Base de dados : MEDLINE
Pesquisa : C13.703.277.220 [Categoria DeCS]
Referências encontradas : 3754 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 376 ir para página                         

  1 / 3754 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460370
[Au] Autor:Weyrauch D; Schwartz M; Hart B; Klug MG; Burd L
[Ad] Endereço:Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.
[Ti] Título:Comorbid Mental Disorders in Fetal Alcohol Spectrum Disorders: A Systematic Review.
[So] Source:J Dev Behav Pediatr;38(4):283-291, 2017 May.
[Is] ISSN:1536-7312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A systematic review of published literature to estimate prevalence of comorbid mental disorders in fetal alcohol spectrum disorders (FASDs) and compare with general population prevalence estimates. METHODS: A PubMed search was used to locate articles reporting on FASD and mental disorders published through June 2015. Next, lists of published studies from all issues of the National Organisation for Foetal Alcohol Syndrome-UK publication Fetal Alcohol Forum-were searched. Weighted average prevalence was estimated for the comorbid mental disorders with sufficient data for analysis. We then compared prevalence of mental disorders in the FASD population with rates in the mental health literature. RESULTS: We identified 26 articles reporting 5984 cases of FASD. Of the 15 comorbid mental disorders, 11 had sufficient data for inclusion in the analysis. Attention-deficit/hyperactivity disorder occurred in 50% of persons with FASD (10 times the expected rate). Intellectual disability occurred at 23 times the expected rate. In 5 of the 12 disorders, rates in the FASD population significantly exceeded expected rates by 10% to 45%. CONCLUSION: Increased rates of mental disorders in people with FASD are commonly reported. Mental health providers should routinely consider FASD in the diagnosis and management of mental illness and developmental disorders. The quality of the research and precision of comorbidity estimates would be improved by additional studies including people with FASD and non-FASD comparison subjects. Until these studies are available, this review provides the best available estimates of comorbid mental disorders in people with FASD.
[Mh] Termos MeSH primário: Transtornos do Espectro Alcoólico Fetal/epidemiologia
Transtornos Mentais/epidemiologia
[Mh] Termos MeSH secundário: Comorbidade
Seres Humanos
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1097/DBP.0000000000000440


  2 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29236375
[Au] Autor:Sabourin G
[Ti] Título:Trouble du spectre de l'alcoolsation foetale. Nouvelles lignes directrices..
[So] Source:Perspect Infirm;14(2):64, 2017 Mar-Apr.
[Is] ISSN:1708-1890
[Cp] País de publicação:Canada
[La] Idioma:fre
[Mh] Termos MeSH primário: Transtornos do Espectro Alcoólico Fetal/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Guias de Prática Clínica como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  3 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29411031
[Au] Autor:May PA; Chambers CD; Kalberg WO; Zellner J; Feldman H; Buckley D; Kopald D; Hasken JM; Xu R; Honerkamp-Smith G; Taras H; Manning MA; Robinson LK; Adam MP; Abdul-Rahman O; Vaux K; Jewett T; Elliott AJ; Kable JA; Akshoomoff N; Falk D; Arroyo JA; Hereld D; Riley EP; Charness ME; Coles CD; Warren KR; Jones KL; Hoyme HE
[Ad] Endereço:University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill.
[Ti] Título:Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities.
[So] Source:JAMA;319(5):474-482, 2018 02 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Fetal alcohol spectrum disorders are costly, life-long disabilities. Older data suggested the prevalence of the disorder in the United States was 10 per 1000 children; however, there are few current estimates based on larger, diverse US population samples. Objective: To estimate the prevalence of fetal alcohol spectrum disorders, including fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder, in 4 regions of the United States. Design, Setting, and Participants: Active case ascertainment methods using a cross-sectional design were used to assess children for fetal alcohol spectrum disorders between 2010 and 2016. Children were systematically assessed in the 4 domains that contribute to the fetal alcohol spectrum disorder continuum: dysmorphic features, physical growth, neurobehavioral development, and prenatal alcohol exposure. The settings were 4 communities in the Rocky Mountain, Midwestern, Southeastern, and Pacific Southwestern regions of the United States. First-grade children and their parents or guardians were enrolled. Exposures: Alcohol consumption during pregnancy. Main Outcomes and Measures: Prevalence of fetal alcohol spectrum disorders in the 4 communities was the main outcome. Conservative estimates for the prevalence of the disorder and 95% CIs were calculated using the eligible first-grade population as the denominator. Weighted prevalences and 95% CIs were also estimated, accounting for the sampling schemes and using data restricted to children who received a full evaluation. Results: A total of 6639 children were selected for participation from a population of 13 146 first-graders (boys, 51.9%; mean age, 6.7 years [SD, 0.41] and white maternal race, 79.3%). A total of 222 cases of fetal alcohol spectrum disorders were identified. The conservative prevalence estimates for fetal alcohol spectrum disorders ranged from 11.3 (95% CI, 7.8-15.8) to 50.0 (95% CI, 39.9-61.7) per 1000 children. The weighted prevalence estimates for fetal alcohol spectrum disorders ranged from 31.1 (95% CI, 16.1-54.0) to 98.5 (95% CI, 57.5-139.5) per 1000 children. Conclusions and Relevance: Estimated prevalence of fetal alcohol spectrum disorders among first-graders in 4 US communities ranged from 1.1% to 5.0% using a conservative approach. These findings may represent more accurate US prevalence estimates than previous studies but may not be generalizable to all communities.
[Mh] Termos MeSH primário: Transtornos do Espectro Alcoólico Fetal/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Criança
Pré-Escolar
Estudos Transversais
Feminino
Transtornos do Espectro Alcoólico Fetal/etnologia
Seres Humanos
Masculino
Mães
Prevalência
Amostragem
Fatores Socioeconômicos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.21896


  4 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29225110
[Au] Autor:Bhattacharya D; Majrashi M; Ramesh S; Govindarajulu M; Bloemer J; Fujihashi A; Crump BR; Hightower H; Bhattacharya S; Moore T; Suppiramaniam V; Dhanasekaran M
[Ad] Endereço:Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, USA.
[Ti] Título:Assessment of the cerebellar neurotoxic effects of nicotine in prenatal alcohol exposure in rats.
[So] Source:Life Sci;194:177-184, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individuals quit after learning of their pregnancy. However, there are very few scientific reports on the effect of nicotine in prenatal alcohol exposure on the cerebellum of the offspring. Therefore, this study was conducted to investigate the cerebellar neurotoxic effects of nicotine in a rodent model of Fetal Alcohol Spectrum Disorder (FASD). In this study, we evaluated the behavioral changes, biochemical markers of oxidative stress and apoptosis, mitochondrial functions and the molecular mechanisms associated with nicotine in prenatal alcohol exposure on the cerebellum. Prenatal nicotine and alcohol exposure induced oxidative stress, did not affect the mitochondrial functions, increased the monoamine oxidase activity, increased caspase expression and decreased ILK, PSD-95 and GLUR1 expression without affecting the GSK-3ß. Thus, our current study of prenatal alcohol and nicotine exposure on cerebellar neurotoxicity may lead to new scientific perceptions and novel and suitable therapeutic actions in the future.
[Mh] Termos MeSH primário: Cerebelo/efeitos dos fármacos
Cerebelo/embriologia
Transtornos do Espectro Alcoólico Fetal/patologia
Neurotoxinas/toxicidade
Nicotina/toxicidade
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Cerebelo/metabolismo
Cerebelo/patologia
Feminino
Transtornos do Espectro Alcoólico Fetal/metabolismo
Seres Humanos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Mitocôndrias/patologia
Estresse Oxidativo/efeitos dos fármacos
Gravidez
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Efeitos Tardios da Exposição Pré-Natal/patologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotoxins); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  5 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29411016
[Au] Autor:Lange S; Rehm J; Popova S
[Ad] Endereço:Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
[Ti] Título:Implications of Higher Than Expected Prevalence of Fetal Alcohol Spectrum Disorders.
[So] Source:JAMA;319(5):448-449, 2018 02 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos do Espectro Alcoólico Fetal
[Mh] Termos MeSH secundário: Feminino
Gravidez
Prevalência
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.21895


  6 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28987617
[Au] Autor:Goodfellow MJ; Shin YJ; Lindquist DH
[Ad] Endereço:Department of Psychology, The Ohio State University, 1835 Neil Ave., Columbus, OH 43210, USA. Electronic address: mgoodfellow@som.umaryland.edu.
[Ti] Título:Mitigation of postnatal ethanol-induced neuroinflammation ameliorates trace fear memory deficits in juvenile rats.
[So] Source:Behav Brain Res;338:28-31, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats. Phosphate buffered saline vehicle (VEH) or IBU was injected 2h following ethanol exposure over PD4-9, followed by quantification of inflammation-related genes in the dorsal hippocampus of PD10 rats. The 5E-VEH rats exhibited significant increases in Il1b and Tnf, but not Itgam or Gfap, relative to NC, SI-VEH, and 5E-IBU rats. In separate groups of PD31-33 rats, conditioned fear (freezing) was significantly reduced in 5E-VEH rats during TFC testing, but not acquisition, compared to SI-VEH and, critically, 5E-IBU rats. Results suggest neuroimmune activation in response to ethanol within the neonate hippocampus contributes to later-life cognitive dysfunction.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Encéfalo/efeitos dos fármacos
Citocinas/metabolismo
Etanol/administração & dosagem
Transtornos do Espectro Alcoólico Fetal/metabolismo
Ibuprofeno/uso terapêutico
Transtornos da Memória/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Citocinas/genética
Modelos Animais de Doenças
Medo/efeitos dos fármacos
Medo/fisiologia
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Transtornos da Memória/metabolismo
Ratos
Ratos Long-Evans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 3K9958V90M (Ethanol); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  7 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29187580
[Au] Autor:Valentine M; Bihm DCJ; Wolf L; Hoyme HE; May PA; Buckley D; Kalberg W; Abdul-Rahman OA
[Ad] Endereço:Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi.
[Ti] Título:Computer-Aided Recognition of Facial Attributes for Fetal Alcohol Spectrum Disorders.
[So] Source:Pediatrics;140(6), 2017 Dec.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To compare the detection of facial attributes by computer-based facial recognition software of 2-D images against standard, manual examination in fetal alcohol spectrum disorders (FASD). METHODS: Participants were gathered from the Fetal Alcohol Syndrome Epidemiology Research database. Standard frontal and oblique photographs of children were obtained during a manual, in-person dysmorphology assessment. Images were submitted for facial analysis conducted by the facial dysmorphology novel analysis technology (an automated system), which assesses ratios of measurements between various facial landmarks to determine the presence of dysmorphic features. Manual blinded dysmorphology assessments were compared with those obtained via the computer-aided system. RESULTS: Areas under the curve values for individual receiver-operating characteristic curves revealed the computer-aided system (0.88 ± 0.02) to be comparable to the manual method (0.86 ± 0.03) in detecting patients with FASD. Interestingly, cases of alcohol-related neurodevelopmental disorder (ARND) were identified more efficiently by the computer-aided system (0.84 ± 0.07) in comparison to the manual method (0.74 ± 0.04). A facial gestalt analysis of patients with ARND also identified more generalized facial findings compared to the cardinal facial features seen in more severe forms of FASD. CONCLUSIONS: We found there was an increased diagnostic accuracy for ARND via our computer-aided method. As this category has been historically difficult to diagnose, we believe our experiment demonstrates that facial dysmorphology novel analysis technology can potentially improve ARND diagnosis by introducing a standardized metric for recognizing FASD-associated facial anomalies. Earlier recognition of these patients will lead to earlier intervention with improved patient outcomes.
[Mh] Termos MeSH primário: Identificação Biométrica/métodos
Transtornos do Espectro Alcoólico Fetal/diagnóstico
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Computadores
Bases de Dados Factuais
Face
Feminino
Seres Humanos
Masculino
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  8 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28947208
[Au] Autor:Nogales F; Ojeda ML; Jotty K; Murillo ML; Carreras O
[Ad] Endereço:Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain.
[Ti] Título:Maternal ethanol consumption reduces Se antioxidant function in placenta and liver of embryos and breastfeeding pups.
[So] Source:Life Sci;190:1-6, 2017 Dec 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIM: The fetal alcohol exposition during pregnancy leads to different disorders in offspring, related to the oxidative stress generated by alcohol. It is well-documented that there is an impairment of the antioxidant selenoprotein Glutathione peroxidase (GPx) activity in ethanol offspring during the embryo period, although no-one has described Selenium (Se) status. The aim is to analyze for the first time Se deposits in vivo and Se's biological implication in embryos and placenta after alcohol exposure and in offspring whose mothers continued to drink ethanol during lactation. MATERIALS AND METHODS: Se deposits, GPx and glutathione reductase (GR) activity, lipid and protein oxidation and the expression of GPx1 were measured in placenta and liver of both embryos (E-19) and breastfeeding pups (L-21) in control and ethanol groups (20% v/v). KEY FINDINGS: Ethanol consumption decreased Se deposits, GPx activity and GPx1 expression, while increasing biomolecular oxidation in placenta and in the liver of E-19 and L-21. The GR/GPx ratio decreased in placenta and in E-19, together with an increase in lipid oxidation, while increased in the liver of L-21 pups with protein oxidation. Ethanol also decreased the GPx1 expression/GPx activity ratio in the liver of E-19 and L-21, indicating that alcohol decreases GPx activity by both depleting Se deposits and promoting GPx inactivation. In placenta GPx activity is proportional to the GPx1 expression found, so the ethanol affects GPx activity in offspring more than in dams. SIGNIFICANCE: Therefore, Se supplementation therapy in dams could contribute as an interesting antioxidant that prevents fetal alcohol syndrome.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/efeitos adversos
Antioxidantes/metabolismo
Etanol/toxicidade
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Selênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Aleitamento Materno
Etanol/administração & dosagem
Feminino
Transtornos do Espectro Alcoólico Fetal/prevenção & controle
Glutationa Peroxidase/metabolismo
Lactação
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Placenta/metabolismo
Gravidez
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 3K9958V90M (Ethanol); EC 1.11.1.- (glutathione peroxidase GPX1); EC 1.11.1.9 (Glutathione Peroxidase); H6241UJ22B (Selenium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


  9 / 3754 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28919490
[Au] Autor:Zhang P; Wang G; Lin Z; Wu Y; Zhang J; Liu M; Lee KKH; Chuai M; Yang X
[Ad] Endereço:Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology & Embryology, Medical College, Jinan University, Guangzhou 510632, China.
[Ti] Título:Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development.
[So] Source:Toxicol Lett;281:53-64, 2017 Nov 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus. Immunofluorescent staining revealed that ethanol treatment downregulated Ap-2É‘, Pax7 and HNK-1 expressions by cranial NCCs. Using double-immunofluorescent stainings for Ap-2É‘/pHIS3 and Ap-2É‘/c-Caspase3, we showed that ethanol treatment inhibited cranial NCC proliferation and increased NCC apoptosis, respectively. Moreover, ethanol treatment of the dorsal neuroepithelium increased Laminin, N-Cadherin and Cadherin 6B expressions while Cadherin 7 expression was repressed. In situ hybridization also revealed that ethanol treatment up-regulated Cadherin 6B expression but down-regulated slug, Msx1, FoxD3 and BMP4 expressions. In summary, our experimental results demonstrated that ethanol treatment interferes with the production of cranial NCCs by affecting the proliferation and apoptosis of these cells. In addition, ethanol affected the delamination, epithelial-mesenchymal transition (EMT) and cell migration of cranial NCCs, which may have contributed to the etiology of the craniofacial defects.
[Mh] Termos MeSH primário: Anormalidades Craniofaciais/patologia
Etanol/toxicidade
Regulação da Expressão Gênica no Desenvolvimento
Crista Neural/efeitos dos fármacos
Organogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Proteína Morfogenética Óssea 4/genética
Proteína Morfogenética Óssea 4/metabolismo
Antígenos CD57/genética
Antígenos CD57/metabolismo
Caderinas/genética
Caderinas/metabolismo
Embrião de Galinha
Anormalidades Craniofaciais/induzido quimicamente
Modelos Animais de Doenças
Regulação para Baixo
Transtornos do Espectro Alcoólico Fetal/fisiopatologia
Laminina/genética
Laminina/metabolismo
Crista Neural/patologia
Fator de Transcrição PAX7/genética
Fator de Transcrição PAX7/metabolismo
Fator de Transcrição AP-2/genética
Fator de Transcrição AP-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 4); 0 (CD57 Antigens); 0 (Cadherins); 0 (Laminin); 0 (PAX7 Transcription Factor); 0 (Transcription Factor AP-2); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


  10 / 3754 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28859338
[Au] Autor:Jarmasz JS; Basalah DA; Chudley AE; Del Bigio MR
[Ad] Endereço:Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada; Department of Pathology, University of Manitoba, Winnipeg, Manitoba; and Department of Paediatrics and Child Health, Unive
[Ti] Título:Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder.
[So] Source:J Neuropathol Exp Neurol;76(9):813-833, 2017 Sep 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fetal alcohol spectrum disorder (FASD) is a common neurodevelopmental problem, but neuropathologic descriptions are rare and focused on the extreme abnormalities. We conducted a retrospective survey (1980-2016) of autopsies on 174 individuals with prenatal alcohol exposure or an FASD diagnosis. Epidemiologic details and neuropathologic findings were categorized into 5 age groups. Alcohol exposure was difficult to quantify. When documented, almost all mothers smoked tobacco, many abused other substances, and prenatal care was poor or nonexistent. Placental abnormalities were common (68%) in fetal cases. We identified micrencephaly (brain weight <5th percentile) in 31, neural tube defects in 5, isolated hydrocephalus in 6, corpus callosum defects in 6 (including some with complex anomalies), probable prenatal ischemic lesions in 5 (excluding complications of prematurity), minor subarachnoid heterotopias in 4, holoprosencephaly in 1, lissencephaly in 1, and cardiac anomalies in 26 cases. The brain abnormalities associated with prenatal alcohol exposure are varied; cause-effect relationships cannot be determined. FASD is likely not a monotoxic disorder. The animal experimental literature, which emphasizes controlled exposure to ethanol alone, is therefore inadequate. Prevention must be the main societal goal, however, a clear understanding of the neuropathology is necessary for provision of care to individuals already affected.
[Mh] Termos MeSH primário: Álcoois/toxicidade
Encéfalo/anormalidades
Encéfalo/patologia
Transtornos do Espectro Alcoólico Fetal/patologia
Efeitos Tardios da Exposição Pré-Natal/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Encéfalo/efeitos dos fármacos
Criança
Pré-Escolar
Feminino
Transtornos do Espectro Alcoólico Fetal/epidemiologia
Feto
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Gravidez
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
Estudos Retrospectivos
Natimorto/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx064



página 1 de 376 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde