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[PMID]:29231001
[Au] Autor:Wu JY; Wang D; Kong J; Wang XX; Yu XJ
[Ad] Endereço:Department of Forensic Pathology, Medical College, Shantou University, Shantou 515041, China.
[Ti] Título:[Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia].
[So] Source:Fa Yi Xue Za Zhi;33(1):11-16, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the metabolic characteristics of lethal bradycardia induced by myocardial ischemia in rat's serum. METHODS: A rat myocardial ischemia-bradycardia-sudden cardiac death (MI-B-SCD) model was established, which was compared with the sham-operation group. The metabolic profile of postmortem serum was analyzed by gas chromatography-mass spectrometry (GC-MS), coupled with the analysis of serum metabolic characteristics using metabolomics strategies. RESULTS: The serum metabolic profiles were significantly different between the MI-B-SCD rats and the control rats. Compared to the control rats, the MI-B-SCD rats had significantly higher levels of lysine, ornithine, purine, serine, alanine, urea and lactic acid; and significantly lower levels of succinate, hexadecanoic acid, 2-ketoadipic acid, glyceraldehyde, hexendioic acid and octanedioic acid in the serum. There were some correlations among different metabolites. CONCLUSIONS: There is obvious metabolic alterations in the serum of MI-B-SCD rat. Both lysine and purine have a high value in diagnosing MI-B-SCD. The results are expected to provide references for forensic and clinical applications of prevention and control of sudden cardiac death.
[Mh] Termos MeSH primário: Bradicardia/metabolismo
Morte Súbita Cardíaca
Cromatografia Gasosa-Espectrometria de Massas/métodos
Metabolômica/métodos
Isquemia Miocárdica/metabolismo
[Mh] Termos MeSH secundário: Animais
Bradicardia/patologia
Doença da Artéria Coronariana
Modelos Animais de Doenças
Lisina/sangue
Lisina/metabolismo
Isquemia Miocárdica/diagnóstico
Purinas/sangue
Purinas/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Purines); K3Z4F929H6 (Lysine); W60KTZ3IZY (purine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.003


  2 / 35625 MEDLINE  
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[PMID]:29419394
[Au] Autor:Morley RL; Sharma A; Horsch AD; Hinchliffe RJ
[Ad] Endereço:North Bristol NHS Trust, Bristol, Bristol, UK.
[Ti] Título:Peripheral artery disease.
[So] Source:BMJ;360:j5842, 2018 02 01.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Aterosclerose/complicações
Transtornos Cerebrovasculares/complicações
Isquemia Miocárdica/complicações
Doença Arterial Periférica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Aterosclerose/patologia
Transtornos Cerebrovasculares/epidemiologia
Complicações do Diabetes
Diagnóstico Diferencial
Inglaterra/epidemiologia
Seres Humanos
Meia-Idade
Isquemia Miocárdica/epidemiologia
Doença Arterial Periférica/complicações
Doença Arterial Periférica/epidemiologia
Doença Arterial Periférica/fisiopatologia
Guias de Prática Clínica como Assunto
Atenção Primária à Saúde/normas
Medição de Risco
Fatores de Risco
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5842


  3 / 35625 MEDLINE  
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[PMID]:28460644
[Au] Autor:Teringova E; Tousek P
[Ad] Endereço:Cardiocenter, Department of Cardiology, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Prague 10, Czech Republic.
[Ti] Título:Apoptosis in ischemic heart disease.
[So] Source:J Transl Med;15(1):87, 2017 May 01.
[Is] ISSN:1479-5876
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice.
[Mh] Termos MeSH primário: Apoptose
Isquemia Miocárdica/patologia
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Seres Humanos
Modelos Biológicos
Isquemia Miocárdica/metabolismo
Receptores de Morte Celular/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Receptors, Death Domain)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s12967-017-1191-y


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[PMID]:27776422
[Au] Autor:Schmidt E; Schöpf AC; Farin E
[Ad] Endereço:a Faculty of Medicine, Section of Health Care Research and Rehabilitation Research , University of Freiburg , Freiburg , Germany.
[Ti] Título:What is competent communication behaviour of patients in physician consultations? - Chronically-ill patients answer in focus groups.
[So] Source:Psychol Health Med;22(8):987-1000, 2017 Sep.
[Is] ISSN:1465-3966
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Many desirable outcomes depend on good patient-physician communication. Patient-based perspectives of what constitutes competent communication behavior with physicians are needed for patient-oriented health care. Therefore it was our main aim to identify competent patient communication skills from the patient's perspective. We also wanted to reveal any differences in opinion among various groups (chronic ischemic heart disease, chronic low back pain, breast cancer). This study examined nine guideline-supported focus groups in rehabilitation centers. The criterion for study inclusion was any one of the three diagnoses. Enrolled in the study were N = 49 patients (32 women) aged M = 60.1 (SD = 12.8). The interview recordings were transcribed and subjected to content analysis. We documented 396 commentaries in these interviews that were allocated to 82 different codes; these in turn resulted in the formation of 12 main topics. Examples are: posing questions, being an active and participatory patient, being aware of emotions and communicating them. This study represents stage two ('documentation of patient and clinician views') in the seven-stage model of communication research. Findings reveal that chronically-ill patients name behaviours that contribute to successful discussion with a physician. These enable us to develop communication trainings and design-measuring tools used for patient-based communication skills.
[Mh] Termos MeSH primário: Neoplasias da Mama/psicologia
Comunicação
Grupos Focais
Alfabetização em Saúde
Dor Lombar/psicologia
Isquemia Miocárdica/psicologia
Relações Médico-Paciente
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Atitude Frente à Saúde
Neoplasias da Mama/reabilitação
Feminino
Seres Humanos
Dor Lombar/reabilitação
Masculino
Meia-Idade
Isquemia Miocárdica/reabilitação
Participação do Paciente
Centros de Reabilitação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1080/13548506.2016.1248450


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[PMID]:29442001
[Au] Autor:Liu C; Zheng H; Xie L; Zhang J
[Ti] Título:Decreased miR-208 induced ischemia myocardial and reperfusion injury by targeting p21.
[So] Source:Pharmazie;71(12):719-723, 2016 Dec 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aberrant expression of miR-208 was previously reported in cardiomyocytes after cardiac ischemia reperfusion (CIR) injury. However, the underlying mechanism has never been elucidated. In the current study, the relative level of miR-208 was determined in the hearts of CIR injury mice models using real time PCR. The effect of miR-208 on cardiomyocytes apoptosis was determined by Hoechst staining and annexin V-PI staining. Meanwhile, caspase3 activity was explored using an assay kit. To identify left ventricular fraction and relative wall thickness, the two-dimensional echocardiography was applied. Dual luciferase assay was applied to determine the target gene of miR-208. Compared with normal control, the level of miR-208 was significantly reduced in the hearts of CIR injury mouse models. Further studies revealed that reduction of miR-208 contributed to reactive oxygen species (ROS) production in the cardiomyocytes. We also found that inhibition of miR-208 prompted cardiomyocyte apoptosis. More importantly, the phosphorylation level of Akt and p38 was enhanced in primary cardiomyocytes transfected with miR-208 inhibitor, indicating a potential stress-response after CIR injury in primary cardiomyocytes. Dual luciferase assay and western blot analysis showed that transfection with miR-208 markedly suppressed the protein expression of p21, suggesting p21 was a target gene of miR-208. To conclude, we showed that reduced miR-208 level enhanced cardiomyocyte apoptosis mainly by targeting p21.
[Mh] Termos MeSH primário: MicroRNAs/genética
Isquemia Miocárdica/genética
Traumatismo por Reperfusão Miocárdica/genética
Proteína Oncogênica p21(ras)/genética
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Caspase 3/biossíntese
Caspase 3/genética
Masculino
Camundongos
MicroRNAs/antagonistas & inibidores
Isquemia Miocárdica/fisiopatologia
Traumatismo por Reperfusão Miocárdica/fisiopatologia
Miócitos Cardíacos/metabolismo
Proteína Oncogênica v-akt/metabolismo
Fosforilação
Cultura Primária de Células
Espécies Reativas de Oxigênio/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Mirn208 microRNA, mouse); 0 (Reactive Oxygen Species); EC 2.7.11.1 (Oncogene Protein v-akt); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.22.- (Casp3 protein, mouse); EC 3.4.22.- (Caspase 3); EC 3.6.5.2 (Oncogene Protein p21(ras))
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6740


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[PMID]:28460026
[Au] Autor:Perrino C; Barabási AL; Condorelli G; Davidson SM; De Windt L; Dimmeler S; Engel FB; Hausenloy DJ; Hill JA; Van Laake LW; Lecour S; Leor J; Madonna R; Mayr M; Prunier F; Sluijter JPG; Schulz R; Thum T; Ytrehus K; Ferdinandy P
[Ad] Endereço:Department of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
[Ti] Título:Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.
[So] Source:Cardiovasc Res;113(7):725-736, 2017 Jun 01.
[Is] ISSN:1755-3245
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischaemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signalling networks activated in the ischaemic/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications, and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischaemia, putting it in the context of the human 'diseasome'. Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischaemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. Thus, the scope of this Position Paper will be to highlight potentials and limitations of these approaches, and to provide recommendations to optimize the search for novel diagnostic or therapeutic targets for acute ischaemia/reperfusion injury and ischaemic heart failure in the post-genomic era.
[Mh] Termos MeSH primário: Cardiologia/normas
Epigênese Genética
Epigenômica/normas
Perfilação da Expressão Gênica/normas
Isquemia Miocárdica/genética
Medicina de Precisão/normas
Transcriptoma
[Mh] Termos MeSH secundário: Biologia Computacional/normas
Bases de Dados Genéticas/normas
Marcadores Genéticos
Predisposição Genética para Doença
Seres Humanos
Isquemia Miocárdica/diagnóstico
Isquemia Miocárdica/terapia
Seleção de Pacientes
Fenótipo
Valor Preditivo dos Testes
Prognóstico
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/cvr/cvx070


  7 / 35625 MEDLINE  
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[PMID]:29177255
[Au] Autor:Qin C; Xia X; Pei Z; Zhang Y; Lan X
[Ad] Endereço:Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. LXL730724@hotmail.com.
[Ti] Título:Cell and gene therapy with reporter gene imaging in myocardial ischemia.
[So] Source:Hell J Nucl Med;20(3):198-203, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Reporter gene/probe systems have proved to be reliable for monitoring gene/cell therapy. We sought to evaluate whether a reporter gene/probe system, namely the human estrogen receptor ligand binding domain (hERL)/16α- F fluoro-17ß-estradiol ( F-FES), could be used for monitoring vascular endothelial growth factor (VEGF) gene expression and response to bone marrow mesenchymal stem cell (MSCs) therapy in ischemic heart disease. ANIMALS AND METHODS: Reporter gene hERL and therapeutic gene VEGF165 were linked through internal ribosome entry site (IRES), and then the recombinant adenovirus vector Adenovirus 5-hERL-IRES-VEGF (Ad5-EIV) was constructed and transfected into MSCs, and named Ad5-EIV-MSCs. Rat myocardial infarction was induced by coronary arterial branch ligature, and Ad5-EIV-MSCs were transplanted by injection into the peripheral myocardium, while non-transfected MSCs transplantation used as controls. Fluorine-18-FDG micro-PET imaging was performed to confirm myocardial infarction 1 day after surgery. Fluorine-18-FES micro-PET/CT images were acquired 2 days after Ad5-EIV-MSCs transplantation. Myocardial specimens were obtained and stained with hematoxylin-eosin (H&E) staining to verify the myocardial infarction. The expression of estrogen receptor (ER) and VEGF was detected using immunohistochemistry (IHC). RESULTS: Rat myocardial infarction models were successfully produced and confirmed by H&E staining. Images of F-FDG PET showed obvious reduced or absent uptake of F-FDG on the infarct myocardium, while uniform and well-distribution on the normal myocardium. F-FES micro-PET/CT showed the tracer notable accumulated in the apical region where Ad5-EIV-MSCs were injected with an uptake value of 0.38±0.09%ID/g, which was much higher than that of surrounding normal myocardium with nearly no uptake of F-FES (0.10±0.03%ID/g, n=5, P<0.05). In the group of non-transfected MSCs, the apical uptake was similar to that of normal myocardium. Immunohistochemistry studies demonstrated positive expression of both ER and VEGF in the involved region accompanied by active angiogenesis. CONCLUSION: This study confirmed that hERL/ F-FES could be used as a reporter gene/probe system for monitoring gene and cell therapy in the ischemic heart disease.
[Mh] Termos MeSH primário: Fluordesoxiglucose F18
Genes Reporter/genética
Terapia Genética/métodos
Transplante de Células-Tronco Mesenquimais/métodos
Isquemia Miocárdica/diagnóstico por imagem
Isquemia Miocárdica/terapia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Animais
Terapia Combinada/métodos
Masculino
Compostos Radiofarmacêuticos
Ratos
Ratos Sprague-Dawley
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910601


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[PMID]:29351337
[Au] Autor:Ghasemi-Roudsari S; Al-Shimary A; Varcoe B; Byrom R; Kearney L; Kearney M
[Ad] Endereço:Department of Physics and Astronomy, University of Leeds, Leeds, United Kingdom.
[Ti] Título:A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain.
[So] Source:PLoS One;13(1):e0191241, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Magnetocardiography (MCG) is a non-invasive technique used to measure and map cardiac magnetic fields. We describe the predictive performance of a portable prototype magnetometer designed for use in acute and routine clinical settings. We assessed the predictive ability of the measurements derived from the magnetometer for the ruling-out of healthy subjects and patients whose chest pain has a non-ischemic origin from those with ischemic heart disease (IHD). METHODS: MCG data were analyzed from a technical performance study, a pilot clinical study, and a young healthy reference group. Participants were grouped to enable differentiation of those with IHD versus non-IHD versus controls: Group A (70 IHD patients); Group B (69 controls); Group C (37 young healthy volunteers). Scans were recorded in an unshielded room. Between-group differences were explored using analysis of variance. The ability of 10 candidate MCG predictors to predict normal/abnormal cases was analyzed using logistic regression. Predictive performance was internally validated using repeated five-fold cross-validation. RESULTS: Three MCG predictors showed a significant difference between patients and age-matched controls (P<0.001); eight predictors showed a significant difference between patients and young healthy volunteers (P<0.001). Logistic regression comparing patients with controls yielded a specificity of 35.0%, sensitivity of 95.4%, and negative predictive value for the ruling-out of IHD of 97.8% (area under the curve 0.78). CONCLUSION: This analysis represents a preliminary indication that the portable magnetometer can help rule-out healthy subjects and patients whose chest pain has a non-ischemic origin from those with IHD.
[Mh] Termos MeSH primário: Cardiopatias/diagnóstico
Magnetocardiografia/instrumentação
Isquemia Miocárdica/diagnóstico
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/diagnóstico
Idoso
Estudos de Casos e Controles
Dor no Peito/diagnóstico
Diagnóstico Diferencial
Feminino
Seres Humanos
Modelos Logísticos
Magnetocardiografia/estatística & dados numéricos
Masculino
Meia-Idade
Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico
Projetos Piloto
Valor Preditivo dos Testes
[Pt] Tipo de publicação:CLINICAL STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191241


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[PMID]:29211220
[Au] Autor:Campos IC; Tanganelli V; Maues HP; Coelho MCM; Martins FA; Munhoz G; Egito JGT; Souza HCC; Giannini CMC; Farsky PS
[Ad] Endereço:Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil.
[Ti] Título:Blood Transfusion and Increased Perioperative Risk in Coronary Artery Bypass Grafts.
[So] Source:Braz J Cardiovasc Surg;32(5):394-400, 2017 Sep-Oct.
[Is] ISSN:1678-9741
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To correlate blood transfusions and clinical outcomes during hospitalization in coronary artery bypass grafting surgery (CABG). METHODS: Transfusion, clinical and hematological data were collected for 1,378 patients undergoing isolated or combined CABG between January 2011 and December 2012. The effect of blood transfusions was evaluated through multivariate analysis to predict three co-primary outcomes: composite ischemic events, composite infectious complications and hospital mortality. Because higher risk patients receive more transfusions, the hospital mortality outcome was also tested on a stratum of low-risk patients to isolate the effect of preoperative risk on the results. RESULTS: The transfusion rate was 63.9%. The use of blood products was associated with a higher incidence of the three coprimary outcomes: composite infectious complications (OR 2.67, 95% CI 1.70 to 4.19; P<0.001), composite ischemic events (OR 2.42, 95% CI 1.70 to 3.46; P<0.001) and hospital mortality (OR 3.07, 95% CI 1.53 to 6.13; P<0.001). When only patients with logistic EuroSCORE ≤ 2% were evaluated, i.e., low-risk individuals, the mortality rate and the incidence of ischemic events and infectious complications composites remained higher among the transfused patients [6% vs. 0.4% (P<0.001), 11.7% vs. 24,3% (P<0.001) and 6.5% vs. 12.7% (P=0.002), respectively]. CONCLUSION: The use of blood components in patients undergoing CABG was associated with ischemic events, infectious complications and hospital mortality, even in low-risk patients.
[Mh] Termos MeSH primário: Transfusão de Sangue/estatística & dados numéricos
Ponte de Artéria Coronária/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Transfusão de Sangue/mortalidade
Ponte de Artéria Coronária/métodos
Ponte de Artéria Coronária/mortalidade
Feminino
Mortalidade Hospitalar
Seres Humanos
Infecção/etiologia
Masculino
Meia-Idade
Isquemia Miocárdica/etiologia
Período Perioperatório
Complicações Pós-Operatórias
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  10 / 35625 MEDLINE  
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[PMID]:29374938
[Au] Autor:Zeng Q; Li P; Ni Y; Li GX; Wang DZ; Pan XC; Jiang GH
[Ad] Endereço:Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
[Ti] Título:[Research on the relationship between atmospheric inhalable particulate matter and cardiovascular diseases burden in Tianjin].
[So] Source:Zhonghua Xin Xue Guan Bing Za Zhi;46(1):50-55, 2018 Jan 24.
[Is] ISSN:0253-3758
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the association between atmospheric inhalable particulate matter (PM(10)) concentration and cardiovascular diseases burden in Tianjin. The data on daily mean concentrations of main pollutants (PM(10), nitrogen dioxide(NO(2)) and sulfur dioxide(SO(2))), meteorological factors (temperature and relative humidity) and population death monitoring data in Tianjin, from January 1, 2001 to December 31, 2010, were collected and analyzed in this study. The death counts and years of life lost were simultaneously used as the indicators of disease burden. The generalized additive model was used to assess the associations between PM(10) and daily death counts and years of life lost due to cardiovascular system diseases in Tianjin by adjusting the confounding factors such as long-term trend, seasons, meteorological factors and other factors related to the long-term variability. The daily average concentration of PM(10) was 117.6 µg/m³ in Tianjin during 2001 to 2011. The daily average number of deaths of cardiovascular system diseases, cerebrovascular diseases and ischemic heart diseases in Tianjin were 38.4, 14.8 and 17.2 people respectively, and the daily average years of life lost were 776.8, 306.5 and 326.1 person years respectively. The effects of PM(10) on the daily death counts of the three diseases categories were statistically significant (all 0.01) in Tianjin and the maximum effect occurs at the moment when PM(1)0 was at moving average concentration of today and lagged 1-day (Lag01). The effects of decreasing order were ischemic heart diseases, cardiovascular system diseases and cerebrovascular diseases, excess risks were 0.53% (95% 0.35%-0.71%), 0.40% (95% 0.28%-0.53%) and 0.38% (95% 0.19%-0.56%). The effects of atmospheric PM(10) on the years of life lost of the three diseases were also statistically significant on the different lag days (all 0.01) in Tianjin and the maximum effect of PM(10) appeared in Lag01. The effects from the largest to the lowest were 2.86 (95% 1.79-3.93) person years for cardiovascular system diseases, 1.59 (95% 0.95-2.23) person years for ischemic heart diseases and 1.07 (95% 0.43-1.71) person years for cerebrovascular diseases, respectively. In multi-pollutant models, after controlling SO(2), the effect of PM(10) on the daily life loss of above 3 kinds of diseases was higher than that of single pollutant model. In contrast, after controlling SO(2) or SO(2) with NO(2), the effect was lower. After controlling NO(2), the effect of PM(10) on the daily life loss of cerebrovascular disease was no longer statistically significant ( 0.05). Exposure to atmospheric PM(10) can significantly increase the cardiovascular diseases burden in Tianjin, especially for ischemic heart diseases. These results suggested that particular attention should be paid to reduce the exposure to atmospheric inhalable particulate matter for patients with ischemic heart diseases.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Doenças Cardiovasculares/epidemiologia
Isquemia Miocárdica/epidemiologia
[Mh] Termos MeSH secundário: Poluição do Ar
China/epidemiologia
Seres Humanos
Material Particulado
Estações do Ano
Dióxido de Enxofre
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Particulate Matter); 0UZA3422Q4 (Sulfur Dioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3758.2018.01.009



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