Base de dados : MEDLINE
Pesquisa : C14.280 [Categoria DeCS]
Referências encontradas : 54735 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 5474 ir para página                         

  1 / 54735 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29287886
[Au] Autor:Samdani S; Jain A; Meena V; Meena CB
[Ad] Endereço:Department of Otorhinolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India.
[Ti] Título:Cardiac complications in diphtheria and predictors of outcomes.
[So] Source:Int J Pediatr Otorhinolaryngol;104:76-78, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study the cardiac complications in diphtheria patients and to study the predictors of outcomes. STUDY DESIGN: Single centre prospective analysis of cardiac complications in diphtheria patients. RESULTS: In this study, there were 60 patients diagnosed with diphtheria with ECG changes. The ECG changes seen were sinus tachycardia (68.3%), T wave inversion (20%), ST segment depression (13.3%), right bundle branch block (5%), multiple atrial ectopics (3.3%). The case fatality rate in our study was 25% (15 patients). High CPK-MB, myoglobulin and cardiac troponin levels were associated with cardiac mortality. In our study, cardiac troponin T had the highest sensitivity (80%) and CK-MB had the highest specificity (95.56%). CONCLUSION: Cardiac involvement is a common complication of infection with C. diphtheria and is associated with high mortality. As diphtheria can be prevented by adequate vaccination, efforts should be maximized for high vaccine coverage with booster doses.
[Mh] Termos MeSH primário: Difteria/complicações
Cardiopatias/etiologia
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores
Criança
Pré-Escolar
Creatina Quinase
Eletrocardiografia
Feminino
Cardiopatias/epidemiologia
Seres Humanos
Lactente
Masculino
Estudos Prospectivos
Sensibilidade e Especificidade
Troponina T
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Troponin T); EC 2.7.3.2 (Creatine Kinase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  2 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28459983
[Au] Autor:Chan JL; Kobashigawa JA; Aintablian TL; Li Y; Perry PA; Patel JK; Kittleson MM; Czer LS; Zarrini P; Velleca A; Rush J; Arabia FA; Trento A; Esmailian F
[Ad] Endereço:Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
[Ti] Título:Vasoplegia after heart transplantation: outcomes at 1 year.
[So] Source:Interact Cardiovasc Thorac Surg;25(2):212-217, 2017 08 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Vasoplegia syndrome is a potentially life-threatening condition that can occur following cardiopulmonary bypass. Heart transplantation is a recognized risk factor for developing this vasodilatory state. The objective of this study was to determine the effects of vasoplegia syndrome on 1-year heart transplant outcomes. METHODS: A retrospective review of orthotopic heart transplants at a single institution between November 2010 and December 2014 was performed. Of the 347 consecutive adult patients, 107 patients (30.8%) met criteria for vasoplegia syndrome. Preoperative factors and intraoperative variables were collected and compared between vasoplegia and non-vasoplegia cohorts. The incidence of postoperative complications, transplant rejection and patient survival within 1 year were evaluated. RESULTS: Demographics and preoperative medication profiles were similar in both groups, while mechanical circulatory support device use was associated with vasoplegia syndrome (30.8% vs 20.0%; P = 0.039). Perioperative characteristics such as longer cardiopulmonary bypass [165.0 (interquartile range [IQR] 74) min vs 140.0 (IQR 42.7) min; P < 0.001] and increased blood product usage (24.7 ± 17.2 units vs 17.7 ± 14.3 units; P < 0.001) were associated with vasoplegia. Non-vasoplegia patients were more likely to be extubated [42.9 (IQR 37.3) h vs 66.8 (IQR 50.2) h; P < 0.001] and discharged earlier [10.0 (IQR 6) days vs 14.0 (IQR 11.5) days; P < 0.001]. One-year patient survival (92.0% vs 88.6%; P = 0.338) and any-treated rejection rates (82.7% vs 84.3%; P = 0.569) were not significantly different between groups. CONCLUSIONS: Although vasoplegia syndrome was associated with an increase in perioperative morbidity, including greater mechanical ventilation time and hospital length of stay, no significant differences in survival or allograft rejection at 1 year was demonstrated.
[Mh] Termos MeSH primário: Ponte Cardiopulmonar/efeitos adversos
Transplante de Coração/efeitos adversos
Complicações Pós-Operatórias
Vasoplegia/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Cardiopatias/cirurgia
Seres Humanos
Incidência
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Taxa de Sobrevida/tendências
Fatores de Tempo
Estados Unidos/epidemiologia
Vasoplegia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivx081


  3 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468613
[Au] Autor:Ostermann M; Hall A; Crichton S
[Ad] Endereço:Department of Critical Care, King's College London, Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge Road SE1 7 EH, London, UK. Marlies.Ostermann@gstt.nhs.uk.
[Ti] Título:Low mean perfusion pressure is a risk factor for progression of acute kidney injury in critically ill patients - A retrospective analysis.
[So] Source:BMC Nephrol;18(1):151, 2017 May 03.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim was to investigate whether mean perfusion pressure (MPP) calculated as the difference between mean arterial pressure (MAP) and central venous pressure (CVP) was associated with risk of progression from AKI I to AKI III in critically ill patients. METHODS: Retrospective analysis of adult patients admitted to a multi-disciplinary adult intensive care unit (ICU) between July 2007 and June 2009 who developed AKI I and in whom advanced haemodynamic monitoring was initiated within 12 h of diagnosis of AKI I. We compared patients with a MPP above and below the median value in the first 12 h of diagnosis of AKI. Multivariable logistic regression analyses were performed to identify independent risk factors for progression to AKI III, to explore the impact of MAP and CVP separately, and to investigate the impact of MPP in pre-defined sub-groups. RESULTS: Among 2118 ICU patients, 790 patients (37%) developed AKI I of whom 205 underwent advanced haemodynamic monitoring within 12 h of AKI stage I. Their median MPP was 59 mmHg. AKI I patients with a MPP ≤59 mmHg had a significantly higher risk of progressing to AKI stage III (48.6% versus 34%, respectively; p = 0.0034). This association was stronger in patients with ischemic heart disease, congestive cardiac failure or without pre-existing hypertension and in patients with a MAP <65 mmHg for >1 h. As individual components, a raised CVP was independently associated with progression to AKI stage III but MAP alone was not an independent risk factor for AKI progression. CONCLUSION: MPP <60 mmHg was independently associated with AKI progression. CVP was the key component of MPP.
[Mh] Termos MeSH primário: Lesão Renal Aguda/diagnóstico
Lesão Renal Aguda/epidemiologia
Pressão Sanguínea
Pressão Venosa Central
Estado Terminal/mortalidade
Progressão da Doença
[Mh] Termos MeSH secundário: Lesão Renal Aguda/fisiopatologia
Idoso
Comorbidade
Feminino
Cardiopatias
Seres Humanos
Londres/epidemiologia
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Fatores de Risco
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-017-0568-8


  4 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29300073
[Au] Autor:Travin N; Shevchenko Y
[Ad] Endereço:Central Military Clinical Hospital n.a. P.V. Mandryka, Moscow, Russia.
[Ti] Título:Heart echinococcosis: Current problems and surgical treatment.
[So] Source:Multimed Man Cardiothorac Surg;2017, 2017 Sep 26.
[Is] ISSN:1813-9175
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present historical, epidemiological, and statistical data on heart echinococcosis (also known as hydatid disease) and concomitant lesions of different organs, as well as a demonstration of its surgical management. The diagnosis of heart echinococcosis is based on review and identification of the cyst and we evaluate the various common diagnostic methods. Surgical treatment of patients with heart echinococcosis may require cardiopulmonary bypass or may be an off-pump procedure depending on the location of the cysts.  Finally, we present some additional techniques for prevention of recurrence.
[Mh] Termos MeSH primário: Equinococose/cirurgia
Cardiopatias/cirurgia
[Mh] Termos MeSH secundário: Ponte Cardiopulmonar
Equinococose/diagnóstico
Cardiopatias/diagnóstico
Seres Humanos
[Pt] Tipo de publicação:VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1510/mmcts.2017.017


  5 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460759
[Au] Autor:Patel A; Tomar NS; Bharani A
[Ad] Endereço:Department of Medicine, M.G.M. Medical College, Indore, M.P., India.
[Ti] Título:Utility of physical examination and comparison to echocardiography for cardiac diagnosis.
[So] Source:Indian Heart J;69(2):141-145, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To find out the accuracy of cardiac auscultation using non-digital stethoscope in physical diagnosis of cardiac diseases. METHODS: We enrolled 104 consecutive patients with abnormal cardiac auscultatory findings attending cardiology clinic and not previously evaluated by echocardiography. One time detailed cardiac physical examination followed by echocardiography within 1 month was undertaken. Agreement between two methods was calculated using mean pair percentage agreement, kappa statistics (κ) and calculation of 95% confidence interval (CI) for kappa statistics. RESULTS: Using kappa statistics, there was almost perfect agreement between cardiac auscultation and echocardiography for the detection of mitral stenosis (κ=0.865; CI 0.76-0.97) and ventricular septal defect (κ=0.872; CI=0.73-1.01). Substantial agreement was noted for aortic stenosis (κ=0.752; CI=0.56-0.94), pulmonary stenosis (κ=0.647; CI=0.33-0.97) and atrial septal defect (κ=0.646; CI=0.32-0.97), while moderate agreement was found for mitral regurgitation (κ=0.470; CI=0.30-0.64), aortic regurgitation (κ=0.456; CI=0.25-0.66) and tricuspid regurgitation (κ=0.575; CI=0.38-0.77). For combined mitral stenosis and mitral regurgitation lesions, almost perfect agreement was found for mitral stenosis (κ=0.842; CI=0.691-0.993) while fair agreement noted for mitral regurgitation (κ=0.255; CI=-0.008 to 0.518). CONCLUSION: Careful clinical auscultation using a stethoscope remains a valuable tool for cardiac diagnosis. Decision on initial diagnosis and management of valvular and congenital heart diseases should be based on clinical examination and integrating such information with echocardiography as required.
[Mh] Termos MeSH primário: Ecocardiografia/utilização
Cardiopatias/diagnóstico
Exame Físico/utilização
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Estudos Transversais
Feminino
Auscultação Cardíaca/métodos
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  6 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29360851
[Au] Autor:Wang X; Wang C; Ye M; Lin J; Jin J; Hu Q; Zhu C; Chen B
[Ad] Endereço:Department of Thoracic and Cardiovascular Surgery, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, China.
[Ti] Título:Left atrial concomitant surgical ablation for treatment of atrial fibrillation in cardiac surgery: A meta-analysis of randomized controlled trials.
[So] Source:PLoS One;13(1):e0191354, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Surgical ablation is a generally established treatment for patients with atrial fibrillation undergoing concomitant cardiac surgery. Left atrial (LA) lesion set for ablation is a simplified procedure suggested to reduce the surgery time and morbidity after procedure. The present meta-analysis aims to explore the outcomes of left atrial lesion set versus no ablative treatment in patients with AF undergoing cardiac surgery. METHODS: A literature research was performed in six database from their inception to July 2017, identifying all relevant randomized controlled trials (RCTs) comparing left atrial lesion set versus no ablative treatment in AF patient undergoing cardiac surgery. Data were extracted and analyzed according to predefined clinical endpoints. RESULTS: Eleven relevant RCTs were included for analysis in the present study. The prevalence of sinus rhythm in ablation group was significantly higher at discharge, 6-month and 1-year follow-up period. The morbidity including 30 day mortality, late all-cause mortality, reoperation for bleeding, permanent pacemaker implantation and neurological events were of no significant difference between two groups. CONCLUSIONS: The result of our meta-analysis demonstrates that left atrial lesion set is an effective and safe surgical ablation strategy for AF patients undergoing concomitant cardiac surgery.
[Mh] Termos MeSH primário: Fibrilação Atrial/cirurgia
Procedimentos Cirúrgicos Cardíacos/métodos
Ablação por Cateter/métodos
[Mh] Termos MeSH secundário: Fibrilação Atrial/complicações
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Procedimentos Cirúrgicos Cardíacos/mortalidade
Ablação por Cateter/efeitos adversos
Ablação por Cateter/mortalidade
Átrios do Coração/cirurgia
Cardiopatias/complicações
Cardiopatias/cirurgia
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191354


  7 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29269690
[Au] Autor:Kikuno M; Koga M; Kume Y; Ohtsuka T; Hayakawa M; Toyoda K
[Ad] Endereço:Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
[Ti] Título:[A case of cardiogenic embolism, which occurred under appropriate warfarin use, treated with thoracoscopic left atrial appendectomy].
[So] Source:Rinsho Shinkeigaku;58(1):9-14, 2018 Jan 26.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 74-year-old man with a past medical history of bradycardiac atrial fibrillation and an old cerebral infarction presented with dysarthria. He had been treated with warfarin and PT-INR on admission was 2.0. MRI of the head revealed an acute ischemic stroke involving the cerebellum and left occipital lobe. Because transesophageal cardiac echography showed a thrombus in the left atrial appendage, anticoagulant treatment with warfarin and heparin was initiated. The thrombus was enlarging; therefore, we changed the anticoagulant therapy to apixaban with heparin on day 11. On day 17, a hemorrhagic cerebral infarction occurred. After the hemorrhage diminished, we treated him with warfarin aiming for a PT-INR between 3 and 4. The thrombus gradually shrank and disappeared on day 110. Finally, a thoracoscopic left atrial appendectomy was performed as a secondary prevention, with no recurrence till date.
[Mh] Termos MeSH primário: Anticoagulantes/administração & dosagem
Procedimentos Cirúrgicos Cardíacos/métodos
Infarto Cerebral/etiologia
Átrios do Coração/cirurgia
Cardiopatias/etiologia
Toracoscopia/métodos
Trombose/etiologia
Varfarina/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Quimioterapia Combinada
Cardiopatias/terapia
Heparina/administração & dosagem
Seres Humanos
Coeficiente Internacional Normatizado
Masculino
Pirazóis/administração & dosagem
Piridonas/administração & dosagem
Recidiva
Síndrome do Nó Sinusal/complicações
Trombose/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Pyrazoles); 0 (Pyridones); 3Z9Y7UWC1J (apixaban); 5Q7ZVV76EI (Warfarin); 9005-49-6 (Heparin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001065


  8 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776978
[Au] Autor:Wang Z; Wang G; Xia Q; Shang Z; Yu X; Wang M; Jin X
[Ad] Endereço:Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
[Ti] Título:Partial nephrectomy vs. radical nephrectomy for renal tumors: A meta-analysis of renal function and cardiovascular outcomes.
[So] Source:Urol Oncol;34(12):533.e11-533.e19, 2016 12.
[Is] ISSN:1873-2496
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The widespread use of partial nephrectomy (PN) has led to the preservation of functional renal parenchyma. However, the benefits of PN on renal function and cardiovascular outcomes remain controversial. Thus, a meta-analysis was performed to reconcile the conflicting results. MATERIALS AND METHODS: PubMed, Embase, and the Cochrane Library were searched from inception to August 2015, and databases with all relevant comparative studies were included. The Mantel-Haenszel method with random-effects models was used to determine the pooled hazard ratios (HRs) for each outcome. RESULTS: In total, 26 studies were pooled for new-onset chronic kidney disease, and 6 studies were pooled for cardiovascular outcomes. According to the pooled estimates, PN correlated with a 73% risk reduction of new-onset chronic kidney disease in all included patients (HR = 0.27, P<0.0001) and a 65% risk reduction in patients with tumors>4cm (HR = 0.35, P<0.0001) compared with radical nephrectomy. There were no significant differences between groups regarding postsurgery cardiovascular events (HR = 0.86, P = 0.238) and cardiovascular death (HR = 0.79, P = 0.196). Despite inherent selection biases, the pooled estimates were robust in sensitivity and subgroup analyses. CONCLUSIONS: Our findings suggest that PN lowers the postoperative risk of new-onset chronic kidney disease. Nevertheless, the protection of renal function by PN did not reduce the risk of cardiovascular outcomes. However, this result remains controversial, and additional large-scale evaluations are warranted.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/cirurgia
Neoplasias Renais/cirurgia
Rim/fisiopatologia
Nefrectomia/métodos
[Mh] Termos MeSH secundário: Carcinoma de Células Renais/fisiopatologia
Estudos de Casos e Controles
Estudos de Coortes
Seguimentos
Cardiopatias/epidemiologia
Cardiopatias/prevenção & controle
Seres Humanos
Neoplasias Renais/fisiopatologia
Insuficiência Renal Crônica/epidemiologia
Insuficiência Renal Crônica/prevenção & controle
Estudos Retrospectivos
Comportamento de Redução do Risco
Viés de Seleção
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  9 / 54735 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29351337
[Au] Autor:Ghasemi-Roudsari S; Al-Shimary A; Varcoe B; Byrom R; Kearney L; Kearney M
[Ad] Endereço:Department of Physics and Astronomy, University of Leeds, Leeds, United Kingdom.
[Ti] Título:A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain.
[So] Source:PLoS One;13(1):e0191241, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Magnetocardiography (MCG) is a non-invasive technique used to measure and map cardiac magnetic fields. We describe the predictive performance of a portable prototype magnetometer designed for use in acute and routine clinical settings. We assessed the predictive ability of the measurements derived from the magnetometer for the ruling-out of healthy subjects and patients whose chest pain has a non-ischemic origin from those with ischemic heart disease (IHD). METHODS: MCG data were analyzed from a technical performance study, a pilot clinical study, and a young healthy reference group. Participants were grouped to enable differentiation of those with IHD versus non-IHD versus controls: Group A (70 IHD patients); Group B (69 controls); Group C (37 young healthy volunteers). Scans were recorded in an unshielded room. Between-group differences were explored using analysis of variance. The ability of 10 candidate MCG predictors to predict normal/abnormal cases was analyzed using logistic regression. Predictive performance was internally validated using repeated five-fold cross-validation. RESULTS: Three MCG predictors showed a significant difference between patients and age-matched controls (P<0.001); eight predictors showed a significant difference between patients and young healthy volunteers (P<0.001). Logistic regression comparing patients with controls yielded a specificity of 35.0%, sensitivity of 95.4%, and negative predictive value for the ruling-out of IHD of 97.8% (area under the curve 0.78). CONCLUSION: This analysis represents a preliminary indication that the portable magnetometer can help rule-out healthy subjects and patients whose chest pain has a non-ischemic origin from those with IHD.
[Mh] Termos MeSH primário: Cardiopatias/diagnóstico
Magnetocardiografia/instrumentação
Isquemia Miocárdica/diagnóstico
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/diagnóstico
Idoso
Estudos de Casos e Controles
Dor no Peito/diagnóstico
Diagnóstico Diferencial
Feminino
Seres Humanos
Modelos Logísticos
Magnetocardiografia/estatística & dados numéricos
Masculino
Meia-Idade
Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico
Projetos Piloto
Valor Preditivo dos Testes
[Pt] Tipo de publicação:CLINICAL STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191241


  10 / 54735 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29355689
[Au] Autor:Gryshkova V; Fleming A; McGhan P; De Ron P; Fleurance R; Valentin JP; Nogueira da Costa A
[Ad] Endereço:Investigative Toxicology, Non-Clinical Development, UCB Biopharma SPRL, Belgium.
[Ti] Título:miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.
[So] Source:Toxicol Lett;286:31-38, 2018 Apr.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Investigation of genomic changes in cardiotoxicity can provide novel biomarkers and insights into molecular mechanisms of drug-induced cardiac injury (DICI). The main objective of this study was to identify and characterize dysregulated microRNAs (miRNAs) in the heart associated with cardiotoxicity. Wistar rats were dosed once with either isoproterenol (1.5 mg/kg, i.p), allylamine (100 mg/kg, p.o.) or the respective vehicle controls. Heart tissue was collected at 24 h, 48 h and 72 h post-drug administration and used for histopathological assessment, miRNA profiling, immunohistochemical analysis and in situ hybridization. Multiplex analysis of 68 miRNAs in the heart revealed a significant upregulation of several miRNAs (miR-19a-3p, miR-142-3p, miR-155-5p, miR-208b-3p, miR-21-5p) after isoproterenol and one miRNA (miR-21-5p) after allylamine administration. Localization of miR-21-5p was specific to inflammatory cell infiltrates in the heart after both treatments. Immunohistochemical analysis of Stat3, a known miR-21-5p regulator, also confirmed its upregulation in cardiomyocytes and inflammatory cell infiltrates. The toxicity signatures based on miRNA networks, identified in vivo, can potentially be used as mechanistic biomarkers as well as to study cardiotoxicity in vitro in order to develop sensitive tools for early hazard identification and risk assessment.
[Mh] Termos MeSH primário: Cardiopatias/induzido quimicamente
Inflamação/induzido quimicamente
MicroRNAs/genética
Miocárdio/metabolismo
[Mh] Termos MeSH secundário: Alilamina
Animais
Cardiotoxicidade
Modelos Animais de Doenças
Perfilação da Expressão Gênica/métodos
Regulação da Expressão Gênica
Marcadores Genéticos
Cardiopatias/genética
Cardiopatias/metabolismo
Cardiopatias/patologia
Hibridização In Situ
Inflamação/genética
Inflamação/metabolismo
Inflamação/patologia
Isoproterenol
Masculino
MicroRNAs/metabolismo
Reação em Cadeia da Polimerase Multiplex
Miocárdio/patologia
Análise de Sequência com Séries de Oligonucleotídeos
Ratos Wistar
Medição de Risco
Fator de Transcrição STAT3/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 0 (MicroRNAs); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, rat); 0 (mirn21 microRNA, rat); 48G762T011 (Allylamine); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE



página 1 de 5474 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde