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[PMID]:28453792
[Au] Autor:Risteski P; Monsefi N; Miskovic A; Josic T; Bala S; Salem R; Zierer A; Moritz A
[Ad] Endereço:Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.
[Ti] Título:Triple valve surgery through a less invasive approach: early and mid-term results.
[So] Source:Interact Cardiovasc Thorac Surg;24(5):677-682, 2017 05 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: A partial upper sternotomy has become established as a less invasive approach mainly for single and double valve surgery. This report evaluates the clinical outcomes of triple valve surgery performed through a partial upper sternotomy. METHODS: We reviewed the medical records of 37 consecutive patients (28 men, 76%) who underwent triple valve surgery through a partial upper sternotomy between 2005 and 2015. The patients' mean age was 67 ± 17 years; 27 (73%) were in New York Heart Association Class III or IV. Aortic and mitral valve insufficiency was more common than stenosis. Ninety-three percent of surviving patients were followed for a mean period of 58 ± 24 months. RESULTS: Aortic valve procedures consisted of 24 (65%) replacements and 13 (35%) repairs. The mitral valve was repaired in 28 (76%) patients, whereas tricuspid valve repair was feasible in all patients. No conversion to full sternotomy was necessary. Myocardial infarction was not observed. Chest tube drainage was 330 ± 190 ml, and 4 patients required reopening for bleeding (1, 3%) or tamponade (3, 8%). One stroke was observed due to heparin-induced thrombocytopaenia after initial unremarkable neurological recovery. Early mortality included 5 (13.5%) patients. Actuarial survival at 5 years was 52 ± 10%. CONCLUSIONS: A partial upper sternotomy provides adequate exposure to all heart valves. We did not experience technical limitations with this approach. Wound dehiscence, postoperative bleeding, intensive care unit and hospital stay and early deaths were low compared to data from other published series of triple valve surgery through a full median sternotomy. Early and mid-term outcomes were not adversely affected by this less invasive approach.
[Mh] Termos MeSH primário: Valva Aórtica/cirurgia
Procedimentos Cirúrgicos Cardíacos/métodos
Doenças das Valvas Cardíacas/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Valva Mitral/cirurgia
Esternotomia/métodos
Valva Tricúspide/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Tempo de Internação
Masculino
Meia-Idade
Insuficiência da Valva Mitral/cirurgia
Estudos Retrospectivos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivw430


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[PMID]:29300071
[Au] Autor:Del Forno B; Castiglioni A; Sala A; Geretto A; Giacomini A; Denti P; De Bonis M; Alfieri O
[Ad] Endereço:Cardiac Surgery Unit San Raffaele Hospital - Scientific Institute Via Olgettina, 60 20132. Milano, Italy.
[Ti] Título:Mitral valve annuloplasty.
[So] Source:Multimed Man Cardiothorac Surg;2017, 2017 Oct 06.
[Is] ISSN:1813-9175
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mitral valve prosthetic ring annuloplasty represents a key milestone in the history of mitral valve repair, delivering restoration of annular shape and size. Increased leaflet coaptation, together with significant reduction in stress on sutures, has ensured predictability and immediate stability for valve repair, both of which were lacking with previous techniques. Long-term durability of repair seems to be positively affected by placement of an annuloplasty ring, and by following the well-established, standardized approach described in our tutorial, this procedure can be performed with a very low surgical risk.
[Mh] Termos MeSH primário: Doenças das Valvas Cardíacas/cirurgia
Anuloplastia da Valva Mitral/métodos
Valva Mitral/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1510/mmcts.2017.016


  3 / 19865 MEDLINE  
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[PMID]:29366749
[Au] Autor:Gonzalez EA; Martins GR; Tavares AMV; Viegas M; Poletto E; Giugliani R; Matte U; Baldo G
[Ad] Endereço:Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil.
[Ti] Título:Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice.
[So] Source:Life Sci;196:102-109, 2018 Mar 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder with multisystemic features, including heart enlargement, heart valve dysfunction, and aortic stiffness and dilatation. Previous studies have shown that MPS I mice overexpress cathepsin B (CtsB) in multiple tissues, including those from the cardiovascular system. Here, we hypothesized that inhibition of CtsB could ameliorate cardiac function parameters, as well as aorta and valve abnormalities found in MPS I. First, we found that total elastase activity in an MPS I aorta is elevated. Following that, we demonstrated that CtsB leaks from the lysosome in MPS I human fibroblasts, possibly acting as a degradative agent of extracellular matrix components from the aorta, cardiac muscle, and heart valves. We then used a CtsB inhibitor in vivo in the MPS I mouse model. After 4 months of treatment, partial inhibition of CtsB activity in treated mice reduced aortic dilatation, as well as heart valve thickening, and led to improvements in cardiac function parameters, although none of these were completely normalized. Based on these results, we conclude that lysosomal alterations in this disease promote leakage of CtsB to outside the organelle, where this protein can have multiple pathological roles. CtsB inhibition improved cardiovascular parameters in MPS I mice and can have a potential benefit in this disease.
[Mh] Termos MeSH primário: Sistema Cardiovascular/patologia
Catepsina B/antagonistas & inibidores
Inibidores de Cisteína Proteinase/uso terapêutico
Dipeptídeos/uso terapêutico
Mucopolissacaridose I/diagnóstico por imagem
Mucopolissacaridose I/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Aorta/patologia
Aorta/fisiopatologia
Sistema Cardiovascular/diagnóstico por imagem
Catepsina B/metabolismo
Colagenases/metabolismo
Feminino
Fibroblastos/metabolismo
Testes de Função Cardíaca
Doenças das Valvas Cardíacas/diagnóstico por imagem
Doenças das Valvas Cardíacas/tratamento farmacológico
Doenças das Valvas Cardíacas/patologia
Seres Humanos
Lisossomos/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Mucopolissacaridose I/patologia
Elastase Pancreática/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cysteine Proteinase Inhibitors); 0 (Dipeptides); 134448-10-5 (N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline); EC 3.4.21.36 (Pancreatic Elastase); EC 3.4.22.1 (Cathepsin B); EC 3.4.24.- (Collagenases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29384880
[Au] Autor:Rong S; Qiu X; Jin X; Shang M; Huang Y; Tang Z; Yuan W
[Ad] Endereço:Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai.
[Ti] Título:Risk factors for heart valve calcification in chronic kidney disease.
[So] Source:Medicine (Baltimore);97(5):e9804, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC, respectively) are critical indicators of CVD and all-cause mortality in CKD patients.We conducted a single center retrospective study of Chinese inpatients with CKD to identify risk factors associated with valve calcification (VC).Of 288 enrolled CKD patients, 22.9% had VC, all of which exhibited AVC, while 21.2% exhibited MVC. The VC group were significantly older than the non-VC group (70.42 ±â€Š11.83 vs 56.47 ±â€Š15.00, P < .001), and contained more patients with history of coronary artery disease (12.1% vs 4.5%, P = .025) or stroke (18.2% vs 5.4%, P < .001). Subjective global assessment scoring indicated that more VC patients were mid/severely malnourished. Levels of prealbumin, cholesterol (Ch), triglycerides, low-density lipoprotein (LDL), apolipoprotein E, ejection fraction, and fraction shortening were significantly lower, and blood C reactive protein, IL-6, left ventricular internal end diastole diameter measured in end diastole, and interventricular septum thickness (IVST) levels were significantly higher in the VC group. Bone metabolism did not differ significantly between the 2 groups. Multivariable logistic regression analysis indicated that age, blood Ch, and LDL levels were significantly associated with VC.Advanced age, increased IVST, hypocholesterolemia, and hyper-LDL cholesterolemia were key risk factors for VC in Han patients with CKD.
[Mh] Termos MeSH primário: Calcinose/etiologia
Doenças das Valvas Cardíacas/etiologia
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Calcinose/diagnóstico
Calcinose/terapia
China
Feminino
Doenças das Valvas Cardíacas/diagnóstico
Doenças das Valvas Cardíacas/terapia
Seres Humanos
Masculino
Meia-Idade
Insuficiência Renal Crônica/metabolismo
Insuficiência Renal Crônica/terapia
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009804


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[PMID]:29338037
[Au] Autor:Schaefer A; Dickow J; Schoen G; Westhofen S; Kloss L; Al-Saydali T; Reichenspurner H; Philipp SA; Detter C
[Ad] Endereço:Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.
[Ti] Título:Stentless vs. stented bioprosthesis for aortic valve replacement: A case matched comparison of long-term follow-up and subgroup analysis of patients with native valve endocarditis.
[So] Source:PLoS One;13(1):e0191171, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Current retrospective evidence suggests similar clinical and superior hemodynamic outcomes of the Sorin Freedom Solo stentless aortic valve (SFS) (LivaNova PLC, London, UK) compared to the Carpentier Edwards Perimount stented aortic valve (CEP) (Edwards Lifesciences Inc., Irvine, California, USA). To date, no reports exist describing case-matched long-term outcomes and analysis for treatment of native valve endocarditis (NVE). METHODS: From 2004 through 2014, 77 consecutive patients (study group, 59.7% male, 68.9 ± 12.5 years, logEuroSCORE II 7.6 ± 12.3%) received surgical aortic valve replacement (SAVR) with the SFS. A control group of patients after SAVR with the CEP was retrieved from our database and matched to the study group regarding 15 parameters including preoperative endocarditis. Acute perioperative outcomes and follow-up data (mean follow-up time 48.7±29.8 months, 95% complete) were retrospectively analyzed. RESULTS: No differences in early mortality occurred during 30-day follow up (3/77; 3.9% vs. 4/77; 5.2%; p = 0.699). Echocardiographic findings revealed lower postprocedural transvalvular pressure gradients (max. 17.0 ± 8.2 vs. 24.5 ± 9.2 mmHg, p< 0.001/ mean pressure of 8.4 ± 4.1 vs. 13.1 ± 5.9 mmHg, p< 0.001) in the SFS group. Structural valve degeneration (SVD) (5.2% vs. 0%; p = 0.04) and valve explantation due to SVD or prosthetic valve endocarditis (PVE) (9.1% vs. 1.3%; p = 0.04) was more frequent in the SFS group. All-cause mortality during follow-up was 20.8% vs. 14.3% (p = 0.397). When patients were divided into subgroups of NVE and respective utilized bioprosthesis, the SFS presented impaired outcomes regarding mortality in NVE cases (p = 0.031). CONCLUSIONS: The hemodynamic superiority of the SFS was confirmed in this comparison. However, clinical outcomes in terms of SVD and PVE rates, as well as survival after NVE, were inferior in this study. Therefore, we are reluctant to recommend utilization of the SFS for treatment of NVE.
[Mh] Termos MeSH primário: Valva Aórtica/cirurgia
Bioprótese
Endocardite/cirurgia
Doenças das Valvas Cardíacas/cirurgia
Próteses Valvulares Cardíacas
Desenho de Prótese
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Valva Aórtica/diagnóstico por imagem
Valva Aórtica/fisiopatologia
Bioprótese/efeitos adversos
Estudos de Casos e Controles
Ecocardiografia
Endocardite/diagnóstico por imagem
Endocardite/fisiopatologia
Feminino
Seguimentos
Doenças das Valvas Cardíacas/diagnóstico por imagem
Doenças das Valvas Cardíacas/fisiopatologia
Próteses Valvulares Cardíacas/efeitos adversos
Hemodinâmica
Seres Humanos
Masculino
Meia-Idade
Desenho de Prótese/efeitos adversos
Falha de Prótese
Stents/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191171


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[PMID]:29374937
[Au] Autor:Liu ZJ; Shi B; Deng CC; Xu GX; Zhao RZ; Shen CY; Wang ZL; Liu HL
[Ad] Endereço:Department of Cardiology, First Affiliated Hospital, Zunyi Medical College, Zunyi 563003, China.
[Ti] Título:[Optical coherence tomographic analysis of in-stent neoatherosclerosis in lesions with restenosis after drug-eluting stent implantation].
[So] Source:Zhonghua Xin Xue Guan Bing Za Zhi;46(1):44-49, 2018 Jan 24.
[Is] ISSN:0253-3758
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the imaging characteristics and related influencing factors of in-stent neoatherosclerosis (ISNA) in patients with restenosis after drug-eluting stent(DES) implantation with optical coherence tomography(OCT). A total of 25 cases of coronary heart disease patients(DES placement time ≥8 months) with coronary artery angiography showing DES in-stent restenosis (ISR) in Zunyi medical college affiliated hospital from July 2013 to December 2015 were included in this study and patient's data were retrospectively analyzed.In these patients with ISR, OCT images were acquired before percutaneous coronary intervention. Patients were divided into the ISNA group (12 patients and 12 lesions) and non-ISNA group(13 patients and 13 lesions) according to the result of OCT. ISNA on OCT was defined as neointima formation with the presence of lipids or calcification. (1) The incidence of chronic kidney disease and increased low-density lipoprotein cholesterol level in ISNA group were significant higher than that in non-ISNA group(all 0.05). The stent implantation time in ISNA group was longer than that in the non-ISNA group(53.0(14.0, 81.0) months vs. 15.0(8.5, 32.5) months, 0.01). In addition, clinical manifestation of acute coronary syndrome was present in 8 out of 12 patientsin ISNA group, and stable angina pectoris was found in 10 out of 13 casesin non-ISNA group( 0.01). (2) Quantitative analysis of OCT showed that the lumen area was less in ISNA group than in non-ISNA group((3.45±1.82)mm(2) vs. (4.17±1.68)mm(2), 0.01), and neointimal area(3.89(2.26, 5.52)mm(2) vs. 2.96(1.99, 4.22)mm(2), 0.01), neointimal load (53.15(40.18, 67.30)% vs. 41.54(32.08, 56.91)%, 0.01), neointimal thickness(0.98(0.63, 1.36)µm vs. 0.72(0.51, 1.03)µm, 0.01) were higher in ISNA group than in non-ISNA group.(3)Qualitative analysis of OCT showed that the prevalence of homogeneous intima was less in the ISNA group than in the non-ISNA group ((41.42±22.56)% vs.(72.06±18.68)%, 0.05), on the contrary, the heterogeneous intima was more common in the ISNA group ((58.57±22.56)% vs. (27.94±18.68)%, 0.05). There was no significant difference between two groups in the peri-stentmicrovessels (9/12 vs. 5/13, 0.05), and prevalence of intraintimalmicrovessels was higher in the ISNA group than in non-ISNA group (7/12 vs. 2/13, 0.05). In addition, thin cap fibrous plaque(7/12 vs. 0, 0.01), disrupted intima with visible cavity (7/12 vs. 1/13, 0.05),andintraluminal red thrombus(7/12 vs. 1/13, 0.05) were significantly higher in ISNA group than in non-ISNA group. Results of OCT show that ISNA occurs frequently in patients with ISR after DES implantation. The stent implantation time, incidence of chronic kidney disease and higher low-density lipoprotein cholesterol level are associated with the formation of ISNA in these patients.
[Mh] Termos MeSH primário: Reestenose Coronária/terapia
Stents Farmacológicos
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Constrição Patológica
Angiografia Coronária
Vasos Coronários
Doenças das Valvas Cardíacas
Seres Humanos
Neointima
Intervenção Coronária Percutânea
Placa Aterosclerótica
Estudos Retrospectivos
Stents
Fatores de Tempo
Túnica Íntima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3758.2018.01.008


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[PMID]:29269712
[Au] Autor:Liu S; Ren W; Ma C; Yang J
[Ad] Endereço:Department of Cardiovascular Ultrasound, The First Hospital of China Medical University.
[Ti] Título:Congenital Double-Orifice Mitral Valve in Asymptomatic Patients.
[So] Source:Int Heart J;59(1):213-215, 2018 Jan 27.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Congenital double-orifice mitral valve (DOMV) is a rare malformation that may affect both mitral valve and apparatus, and it is usually associated with other cardiac disorders. Asymptomatic DOMV is extremely rare. We present two similar cases of asymptomatic congenital double-orifice mitral valve. Both cases presented functionally normal mitral valve apparatus with two equally sized orifices, which were formed by a central fibrosis. In addition, final confirmatory diagnosis was made using three-dimensional (3D) echocardiography in both cases.
[Mh] Termos MeSH primário: Ecocardiografia Tridimensional/métodos
Doenças das Valvas Cardíacas/congênito
Valva Mitral/anormalidades
[Mh] Termos MeSH secundário: Doenças Assintomáticas
Diagnóstico Diferencial
Doenças das Valvas Cardíacas/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Valva Mitral/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.17-033


  8 / 19865 MEDLINE  
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[PMID]:29176317
[Au] Autor:Du J; Zheng R; Xiao F; Zhang S; He K; Zhang J; Shao Y
[Ad] Endereço:Department of Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
[Ti] Título:Downregulated MicroRNA-195 in the Bicuspid Aortic Valve Promotes Calcification of Valve Interstitial Cells via Targeting SMAD7.
[So] Source:Cell Physiol Biochem;44(3):884-896, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Aortic stenosis caused by leaflet calcification in the bicuspid aortic valve (BAV) is more accelerative than that in the tricuspid aortic valve (TAV). MicroRNA-195 (miR-195) is downregulated more in stenotic than in insufficient BAVs, but its expression in BAVs compared with TAVs is unclear. We aimed to investigate the roles of miR-195 and its calcification-related target SMAD7 in stenotic BAVs compared with those in TAVs. METHODS: Twenty-one stenotic BAV and 29 TAV samples were collected from surgical patients and examined for the expression of miR-195 and SMAD7 by RT-PCR. The samples were also assessed by western blotting and immunohistochemistry for the functional protein alteration associated with calcification. Dual-luciferase assay was performed to determine the putative target of miR-195 before the effects of miR-195 expression on osteogenic progression was demonstrated in cultured porcine valve interstitial cells (VICs). RESULTS: Compared with TAV, the expression of miR-195 was remarkably lower in the BAV leaflet with higher expression of SMAD7, which was then validated as a direct target of miR-195. Their negative correlation was then confirmed in cultured VICs. Under an osteogenic environment, the cellular calcification was promoted in miR-195-repressed VICs expressing higher BMP-2 and Runx2 and higher activity of MMP-2 compared with the controls. Finally, higher MMP-2 and MMP-9 expression and more collagen distribution were observed in BAV than TAV samples. CONCLUSIONS: miR-195 is downregulated more in stenotic BAV than TAV in this study. The downregulation of miR-195 is associated with valvular calcification via targeting SMAD7, which promotes the remodeling of the extracellular matrix.
[Mh] Termos MeSH primário: Valva Aórtica/anormalidades
Doenças das Valvas Cardíacas/metabolismo
MicroRNAs/metabolismo
Proteína Smad7/metabolismo
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Adulto
Idoso
Animais
Antagomirs/metabolismo
Valva Aórtica/metabolismo
Estenose da Valva Aórtica/metabolismo
Estenose da Valva Aórtica/patologia
Sequência de Bases
Proteína Morfogenética Óssea 2/metabolismo
Linhagem Celular
Colágeno/metabolismo
Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo
Feminino
Células HEK293
Seres Humanos
Imuno-Histoquímica
Masculino
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
MicroRNAs/antagonistas & inibidores
MicroRNAs/genética
Meia-Idade
Reação em Cadeia da Polimerase em Tempo Real
Alinhamento de Sequência
Proteína Smad7/antagonistas & inibidores
Proteína Smad7/genética
Suínos
Valva Tricúspide/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (Antagomirs); 0 (Bone Morphogenetic Protein 2); 0 (Core Binding Factor Alpha 1 Subunit); 0 (MIRN195 microRNA, human); 0 (MicroRNAs); 0 (SMAD7 protein, human); 0 (Smad7 Protein); 9007-34-5 (Collagen); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1159/000485356


  9 / 19865 MEDLINE  
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[PMID]:29241483
[Au] Autor:Zack CJ; Fender EA; Chandrashekar P; Reddy YNV; Bennett CE; Stulak JM; Miller VM; Nishimura RA
[Ad] Endereço:Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:National Trends and Outcomes in Isolated Tricuspid Valve Surgery.
[So] Source:J Am Coll Cardiol;70(24):2953-2960, 2017 Dec 19.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Severe isolated disease of the tricuspid valve (TV) is increasing and results in intractable right heart failure. However, isolated TV surgery is rarely performed, and there are little data describing surgical outcomes. OBJECTIVES: The purpose of this study was to evaluate contemporary utilization trends and in-hospital outcomes for isolated TV surgery in the United States. METHODS: Patients age >18 years who underwent TV repair or replacement from 2004 to 2013 were identified using the National Inpatient Sample. Patients with congenital heart disease, with endocarditis, and undergoing concomitant cardiac operations except for coronary bypass surgery were excluded. RESULTS: Over a 10-year period, a total of 5,005 isolated TV operations were performed nationally. Operations per year increased from 290 in 2004 to 780 in 2013 (p < 0.001 for trend). In-hospital mortality was 8.8% and did not vary across the study period. Adjusted in-hospital mortality for TV replacement was significantly higher than TV repair (odds ratio: 1.91; 95% confidence interval: 1.18 to 3.09; p = 0.009). CONCLUSIONS: Isolated TV surgery is rarely performed, although utilization has increased over time. However, despite an increase in surgical volume, operative mortality has not changed. Mortality is greatest in patients undergoing valve replacement. Given the increasing prevalence of isolated TV disease in the population, research into optimal surgical timing and patient selection is critical.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos/utilização
Previsões
Doenças das Valvas Cardíacas/cirurgia
Avaliação de Resultados (Cuidados de Saúde)/tendências
Complicações Pós-Operatórias/epidemiologia
Medição de Risco/métodos
Valva Tricúspide/cirurgia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
Doenças das Valvas Cardíacas/epidemiologia
Mortalidade Hospitalar/tendências
Seres Humanos
Incidência
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Taxa de Sobrevida/tendências
Fatores de Tempo
Resultado do Tratamento
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:29233359
[Au] Autor:Yamauchi S; Iwai S; Tominaga Y; Kugo Y; Hasegawa M; Kayatani F; Takahashi K; Aoki H; Kawata H
[Ad] Endereço:Department of Cardiovascular Surgery, Osaka Women's and Children's Hospital, Osaka, Japan. Electronic address: sanae-y@nyc.odn.ne.jp.
[Ti] Título:Supra-Annular Mitral Valve Replacement in an Infant With Infective Endocarditis.
[So] Source:Ann Thorac Surg;105(1):e27-e29, 2018 Jan.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report the case of a female neonate born at 40 weeks' gestation with no known risk factors. On postnatal day 27, she was transferred to the pediatric intensive care unit and intubated for cardiorespiratory failure; she was diagnosed with group B streptococcus infective endocarditis. Mitral valve vegetations did not improve with antibiotic therapy. Mitral valve surgery was performed on postnatal day 36. A mechanical mitral valve with short-segment polytetrafluoroethylene skirt was inserted into the supra-annular position; gentian violet was applied to the sewing ring and skirt. She was discharged from the hospital after 6 weeks with good cardiac function and normal sinus rhythm.
[Mh] Termos MeSH primário: Endocardite Bacteriana/complicações
Doenças das Valvas Cardíacas/cirurgia
Implante de Prótese de Valva Cardíaca/métodos
Infecções Estreptocócicas/complicações
Streptococcus agalactiae
[Mh] Termos MeSH secundário: Endocardite Bacteriana/diagnóstico por imagem
Endocardite Bacteriana/terapia
Feminino
Doenças das Valvas Cardíacas/diagnóstico
Doenças das Valvas Cardíacas/etiologia
Seres Humanos
Recém-Nascido
Infecções Estreptocócicas/diagnóstico por imagem
Infecções Estreptocócicas/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE



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