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[PMID]:28462756
[Au] Autor:Firl KC; King JS; Makambi KH; Loffredo CA
[Ad] Endereço:1Department of Biostatistics, Bioinformatics and Biomathematics,Georgetown University Medical Center,Washington,District of Columbia,United States of America.
[Ti] Título:Changes in the diagnosis of congenital cardiovascular malformations during the 1st year of life: impacts on epidemiological risk factor associations.
[So] Source:Cardiol Young;27(4):770-781, 2017 May.
[Is] ISSN:1467-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Many epidemiological studies base their classification of congenital cardiovascular malformations in newborns upon a single, initial diagnosis. This study aimed to evaluate the effect of subsequent diagnostic investigations on the results of epidemiological studies. We used diagnostic codes from the Baltimore-Washington Infant Study from the time of birth and at ~1 year of age. Odds ratios and 95% confidence intervals were used to identify associations between changes in diagnoses and infant characteristics, time period, that is, before and after introduction of color flow Doppler imaging, and diagnostic variables. Of the 3054 patients with data at both time points, 400 (13.1%) had diagnostic changes. For congenital cardiovascular malformations of early cardiogenesis, such as laterality and looping defects, conotruncal malformations, and atrioventricular septal defects, significant associations were observed between diagnostic change and case infants large for gestational age (odds ratio=0.22, p=0.01), diagnosed initially by echocardiography only (odds ratio=2.05, p=0.001), or with non-cardiac malformations (odds ratio=0.60, p=0.03). For all other congenital cardiovascular malformations, significant associations were observed with echocardiography-only diagnosis (odds ratio=1.43, p=0.04) and non-cardiac malformations (odds ratio=0.57, p<0.001). We found no statistically significant differences between risk factor odds ratios calculated using initial diagnoses versus those calculated using 1-year update diagnoses. Changes in congenital cardiovascular malformation diagnoses from birth to year 1 interval were significantly associated with infant characteristics and diagnostic modality but did not materially affect the outcome of risk factor associations.
[Mh] Termos MeSH primário: Cardiopatias Congênitas/diagnóstico por imagem
Cardiopatias Congênitas/epidemiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Ecocardiografia Doppler em Cores
Feminino
Idade Gestacional
Seres Humanos
Lactente
Recém-Nascido
Modelos Logísticos
Masculino
Análise Multivariada
Fatores de Risco
Fatores de Tempo
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S104795111600130X


  2 / 42826 MEDLINE  
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[PMID]:28470155
[Au] Autor:Shin N; Jang Y; Kang Y
[Ad] Endereço:College of Nursing, Ewha Womans University, Seoul, Korea.
[Ti] Título:[The Relationships among Perceived Parental Bonding, Illness Perception, and Anxiety in Adult Patients with Congenital Heart Diseases].
[So] Source:J Korean Acad Nurs;47(2):178-187, 2017 Apr.
[Is] ISSN:2093-758X
[Cp] País de publicação:Korea (South)
[La] Idioma:kor
[Ab] Resumo:PURPOSE: The purposes of this study were to identify the relationships among perceived parental bonding, illness perception, and anxiety and to determine the influences of perceived parental bonding and illness perception on anxiety in adult patients with congenital heart diseases. METHODS: In this study a descriptive correlational design with survey method was utilized. The participants were 143 adult patients with congenital heart disease being cared for in the cardiology out-patient clinic of A medical center. Data were collected using the Parental Bonding Instrument, Illness Perception Questionnaire Revised Scale, and Cardiac Anxiety Questionnaire Scale. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation analysis, and hierarchial regression analyses. RESULTS: There showed significant positive relationships of anxiety with maternal overprotection, consequences, and personal control respectively. Among predictors, maternal overprotection (ß=.45), consequence (ß=.26), and personal control (ß=-.03) had statistically significant influence on anxiety. CONCLUSION: Nursing interventions to decrease maternal overprotection and negative consequence, and to enhance personal control are essential to decrease the anxiety of adult patients with congenital heart diseases.
[Mh] Termos MeSH primário: Ansiedade
Cardiopatias Congênitas/psicologia
Relações Pais-Filho
[Mh] Termos MeSH secundário: Adulto
Feminino
Cardiopatias Congênitas/patologia
Seres Humanos
Masculino
Meia-Idade
Poder Familiar
Percepção
Índice de Gravidade de Doença
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4040/jkan.2017.47.2.178


  3 / 42826 MEDLINE  
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[PMID]:28453807
[Au] Autor:Polimenakos AC; Subramanian S; ElZein C; Ilbawi MN
[Ad] Endereço:Division of Pediatric Cardiovascular Surgery, Advocate Children's Hospital, Oak Lawn, IL, USA.
[Ti] Título:Attrition in patients with single ventricle and trisomy 21: outcomes after a total cavopulmonary connection.
[So] Source:Interact Cardiovasc Thorac Surg;24(5):747-754, 2017 05 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Data are limited regarding the management of children with trisomy 21 (T21) syndrome and a functional single ventricle (FSV). We evaluated patients with T21 and a FSV who had a total cavopulmonary connection (TCPC). METHODS: From September 1999 to August 2012, 139 patients with a FSV underwent a TCPC. Sixty-five had unbalanced atrioventricular septal defect. Thirteen had T21. Three (of 13) had heterotaxy syndrome. The mean age at the Fontan operation was 27.6 ± 12.1 months. RESULTS: The initial procedure was pulmonary artery banding in 9 patients, systemic-to-pulmonary shunt in 2 and Damus-Kaye-Stansel/Norwood procedure in 2. Median follow-up was 69 months (interquartile range 25-75, 21-99). There was 1 death after a Damus-Kaye-Stansel/Norwood procedure and one interstage death after a bidirectional Glenn procedure. Nine (of 11) survivors underwent a Fontan operation. A fenestrated Fontan procedure was the predominate operation in 78%. One patient was deemed unsuitable for a Fontan operation. There was 1 takedown and 1 late death after the Fontan operation. Heterotaxy syndrome did not affect outcome ( P > 0.05). There was no statistical difference in the pre-Fontan McGoon ratio, hospital length of stay, duration of pleural drainage and Fontan-related adverse events between patients with a dominant right ventricle and those with a left ( P > 0.05). CONCLUSIONS: A TCPC in patients with T21 and an FSV is associated with reproducible, satisfactory outcomes. An assisted-Glenn procedure with pulsatile pulmonary blood flow and a fenestrated Fontan may be associated with attenuated perioperative morbidity and late attrition.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Síndrome de Down/diagnóstico
Derivação Cardíaca Direita/métodos
Cardiopatias Congênitas/cirurgia
Ventrículos do Coração/anormalidades
Complicações Pós-Operatórias/epidemiologia
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Cardiopatias Congênitas/diagnóstico
Ventrículos do Coração/cirurgia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Fatores de Tempo
Resultado do Tratamento
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivw413


  4 / 42826 MEDLINE  
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[PMID]:28453799
[Au] Autor:Metras A; Fouilloux V; Al-Yamani M; Roques X; Macé L; Thambo JB; Metras D; Kreitmann B; Roubertie F
[Ad] Endereço:Department of Cardiovascular Surgery, Bordeaux Heart University Hospital, University of Bordeaux II, France.
[Ti] Título:Early to mid-term results after total cavopulmonary connection performed in the second decade of life.
[So] Source:Interact Cardiovasc Thorac Surg;24(5):762-767, 2017 05 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Total cavopulmonary connection (TCPC) performed in the second decade of life has rarely been studied. Thus, we investigated (bicentric study) early and late morbidity and mortality following completion of TCPC in these patients. METHODS: From January 1999 to June 2014, 63 patients (14.5 ± 2.9 years) underwent TCPC (extracardiac conduit). Palliation before completion was an isolated bidirectional cavopulmonary shunt (BCPS) in 3 patients or BCPS associated with additional pulmonary blood flow (APBF) that was either antegrade (Group 1) in 38 (63%) or retrograde (Group 2) in 22 (37%). Preoperative and perioperative data were reviewed retrospectively. RESULTS: Mean pulmonary arterial and ventricular end-diastolic pressures were 12.2 and 9.2 mmHg, respectively. Mean Nakata index was 279 ± 123 and 228 ± 87 mm 2 /m 2 in Groups 1 and 2, respectively ( P = 0.01). Aortic cross-clamping was performed in 22 from Group 1 and 8 from Group 2 ( P = 0.04). Mean follow-up was 4.57 years [0.8-15]. Nine patients had prolonged stays in the intensive care unit (>6 days). There were 1 early and 2 late deaths (non-cardiac related). Actuarial survival was 96% at 4 years. At last follow-up, single-ventricle function remained normal or improved in all patients (Group 1) compared to 82% in Group 2 ( P = 0.02). New York Heart Association (NYHA) class had improved in both groups: 47 patients were NYHA class II and 16 class III preoperatively vs 50 class I and 10 class II postoperatively ( P < 0.001). CONCLUSIONS: Single-ventricle palliation with BCPS and APBF allowed completion of TCPC in the second decade of life, with encouraging mid-term results. However, BCPS with retrograde APBF was associated with single-ventricle dysfunction: thus, this technique needs to be used cautiously as long-lasting palliation.
[Mh] Termos MeSH primário: Técnica de Fontan/métodos
Cardiopatias Congênitas/cirurgia
Hemodinâmica/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seguimentos
França/epidemiologia
Cardiopatias Congênitas/mortalidade
Cardiopatias Congênitas/fisiopatologia
Seres Humanos
Masculino
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivw427


  5 / 42826 MEDLINE  
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[PMID]:29237533
[Au] Autor:Wang J; Wang F; Gui YH
[Ad] Endereço:Department of Cardiovascular Medicine, Children's Hospital of Fudan University, Shanghai 200023, China. yhgui@shmu.edu.cn.
[Ti] Título:[Research advances in the mechanism of congenital heart disease induced by pregestational diabetes mellitus].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1297-1300, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Congenital heart disease (CHD) is the most common birth defect at present and has a complex etiology which involves the combined effect of genetic and environmental factors. Pregestational diabetes mellitus is significantly associated with the development of CHD, but the detailed mechanism remains unknown. This article reviews the research advances in the molecular mechanism of CHD caused by pregestational diabetes mellitus.
[Mh] Termos MeSH primário: Cardiopatias Congênitas/etiologia
Gravidez em Diabéticas
[Mh] Termos MeSH secundário: Animais
Apoptose
Movimento Celular
Feminino
Seres Humanos
Crista Neural/fisiologia
Gravidez
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Reactive Oxygen Species)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  6 / 42826 MEDLINE  
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[PMID]:29237532
[Au] Autor:Peng SH; Yang KY; Chen SY; Ji Y
[Ad] Endereço:Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. jijiyuanyuan@163.com.
[Ti] Título:[Research progresses in the pathogenesis, diagnosis and treatment of infantile hemangioma with PHACE syndrome].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1291-1296, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Infant hemangioma, the most common benign tumor in children, is characterized by rapid proliferation, followed by slower spontaneous involution. However, some patients with facial segmental hemangioma are associated with PHACE syndrome. PHACE syndrome is characterized by vascular nerve and vascular cutaneous lesions of multiple systemic systems, often resulting in structural and functional impairments. Recent studies have demonstrated that the possible pathogeneses of PHACE syndrome mainly include hypoxia, abnormality of mesodermal vascular endothelial cells, genetic abnormality, and abnormality of interstitial mesenchymal stem cells. The current medications for hemangioma with PHACE syndrome include beta blockers, glucocorticoids, and mTOR inhibitors. This review article mainly describes the pathogenesis, diagnoses and treatments of PHACE syndrome, in order to provide directions for diagnosis and treatment of this disorder.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/terapia
Anormalidades do Olho/terapia
Cardiopatias Congênitas/terapia
Hemangioma/terapia
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/diagnóstico
Anormalidades Múltiplas/etiologia
Anormalidades do Olho/diagnóstico
Anormalidades do Olho/etiologia
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/etiologia
Hemangioma/diagnóstico
Hemangioma/etiologia
Seres Humanos
Lactente
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  7 / 42826 MEDLINE  
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[PMID]:29406656
[Au] Autor:Gentille J
[Ti] Título:How Heroes Saved My Life.
[So] Source:Pediatr Nurs;42(6):310-1, 2016 Nov-Dec.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por HIV/etiologia
Infecções por HIV/psicologia
Cardiopatias Congênitas/complicações
Cardiopatias Congênitas/enfermagem
Relações Enfermeiro-Paciente
Enfermeiras Pediátricas/psicologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Infecções por HIV/enfermagem
Seres Humanos
Lactente
National Institutes of Health (U.S.)
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  8 / 42826 MEDLINE  
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[PMID]:29371594
[Au] Autor:Rhee S; Chung JI; King DA; D'amato G; Paik DT; Duan A; Chang A; Nagelberg D; Sharma B; Jeong Y; Diehn M; Wu JC; Morrison AJ; Red-Horse K
[Ad] Endereço:Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA, 94305, USA.
[Ti] Título:Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
[So] Source:Nat Commun;9(1):368, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During development, the formation of a mature, well-functioning heart requires transformation of the ventricular wall from a loose trabecular network into a dense compact myocardium at mid-gestation. Failure to compact is associated in humans with congenital diseases such as left ventricular non-compaction (LVNC). The mechanisms regulating myocardial compaction are however still poorly understood. Here, we show that deletion of the Ino80 chromatin remodeler in vascular endothelial cells prevents ventricular compaction in the developing mouse heart. This correlates with defective coronary vascularization, and specific deletion of Ino80 in the two major coronary progenitor tissues-sinus venosus and endocardium-causes intermediate phenotypes. In vitro, endothelial cells promote myocardial expansion independently of blood flow in an Ino80-dependent manner. Ino80 deletion increases the expression of E2F-activated genes and endothelial cell S-phase occupancy. Thus, Ino80 is essential for coronary angiogenesis and allows coronary vessels to support proper compaction of the heart wall.
[Mh] Termos MeSH primário: Adenosina Trifosfatases/metabolismo
Endotélio Vascular/metabolismo
Cardiopatias Congênitas/metabolismo
Neovascularização Patológica/metabolismo
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/genética
Animais
Vasos Coronários/metabolismo
DNA Helicases/genética
DNA Helicases/metabolismo
Endocárdio/metabolismo
Endocárdio/patologia
Células Endoteliais/enzimologia
Células Endoteliais/metabolismo
Endotélio Vascular/patologia
Cardiopatias Congênitas/genética
Ventrículos do Coração/metabolismo
Ventrículos do Coração/patologia
Seres Humanos
Camundongos Knockout
Camundongos Transgênicos
Miocárdio/metabolismo
Miocárdio/patologia
Neovascularização Patológica/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.1.- (INO80 protein, mouse); EC 3.6.4.- (DNA Helicases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02796-3


  9 / 42826 MEDLINE  
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[PMID]:28460773
[Au] Autor:Balaji S; Sreeram N
[Ad] Endereço:Departments of Pediatrics (Cardiology), Oregon Health & Science University, Portland, OR, United States. Electronic address: balajis@ohsu.edu.
[Ti] Título:The development of pacing induced ventricular dysfunction is influenced by the underlying structural heart defect in children with congenital heart disease.
[So] Source:Indian Heart J;69(2):240-243, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Right ventricular pacing can cause pacing-induced ventricular dysfunction (PIVD) correctable with biventricular pacing (BiVP). Factors associated with PIVD are poorly understood. METHODS: We reviewed children receiving epicardial dual-chamber pacemakers for complete heart block (CHB) after congenital heart disease (CHD) surgery. PIVD was defined as% fractional shortening <15% improving after BiVP. RESULTS: Between 2005 and 2014, 47 children <2years developed CHB after CHD surgery. All had biventricular hearts and underwent epicardial dual chamber pacemaker implantation. Nine of the 47 (19%) developed PIVD. PIVD occurred in 0/10 with ventricular septal defect (VSD), 0/6 with tetralogy of Fallot, 2/6 with double outlet right ventricle, 2/6 with transposition and VSD, 3/9 with atrioventricular canal defect, 1/2 with mitral valve replacement; 1/3 with congenitally corrected TGA repair; and 0/3 with atrioventricular canal plus tetralogy of Fallot and 0/1 with subaortic membrane. QRS duration (QRSD) was 84-170 (median 135ms) in the non PIVD group and 100-168 (median 124) ms in the PIVD group. Percentage fractional shortening (%FS) while paced was 16-46, median 30% in the non-PIVD group and 6-15 (median 11%) in the PIVD group.%FS post upgrade to BiVP (with an epicardial LV lead) in the 9 patients with PIVD was 23-33 (median 29%). CONCLUSIONS: PIVD occurred in certain CHD but not others. Prolonged QRSD was not associated with PIVD. The predilection for RV pacing to result in PIVD in certain types of CHD needs further study.
[Mh] Termos MeSH primário: Terapia de Ressincronização Cardíaca/efeitos adversos
Sistema de Condução Cardíaco/fisiopatologia
Cardiopatias Congênitas/terapia
Ventrículos do Coração/fisiopatologia
Disfunção Ventricular Esquerda/etiologia
[Mh] Termos MeSH secundário: Eletrocardiografia
Feminino
Cardiopatias Congênitas/fisiopatologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estudos Retrospectivos
Disfunção Ventricular Esquerda/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  10 / 42826 MEDLINE  
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[PMID]:29441924
[Au] Autor:Zhou C; Guo X; Cui Q; Liu X; Su G; Zhang J
[Ti] Título:Sildenafil improves the function of endothelial cells in patients suffering from congenital heart disease with pulmonary hypertension.
[So] Source:Pharmazie;71(10):570-574, 2016 Oct 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aim of this study was to investigate the potential effects of sildenafil on the function of endothelial cells from patients with congenital heart disease with pulmonary hypertension (CHDPH). Patients who are diagnosed as CHD with PH (n=30) or without PH (n=30), and 30 healthy persons (control) were enrolled in this study. The 30 CHDPH cases were separated into two groups, one was given aspirin while the other received aspirin and sildenafil. An ELISA assay was used to detect the biological indexes for endothelial cells. Furthermore, 24 male New Zealand white rabbits were used to construct the CHDPH model. The signal pathway-related protein expression was analyzed using RT-PCR and western blotting. Compared to that in healthy people, levels for flowmediated dilatation (FDM), NO, and adiponectin (APN) were significantly decreased while endothelin (ET-1) was significantly increased in CHD patients, while their levels were drastically changed in CHDPH patients (P<0.01). Besides, no significant differences for expression levels including FDM, APN, NO, and ET-1 was observed in CHDPH patients receiving aspirin. But the levels for FDM, APN, NO, and ET-1 were significantly changed in CHDPH patients after treatment with sildenafil for 3 months (P<0.01). The mRNA and protein levels for JNK1/2, MAPK, and NF-κB were significantly increased in CHDPH rabbits compared to the control (P<0.01), but their levels were significantly suppressed by the sildenafil application compared to the CHDPH group (P<0.01). Taken together, our study suggested that sildenafil may play a protective role on endothelial function via suppressing the JNK and NF-κB signal pathways in CHDPH patients.
[Mh] Termos MeSH primário: Células Endoteliais/efeitos dos fármacos
Cardiopatias Congênitas/tratamento farmacológico
Hipertensão Pulmonar/tratamento farmacológico
Citrato de Sildenafila/uso terapêutico
Vasodilatadores/uso terapêutico
[Mh] Termos MeSH secundário: Adiponectina/metabolismo
Animais
Aspirina/uso terapêutico
Endotelina-1/metabolismo
Ensaio de Imunoadsorção Enzimática
Voluntários Saudáveis
Cardiopatias Congênitas/fisiopatologia
Seres Humanos
Hipertensão Pulmonar/fisiopatologia
Masculino
NF-kappa B/efeitos dos fármacos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Inibidores da Agregação de Plaquetas/uso terapêutico
Coelhos
Transdução de Sinais/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (Adiponectin); 0 (Endothelin-1); 0 (NF-kappa B); 0 (Platelet Aggregation Inhibitors); 0 (Vasodilator Agents); 31C4KY9ESH (Nitric Oxide); BW9B0ZE037 (Sildenafil Citrate); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6510



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