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[PMID]:29406050
[Au] Autor:Cheung CC; Constantine M; Ahmadi A; Shiau C; Chen LYC
[Ad] Endereço:Division of Hematology, Gordon and Leslie Diamond Health Care Centre, University of British Columbia, Vancouver, British Columbia, Canada.
[Ti] Título:Lymphocyte-Variant Hypereosinophilic Syndrome With Eosinophilic Myocarditis Treated With Steroids and Pegylated Interferon Alfa-2a.
[So] Source:Am J Med Sci;355(2):201-202, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Angiografia Coronária
Eletrocardiografia
Síndrome Hipereosinofílica
Interferon-alfa/administração & dosagem
Imagem por Ressonância Magnética
Miocardite
Polietilenoglicóis/administração & dosagem
Prednisona/administração & dosagem
[Mh] Termos MeSH secundário: Eosinófilos/metabolismo
Feminino
Seres Humanos
Síndrome Hipereosinofílica/sangue
Síndrome Hipereosinofílica/diagnóstico por imagem
Síndrome Hipereosinofílica/tratamento farmacológico
Síndrome Hipereosinofílica/fisiopatologia
Contagem de Leucócitos
Linfócitos/metabolismo
Meia-Idade
Miocardite/sangue
Miocardite/diagnóstico por imagem
Miocardite/tratamento farmacológico
Miocardite/fisiopatologia
Proteínas Recombinantes/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon-alpha); 0 (Recombinant Proteins); 30IQX730WE (Polyethylene Glycols); Q46947FE7K (peginterferon alfa-2a); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  2 / 11552 MEDLINE  
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[PMID]:29340528
[Au] Autor:Hong C; Zhou X; Huang W; Shan P; Dong F
[Ad] Endereço:Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Título:Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units.
[So] Source:Braz J Med Biol Res;51(3):e7050, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. The results showed that compound 1 can improve hemodynamic parameters of, and it may be a good therapeutic option for heart failure in the future.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Cristalografia por Raios X
Elementos da Série dos Lantanídeos/química
Estruturas Metalorgânicas/química
Miocardite/terapia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Masculino
Estruturas Metalorgânicas/uso terapêutico
Camundongos
Modelos Moleculares
Difração de Pó
Termogravimetria
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lanthanoid Series Elements); 0 (Metal-Organic Frameworks)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


  3 / 11552 MEDLINE  
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[PMID]:29278700
[Au] Autor:Wang EW; Han YY; Jia XS
[Ad] Endereço:Department of Cardiac Surgery, Linyi People's Hospital, Linyi 276000, China.
[Ti] Título:PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis.
[So] Source:Biochem Biophys Res Commun;495(4):2475-2481, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types. The study is aimed to explore if PAFR could modulate myocardial I/R injury in mice. PAFR expressions began to up-regulate at 1 h, and reached peak at 24 h. PAFR deletion markedly attenuated myocardial I/R injury, evidenced by the reduced infarct size and the improved cardiac function. Furthermore, PAFR-knockout inhibited inflammatory response, as demonstrated by down-regulated pro-inflammatory cytokines and chemokine, as well as the inactivation of nuclear factor κB (NF-κB). Additionally, PAFR-absence ameliorated oxidative stress induced by myocardial I/R, associated with the up-regulation of superoxide dismutase (SOD) and nuclear respiratory factor 2 (Nrf-2) activity. Finally, PAFR-deficiency impeded apoptosis, which was proved by the decreasing in terminal deoxynucleotidyl transferase (TdT)-mediated dNTP nick end labeling (TUNEL)-positive myocytes, and Caspase-3 cleavage. And the activation of Janus kinase 1-signal transducer and activator of transcription 1 (JAK1/STAT1) pathway was also suppressed by PAFR-knockout. The findings above were confirmed in lipopolysaccharide (LPS)-incubated cardiomyocytes with or without PAFR expressions in vitro. In summary, we supposed that inhibiting PAFR reduced inflammation, oxidative stress and apoptosis, and thus might be a promising therapeutic strategy to alleviate myocardial I/R injury.
[Mh] Termos MeSH primário: Apoptose/imunologia
Traumatismo por Reperfusão Miocárdica/imunologia
Miocardite/imunologia
Estresse Oxidativo/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Traumatismo por Reperfusão Miocárdica/patologia
Miocardite/patologia
Glicoproteínas da Membrana de Plaquetas/genética
Glicoproteínas da Membrana de Plaquetas/imunologia
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Platelet Membrane Glycoproteins); 0 (Receptors, G-Protein-Coupled); 0 (platelet activating factor receptor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:29173361
[Au] Autor:Cheung CC; Constantine M; Ahmadi A; Shiau C; Chen LYC
[Ad] Endereço:Division of Cardiology, University of British Columbia, Vancouver, British Columbia.
[Ti] Título:Eosinophilic Myocarditis.
[So] Source:Am J Med Sci;354(5):486-492, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Persistent eosinophilia can cause cardiac tissue damage, typically in the form of eosinophilic myocarditis, whether the underlying cause is reactive, a clonal myeloid disorder, or idiopathic hypereosinophilic syndrome (HES). Eosinophilic myocarditis ranges from mild localized disease to multifocal widespread infiltrates associated with myocardial necrosis, thrombotic complications and endomyocardial fibrosis. Systemic treatment varies widely depending on the underlying cause, so thorough investigation and precise diagnosis are essential. Evaluation includes assessment for reactive causes of eosinophilia (vasculitis such as eosinophilic granulomatosis and polyangiitis or Churg-Strauss, parasitic infection, autoimmune disease, immunoglobulinG4-related disease, medications and other causes), genetic lesions characteristic of clonal myeloid disorders (platelet-derived growth factor receptor-α, platelet-derived growth factor receptor-ß and fibroblast growth factor receptor 1) and flow cytometry and molecular studies for the aberrant T cells characteristic of lymphocyte-variant HES . Patients with reactive eosinophilia require treatment for the underlying cause, such as antiparasitic therapy for helminthic infection or immunosuppression for eosinophilic granulomatosis and polyangiitis or Churg-Strauss. Those with a myeloid clone often benefit from the tyrosine kinase inhibitor imatinib. Steroids are the first-line treatment for idiopathic HES and lymphocyte-variant HES, and hydroxyurea or (pegylated) interferon-α may be used for relapsed or refractory disease. Mepolizumab, an anti-interleukin-5 monoclonal antibody, is an effective steroid-sparing agent in HES but is not widely available for this indication.
[Mh] Termos MeSH primário: Miocardite
[Mh] Termos MeSH secundário: Seres Humanos
Síndrome Hipereosinofílica/complicações
Síndrome Hipereosinofílica/etiologia
Síndrome Hipereosinofílica/patologia
Síndrome Hipereosinofílica/terapia
Miocardite/diagnóstico
Miocardite/etiologia
Miocardite/patologia
Miocardite/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  5 / 11552 MEDLINE  
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[PMID]:29384884
[Au] Autor:Xu M; Jiang T; Zhou Y; Yang X
[Ad] Endereço:Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.
[Ti] Título:Influence of echocardiographic measurements and renal impairments on the prognosis of fulminant myocarditis.
[So] Source:Medicine (Baltimore);97(5):e9812, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fulminant myocarditis is a severe cardiac emergency that may lead to death if effective cardiopulmonary supports are not provided. This study aimed to evaluate the prognostic predictors in patients with fulminant myocarditis.We retrospectively analyzed the clinical characteristics, complications, laboratory findings, treatments, as well as electrocardiographic and echocardiographic data of 73 consecutive subjects diagnosed with fulminant myocarditis from June 2012 to June 2016. Logistic regression analysis was used to identify the independent predictive factors of nonsurvivor fulminant myocarditis.Ten patients and 63 patients were assigned to the nonsurvivor and survivor fulminant myocarditis groups, respectively. Patients in the nonsurvivor fulminant myocarditis group had higher heart rates; were more likely to develop clinical complications and supraventricular tachycardia (SVT); and had higher serum creatinine (Scr) level, and had higher white blood cell (WBC) counts, and lower abbreviated estimated glomerular filtration rates (eGFR) than the patients in the survivor fulminant myocarditis group. Moreover, we observed larger left atrium dimension (LAd), larger left ventricular end systolic dimensions, and lower left ventricular ejection fraction in the patients from the nonsurvivor fulminant myocarditis group than in those from the other group. A logistic regression model was constructed and demonstrated that eGFR and LAd were 2 independent predictors of mortality in patients with fulminant myocarditis.Higher heart rates, higher incidences of clinical complication, SVT, higher admission levels of Scr and eGFR, higher WBC counts, higher Scr and eGFR at stage of most severe renal damage, and abnormal echocardiographic findings were associated with high risk of mortality in patients with fulminant myocarditis. The major finding was that eGFR and LAd were independent predictors for in-hospital mortality in patients with fulminant myocarditis.
[Mh] Termos MeSH primário: Ecocardiografia
Miocardite/complicações
Miocardite/diagnóstico por imagem
Insuficiência Renal/complicações
[Mh] Termos MeSH secundário: Adulto
Eletrocardiografia
Feminino
Mortalidade Hospitalar
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Miocardite/mortalidade
Prognóstico
Insuficiência Renal/diagnóstico
Insuficiência Renal/mortalidade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009812


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[PMID]:29375113
[Au] Autor:Komuro J; Ueda K; Kaneko M; Nitta S; Kasao M; Yokoyama M
[Ad] Endereço:Department of Cardiology, Tokyo Metropolitan Police Hospital.
[Ti] Título:Various Cardiac Abnormalities Caused by Bacterial Myocarditis.
[So] Source:Int Heart J;59(1):229-232, 2018.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A 69-year-old woman without any past disease history was hospitalized for heart failure. After hospitalization, she showed myocardial infarction, atrioventricular dissociation, and cardiac dysfunction, and finally she passed away despite intensive care. Autopsy revealed that the cardiac abnormalities were due to bacterial myocarditis possibly resulting from urinary tract infection by E. coli. Although bacterial myocarditis is rare in developed countries, we should consider its possibility when patients show various cardiac abnormalities with bacterial infection.
[Mh] Termos MeSH primário: Infecções por Escherichia coli/complicações
Escherichia coli/isolamento & purificação
Bloqueio Cardíaco/etiologia
Infarto do Miocárdio/etiologia
Miocardite/complicações
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Diagnóstico Diferencial
Eletrocardiografia
Infecções por Escherichia coli/diagnóstico
Infecções por Escherichia coli/microbiologia
Evolução Fatal
Feminino
Bloqueio Cardíaco/diagnóstico
Seres Humanos
Infarto do Miocárdio/diagnóstico
Miocardite/diagnóstico
Miocardite/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-651


  7 / 11552 MEDLINE  
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[PMID]:29220410
[Au] Autor:Qiu Y; Ye X; Zhang HM; Hanson P; Zhao G; Tong L; Xie R; Yang D
[Ad] Endereço:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
[Ti] Título:Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.
[So] Source:PLoS Pathog;13(12):e1006744, 2017 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nuclear factor of activated T cells 5 (NFAT5)/Tonicity enhancer binding protein (TonEBP) is a transcription factor induced by hypertonic stress in the kidney. However, the function of NFAT5 in other organs has rarely been studied, even though it is ubiquitously expressed. Indeed, although NFAT5 was reported to be critical for heart development and function, its role in infectious heart diseases has remained obscure. In this study, we aimed to understand the mechanism by which NFAT5 interferes with infection of Coxsackievirus B3 (CVB3), a major cause of viral myocarditis. Our initial results demonstrated that although the mRNA level of NFAT5 remained constant during CVB3 infection, NFAT5 protein level decreased because the protein was cleaved. Bioinformatic prediction and verification of the predicted site by site-directed mutagenesis experiments determined that the NFAT5 protein was cleaved by CVB3 protease 2A at Glycine 503. Such cleavage led to the inactivation of NFAT5, and the 70-kDa N-terminal cleavage product (p70-NFAT5) exerted a dominant negative effect on the full-length NFAT5 protein. We further showed that elevated expression of NFAT5 to counteract viral protease cleavage, especially overexpression of a non-cleavable mutant of NFAT5, significantly inhibited CVB3 replication. Ectopic expression of NFAT5 resulted in elevated expression of inducible nitric oxide synthase (iNOS), a factor reported to inhibit CVB3 replication. The necessity of iNOS for the anti-CVB3 effect of NFAT5 was supported by the observation that inhibition of iNOS blocked the anti-CVB3 effect of NFAT5. In a murine model of viral myocarditis, we observed that treatment with hypertonic saline or mannitol solution upregulated NFAT5 and iNOS expression, inhibited CVB3 replication and reduced tissue damage in the heart. Taken together, our data demonstrate that the anti-CVB3 activity of NFAT5 is impaired during CVB3 infection due to 2A-mediated cleavage of NFAT5. Thus induction of NFAT5 by hypertonic agents may be a promising strategy for the development of anti-CVB3 therapeutics.
[Mh] Termos MeSH primário: Infecções por Coxsackievirus/virologia
Cisteína Endopeptidases/metabolismo
Enterovirus Humano B/enzimologia
Miocardite/virologia
Miócitos Cardíacos/virologia
Fatores de Transcrição/metabolismo
Proteínas Virais/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Animais
Linhagem Celular
Infecções por Coxsackievirus/imunologia
Infecções por Coxsackievirus/metabolismo
Infecções por Coxsackievirus/patologia
Enterovirus Humano B/imunologia
Enterovirus Humano B/fisiologia
Regulação da Expressão Gênica
Seres Humanos
Masculino
Camundongos Endogâmicos A
Mutação
Miocardite/imunologia
Miocardite/metabolismo
Miocardite/patologia
Miócitos Cardíacos/imunologia
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/patologia
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Óxido Nítrico Sintase Tipo II/química
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/metabolismo
Proteólise
Interferência de RNA
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Especificidade por Substrato
Fatores de Transcrição/antagonistas & inibidores
Fatores de Transcrição/química
Fatores de Transcrição/genética
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NFAT5 protein, human); 0 (Nfat5 protein, mouse); 0 (Peptide Fragments); 0 (Recombinant Fusion Proteins); 0 (Transcription Factors); 0 (Viral Proteins); EC 1.14.13.39 (NOS2 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 3.4.22.- (Cysteine Endopeptidases); EC 3.4.22.29 (picornain 2A, Picornavirus)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006744


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[PMID]:29228412
[Au] Autor:Ozawa H; Taoda A; Shinoda T; Yanagi H; Oki M; Takagi A
[Ad] Endereço:Department of General Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya Isehara kanagawa 259-1193, Japan. hide1012@is.icc.u-toka.ac.jp.
[Ti] Título:A Case of Eosinophilic Myocarditis Associated with Cardiogenic Shock.
[So] Source:Tokai J Exp Clin Med;42(4):156-159, 2017 Dec 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The patient was a 32-year-old man with a previous history of bronchial asthma. He was admitted with chief complaints of dyspnea and skin rash associated with itching of the palms and soles of the feet, which began 2 weeks earlier. Because of the presence of cardiac failure and increase in the peripheral blood eosinophil count, eosinophilic myocarditis (EM) was suspected. His blood pressure gradually decreased and the patient went into cardiogenic shock. Therefore, endomyocardial biopsy was performed and was immediately followed by corticosteroid therapy and intra-aortic balloon pump (IABP) placement. With the findings of eosinophil infiltration associated with myocardial interstitial edema on endomyocardial biopsy, EM was diagnosed. In this case, early therapeutic intervention led to resolution of shock resolved and improvement of the peripheral blood eosinophilia and cardiac function; the patient was discharged 33 days after the onset of symptoms. EM is a rare cardiomyopathy in which myocardial eosinophil infiltration is seen. Although it has been perceived as having a mild clinical course, this report described a severe case of EM associated with cardiogenic shock, which improved as a result of early diagnosis and therapeutic intervention.
[Mh] Termos MeSH primário: Eosinofilia/complicações
Miocardite/complicações
Choque Cardiogênico/etiologia
[Mh] Termos MeSH secundário: Adulto
Biópsia
Diagnóstico Precoce
Eosinofilia/diagnóstico
Eosinofilia/patologia
Eosinofilia/terapia
Seres Humanos
Balão Intra-Aórtico
Masculino
Metilprednisolona/administração & dosagem
Miocardite/diagnóstico
Miocardite/patologia
Miocardite/terapia
Miocárdio/patologia
Prednisona/administração & dosagem
Pulsoterapia
Índice de Gravidade de Doença
Choque Cardiogênico/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
VB0R961HZT (Prednisone); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  9 / 11552 MEDLINE  
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[PMID]:29096807
[Au] Autor:Brambatti M; Matassini MV; Adler ED; Klingel K; Camici PG; Ammirati E
[Ad] Endereço:Division of Cardiology, Department of Medicine, University of California San Diego, San Diego, California.
[Ti] Título:Eosinophilic Myocarditis: Characteristics, Treatment, and Outcomes.
[So] Source:J Am Coll Cardiol;70(19):2363-2375, 2017 Nov 07.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Eosinophilic myocarditis (EM) is an acute life-threatening inflammatory disease of the heart. Neither large case series nor clinical trials on this specific myocarditis have been reported. OBJECTIVES: Based on a systematic revision of all published histologically proven cases, this study aimed to describe the clinical presentation, treatment, and outcome of EM. METHODS: The study screened 443 manuscripts in MEDLINE and EMBASE on cases of EM published until June 2017. The authors identified 264 patients and included in the main analysis 179 patients admitted to hospital with histologically proven EM. RESULTS: Median age was 41 years (interquartile range: 27 to 53 years) with similar prevalence in both sexes; pediatric cases (≤16 years of age) accounted for 10.1%. The main symptom at presentation was dyspnea (59.4%), with peripheral eosinophilia observed in 75.9%. Median left ventricular ejection fraction at presentation was 35% (interquartile range: 25% to 50%). The disorders most frequently associated with EM were hypersensitivity and eosinophilic granulomatosis with polyangiitis, which accounted for 34.1% and 12.8% of cases, respectively, whereas idiopathic or undefined forms accounted for 35.7% of cases. Steroids were administered in 77.7% of patients. A temporary mechanical circulatory support (n = 30) was instituted in 16.8% of patients. In-hospital death was 22.3% (n = 40), with the highest occurrence in the hypersensitivity form (36.1%; p = 0.026). CONCLUSIONS: EM has a poor prognosis during the acute phase, despite a publication bias that could have led to an overestimation of mortality. Associated conditions are identified in approximately 65% of cases. Specific trials and multicenter registries are needed to provide evidence-based treatments to improve in-hospital outcome.
[Mh] Termos MeSH primário: Eosinofilia/diagnóstico por imagem
Eosinofilia/terapia
Miocardite/diagnóstico por imagem
Miocardite/terapia
[Mh] Termos MeSH secundário: Adulto
Angiografia Coronária/tendências
Eosinofilia/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Miocardite/epidemiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  10 / 11552 MEDLINE  
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[PMID]:29025554
[Au] Autor:Aquaro GD; Perfetti M; Camastra G; Monti L; Dellegrottaglie S; Moro C; Pepe A; Todiere G; Lanzillo C; Scatteia A; Di Roma M; Pontone G; Perazzolo Marra M; Barison A; Di Bella G; Cardiac Magnetic Resonance Working Group of the Italian Society of Cardiology
[Ad] Endereço:Gabriele Monasterio Foundation, Tuscan Region, Pisa, Italy. Electronic address: aquaro@ftgm.it.
[Ti] Título:Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis With Preserved Systolic Function: ITAMY Study.
[So] Source:J Am Coll Cardiol;70(16):1977-1987, 2017 Oct 17.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prognostic role of cardiac magnetic resonance (CMR) and late gadolinium enhancement (LGE) has not been clarified in acute myocarditis (AM) with preserved left ventricular (LV) ejection fraction (EF). OBJECTIVES: This study sought to evaluate the role of CMR and LGE in the prognosis of AM with preserved LVEF. METHODS: This study analyzed data from ITAMY (ITalian multicenter study on Acute MYocarditis) and evaluated CMR results from 386 patients (299 male; mean age 35 ± 15 years) with AM and preserved LVEF. Clinical follow-up was performed for a median of 1,572 days. A clinical combined endpoint of cardiac death, appropriate implantable cardioverter-defibrillator firing, resuscitated cardiac arrest, and hospitalization for heart failure was used. RESULTS: Among the 374 patients with suitable images, LGE involved the subepicardial layer inferior and lateral wall in 154 patients (41%; IL group), the midwall layer of the anteroseptal wall in 135 patients (36%; AS [anteroseptal] group), and other segments in 59 patients (16%; other-LGE group), and it was absent in 26 patients (no-LGE group). The AS group had a greater extent of LGE and a higher LV end-diastolic volume index than other groups, but levels of inflammatory markers were lower than in the other groups. Kaplan-Meier curve analysis indicated that the AS group had a worse prognosis than the other groups (p < 0.0001). Finally, in multivariable analysis, AS LGE was the best independent CMR predictor of the combined endpoint (odds ratio: 2.73; 95% confidence interval: 1.2 to 5.9; p = 0.01). CONCLUSIONS: In patients with AM and preserved LVEF, LGE in the midwall layer of the AS myocardial segment is associated with a worse prognosis than other patterns of presentation.
[Mh] Termos MeSH primário: Gadolínio
Imagem Cinética por Ressonância Magnética/métodos
Miocardite/diagnóstico por imagem
Miocardite/epidemiologia
Radioisótopos
Função Ventricular Esquerda/fisiologia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Angiografia Coronária/métodos
Feminino
Seguimentos
Seres Humanos
Itália/epidemiologia
Masculino
Meia-Idade
Miocardite/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Radioisotopes); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE



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