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  1 / 13313 MEDLINE  
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[PMID]:29231001
[Au] Autor:Wu JY; Wang D; Kong J; Wang XX; Yu XJ
[Ad] Endereço:Department of Forensic Pathology, Medical College, Shantou University, Shantou 515041, China.
[Ti] Título:[Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia].
[So] Source:Fa Yi Xue Za Zhi;33(1):11-16, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the metabolic characteristics of lethal bradycardia induced by myocardial ischemia in rat's serum. METHODS: A rat myocardial ischemia-bradycardia-sudden cardiac death (MI-B-SCD) model was established, which was compared with the sham-operation group. The metabolic profile of postmortem serum was analyzed by gas chromatography-mass spectrometry (GC-MS), coupled with the analysis of serum metabolic characteristics using metabolomics strategies. RESULTS: The serum metabolic profiles were significantly different between the MI-B-SCD rats and the control rats. Compared to the control rats, the MI-B-SCD rats had significantly higher levels of lysine, ornithine, purine, serine, alanine, urea and lactic acid; and significantly lower levels of succinate, hexadecanoic acid, 2-ketoadipic acid, glyceraldehyde, hexendioic acid and octanedioic acid in the serum. There were some correlations among different metabolites. CONCLUSIONS: There is obvious metabolic alterations in the serum of MI-B-SCD rat. Both lysine and purine have a high value in diagnosing MI-B-SCD. The results are expected to provide references for forensic and clinical applications of prevention and control of sudden cardiac death.
[Mh] Termos MeSH primário: Bradicardia/metabolismo
Morte Súbita Cardíaca
Cromatografia Gasosa-Espectrometria de Massas/métodos
Metabolômica/métodos
Isquemia Miocárdica/metabolismo
[Mh] Termos MeSH secundário: Animais
Bradicardia/patologia
Doença da Artéria Coronariana
Modelos Animais de Doenças
Lisina/sangue
Lisina/metabolismo
Isquemia Miocárdica/diagnóstico
Purinas/sangue
Purinas/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Purines); K3Z4F929H6 (Lysine); W60KTZ3IZY (purine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.003


  2 / 13313 MEDLINE  
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[PMID]:29231026
[Au] Autor:Song RY; Ding RT; Cui W
[Ad] Endereço:Medical College of Qingdao University, Qingdao 266000, China.
[Ti] Título:[Impact of Myocardial Infarction and Abnormalities of Cardiac Conduction System on Sudden Cardiac Death].
[So] Source:Fa Yi Xue Za Zhi;33(2):171-174, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Sudden cardiac death (SCD), most commonly seen in coronary heart disease, is a kind of sudden death caused by series of cardiac parameters, which usually combines with myocardial infarction. However, some SCDs (including early myocardial infarction) happen suddenly and cause death in a very short time. In these circumstances, typical morphological changes are lack in macroscopic or microscopic fields, which make such SCDs become the emphasis and difficulty in the present research. SCD caused by myocardial infarction and abnormalities of cardiac conduction system (CCS) is related to atherosclerosis of coronary artery closely. This paper reviews cardiac dysfunction caused by myocardial infarction and diseases of CCS from morphology and molecular biology, and explores potential relationship between them. This paper aims to provide clues to the mechanism of myocardial infarction related sudden death and possible assistance for forensic diagnosis of SCD.
[Mh] Termos MeSH primário: Morte Súbita Cardíaca
Sistema de Condução Cardíaco/fisiopatologia
Infarto do Miocárdio/complicações
[Mh] Termos MeSH secundário: Doença das Coronárias
Morte Súbita Cardíaca/etiologia
Seres Humanos
Infarto do Miocárdio/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.014


  3 / 13313 MEDLINE  
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[PMID]:29324812
[Au] Autor:Pujades-Rodriguez M; Guttmann OP; Gonzalez-Izquierdo A; Duyx B; O'Mahony C; Elliott P; Hemingway H
[Ad] Endereço:Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.
[Ti] Título:Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records.
[So] Source:PLoS One;13(1):e0191214, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: To evaluate unmet clinical need in unselected hypertrophic cardiomyopathy (HCM) patients to determine the risk of a wide range of subsequent cardiovascular disease endpoints and safety endpoints relevant for trial design. METHODS: Population based cohort (CALIBER, linked primary care, hospital and mortality records in England, period 1997-2010), all people diagnosed with HCM were identified and matched by age, sex and general practice with ten randomly selected people without HCM. Random-effects Poisson models were used to assess the associations between HCM and cardiovascular diseases and bleeding. RESULTS: Among 3,290,455 eligible people a diagnosis of hypertrophic cardiomyopathy was found in 4 per 10,000. Forty-one percent of the 1,160 individuals with hypertrophic cardiomyopathy were women and the median age was 57 years. The median follow-up was 4.0 years. Compared to general population controls, people with HCM had higher risk of ventricular arrhythmia (incidence rate ratio = 23.53, [95% confidence interval 12.67-43.72]), cardiac arrest or sudden cardiac death (6.33 [3.69-10.85]), heart failure (4.31, [3.30-5.62]), and atrial fibrillation (3.80 [3.04-4.75]). HCM was also associated with a higher incidence of myocardial infarction ([MI] 1.90 [1.27-2.84]) and coronary revascularisation (2.32 [1.46-3.69]).The absolute Kaplan-Meier risks at 3 years were 8.8% for the composite endpoint of cardiovascular death or heart failure, 8.4% for the composite of cardiovascular death, stroke or myocardial infarction, and 1.5% for major bleeding. CONCLUSIONS: Our study identified major unmet need in HCM and highlighted the importance of implementing improved cardiovascular prevention strategies to increase life-expectancy of the contemporary HCM population. They also show that national electronic health records provide an effective method for identifying outcomes and clinically relevant estimates of composite efficacy and safety endpoints essential for trial design in rare diseases.
[Mh] Termos MeSH primário: Cardiomiopatia Hipertrófica/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Algoritmos
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/mortalidade
Estudos de Coortes
Morte Súbita Cardíaca/etiologia
Registros Eletrônicos de Saúde
Inglaterra
Feminino
Insuficiência Cardíaca/etiologia
Hemorragia/etiologia
Seres Humanos
Incidência
Masculino
Meia-Idade
Infarto do Miocárdio/etiologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191214


  4 / 13313 MEDLINE  
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[PMID]:29381985
[Au] Autor:Mu J; Zhang G; Xue D; Xi M; Qi J; Dong H
[Ad] Endereço:Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei.
[Ti] Título:Sudden cardiac death owing to arrhythmogenic right ventricular cardiomyopathy: Two case reports and systematic literature review.
[So] Source:Medicine (Baltimore);96(47):e8808, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is increasingly recognized in forensic practice with controversial diagnosis. Here we described the epidemiological characteristics and reported the pathogenetic mechanism, diagnostic challenges, and forensic implications of Chinese ARVC autopsy cases. METHODS: Two cases of sudden cardiac death owing to ARVC were reported. Retrospective analysis were performed on such 2 cases and 45 cases of separate ARVC complete autopsy case reports through Chinese literature databases in the last 30 years. RESULTS: There were 27 males and 20 females, and the mean age at death was 35 years. Sudden cardiac death was the first manifestation observed in most patients, with no previous family and medical history. Exercise, acute stress, increased cardiac workload, and ethanol are frequently involved. The mean heart weight was 393 g (range, 240-590 g), and 10 cases had relative heart hypertrophy. Microscopic abnormalities included replacement of myocardium by adipose infiltration in 68.09% cases and fibroadipose in 31.91% cases; 80.85% cases were restricted to the right ventricle (RV), whereas biventricular subtype was seen in the remaining 19.15% cases. The preliminary quantitative histology showed 60.7% of fat tissues, 12.1% of fibrosis, and 27.2% residual myocytes in RV. Inflammatory cell infiltration was found in 25.53% cases, but myocyte necrosis was found in only 1 case. In 10.64% of cases, cardiac conduction was infiltrated by fibrosis, adipose, or both. CONCLUSION: In this review, the most characteristic and distinct histopathologic features that are diagnostic or highly suggestive of ARVC for forensic pathologists were identified. Combining gross and histological examinations with postmortem genetic analysis is recommended for identifying ARVC.
[Mh] Termos MeSH primário: Displasia Arritmogênica Ventricular Direita/complicações
Morte Súbita Cardíaca/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Displasia Arritmogênica Ventricular Direita/patologia
Autopsia
Cardiomegalia/complicações
Cardiomegalia/patologia
Feminino
Ventrículos do Coração/patologia
Seres Humanos
Masculino
Meia-Idade
Miocárdio/patologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008808


  5 / 13313 MEDLINE  
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[PMID]:29382016
[Au] Autor:Chun DI; Lee S; Won SH; Cho J
[Ad] Endereço:Department of Orthopedic Surgery, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul.
[Ti] Título:Fatal pulmonary thromboembolism after Achilles tendon open repair: A rare case report.
[So] Source:Medicine (Baltimore);96(47):e8887, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The operative procedure for Achilles tendon rupture is relatively simple, but venous thromboembolism is serious complication with a high incidence after Achilles tendon rupture. However, the guideline for thromboprophylaxis in Achilles tendon rupture is unclear. PATIENT CONCERNS: The patient was 32-year-old male and underwent Achilles tendon open repair surgery. He was healthy and there are no abnormal findings other than Achilles tendon rupture. At 3 weeks after operation, the episode of loss of consciousness with convulsive movement occurred. The next day, suddenly cardiac arrest occurred. DIAGNOSES: Extensive pulmonary thromboembolism in both pulmonary arteries was identified in chest computed tomography and thrombus was also identified at the left popliteal vein on ultrasonography. INTERVENTION: Anticoagulant therapy with heparin sodium was performed to manage the pulmonary thromboembolism. OUTCOMES: Brain swelling after ischemic brain damage, acute kidney injury, and pneumonia gradually occurred and aggravated. His condition became worse and he died about 2 weeks after the cardiac arrest episode. LESSONS: Although the incidence of venous thromboembolism in Achilles tendon rupture is higher than that in lower leg injury patients, guideline for thromboprophylaxis is unclear. We suggest that thromboprophylaxis for Achilles tendon rupture should be considered and appropriate guidelines should be established.
[Mh] Termos MeSH primário: Tendão do Calcâneo/cirurgia
Morte Súbita Cardíaca/etiologia
Complicações Pós-Operatórias
Embolia Pulmonar/etiologia
Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos
Ruptura/cirurgia
[Mh] Termos MeSH secundário: Tendão do Calcâneo/lesões
Adulto
Evolução Fatal
Seres Humanos
Masculino
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008887


  6 / 13313 MEDLINE  
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[PMID]:29178898
[Au] Autor:Castro L; Pecha S; Linder M; Vogler J; Gosau N; Meyer C; Willems S; Reichenspurner H; Hakmi S
[Ad] Endereço:Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany. l.castro@uke.de.
[Ti] Título:The wearable cardioverter defibrillator as a bridge to reimplantation in patients with ICD or CRT-D-related infections.
[So] Source:J Cardiothorac Surg;12(1):99, 2017 Nov 25.
[Is] ISSN:1749-8090
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The approach to treat device infection in patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) is a challenging procedure. Optimal treatment is complete extraction of the infected device. To protect these patients from sudden cardiac arrest while waiting for reimplantation and to avoid recurrent infection, a wearable cardioverter defibrillator (WCD) seems to be a valuable solution. Therefore, we investigated the management and outcome of patients with ICD or CRT-D infections using the WCD as a bridge to re-implantation after lead extraction procedures. METHODS: We conducted a retrospective study on consecutive patients who underwent ICD or CRT-D removal due to device-related local or systemic infections. All patients were prescribed a WCD at our center between 01/2012 and 10/2015. All patients returned to our outpatient clinic for regular ICD or CRT-D monitoring initially 1 and 3 months after reimplantation followed by 6-months intervals. RESULTS: Twenty-one patients (mean age 65.0 ± 8.0 years, male 76.2%) were included in the study. Complete lead extraction was achieved in all patients. While waiting for reimplantation one patient experienced a symptomatic episode of sustained ventricular tachycardia. This episode was converted successfully into sinus rhythm by a single 150 J shock. Mean follow-up time 392 ± 206 days, showing survival rate of 100% and freedom from reinfection in all patients. CONCLUSION: The WCD seems to be a valuable bridging option for patients with ICD or CRT-D infections, showing no recurrent device infection.
[Mh] Termos MeSH primário: Morte Súbita Cardíaca/prevenção & controle
Desfibriladores Implantáveis
Cardioversão Elétrica/instrumentação
Infecções Relacionadas à Prótese/epidemiologia
Taquicardia Ventricular/terapia
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/uso terapêutico
Remoção de Dispositivo
Eletrocardiografia
Feminino
Alemanha/epidemiologia
Seres Humanos
Incidência
Masculino
Infecções Relacionadas à Prótese/etiologia
Infecções Relacionadas à Prótese/terapia
Reimplante
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Taquicardia Ventricular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1186/s13019-017-0669-2


  7 / 13313 MEDLINE  
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[PMID]:28452637
[Au] Autor:Asif IM; Harmon KG
[Ad] Endereço:Department of Family Medicine, Greenville Health System, University of South Carolina-Greenville School of Medicine, Greenville, South Carolina.
[Ti] Título:Incidence and Etiology of Sudden Cardiac Death: New Updates for Athletic Departments.
[So] Source:Sports Health;9(3):268-279, 2017 May/Jun.
[Is] ISSN:1941-0921
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Sudden cardiac death (SCD) in a young athlete is a tragic event and is the leading medical cause of death in this population. The precise incidence of SCD in young athletes has been subject of debate, with studies reporting drastically different rates (1:917,000 athlete-years (AYs) to 1:3000 AYs) depending on the methodological design of the investigation or the targeted population. EVIDENCE ACQUISITION: A literature search was performed in PubMed using the terms: incidence, sudden cardiac death, sudden death, sudden cardiac arrest, etiology, pathology, registry, athlete, young, children, and adolescents. Articles were reviewed for relevance and included if they contained information on the incidence of SCD in athletes or young persons up to the age of 35 years. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 5. RESULTS: Studies of high quality and rigor consistently yield an incidence of 1:50,000 AYs in college athletes and between 1:50,000 and 1:80,000 AYs for high school athletes, with certain subgroups that appear to be at particularly high risk, including the following: men, basketball players, and African Americans. Initial reports suggest that the most common cause of SCD is hypertrophic cardiomyopathy (HCM). However, more comprehensive investigations in the United States and international populations-athletes, nonathletes, and military-support that the most common finding on autopsy in young individuals with SCD is actually a structurally normal heart (autopsy-negative sudden unexplained death). CONCLUSION: SCD is the leading cause of death in athletes during exercise and usually results from intrinsic cardiac conditions that are triggered by the physiologic demands of vigorous exercise. Current rates of SCD appear to be at least 4 to 5 times higher than previously estimated, with men, African Americans, and male basketball players being at greatest risk. Emerging data suggest that the leading finding associated with SCD in athletes is actually a structurally normal heart (autopsy-negative sudden unexplained death).
[Mh] Termos MeSH primário: Morte Súbita Cardíaca/epidemiologia
Morte Súbita Cardíaca/etiologia
Esportes/estatística & dados numéricos
[Mh] Termos MeSH secundário: Autopsia/estatística & dados numéricos
Cardiomiopatia Hipertrófica/complicações
Morte Súbita Cardíaca/prevenção & controle
Exercício/fisiologia
Seres Humanos
Incidência
Programas de Rastreamento
Militares/estatística & dados numéricos
Estudantes/estatística & dados numéricos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1177/1941738117694153


  8 / 13313 MEDLINE  
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[PMID]:29173409
[Au] Autor:Huang WA; Boyle NG; Vaseghi M
[Ad] Endereço:UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, 100 MP, Suite 660, Los Angeles, CA 90095, USA.
[Ti] Título:Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.
[So] Source:Card Electrophysiol Clin;9(4):665-679, 2017 Dec.
[Is] ISSN:1877-9190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural remodeling in the autonomic nervous system contributes to sudden cardiac death. The fabric of cardiac excitability and propagation is controlled by autonomic innervation. Heart disease predisposes to malignant ventricular arrhythmias by causing neural remodeling at the level of the myocardium, the intrinsic cardiac ganglia, extracardiac intrathoracic sympathetic ganglia, extrathoracic ganglia, spinal cord, and the brainstem, as well as the higher centers and the cortex. Therapeutic strategies at each of these levels aim to restore the balance between the sympathetic and parasympathetic branches. Understanding this complex neural network will provide important therapeutic insights into the treatment of sudden cardiac death.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo
Morte Súbita Cardíaca
Coração/inervação
[Mh] Termos MeSH secundário: Seres Humanos
Taquicardia Ventricular
Fibrilação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  9 / 13313 MEDLINE  
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[PMID]:29310415
[Au] Autor:Abramavicius S; Zemaitis M; Pilvinis V; Kadusevicius E
[Ad] Endereço:Institute of Physiology and Pharmacology.
[Ti] Título:Cisplatin-induced sudden cardiac death with hemodynamic collapse: a severe adverse drug reaction: Case report.
[So] Source:Medicine (Baltimore);96(48):e8995, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cisplatin is responsible for a significant percentage of adverse drug reactions (ADRs) in oncology setting. A great proportion of cisplatin-induced severe adverse events are difficult to foresee, and giving premedication does not always prevent the occurrence of such events. PATIENT CONCERNS: A 53-year-old woman with progressive T4 N0 M0 stage IV pleural mesothelioma experienced cardiac arrest with hemodynamic collapse after cisplatin and pemetrexed chemotherapy administration. DIAGNOSES: Progressive pleural T4 N0 M0 stage IV mesothelioma of the right lung, primary arterial hypertension, and cardiac arrest with hemodynamic collapse. INTERVENTIONS: The cisplatin and pemetrexed chemotherapy was administered intravenously for progressive pleural T4 N0 M0 stage IV mesothelioma of the right lung. During infusion of cisplatin the patient developed cardiac arrest, and cardiopulmonary resuscitation was initiated. OUTCOMES: The patient was treated in intensive care unit and recovered successfully. Further chemotherapy with cisplatin and pemetrexed was withheld due to this severe adverse reaction to cisplatin. LESSONS: Cisplatin therapy should be thoroughly monitored including electrolyte, especially magnesium levels. Absence of previous ADRs to cisplatin and premedication should not give false sense of security.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Cisplatino/efeitos adversos
Morte Súbita Cardíaca/etiologia
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Cisplatino/uso terapêutico
Feminino
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Mesotelioma/tratamento farmacológico
Meia-Idade
Pemetrexede/uso terapêutico
Neoplasias Pleurais/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 04Q9AIZ7NO (Pemetrexed); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008995


  10 / 13313 MEDLINE  
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[PMID]:29240772
[Au] Autor:Roberts PR; Zachariah D; Morgan JM; Yue AM; Greenwood EF; Phillips PC; Kalra PA; Green D; Lewis RJ; Kalra PR
[Ad] Endereço:Southampton University Hospitals, Southampton, United Kingdom.
[Ti] Título:Monitoring of arrhythmia and sudden death in a hemodialysis population: The CRASH-ILR Study.
[So] Source:PLoS One;12(12):e0188713, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: It has been suggested that sudden cardiac death (SCD) contributes around 50% of cardiovascular and 27% of all-cause mortality in hemodialysis patients. The true burden of arrhythmias and arrhythmic deaths in this population, however, remains poorly characterised. Cardio Renal Arrhythmia Study in Hemodialysis (CRASH-ILR) is a prospective, implantable loop recorder single centre study of 30 established hemodialysis patients and one of the first to provide long-term ambulatory ECG monitoring. METHODS: 30 patients (60% male) aged 68±12 years receiving hemodialysis for 45±40 months with varied etiology (diabetes 37%, hypertension 23%) and left ventricular ejection fraction (LVEF) 55±8% received a Reveal XT implantable loop recorder (Medtronic, USA) between August 2011 and October 2014. ECG data from loop recorders were transmitted at each hemodialysis session using a remote monitoring system. Primary outcome was SCD or implantation of a (tachy or bradyarrhythmia controlling) device and secondary outcome, the development of arrhythmia necessitating medical intervention. RESULTS: During 379,512 hours of continuous ECG monitoring (mean 12,648±9,024 hours/patient), there were 8 deaths-2 SCD and 6 due to generalised deterioration/sepsis. 5 (20%) patients had a primary outcome event (2 SCD, 3 pacemaker implantations for bradyarrhythmia). 10 (33%) patients reached an arrhythmic primary or secondary end point. Median event free survival for any arrhythmia was 2.6 years (95% confidence intervals 1.6-3.6 years). CONCLUSIONS: The findings confirm the high mortality rate seen in hemodialysis populations and contrary to initial expectations, bradyarrhythmias emerged as a common and potentially significant arrhythmic event.
[Mh] Termos MeSH primário: Arritmias Cardíacas/fisiopatologia
Morte Súbita Cardíaca
Monitorização Fisiológica
Diálise Renal
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188713



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