Base de dados : MEDLINE
Pesquisa : C14.280.067.845.940 [Categoria DeCS]
Referências encontradas : 12359 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1236 ir para página                         

  1 / 12359 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29289261
[Au] Autor:Yu M; Chen T; Hu S; Zou S; Wang C; Zeng C; Chen W; Tan X
[Ad] Endereço:Department of Cardiology, The First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.
[Ti] Título:R-Wave Peak Time at Lead II in Adults With Ventricular Premature Beats, Bundle Branch Block and Left Anterior Fascicular Block.
[So] Source:Am J Med Sci;355(1):44-47, 2018 01.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recently, the R-wave peak time (RWPT) at lead II was reported to be a helpful and simple tool for differentiating wide QRS complex tachycardias with a RWPT ≥ 50ms for ventricular tachycardia diagnosis. Our previous study showed that the duration of RWPT at lead II in adults was ≈29ms. However, the effects of ventricular premature beats (VPBs), bundle branch block (BBB) or left anterior fascicular block (LAFB) on RWPT at lead II remain unknown. METHODS: The study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China. Adults with VPBs, BBB or LAFB were included. RWPT at lead II was determined. RESULTS: Compared with the control groups, the right BBB, LAFB, RWPT were longer in groups with left BBB and VPBs. Compared with the group with left BBB, the group with VPBs had a significantly longer RWPT at lead II (54.20 ± 18.52 versus 84.76 ± 16.38ms, P < 0.01). CONCLUSION: Our study showed that there is a significant difference in the RWPT at lead II between groups with left BBB, ventricular premature beat, right BBB and LAFB. A RWPT of 50ms may be optimal to differentiate between ventricular tachycardia and supraventricular tachycardia with right left BBB and LAFB, but not with left BBB.
[Mh] Termos MeSH primário: Bloqueio de Ramo/diagnóstico
Bloqueio de Ramo/fisiopatologia
Taquicardia Ventricular/diagnóstico
Taquicardia Ventricular/fisiopatologia
Complexos Ventriculares Prematuros/diagnóstico
Complexos Ventriculares Prematuros/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Bloqueio de Ramo/epidemiologia
Eletrocardiografia/métodos
Feminino
Seres Humanos
Masculino
Taquicardia Ventricular/epidemiologia
Fatores de Tempo
Complexos Ventriculares Prematuros/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  2 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460764
[Au] Autor:Pandian J; Kaur D; Yalagudri S; Devidutta S; Sundar G; Chennapragada S; Narasimhan C
[Ad] Endereço:CARE Hospital, Road No.1, Banjara Hills, Hyderabad 500 034, India.
[Ti] Título:Safety and efficacy of epicardial approach to catheter ablation of ventricular tachycardia - An institutional experience.
[So] Source:Indian Heart J;69(2):170-175, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: Epicardial approach to VT ablation increases the success rate of ablation but is not without complications. We studied the safety and efficacy of epicardial VT ablations performed at our institute. METHODS: All patients who underwent epicardial VT ablation at our institute were studied retrospectively. The outcome of VT ablation was among three groups: ischaemic cardiomyopathy (ICM), non-ischaemic cardiomyopathy (NICM) and granulomatous myocarditis (GM). Safety outcomes assessed included all complications considered to be due to pericardial access or epicardial mapping/ablation. RESULTS: A total of 54 patients (total 119 VTs, mean 2.2 (0.9)) were taken up for ablation procedure through epicardial access. Mean age: 47 (10) years, males: 83%. All patients had drug resistant recurrent VTs. The epicardial procedure was abandoned in three patients due to access issues; percutaneous sub-xiphoid access was employed in 48 and surgical approach in four patients. Complete success was achieved in 59% and partial success in 76%. The outcomes were poor in ICM patients as compared to those with GM and NICM. Overall success rates for all clinical VTs were 89% in GM, 90% in NICM and 67% in ICM. Success rates for epicardial VT ablation were 94%, 85% and 78% respectively for GM, NICM and ICM. Procedure related complications occurred in six patients. CONCLUSION: Epicardial ablation for VT offers good immediate outcomes with acceptable safety profile.
[Mh] Termos MeSH primário: Cateterismo Cardíaco/métodos
Ablação por Cateter/métodos
Sistema de Condução Cardíaco/cirurgia
Pericárdio/cirurgia
Taquicardia Ventricular/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Ecocardiografia
Técnicas Eletrofisiológicas Cardíacas/métodos
Feminino
Seguimentos
Sistema de Condução Cardíaco/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Taquicardia Ventricular/diagnóstico
Taquicardia Ventricular/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29178653
[Au] Autor:Josephs K; Patel K; Janson CM; Montagna C; McDonald TV
[Ad] Endereço:Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.
[Ti] Título:Compound heterozygous CASQ2 mutations and long-term course of catecholaminergic polymorphic ventricular tachycardia.
[So] Source:Mol Genet Genomic Med;5(6):788-794, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited cardiac disorder characterized by episodic ventricular tachycardia during adrenergic stimulation. It is associated with significant morbidity and mortality. Knowledge of the underlying genetic cause, pathogenesis, and the natural history of the disease remains incomplete. Approximately 50% of CPVT cases are caused by dominant mutations in the cardiac ryanodine receptor (RYR2) gene, <5% of cases are accounted for by recessive mutations in cardiac calsequestrin (CASQ2) or Triadin (TRDN). METHODS: We report a family with two CASQ2 gene mutations. A research-based next-generation sequencing (NGS) initiative was used in a patient with a severe CPVT phenotype and her clinically unaffected son. Reverse transcription polymerase chain reaction (RT-PCR) from platelet RNA was used to assess the consequences of predicted splice variants. RESULTS: NGS revealed that the proband carried a novel c.199C>T (p.Gln67*) mutation and a previously reported splice site mutation c.532+1G>A in CASQ2. Her son is a heterozygous carrier of the c.199C>T (p.Gln67*) mutation alone and the proband was compound heterozygous at CASQ2. RNA analysis demonstrated that the splice site mutation results in the retention of intron 3 with no full-length CASQ2 mRNA. CONCLUSION: This study describes a novel CPVT genotype and further characterizes the effect of a previously reported CASQ2 splice site mutation. The long-term follow-up of 23 years since first symptom provides additional insight into the natural history of CASQ2-associated CPVT.
[Mh] Termos MeSH primário: Calsequestrina/genética
Taquicardia Ventricular/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Plaquetas/metabolismo
Criança
Eletrocardiografia
Seguimentos
Genótipo
Heterozigoto
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Linhagem
Fenótipo
Polimorfismo de Nucleotídeo Único
RNA/química
RNA/isolamento & purificação
RNA/metabolismo
Sítios de Splice de RNA/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de RNA
Taquicardia Ventricular/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (CASQ2 protein, human); 0 (Calsequestrin); 0 (RNA Splice Sites); 63231-63-0 (RNA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.323


  4 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29178898
[Au] Autor:Castro L; Pecha S; Linder M; Vogler J; Gosau N; Meyer C; Willems S; Reichenspurner H; Hakmi S
[Ad] Endereço:Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany. l.castro@uke.de.
[Ti] Título:The wearable cardioverter defibrillator as a bridge to reimplantation in patients with ICD or CRT-D-related infections.
[So] Source:J Cardiothorac Surg;12(1):99, 2017 Nov 25.
[Is] ISSN:1749-8090
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The approach to treat device infection in patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) is a challenging procedure. Optimal treatment is complete extraction of the infected device. To protect these patients from sudden cardiac arrest while waiting for reimplantation and to avoid recurrent infection, a wearable cardioverter defibrillator (WCD) seems to be a valuable solution. Therefore, we investigated the management and outcome of patients with ICD or CRT-D infections using the WCD as a bridge to re-implantation after lead extraction procedures. METHODS: We conducted a retrospective study on consecutive patients who underwent ICD or CRT-D removal due to device-related local or systemic infections. All patients were prescribed a WCD at our center between 01/2012 and 10/2015. All patients returned to our outpatient clinic for regular ICD or CRT-D monitoring initially 1 and 3 months after reimplantation followed by 6-months intervals. RESULTS: Twenty-one patients (mean age 65.0 ± 8.0 years, male 76.2%) were included in the study. Complete lead extraction was achieved in all patients. While waiting for reimplantation one patient experienced a symptomatic episode of sustained ventricular tachycardia. This episode was converted successfully into sinus rhythm by a single 150 J shock. Mean follow-up time 392 ± 206 days, showing survival rate of 100% and freedom from reinfection in all patients. CONCLUSION: The WCD seems to be a valuable bridging option for patients with ICD or CRT-D infections, showing no recurrent device infection.
[Mh] Termos MeSH primário: Morte Súbita Cardíaca/prevenção & controle
Desfibriladores Implantáveis
Cardioversão Elétrica/instrumentação
Infecções Relacionadas à Prótese/epidemiologia
Taquicardia Ventricular/terapia
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/uso terapêutico
Remoção de Dispositivo
Eletrocardiografia
Feminino
Alemanha/epidemiologia
Seres Humanos
Incidência
Masculino
Infecções Relacionadas à Prótese/etiologia
Infecções Relacionadas à Prótese/terapia
Reimplante
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Taquicardia Ventricular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1186/s13019-017-0669-2


  5 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27777148
[Au] Autor:Bacic D; Carneiro JS; Bento AA; Nearing BD; Rajamani S; Belardinelli L; Verrier RL
[Ad] Endereço:Beth Israel Deaconess Medical Center, Boston, Massachusetts; Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
[Ti] Título:Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model.
[So] Source:Heart Rhythm;14(3):448-454, 2017 Mar.
[Is] ISSN:1556-3871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The capacity of catecholamines to induce ventricular tachycardia (VT) is well documented. OBJECTIVE: The effectiveness of the novel cardiac late sodium inhibitor eleclazine in suppressing catecholamine-induced VT in a large animal model was compared with that of flecainide. METHODS: In 13 closed-chest anesthetized Yorkshire pigs, spontaneous VT and surges in T-wave alternans (TWA) level measured using the Modified Moving Average method were induced by epinephrine (2.0 µg/kg, i.v., bolus over 1 minute). Effects of eleclazine (0.3 mg/kg, i.v., infused over 15 minutes; n = 6) or flecainide (1 mg/kg, i.v., bolus over 2 minutes followed by 1 mg/kg/hr, i.v., for 1 hour; n = 7) on VT incidence and TWA level were measured from right intraventricular electrogram recordings. RESULTS: Epinephrine reproducibly elicited hemodynamically significant spontaneous VT in all 13 pigs and increased TWA level by 33-fold compared to baseline (P < .001). Eleclazine reduced the incidence of epinephrine-induced ventricular premature beats and couplets by 51% (from 31.3 ± 1.91 to 15.2 ± 5.08 episodes; P = .038) and the incidence of 3- to 7-beat VT by 56% (from 10.8 ± 3.45 to 4.7 ± 3.12 episodes; P = .004). Concurrently, the drug reduced the peak epinephrine-induced TWA level by 64% (from 217 ± 22.2 to 78 ± 15.3 µV; P < .001). Flecainide also reduced the incidence of epinephrine-induced ventricular premature beats and couplets by 53% (from 40.4 ± 6.37 to 19.0 ± 2.73 episodes; P = .024) but did not affect the incidence of VT (from 15.0 ± 3.08 to 11.6 ± 2.93 episodes; P = .29) or the peak TWA level (from 207 ± 30.6 to 172 ± 26.2 µV; P = .34). CONCLUSION: Selective inhibition of cardiac late sodium current with eleclazine is more effective than flecainide in reducing catecholamine-induced VT and TWA in an intact porcine model.
[Mh] Termos MeSH primário: Catecolaminas/metabolismo
Flecainida/farmacologia
Oxazepinas/farmacologia
Taquicardia Ventricular
[Mh] Termos MeSH secundário: Administração Intravenosa
Animais
Modelos Animais de Doenças
Monitoramento de Medicamentos/métodos
Eletrocardiografia/métodos
Hemodinâmica/efeitos dos fármacos
Suínos
Taquicardia Ventricular/tratamento farmacológico
Taquicardia Ventricular/metabolismo
Taquicardia Ventricular/fisiopatologia
Resultado do Tratamento
Bloqueadores do Canal de Sódio Disparado por Voltagem/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catecholamines); 0 (Oxazepines); 0 (Voltage-Gated Sodium Channel Blockers); 0 (eleclazine); K94FTS1806 (Flecainide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  6 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29173409
[Au] Autor:Huang WA; Boyle NG; Vaseghi M
[Ad] Endereço:UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, 100 MP, Suite 660, Los Angeles, CA 90095, USA.
[Ti] Título:Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.
[So] Source:Card Electrophysiol Clin;9(4):665-679, 2017 Dec.
[Is] ISSN:1877-9190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural remodeling in the autonomic nervous system contributes to sudden cardiac death. The fabric of cardiac excitability and propagation is controlled by autonomic innervation. Heart disease predisposes to malignant ventricular arrhythmias by causing neural remodeling at the level of the myocardium, the intrinsic cardiac ganglia, extracardiac intrathoracic sympathetic ganglia, extrathoracic ganglia, spinal cord, and the brainstem, as well as the higher centers and the cortex. Therapeutic strategies at each of these levels aim to restore the balance between the sympathetic and parasympathetic branches. Understanding this complex neural network will provide important therapeutic insights into the treatment of sudden cardiac death.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo
Morte Súbita Cardíaca
Coração/inervação
[Mh] Termos MeSH secundário: Seres Humanos
Taquicardia Ventricular
Fibrilação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  7 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27771553
[Au] Autor:Kato T; Yamamoto T; Nakamura Y; Nanno T; Fukui G; Sufu Y; Hamada Y; Maeda T; Nishimura S; Ishiguchi H; Murakami W; Fukuda M; Xu X; Hino A; Ono M; Oda T; Okuda S; Kobayashi S; Koseki N; Kyushiki H; Yano M
[Ad] Endereço:Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
[Ti] Título:Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.
[So] Source:Heart Rhythm;14(1):120-127, 2017 01.
[Is] ISSN:1556-3871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Calmodulin (CaM) is a key modulator of the channel gating function of the ryanodine receptor (RyR). OBJECTIVE: The purpose of this study was to investigate the pathogenic role of RyR-bound CaM in diastolic Ca leakage from the sarcoplasmic reticulum and arrhythmogenesis in pressure-overloaded heart failure. METHODS: Pressure overload was induced in 12-week-old mice by transverse aortic constriction (TAC) using a 27-gauge needle. RESULTS: TAC operation for 8 weeks produced a significant increase in left ventricular end-diastolic diameter and frequent occurrence of lethal arrhythmias after infusion of epinephrine and caffeine in TAC mice. The amount of RyR-bound CaM decreased significantly in TAC mice compared with sham mice. The apparent affinity of CaM binding to RyR decreased in pressure-overloaded cells compared with sham cells and untreated cells. High-affinity calmodulin (HA-CaM; ie, CaM whose binding affinity to RyR was significantly increased) restored a normal level of CaM-RyR binding properties in pressure-overloaded cells. HA-CaM corrected abnormally increased Ca spark frequency in the pressure-overloaded cells to the level seen in the sham cells. The frequency of spontaneous Ca transients in TAC cells during and after 1-5 Hz of field stimulation was 44%, whereas it was significantly attenuated by HA-CaM but not with CaM. CONCLUSION: Several disorders in the RyR channel function characteristic of pressure-overloaded cells (increased spontaneous Ca leakage, delayed afterdepolarization, triggered activity, Ca spark frequency, spontaneous Ca transients) are caused by deteriorated CaM binding to RyR2. These disorders could be rectified by restoring normal CaM binding to RyR2.
[Mh] Termos MeSH primário: Calmodulina/metabolismo
Insuficiência Cardíaca/diagnóstico por imagem
Insuficiência Cardíaca/terapia
Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo
Taquicardia Ventricular/diagnóstico
[Mh] Termos MeSH secundário: Animais
Mapeamento Potencial de Superfície Corporal/métodos
Canais de Cálcio/metabolismo
Sinalização do Cálcio
Células Cultivadas
Modelos Animais de Doenças
Insuficiência Cardíaca/mortalidade
Camundongos
Camundongos Endogâmicos
Miócitos Cardíacos/metabolismo
Distribuição Aleatória
Valores de Referência
Retículo Sarcoplasmático/metabolismo
Sensibilidade e Especificidade
Taquicardia Ventricular/mortalidade
Taquicardia Ventricular/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Calcium Channels); 0 (Calmodulin); 0 (Ryanodine Receptor Calcium Release Channel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  8 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29236642
[Au] Autor:Cuculich PS; Schill MR; Kashani R; Mutic S; Lang A; Cooper D; Faddis M; Gleva M; Noheria A; Smith TW; Hallahan D; Rudy Y; Robinson CG
[Ad] Endereço:From the Department of Internal Medicine, Cardiovascular Division (P.S.C., D.C., M.F., M.G., A.N., T.W.S.), and the Departments of Surgery (M.R.S.), Radiation Oncology (R.K., S.M., D.H., C.G.R.), Pathology (A.L.), and Cell Biology and Physiology, Medicine, Radiology, and Pediatrics (Y.R.), School of
[Ti] Título:Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia.
[So] Source:N Engl J Med;377(24):2325-2336, 2017 12 14.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, noninvasive cardiac radioablation for ventricular tachycardia. METHODS: We targeted arrhythmogenic scar regions by combining anatomical imaging with noninvasive electrocardiographic imaging during ventricular tachycardia that was induced by means of an implantable cardioverter-defibrillator (ICD). SBRT simulation, planning, and treatments were performed with the use of standard techniques. Patients were treated with a single fraction of 25 Gy while awake. Efficacy was assessed by counting episodes of ventricular tachycardia, as recorded by ICDs. Safety was assessed by means of serial cardiac and thoracic imaging. RESULTS: From April through November 2015, five patients with high-risk, refractory ventricular tachycardia underwent treatment. The mean noninvasive ablation time was 14 minutes (range, 11 to 18). During the 3 months before treatment, the patients had a combined history of 6577 episodes of ventricular tachycardia. During a 6-week postablation "blanking period" (when arrhythmias may occur owing to postablation inflammation), there were 680 episodes of ventricular tachycardia. After the 6-week blanking period, there were 4 episodes of ventricular tachycardia over the next 46 patient-months, for a reduction from baseline of 99.9%. A reduction in episodes of ventricular tachycardia occurred in all five patients. The mean left ventricular ejection fraction did not decrease with treatment. At 3 months, adjacent lung showed opacities consistent with mild inflammatory changes, which had resolved by 1 year. CONCLUSIONS: In five patients with refractory ventricular tachycardia, noninvasive treatment with electrophysiology-guided cardiac radioablation markedly reduced the burden of ventricular tachycardia. (Funded by Barnes-Jewish Hospital Foundation and others.).
[Mh] Termos MeSH primário: Ablação por Cateter/métodos
Radiocirurgia
Taquicardia Ventricular/radioterapia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cicatriz/complicações
Cicatriz/patologia
Desfibriladores Implantáveis
Eletrocardiografia
Técnicas Eletrofisiológicas Cardíacas
Evolução Fatal
Feminino
Ventrículos do Coração/diagnóstico por imagem
Ventrículos do Coração/patologia
Ventrículos do Coração/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Miocárdio/patologia
Radiocirurgia/efeitos adversos
Radiocirurgia/métodos
Acidente Vascular Cerebral/etiologia
Volume Sistólico
Taquicardia Ventricular/etiologia
Taquicardia Ventricular/fisiopatologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1613773


  9 / 12359 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29236632
[Au] Autor:John RM; Stevenson WG
[Ad] Endereço:From the Cardiovascular Division, Vanderbilt University Medical Center, Nashville.
[Ti] Título:Noninvasive Ablation of Ventricular Tachycardia.
[So] Source:N Engl J Med;377(24):2388-2390, 2017 12 14.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ablação por Cateter
Taquicardia Ventricular
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/cirurgia
Eletrocardiografia
Seguimentos
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMe1713245


  10 / 12359 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29173417
[Au] Autor:Weinstock J; Madias C
[Ad] Endereço:Division of Cardiology, Cardiac Arrhythmia Center, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA. Electronic address: jweinstock1@tuftsmedicalcenter.org.
[Ti] Título:The Subcutaneous Defibrillator.
[So] Source:Card Electrophysiol Clin;9(4):775-783, 2017 Dec.
[Is] ISSN:1877-9190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The transvenous implantable cardioverter-defibrillator (ICD) has been shown in multiple studies to be effective in the prevention of sudden cardiac death in select populations. The Achilles heel of traditional ICD technology has been the transvenous lead. The subcutaneous ICD provides effective sudden death protection while avoiding lead-related complications of traditional transvenous systems. The subcutaneous ICD is a reasonable option for patients with an ICD indication who do not need bradycardia pacing or cardiac resynchronization therapy.
[Mh] Termos MeSH primário: Morte Súbita Cardíaca/prevenção & controle
Desfibriladores Implantáveis
[Mh] Termos MeSH secundário: Seres Humanos
Taquicardia Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE



página 1 de 1236 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde