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  1 / 16525 MEDLINE  
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[PMID]:29375113
[Au] Autor:Komuro J; Ueda K; Kaneko M; Nitta S; Kasao M; Yokoyama M
[Ad] Endereço:Department of Cardiology, Tokyo Metropolitan Police Hospital.
[Ti] Título:Various Cardiac Abnormalities Caused by Bacterial Myocarditis.
[So] Source:Int Heart J;59(1):229-232, 2018.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A 69-year-old woman without any past disease history was hospitalized for heart failure. After hospitalization, she showed myocardial infarction, atrioventricular dissociation, and cardiac dysfunction, and finally she passed away despite intensive care. Autopsy revealed that the cardiac abnormalities were due to bacterial myocarditis possibly resulting from urinary tract infection by E. coli. Although bacterial myocarditis is rare in developed countries, we should consider its possibility when patients show various cardiac abnormalities with bacterial infection.
[Mh] Termos MeSH primário: Infecções por Escherichia coli/complicações
Escherichia coli/isolamento & purificação
Bloqueio Cardíaco/etiologia
Infarto do Miocárdio/etiologia
Miocardite/complicações
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Diagnóstico Diferencial
Eletrocardiografia
Infecções por Escherichia coli/diagnóstico
Infecções por Escherichia coli/microbiologia
Evolução Fatal
Feminino
Bloqueio Cardíaco/diagnóstico
Seres Humanos
Infarto do Miocárdio/diagnóstico
Miocardite/diagnóstico
Miocardite/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-651


  2 / 16525 MEDLINE  
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[PMID]:28458438
[Au] Autor:Maddala RNM; Ashwal AJ; Rao MS; Padmakumar R
[Ad] Endereço:Department of Medicine, Manipal University, Manipal, Udupi, Karnataka, India.
[Ti] Título:Chronic lithium intoxication: Varying electrocardiogram manifestations.
[So] Source:Indian J Pharmacol;49(1):127-129, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels.
[Mh] Termos MeSH primário: Antimaníacos/efeitos adversos
Arritmias Cardíacas/induzido quimicamente
Compostos de Lítio/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Antimaníacos/administração & dosagem
Antimaníacos/sangue
Arritmias Cardíacas/fisiopatologia
Fibrilação Atrial/induzido quimicamente
Transtorno Bipolar/tratamento farmacológico
Bradicardia/induzido quimicamente
Eletrocardiografia
Feminino
Bloqueio Cardíaco/induzido quimicamente
Seres Humanos
Compostos de Lítio/administração & dosagem
Compostos de Lítio/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Lithium Compounds)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/ijp.IJP_204_16


  3 / 16525 MEDLINE  
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[PMID]:29173414
[Au] Autor:Limipitikul W; Ong CS; Tomaselli GF
[Ad] Endereço:Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
[Ti] Título:Neuromuscular Disease: Cardiac Manifestations and Sudden Death Risk.
[So] Source:Card Electrophysiol Clin;9(4):731-747, 2017 Dec.
[Is] ISSN:1877-9190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiovascular complications of neuromuscular diseases disproportionately affect the cardiac conduction system. Cardiomyopathy and cardiac arrhythmias produce significant morbidity and mortality. Patients with neuromuscular diseases should be carefully and frequently evaluated for the presence of bradycardia, heart block, and tachyarrhythmias. Preemptive treatment with permanent pacemakers or implanted defibrillators is appropriate in patients with conduction system disease or who are at risk for ventricular arrhythmias.
[Mh] Termos MeSH primário: Morte Súbita Cardíaca
Doenças Neuromusculares
[Mh] Termos MeSH secundário: Arritmias Cardíacas
Desfibriladores Implantáveis
Bloqueio Cardíaco
Seres Humanos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  4 / 16525 MEDLINE  
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[PMID]:29045069
[Au] Autor:Ainsworth HC; Marion MC; Bertero T; Brucato A; Cimaz R; Costedoat-Chalumeau N; Fredi M; Gaffney P; Kelly J; Levesque K; Maltret A; Morel N; Ramoni V; Ruffatti A; Langefeld CD; Buyon JP; Clancy RM
[Ad] Endereço:Wake Forest University, Winston-Salem, North Carolina.
[Ti] Título:Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block.
[So] Source:Arthritis Rheumatol;69(11):2170-2174, 2017 Nov.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Fetal exposure to maternal anti-SSA/Ro antibodies is necessary but not sufficient for the development of autoimmune congenital heart block (CHB), suggesting that other factors, such as fetal genetic predisposition, are important. Given the previously described association between major histocompatibility complex alleles and CHB risk, we undertook the present study to test the hypothesis that a variant form of HLA-C Asn80Lys, which binds with high affinity to an inhibitory killer cell immunoglobulin-like receptor (KIR) and thus renders natural killer (NK) cells incapable of restricting inflammation, contributes to the development of CHB. METHODS: Members of 192 pedigrees in the US and Europe (194 cases of CHB, 91 unaffected siblings, 152 fathers, 167 mothers) and 1,073 out-of-study controls were genotyped on the Immunochip single-nucleotide polymorphism microarray. Imputation was used to identify associations at HLA-C Asn80Lys (Asn, C1; Lys, C2) and KIR. Tests for association were performed using logistic regression. McNemar's test and the pedigree disequilibrium test (PDT) were used for matched analyses between affected and unaffected children. RESULTS: Compared with out-of-study controls of the same sex, the C2 allele was less frequent in the mothers (odds ratio [OR] 0.63, P = 0.0014) and more frequent in the fathers (OR 1.40, P = 0.0123), yielding a significant sex-by-C2 interaction (P = 0.0002). The C2 allele was more frequent in affected siblings than in unaffected siblings (OR 3.67, P = 0.0025), which was consistent with the PDT results (P = 0.016); these results were observed in both sexes and across the US and European cohorts. There was no difference in the frequency of the inhibitory KIR genotype (KIR AA) between affected and unaffected children (P = 0.55). CONCLUSION: These data establish C2 as a novel genetic risk factor associated with CHB. This observation supports a model in which fetuses with C2 ligand expression and maternal anti-SSA/Ro positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring.
[Mh] Termos MeSH primário: Antígenos HLA-C/genética
Bloqueio Cardíaco/congênito
[Mh] Termos MeSH secundário: Anticorpos Antinucleares/imunologia
Estudos de Casos e Controles
Ensaio de Imunoadsorção Enzimática
Europa (Continente)
Pai
Feminino
Genótipo
Bloqueio Cardíaco/genética
Bloqueio Cardíaco/imunologia
Seres Humanos
Recém-Nascido
Modelos Logísticos
Masculino
Mães
Razão de Chances
Linhagem
Polimorfismo Genético
Polimorfismo de Nucleotídeo Único
Fatores Sexuais
Irmãos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (HLA-C Antigens); 0 (SS-A antibodies)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1002/art.40228


  5 / 16525 MEDLINE  
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[PMID]:28989025
[Au] Autor:Chan PKW; Geng L; Gao Y; Keung W; Li RA
[Ad] Endereço:Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
[Ti] Título:AAV-mediated conversion of human pluripotent stem cell-derived pacemaker.
[So] Source:Biochem Biophys Res Commun;494(1-2):346-351, 2017 Dec 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malfunction of nodal pacemaker (Pm) cardiomyocytes (CMs) due to diseases or aging leads to rhythm generation disorders, necessitating electronic Pm implantation. We functionally reprogrammed human pluripotent stem cell (hPSC) derived-ventricular (V) CMs into -PmCMs via recombinant adeno-associated virus serotype 9 (rAAV9)-mediated overexpression of engineered HCN1 channel (HCN1ΔΔΔ) whose S3-S4 linker has been strategically deleted by design to promote cardiac pacemaking. rAAV9-HCN1ΔΔΔ-reprogrammed hPSC-PmCMs converted from -VCMs showed automaticity and action potential parameters typical of native nodal PmCMs. Implantation of rAAV9-HCN1ΔΔΔ-based BPm in a preclinical porcine model of complete heart block significantly reduced the dependence on device-supported pacing and generated spontaneous heart rhythms from the BPm. Collectively, these results have further laid the groundwork on BPm for future translation.
[Mh] Termos MeSH primário: Dependovirus/metabolismo
Bloqueio Cardíaco/terapia
Ventrículos do Coração/metabolismo
Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização/metabolismo
Miócitos Cardíacos/metabolismo
Células-Tronco Pluripotentes/metabolismo
Canais de Potássio/metabolismo
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Diferenciação Celular
Reprogramação Celular
Dependovirus/genética
Modelos Animais de Doenças
Expressão Gênica
Genes Reporter
Vetores Genéticos/química
Vetores Genéticos/metabolismo
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Bloqueio Cardíaco/genética
Bloqueio Cardíaco/metabolismo
Bloqueio Cardíaco/fisiopatologia
Frequência Cardíaca/fisiologia
Ventrículos do Coração/patologia
Ventrículos do Coração/fisiopatologia
Células-Tronco Embrionárias Humanas/citologia
Células-Tronco Embrionárias Humanas/metabolismo
Seres Humanos
Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização/genética
Miócitos Cardíacos/citologia
Marca-Passo Artificial
Células-Tronco Pluripotentes/citologia
Canais de Potássio/genética
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HCN1 protein, human); 0 (Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels); 0 (Potassium Channels); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE


  6 / 16525 MEDLINE  
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[PMID]:28981521
[Au] Autor:Mantovani A; Rigolon R; Pichiri I; Bonapace S; Morani G; Zoppini G; Bonora E; Targher G
[Ad] Endereço:Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
[Ti] Título:Nonalcoholic fatty liver disease is associated with an increased risk of heart block in hospitalized patients with type 2 diabetes mellitus.
[So] Source:PLoS One;12(10):e0185459, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiac tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus. The aim of this study was to examine whether an association also exists between NAFLD and heart block. We have retrospectively evaluated a hospital-based cohort of 751 patients with type 2 diabetes discharged from our Division of Diabetes and Endocrinology during years 2007-2014. Standard electrocardiograms were performed on all patients. Diagnosis of NAFLD was based on ultrasonography, whereas the severity of advanced hepatic fibrosis was based on the fibrosis (FIB)-4 score and other non-invasive fibrosis markers. Overall, 524 (69.8%) patients had NAFLD and 202 (26.9%) had heart block (defined as at least one block among first-degree atrio-ventricular block, second-degree block, third-degree block, left bundle branch block, right bundle branch block, left anterior hemi-block or left posterior hemi-block) on electrocardiograms. Patients with NAFLD had a remarkably higher prevalence of any persistent heart block than those without NAFLD (31.3% vs. 16.7%, p<0.001); this prevalence was particularly increased among those with higher FIB-4 score. NAFLD was associated with a threefold increased risk of prevalent heart block (adjusted-odds ratio 3.04, 95% CI 1.81-5.10), independently of age, sex, hypertension, prior ischemic heart disease, hemoglobin A1c, microvascular complication status, use of medications and other potentially confounding factors. In conclusion, this is the largest cross-sectional study to show that NAFLD and its severity are independently associated with an increased risk of prevalent heart block in hospitalized patients with type 2 diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/complicações
Bloqueio Cardíaco/complicações
Hospitalização
Hepatopatia Gordurosa não Alcoólica/complicações
[Mh] Termos MeSH secundário: Idoso
Diabetes Mellitus Tipo 2/fisiopatologia
Eletrocardiografia
Feminino
Bloqueio Cardíaco/fisiopatologia
Seres Humanos
Pacientes Internados
Fígado/diagnóstico por imagem
Masculino
Meia-Idade
Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem
Hepatopatia Gordurosa não Alcoólica/fisiopatologia
Estudos Retrospectivos
Fatores de Risco
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185459


  7 / 16525 MEDLINE  
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[PMID]:28957562
[Au] Autor:Sonesson SE; Hedlund M; Ambrosi A; Wahren-Herlenius M
[Ad] Endereço:Pediatric Cardiology Unit, Department of Women's and Children's Health.
[Ti] Título:Factors influencing fetal cardiac conduction in anti-Ro/SSA-positive pregnancies.
[So] Source:Rheumatology (Oxford);56(10):1755-1762, 2017 Oct 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: Congenital heart block (CHB) develops in 1-2% of anti-Ro/SSA-positive pregnancies and has a recurrence rate of 12-20%, which indicates that factors other than maternal autoantibodies are crucial for CHB to occur. Here, we aimed to evaluate the influence of factors previously associated with CHB on the occurrence of milder forms of fetal cardiac conduction disturbances, shown to occur in up to 30% of anti-Ro/SSA-positive pregnancies, and on neonatal outcome in a large cohort of prospectively followed pregnancies. Methods: The association of maternal age, season of the year and history of atrioventricular block (AVB) with the development of fetal Doppler and neonatal ECG conduction disturbances was evaluated in 212 anti-Ro52/SSA-positive singleton pregnancies. Results: Maternal age was significantly higher in AVB II-III pregnancies but was not correlated with fetal AV time intervals in fetuses without signs of AVB II-III. AV time intervals of fetuses surveilled during the winter were significantly longer than those of fetuses surveilled during the summer. Fetal AV time intervals in consecutive pregnancies from the same women were significantly correlated. A history of AVB II-III was associated with significantly longer AV time intervals, and AVB I-III was observed at birth in 38% of babies born after a sibling with abnormal fetal AV conduction. Conclusion: Our study shows that AV time intervals in anti-Ro/SSA antibody-exposed fetuses during the CHB risk period are influenced by the season of the year, and reveals that the recurrence of conduction disturbances in antibody-exposed fetuses is higher than previously reported when milder forms are taken into account.
[Mh] Termos MeSH primário: Anticorpos Antinucleares
Bloqueio Atrioventricular/fisiopatologia
Coração Fetal/fisiopatologia
Bloqueio Cardíaco/congênito
Complicações Cardiovasculares na Gravidez/imunologia
Estações do Ano
[Mh] Termos MeSH secundário: Adulto
Anticorpos Antinucleares/sangue
Bloqueio Atrioventricular/congênito
Autoanticorpos/sangue
Ecocardiografia Doppler/métodos
Feminino
Coração Fetal/diagnóstico por imagem
Bloqueio Cardíaco/diagnóstico por imagem
Bloqueio Cardíaco/fisiopatologia
Seres Humanos
Gravidez
Complicações Cardiovasculares na Gravidez/sangue
Complicações Cardiovasculares na Gravidez/diagnóstico por imagem
Resultado da Gravidez
Estudos Prospectivos
Ribonucleoproteínas/imunologia
Fatores de Risco
Ultrassonografia Pré-Natal/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Autoantibodies); 0 (Ribonucleoproteins); 0 (SS-A antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex263


  8 / 16525 MEDLINE  
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[PMID]:28863179
[Au] Autor:Kang HJ; Kim SW; Son SH
[Ad] Endereço:Department of Radiation Oncology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
[Ti] Título:The feasibility of a heart block with an electron compensation as an alternative whole breast radiotherapy technique in patients with underlying cardiac or pulmonary disease.
[So] Source:PLoS One;12(9):e0184137, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. METHODS: Twenty patients with left-sided breast cancer who were treated with whole breast radiotherapy (WBRT) were included in this study. Intensity-modulated radiotherapy (IMRT), 3D-CRT, and HBE treatment plans were generated for each patient. Based on the 3D-CRT plan, the HBE plan included a heart block from the medial tangential field to shield the heart and added an electron beam to compensate for the loss in target volume coverage. The dosimetric parameters for the heart and lung and the target volume between the three treatment types were compared. RESULTS: Of the three plans, the HBE plan yielded the most significant reduction in the doses received by the heart and lung (heart Dmean: 5.1 Gy vs. 12.9 Gy vs. 4.0 Gy and lung Dmean: 11.4 Gy vs. 13.2 Gy vs. 10.5 Gy, for 3D-CRT, IMRT, and HBE, respectively). Target coverage with all three techniques was within the acceptable range (Dmean 51.0 Gy vs. 51.2 Gy vs. 50.6 Gy, for 3D-CRT, IMRT, and HBE, respectively). CONCLUSIONS: The HBE plan effectively reduced the amount of radiation exposure to the heart and lung. It could be beneficial for patients who are vulnerable to radiation-related cardiac or pulmonary toxicities.
[Mh] Termos MeSH primário: Neoplasias da Mama/radioterapia
Bloqueio Cardíaco
Cardiopatias/complicações
Pneumopatias/complicações
Radioterapia Conformacional/métodos
Radioterapia/métodos
[Mh] Termos MeSH secundário: Adulto
Neoplasias da Mama/complicações
Elétrons
Estudos de Viabilidade
Feminino
Seres Humanos
Meia-Idade
Lesões por Radiação/prevenção & controle
Radiometria
Dosagem Radioterapêutica
Planejamento da Radioterapia Assistida por Computador/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184137


  9 / 16525 MEDLINE  
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[PMID]:28843963
[Au] Autor:Antoniadis AP; Fragakis N
[Ad] Endereço:Cardiovascular Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[Ti] Título:Intraventricular conduction disturbances: are we just looking at the tip of the iceberg?
[So] Source:Hellenic J Cardiol;58(3):202-203, 2017 May - Jun.
[Is] ISSN:2241-5955
[Cp] País de publicação:Greece
[La] Idioma:eng
[Mh] Termos MeSH primário: Bloqueio Cardíaco
Sistema de Condução Cardíaco
[Mh] Termos MeSH secundário: Eletrocardiografia
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170828
[St] Status:MEDLINE


  10 / 16525 MEDLINE  
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[PMID]:28813535
[Au] Autor:Kienast R; Handler M; Stöger M; Baumgarten D; Hanser F; Baumgartner C
[Ad] Endereço:Institute of Electrical and Biomedical Engineering, UMIT-University for Health Sciences, Medical Informatics and Technology, Hall, Tyrol, Austria.
[Ti] Título:Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG.
[So] Source:PLoS One;12(8):e0182979, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. In this work, we propose a model that describes the cooling-induced electrophysiological alterations in ventricular tissue in a temperature range from 27°C to 37°C. To model the electrophysiological conditions in a 3D left ventricular tissue block it was essential to consider the following anatomical and physiological parameters in the model: the different cell types (endocardial, M, epicardial), the heterogeneous conductivities in longitudinal, transversal and transmural direction depending on the prevailing temperature, the distinct fiber orientations and the transmural repolarization sequences. Cooling-induced alterations on the morphology of the action potential (AP) of single myocardial cells thereby are described by an extension of the selected Bueno-Orovio model for human ventricular tissue using Q10 temperature coefficients. To evaluate alterations on tissue level, the corresponding pseudo electrocardiogram (pECG) was calculated. Simulations show that cooling-induced AP and pECG-related parameters, i.e. AP duration, morphology of the notch of epicardial AP, maximum AP upstroke velocity, AP rise time, QT interval, QRS duration and J wave formation are in good accordance with literature and our experimental data. The proposed model enables us to further enhance our knowledge of cooling-induced electrophysiological alterations from cellular to tissue level in the heart and may help to better understand electrophysiological mechanisms, e.g. in arrhythmias, during hypothermia.
[Mh] Termos MeSH primário: Eletrocardiografia
Ventrículos do Coração/fisiopatologia
Hipotermia Induzida/efeitos adversos
[Mh] Termos MeSH secundário: Potenciais de Ação
Algoritmos
Animais
Galinhas
Bloqueio Cardíaco/fisiopatologia
Sistema de Condução Cardíaco/fisiopatologia
Modelos Biológicos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182979



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