-type Minamata disease (i.e., serious poisoning caused by in utero exposure to methylmercury) were born during the period of severe methylmercury pollution in 1955-1959, although they showed no abnormality during gestation nor at delivery. However, they showed difficulties in head control, sitting, and walking, and showed disturbances in mental development, these symptoms that are similar to those of cerebral palsy, during the growth periods after birth. The impaired development of fetal-type Minamata disease patients was one of the most tragic and characteristic feature of Minamata disease. In this review, we first summarize 1) the effects of prenatal methylmercury exposure in Minamata disease. Then, we introduce the studies that were conducted mainly by Sakamoto et al. as follows: 2) a retrospective study on temporal and regional variations of methylmercury pollution in Minamata area using preserved umbilical cord methylmercury, 3) decline in male sex ratio observed in Minamata area, 4) characteristics of hand tremor and postural sway in fetal-type Minamata disease patients, 5) methylmercury transfer from mothers to infants during gestation and lactation (the role of placenta), 6) extrapolation studies using rat models on the effects of prenatal methylmercury exposure on the human brain, and 7) risks and benefits of fish consumption.
[Mh] Termos MeSH primário: Doenças Fetais/etiologia
Exposição Materna/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/etiologia
Compostos de Metilmercúrio/efeitos adversos
Compostos de Metilmercúrio/envenenamento
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Modelos Animais de Doenças
Feminino
Peixes
Seres Humanos
Japão
Troca Materno-Fetal
Intoxicação do Sistema Nervoso por Mercúrio/metabolismo
Compostos de Metilmercúrio/metabolismo
Placenta/metabolismo
Gravidez
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.72.140


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[PMID]:28906394
[Au] Autor:Guo Y; Sun Y; Yang H
[Ad] Endereço:Obstetrics and Gynecology Department, Peking University First Hospital, Beijing, China.
[Ti] Título:Growth discordance of monoamniotic twin because of difference of cords diameter in forked umbilical cord: Case report.
[So] Source:Medicine (Baltimore);96(37):e8042, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A case of monochorionic-monoamniotic (MCMA) twin pregnancy with growth discordance because of difference of cord diameter in forked umbilical cord is reported.MCMA twins were diagnosed at 12 weeks of gestation and twin growth discordance was considered during the follow-up twice-weekly visits to the ultrasound and prenatal care units. The pregnancy was terminated at 34 weeks. Two live female babies weighing 2510 g and 1940 g were delivered. Examination of placenta and umbilical cords after birth showed that the 2 cords merged into a conjoint cord 1 cm from insertion to the placenta (forked umbilical cord). Placental color injection showed that the 2 fetuses shared the same placenta area. The diameters of the 2 cords were significantly different (1.5 vs 0.8 cm). This caused an unequal distribution of blood and nutrients, which is the real reason of twin growth discordance in this case.This case reveals that the diameter discordance of cords can be an important factor for twin growth discordance. Few relevant cases have previously been reported. Cords diameter measurement is suggested for ultrasound surveillance of twin growth discordance.
[Mh] Termos MeSH primário: Doenças em Gêmeos
Doenças Fetais
Retardo do Crescimento Fetal/etiologia
Gravidez de Gêmeos
Cordão Umbilical/patologia
[Mh] Termos MeSH secundário: Adulto
Doenças em Gêmeos/diagnóstico por imagem
Feminino
Doenças Fetais/diagnóstico por imagem
Retardo do Crescimento Fetal/diagnóstico por imagem
Seres Humanos
Tamanho do Órgão
Placenta/diagnóstico por imagem
Placenta/patologia
Gravidez
Ultrassonografia Pré-Natal
Cordão Umbilical/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008042



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