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[PMID]:27530090
[Au] Autor:Killu AM; Fender EA; Deshmukh AJ; Munger TM; Araoz P; Brady PA; Cha YM; Packer DL; Friedman PA; Asirvatham SJ; Noseworthy PA; Mulpuru SK
[Ad] Endereço:Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Acute Sinus Node Dysfunction after Atrial Ablation: Incidence, Risk Factors, and Management.
[So] Source:Pacing Clin Electrophysiol;39(10):1116-1125, 2016 Oct.
[Is] ISSN:1540-8159
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many patients with atrial fibrillation (AF) or atrial flutter (Aflutter) have concomitant sinus node dysfunction (SND). Ablation may result in injury to the sinus node complex or its blood supply resulting in sinus arrest and need for temporary pacing. We sought to characterize patients who develop acute SND (ASND) during/immediately after AF/Aflutter ablation. METHODS: We performed a retrospective analysis of AF/Aflutter ablation patients between January 1, 2010 and February 28, 2015 to characterize those who required temporary pacemaker (TPM) implantation due to ASND (sinus arrest, sinus bradycardia <40 beats/min, or junctional rhythm with hemodynamic compromise) following atrial ablation. RESULTS: Of 2,151 patients, eight patients (<0.5%) with ASND manifesting as sinus arrest (n = 2), severe sinus bradycardia (n = 2), and junctional rhythm with hemodynamic compromise (n = 4) were identified (all male, age 66 ± 9.9 years, 4/8 [50%] persistent AF). AF ablation was performed in four, atypical Aflutter in one, and AF/Aflutter in three patients. The ablation set consisted of: pulmonary vein (PV) isolation (n = 6), roof line ablation (n = 6), mitral annulus-left inferior PV line ablation (n = 5), left atrial appendage-mitral annulus ablation (n = 1), cavotricuspid isthmus ablation (n = 5), and isolation or ablation near the superior vena cava (SVC, n = 4). Patients with peri-SVC ablation were more likely to develop ASND (P = 0.03). All patients received TPM; six received permanent pacemaker before discharge, performed 3.5 days postablation (range 2-6 days). At 3-month device interrogation, all patients were atrially paced >50%. CONCLUSION: ASND is a rare complication of atrial ablation. It may be more common when peri-SVC ablation is performed and may necessitate permanent pacemaker implantation.
[Mh] Termos MeSH primário: Fibrilação Atrial/cirurgia
Flutter Atrial/cirurgia
Nó Sinoatrial/diagnóstico por imagem
Parada Sinusal Cardíaca/etiologia
[Mh] Termos MeSH secundário: Doença Aguda
Idoso
Técnicas de Ablação Endometrial/efeitos adversos
Técnicas de Ablação Endometrial/métodos
Seres Humanos
Masculino
Meia-Idade
Marca-Passo Artificial
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Complicações Pós-Operatórias
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160818
[St] Status:MEDLINE
[do] DOI:10.1111/pace.12934


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[PMID]:27455832
[Au] Autor:Thiarawat P; Wangtheraprasert A; Jitprapaikulsan J
[Ti] Título:Vagoglossopharyngeal Neuralgia Occurred Concomitantly with Ipsilateral Hemifacial Spasm and Versive Seizure-Like Movement: A First Case Report.
[So] Source:J Med Assoc Thai;99(1):106-10, 2016 Jan.
[Is] ISSN:0125-2208
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:Vagoglossopharyngeal neuralgia (VGPN) is a very rare condition. VGPN with convulsive like attack is even rarer All of the cases had their head turned to the opposite side of facial pain. Hemifacial spasm occurring concurrently with VGPN has never been reported. Herein, we present the first case of VGPN that had ipsilateral hemifacial spasm and versive seizure-like movement to the same side of facial pain. We reported a 71-year-old man presenting with multiple episodes of intermittent sharp shooting pain arising on the right middle neck, followed by hemifacial spasm on right face. Then the patient became syncope while his head and gaze turned to the same side of the painful neck. Electrocardiography showed sinus arrest. Interictal Electroencephalography was normal. This patient initially responded to pregabalin for two weeks, then the symptoms became worse. Microvascular decompression and carbamazepine resulted in the complete remission of all symptoms after six months of follow-up. We could not explain the pathophysiology of unilateral versive seizure like movement.
[Mh] Termos MeSH primário: Epilepsia Motora Parcial/complicações
Doenças do Nervo Glossofaríngeo/complicações
Espasmo Hemifacial/complicações
Neuralgia/complicações
Parada Sinusal Cardíaca/complicações
Síncope/complicações
Doenças do Nervo Vago/complicações
[Mh] Termos MeSH secundário: Idoso
Carbamazepina/uso terapêutico
Eletrocardiografia
Eletroencefalografia
Epilepsia Motora Parcial/diagnóstico
Epilepsia Motora Parcial/terapia
Doenças do Nervo Glossofaríngeo/diagnóstico
Doenças do Nervo Glossofaríngeo/terapia
Espasmo Hemifacial/diagnóstico
Espasmo Hemifacial/terapia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Cirurgia de Descompressão Microvascular/métodos
Neuralgia/diagnóstico
Neuralgia/terapia
Parada Sinusal Cardíaca/diagnóstico
Parada Sinusal Cardíaca/terapia
Síncope/diagnóstico
Síncope/terapia
Doenças do Nervo Vago/diagnóstico
Doenças do Nervo Vago/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
33CM23913M (Carbamazepine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160726
[Lr] Data última revisão:
160726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


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[PMID]:26883019
[Au] Autor:Solomon MD; Yang J; Sung SH; Livingston ML; Sarlas G; Lenane JC; Go AS
[Ad] Endereço:Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. matthew.d.solomon@kp.org.
[Ti] Título:Incidence and timing of potentially high-risk arrhythmias detected through long term continuous ambulatory electrocardiographic monitoring.
[So] Source:BMC Cardiovasc Disord;16:35, 2016 Feb 17.
[Is] ISSN:1471-2261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ambulatory electrocardiographic (ECG) monitoring is the standard to screen for high-risk arrhythmias. We evaluated the clinical utility of a novel, leadless electrode, single-patient-use ECG monitor that stores up to 14 days of a continuous recording to measure the burden and timing of potentially high-risk arrhythmias. METHODS: We examined data from 122,815 long term continuous ambulatory monitors (iRhythm ZIO® Service, San Francisco) prescribed from 2011 to 2013 and categorized potentially high-risk arrhythmias into two types: (1) ventricular arrhythmias including non-sustained and sustained ventricular tachycardia and (2) bradyarrhythmias including sinus pauses >3 s, atrial fibrillation pauses >5 s, and high-grade heart block (Mobitz Type II or third-degree heart block). RESULTS: Of 122,815 ZIO® recordings, median wear time was 9.9 (IQR 6.8-13.8) days and median analyzable time was 9.1 (IQR 6.4-13.1) days. There were 22,443 (18.3%) with at least one episode of non-sustained ventricular tachycardia (NSVT), 238 (0.2%) with sustained VT, 1766 (1.4%) with a sinus pause >3 s (SP), 520 (0.4%) with a pause during atrial fibrillation >5 s (AFP), and 1486 (1.2%) with high-grade heart block (HGHB). Median time to first arrhythmia was 74 h (IQR 26-149 h) for NSVT, 22 h (IQR 5-73 h) for sustained VT, 22 h (IQR 7-64 h) for SP, 31 h (IQR 11-82 h) for AFP, and 40 h (SD 10-118 h) for HGHB. CONCLUSIONS: A significant percentage of potentially high-risk arrhythmias are not identified within 48-h of ambulatory ECG monitoring. Longer-term continuous ambulatory ECG monitoring provides incremental detection of these potentially clinically relevant arrhythmic events.
[Mh] Termos MeSH primário: Bloqueio Atrioventricular/epidemiologia
Bradicardia/epidemiologia
Parada Sinusal Cardíaca/epidemiologia
Taquicardia Ventricular/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Arritmias Cardíacas/diagnóstico
Arritmias Cardíacas/epidemiologia
Bloqueio Atrioventricular/diagnóstico
Bradicardia/diagnóstico
Estudos de Coortes
Eletrocardiografia Ambulatorial
Feminino
Bloqueio Cardíaco/diagnóstico
Bloqueio Cardíaco/epidemiologia
Seres Humanos
Incidência
Masculino
Meia-Idade
Estudos Retrospectivos
Parada Sinusal Cardíaca/diagnóstico
Taquicardia Ventricular/diagnóstico
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160219
[Lr] Data última revisão:
160219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE
[do] DOI:10.1186/s12872-016-0210-x


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[PMID]:26547050
[Au] Autor:Nakou ES; Simantirakis EN; Kallergis EM; Skalidis EI; Vardas PE
[Ad] Endereço:Department of Cardiology, Heraklion University Hospital, 7100, Voutes, Heraklion, Crete, Greece.
[Ti] Título:Long-standing sinus arrest due to the occlusion of sinus node artery during percutaneous coronary intervention: Clinical implications and management.
[So] Source:Int J Cardiol;203:432-3, 2016 Jan 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Vasos Coronários/patologia
Stents Farmacológicos/efeitos adversos
Infarto Miocárdico de Parede Inferior/cirurgia
Intervenção Coronária Percutânea/efeitos adversos
Parada Sinusal Cardíaca/diagnóstico
Parada Sinusal Cardíaca/etiologia
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária/métodos
Diabetes Mellitus Tipo 2/complicações
Feminino
Seres Humanos
Hiperlipidemias/complicações
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151108
[St] Status:MEDLINE


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[PMID]:26378991
[Au] Autor:Charnay AJ; Antisdel-Lomaglio JE; Zelko FA; Rand CM; Le M; Gordon SC; Vitez SF; Tse JW; Brogadir CD; Nelson MN; Berry-Kravis EM; Weese-Mayer DE
[Ad] Endereço:Center for Autonomic Medicine in Pediatrics, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and The Stanley Manne Children's Research Institute, Chicago, IL.
[Ti] Título:Congenital Central Hypoventilation Syndrome: Neurocognition Already Reduced in Preschool-Aged Children.
[So] Source:Chest;149(3):809-15, 2016 Mar.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Congenital Central Hypoventilation Syndrome (CCHS) is a rare neurocristopathy characterized by severe hypoventilation and autonomic dysregulation, with typical presentation in the neonatal period, and deficient cognitive skills in school-aged patients. We hypothesized that younger (preschool) children with CCHS would also show neurocognitive delay and that CCHS-related physiologic factors would impact neurocognitive test results. METHODS: We studied developmental (Bayley) test results collected during routine clinical care in 31 children (mean age 25.0 ± 8.5 months; range, 6-40 months) with PHOX2B mutation-confirmed CCHS by comparing them with the normative reference mean from the Bayley standardization sample; we also examined associations between Bayley scores and CCHS disease-related factors. RESULTS: Preschool patients with CCHS fell significantly below the normative mean of 100 on Bayley indices of mental (mean, 83.35 ± 24.75) and motor (mean, 73.33 ± 20.48) development (P < .001 for both). Significantly lower Bayley mental and motor scores were associated with severe breath-holding spells, prolonged sinus pauses, and need for 24 h/d artificial ventilation. Lower Bayley motor scores were also associated with seizures. Bayley scores differed among children with the three most common polyalanine repeat expansion mutation genotypes (mental, P = .001; motor, P = .006), being essentially normal in children with the 20/25 genotype but significantly lower in the other genotype groups (P < .05). CONCLUSIONS: These results confirm neurodevelopmental impairment of CCHS preschoolers, with severity related to physiologic compromise and PHOX2B genotype. These findings suggest that adverse effects begin early in the disease process, supporting the need for neurodevelopmental monitoring and intervention from early infancy.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso Autônomo/fisiopatologia
Deficiências do Desenvolvimento/fisiopatologia
Hipoventilação/congênito
Convulsões/fisiopatologia
Parada Sinusal Cardíaca/fisiopatologia
Apneia Central do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Suspensão da Respiração
Pré-Escolar
Estudos de Coortes
Expansão das Repetições de DNA
Deficiências do Desenvolvimento/psicologia
Feminino
Genótipo
Proteínas de Homeodomínio/genética
Seres Humanos
Hipoventilação/genética
Hipoventilação/fisiopatologia
Hipoventilação/psicologia
Hipoventilação/terapia
Lactente
Masculino
Destreza Motora/fisiologia
Mutação
Testes Neuropsicológicos
Peptídeos/genética
Fenótipo
Respiração Artificial
Estudos Retrospectivos
Apneia Central do Sono/genética
Apneia Central do Sono/psicologia
Apneia Central do Sono/terapia
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Homeodomain Proteins); 0 (NBPhox protein); 0 (Peptides); 0 (Transcription Factors); 25191-17-7 (polyalanine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160311
[Lr] Data última revisão:
160311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150918
[St] Status:MEDLINE


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[PMID]:25549077
[Au] Autor:Parsai S; Hariri I; Taleb M; Yoon Y
[Ad] Endereço:1College of Medicine and Life Sciences, The University of Toledo, Toledo, OH; 2Department of Medicine, The University of Toledo, Toledo, OH; 3Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH.
[Ti] Título:A Literature Review Revisiting Phenytoin-Induced Sinus Arrest.
[So] Source:Am J Ther;23(4):e1091-3, 2016 Jul-Aug.
[Is] ISSN:1536-3686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Classically, phenytoin (PTN) infusion for the treatment of status epilepticus has been proven to be associated with cardiovascular toxicity, including dysrhythmias, hypotension, and cardiovascular collapse. Subsequently, fosphenytoin (FOS) was introduced on the market in 1997 with claims of having less cardiac toxicity. However, since then, many accounts of cardiac events have been reported undermining these claims. FOS gained popularity due to its water solubility, which allows 3 times faster infusion in comparison with PTN with less venous irritation and local toxicity. FOS is the phosphate ester prodrug of PTN and is rapidly converted to PTN independent of the dose and rate of administration. Intravenous FOS and PTN are bioequivalent. Adverse cardiac effects of both intravenous FOS and PTN have been correlated to the rate of infusion, concentration of the agent, known risk factors, or pre-existing hypersensitivity, and most cases have been identified after infusing a loading dose of these medications. This case report is unique, in that, the patient developed sinus arrest while concurrently receiving oral PTN and intravenous FOS. Clinicians should be more cognizant of the association of FOS and PTN with adverse cardiac events. Baseline electrocardiogram should be obtained on all patients prescribed FOS or PTN to identify underlying cardiac problems that may place the patient in a higher risk category. Telemetry should be performed on all patients receiving PTN in an inpatient setting.
[Mh] Termos MeSH primário: Anticonvulsivantes/efeitos adversos
Fenitoína/análogos & derivados
Fenitoína/efeitos adversos
Convulsões/tratamento farmacológico
Parada Sinusal Cardíaca/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Anticonvulsivantes/administração & dosagem
Quimioterapia Combinada
Eletrocardiografia
Eletroencefalografia
Seres Humanos
Masculino
Fenitoína/administração & dosagem
Pró-Fármacos
Fatores de Risco
Convulsões/etiologia
Transtornos Relacionados ao Uso de Substâncias/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Prodrugs); 6158TKW0C5 (Phenytoin); B4SF212641 (fosphenytoin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141231
[St] Status:MEDLINE
[do] DOI:10.1097/MJT.0000000000000159


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[PMID]:26028658
[Au] Autor:Ibrahim H; Barker CM; Reardon MJ; Kleiman NS
[Ad] Endereço:Houston Methodist DeBakey Heart & Vascular Center, Houston, TX USA. nkleiman@houstonmethodist.org.
[Ti] Título:Suicide left ventricle due to conduction disturbance following transcatheter aortic valve replacement and reversal with restoration of sinus rhythm: is there life after death?
[So] Source:J Invasive Cardiol;27(6):E107-9, 2015 Jun.
[Is] ISSN:1557-2501
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dynamic left ventricular outflow tract obstruction and left ventricular mid-cavity obliteration are phenomena that can complicate the postoperative course in patients who undergo surgical aortic valve replacement for aortic stenosis, and may be markers of increased morbidity and mortality. Recently, reports describing dynamic intraventricular obstruction following transcatheter aortic valve replacement (TAVR) have emerged. We report a case of dynamic left ventricular mid-cavity obstruction due to disordered atrioventricular synchrony immediately following TAVR, and its reversal with restoration of atrioventricular synchrony. This case highlights the essential role of atrial contraction in the management of this phenomenon.
[Mh] Termos MeSH primário: Estenose da Valva Aórtica/cirurgia
Valva Aórtica/cirurgia
Síndrome de Brugada/complicações
Próteses Valvulares Cardíacas
Ventrículos do Coração/fisiopatologia
Parada Sinusal Cardíaca/etiologia
Substituição da Valva Aórtica Transcateter/métodos
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Estenose da Valva Aórtica/diagnóstico por imagem
Cateterismo Cardíaco
Doença do Sistema de Condução Cardíaco
Feminino
Implante de Prótese de Valva Cardíaca
Seres Humanos
Volume Sistólico
Substituição da Valva Aórtica Transcateter/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150602
[St] Status:MEDLINE


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[PMID]:25619267
[Au] Autor:Muto S; Kawano H; Nakatomi D; Yamasa T; Maemura K
[Ad] Endereço:Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Cardiology, Nagasaki Rosai Hospital, Sasebo, Japan.
[Ti] Título:Sinus arrest as a result of rivastigmine in an elderly dementia with Lewy bodies patient.
[So] Source:Geriatr Gerontol Int;15(2):229-30, 2015 Feb.
[Is] ISSN:1447-0594
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Inibidores da Colinesterase/efeitos adversos
Doença por Corpos de Lewy/tratamento farmacológico
Fenilcarbamatos/efeitos adversos
Parada Sinusal Cardíaca/induzido quimicamente
Parada Sinusal Cardíaca/epidemiologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Inibidores da Colinesterase/administração & dosagem
Inibidores da Colinesterase/uso terapêutico
Comorbidade
Eletrocardiografia
Feminino
Insuficiência Cardíaca/epidemiologia
Seres Humanos
Doença por Corpos de Lewy/epidemiologia
Fenilcarbamatos/administração & dosagem
Fenilcarbamatos/uso terapêutico
Rivastigmina
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Phenylcarbamates); PKI06M3IW0 (Rivastigmine)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150127
[St] Status:MEDLINE
[do] DOI:10.1111/ggi.12311


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[PMID]:24351939
[Au] Autor:Yilmaz O; Ciftel M; Ozturk K; Kilic O; Kahveci H; Laloglu F; Ceylan O
[Ad] Endereço:1Department of Pediatric Cardiology,Erzurum District Training and Research Hospital,Erzurum,Turkey.
[Ti] Título:Assessment of heart rate variability in breath holding children by 24 hour Holter monitoring.
[So] Source:Cardiol Young;25(2):317-23, 2015 Feb.
[Is] ISSN:1467-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Previous studies have shown that the underlying pathophysiologic mechanism in children with breath holding may be generalised autonomic dysregulation. Thus, we performed cardiac rhythm and heart rate variability analyses using 24-hour Holter monitoring to evaluate the cardiac effects of autonomic dysregulation in children with breath-holding spells. METHODS: We performed cardiac rhythm and heart rate analyses using 24-hour Holter monitors to evaluate the cardiac effects of autonomic dysregulation in children during a breath-holding spell. Our study group consisted of 68 children with breath-holding spells - 56 cyanotic type and 12 pallid type - and 39 healthy controls. RESULTS: Clinical and heart rate variability results were compared between each spell type - cyanotic or pallid - and the control group; significant differences (p<0.05) in standard deviation of all NN intervals, mean of the standard deviations of all NN intervals for all 5-minute segments, percentage of differences between adjacent RR intervals >50 ms, and square root of the mean of the sum of squares of the differences between adjacent NN intervals values were found between the pallid and cyanotic groups. CONCLUSIONS: Holter monitoring for 24 hours and heart rate variability parameters, particularly in children with pallid spells, are crucial for evaluation of cardiac rhythm changes.
[Mh] Termos MeSH primário: Apneia/diagnóstico
Doenças do Sistema Nervoso Autônomo/diagnóstico
Suspensão da Respiração
Eletrocardiografia Ambulatorial
Frequência Cardíaca/fisiologia
Parada Sinusal Cardíaca/diagnóstico
[Mh] Termos MeSH secundário: Apneia/complicações
Apneia/fisiopatologia
Doenças do Sistema Nervoso Autônomo/complicações
Doenças do Sistema Nervoso Autônomo/fisiopatologia
Estudos de Casos e Controles
Pré-Escolar
Cianose/etiologia
Feminino
Seres Humanos
Lactente
Masculino
Palidez/etiologia
Parada Sinusal Cardíaca/complicações
Parada Sinusal Cardíaca/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150204
[Lr] Data última revisão:
150204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131220
[St] Status:MEDLINE
[do] DOI:10.1017/S1047951113002333


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[PMID]:25342892
[Au] Autor:Lin L; Wang Y; Chen Y; Liu M
[Ad] Endereço:Geriatric Department, Peking University First Hospital, Beijing, People's Republic of China.
[Ti] Título:Bradyarrhythmias secondary to topical levobunolol hydrochloride solution.
[So] Source:Clin Interv Aging;9:1741-5, 2014.
[Is] ISSN:1178-1998
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:An 88-year-old man was admitted with fatigue, dizziness, and heart palpitations. Both the electrocardiogram and Holter confirmed the existence of sinus bradycardia and sinus arrest. One hour prior to the onset of symptoms, he received levobunolol hydrochloride solution topically. The levobunolol hydrochloride solution was discontinued and the bradycardia resolved. He was diagnosed as having intermittent sinus bradycardia and sinus arrest, induced by topical ß-blocker therapy. Levobunolol hydrochloride solution is an effective therapy for ocular hypertension, probably by reducing aqueous fluid production. However, it can induce cardiac side effects such as bradyarrhythmia and should be used with caution in elderly patients or patients with cardiac disease.
[Mh] Termos MeSH primário: Antagonistas Adrenérgicos beta/efeitos adversos
Bradicardia/induzido quimicamente
Levobunolol/efeitos adversos
Hipertensão Ocular/tratamento farmacológico
Parada Sinusal Cardíaca/induzido quimicamente
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/administração & dosagem
Idoso de 80 Anos ou mais
Bradicardia/diagnóstico
Eletrocardiografia Ambulatorial/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Levobunolol/administração & dosagem
Masculino
Soluções Oftálmicas
Parada Sinusal Cardíaca/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Ophthalmic Solutions); G6317AOI7K (Levobunolol)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141025
[St] Status:MEDLINE
[do] DOI:10.2147/CIA.S69420



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