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[PMID]:29046002
[Au] Autor:Ong P; Sechtem U
[Ti] Título:[Optimal Diagnostics and Therapy for Microvascular Angina Pectoris].
[Ti] Título:Optimale Diagnostik und Therapie der mikrovaskulären Angina pectoris..
[So] Source:Dtsch Med Wochenschr;142(21):1586-1593, 2017 Oct.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Patients with microvascular angina are characterized by angina pectoris with proof of myocardial ischemia in the absence of any relevant epicardial stenosis and without myocardial disease (type 1 coronary microvascular dysfunction according to Crea and Camici). Structural and functional alterations of the coronary microvessels (diameter < 500 µm) are the reason for this phenomenon. Frequently such alterations are associated with cardiovascular risk factors. Patients with angina pectoris without epicardial stenoses represent for 10 - 50 % of all patients undergoing coronary angiography depending on the clinical presentation. Diagnostic approaches include non-invasive (e. g. combination of coronary CT-angiography and positron emission tomography/echo Doppler-based coronary flow reserve measurements) as well as invasive procedures (coronary flow reserve measurements in response to adenosine, intracoronary acetylcholine testing). Pharmacological treatment of these patients is often challenging and should be based on the characterization of the underlying mechanisms. Moreover, strict risk factor control and individually titrated combinations of antianginal substances (e. g. beta blockers, calcium channel blockers, nitrates, ranolazine, ivabradine etc.) are recommended.
[Mh] Termos MeSH primário: Angina Microvascular/diagnóstico
Angina Microvascular/terapia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/uso terapêutico
Bloqueadores dos Canais de Cálcio/uso terapêutico
Fármacos Cardiovasculares/uso terapêutico
Vasoespasmo Coronário/complicações
Vasos Coronários/fisiopatologia
Seres Humanos
Neuroestimuladores Implantáveis
Angina Microvascular/fisiopatologia
Isquemia Miocárdica/complicações
Condicionamento Físico Humano
Fatores de Risco
Bloqueadores dos Canais de Sódio/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Calcium Channel Blockers); 0 (Cardiovascular Agents); 0 (Sodium Channel Blockers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104469


  2 / 973 MEDLINE  
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[PMID]:28966326
[Au] Autor:Katoh M; Takeda N; Arimoto T; Abe H; Oda K; Osuga Y; Fujii T; Komuro I
[Ad] Endereço:Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
[Ti] Título:Bevacizumab-Related Microvascular Angina and Its Management with Nicorandil.
[So] Source:Int Heart J;58(5):803-805, 2017 Oct 21.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Bevacizumab, an inhibitor of vascular endothelial growth factor (VEGF)-A, is currently used to treat patients with ovarian or colon cancer. While several cardiovascular toxicities related to bevacizumab-containing regimens have been reported, the effect of bevacizumab on the coronary microcirculation has not been fully elucidated. Here we report a case of 54-year-old female patient who developed microvascular angina after a series of bevacizumab-containing chemotherapeutic regimen. The discontinuation of bevacizumab and nicorandil administration was effective in alleviating her chest discomfort and the ischemic changes on her ECG. This highlights the possibility that coronary microvascular angina can be induced in patients treated with bevacizumab-containing chemotherapy. It should also be noted that nicorandil can be effective in managing microvascular angina.
[Mh] Termos MeSH primário: Bevacizumab/efeitos adversos
Angina Microvascular/tratamento farmacológico
Nicorandil/administração & dosagem
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/efeitos adversos
Inibidores da Angiogênese/uso terapêutico
Bevacizumab/uso terapêutico
Angiografia Coronária
Circulação Coronária/efeitos dos fármacos
Relação Dose-Resposta a Droga
Eletrocardiografia/efeitos dos fármacos
Feminino
Seguimentos
Seres Humanos
Angina Microvascular/induzido quimicamente
Angina Microvascular/diagnóstico
Meia-Idade
Neoplasias Ovarianas/tratamento farmacológico
Vasodilatadores/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Vasodilator Agents); 260456HAM0 (Nicorandil); 2S9ZZM9Q9V (Bevacizumab)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-537


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[PMID]:28429698
[Au] Autor:Panç C; Kocaaga M; Erdogan O; Sarikaya R; Umman S
[Ad] Endereço:Department of Cardiology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey. caferpanc@gmail.com.
[Ti] Título:Coronary microvascular dysfunction equivalent to left main coronary artery disease.
[So] Source:Turk Kardiyol Dern Ars;45(3):278-280, 2017 Apr.
[Is] ISSN:1308-4488
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Coronary microvascular dysfunction, also known as cardiac syndrome X, is a clinical syndrome presenting with typical angina and evidence of myocardial ischemia in the absence of flow-limiting stenosis on coronary angiography. Of patients undergoing coronary angiography due to suspected myocardial ischemia, 50% are found to have normal or near-normal coronary arteries. Described in this case report is a patient who developed hypotension and ST segment depressions during treadmill exercise test. Left main coronary artery or multivessel disease was suspected. Coronary angiography was normal, but coronary flow reserve measurement revealed severe microvascular dysfunction.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana
Angina Microvascular
[Mh] Termos MeSH secundário: Teste de Esforço
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.5543/tkda.2016.02317


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[PMID]:28103808
[Au] Autor:Lutfi MF
[Ad] Endereço:Department of Physiology, Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan. mohamedfaisallutfi@gmail.com.
[Ti] Título:Ventricular late potential in cardiac syndrome X compared to coronary artery disease.
[So] Source:BMC Cardiovasc Disord;17(1):35, 2017 Jan 19.
[Is] ISSN:1471-2261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although ventricular late potential (VLP) was extensively studied in risk stratification of myocardial infarction (MI) patients, comparable researches evaluating presence of VLP in MI-free coronary artery disease (CAD) and cardiac syndrome X (CSX) subjects are scarce. This study aimed to compare presence of VLP between CSX and CAD patients. METHODS: Signal average ECG (SAECG) was performed to 49 patients with a history of typical cardiac pain before undergoing diagnostic coronary angiography (DCA) in Al-Shaab cardiac center, Khartoum, Sudan. QRS duration, duration of the terminal part of the QRS complex with amplitude less than 40 microvolts (LAS40) and the root mean square voltage of the terminal 40 milliseconds (RMS40) of the filtered QRS complex were identified for each patient. Presence of two or more of QRS duration > 120 ms, RMS40 > 38 ms and LAS40 < 20 µV was considered indicative of VLP. Associations between VLP and patients grouped according to DCA results were assessed using appropriate statistical tests. RESULTS: VLP was present in 11.11% (3.63%-24.66%) and 15.38% (2.66%-42.23%) of patients with CAD and CSX respectively. Presence of VLP was comparable in patients with CAD and CSX (OR = 0.69, 95% CI = 0.11-6.05, P = 0.692), even after controlling for the possible variations in gender, age, body mass index (BMI), hypertension and diabetes mellitus in the studied groups. CONCLUSION: Presence of VLP is comparable among CSX and CAD patients.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/diagnóstico
Eletrocardiografia
Ventrículos do Coração/fisiopatologia
Angina Microvascular/diagnóstico
[Mh] Termos MeSH secundário: Potenciais de Ação
Fatores Etários
Idoso
Índice de Massa Corporal
Doença da Artéria Coronariana/complicações
Doença da Artéria Coronariana/fisiopatologia
Diabetes Mellitus
Feminino
Seres Humanos
Hipertensão/complicações
Modelos Logísticos
Masculino
Angina Microvascular/complicações
Angina Microvascular/fisiopatologia
Meia-Idade
Razão de Chances
Valor Preditivo dos Testes
Fatores de Risco
Fatores Sexuais
Sudão
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1186/s12872-017-0469-6


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[PMID]:28081848
[Au] Autor:Safdar B; D'Onofrio G; Dziura J; Russell RR; Johnson C; Sinusas AJ
[Ad] Endereço:Department of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut. Electronic address: basmah.safdar@yale.edu.
[Ti] Título:Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial.
[So] Source:Clin Ther;39(1):55-63, 2017 Jan.
[Is] ISSN:1879-114X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Coronary microvascular dysfunction (CMD) is a common but underdiagnosed cause of chest pain. Literature is scant regarding effective treatments. We explored the effect of ranolazine on coronary flow reserve (CFR) among symptomatic patients with CMD. METHODS: This pilot double-blinded randomized controlled trial included emergency department patients with chest pain and CMD admitted to an observation unit between June 2014 and November 2015. Participants were assessed by cardiac Rb-82 positron emission tomography and computed tomography imaging at baseline and 30 days. CMD was defined as CFR <2 corrected for rate pressure product or <2.5 uncorrected, with no evidence of obstructive or nonobstructive coronary artery disease or calcification. Patients with infarction, hypertensive urgency, heart failure, or prescribed QTc-prolonging drugs were excluded. Participants were assigned to ranolazine or placebo in a 2:1 ratio. Primary outcome was change in CFR at 30 days. FINDINGS: We enrolled 31 patients (71% female, mean [SD] age 50 [6] years) with CMD (mean [SD] corrected CFR 1.6 [0.3]). Ranolazine improved CFR at 30 days by 17% (P = 0.005) compared with 0% with placebo (P = 0.67). However, there was no significant difference in the primary outcome as measured by mean change in CFR (0.27 ranolazine compared with 0.06 placebo; 95% CI, -0.08 to 0.62). IMPLICATIONS: The emergency department offers a unique venue to diagnose CMD with acute symptoms. In an exploratory randomized controlled trial of symptomatic patients with CMD and no coronary artery disease, promising results were seem with ranolazine and CFR improving at 30 days. Large robust clinical trials are needed to verify improvement of CMD in a sex-specific model. ClinicalTrials.gov identifier NCT02052011.
[Mh] Termos MeSH primário: Angina Microvascular/diagnóstico
Tomografia por Emissão de Pósitrons
Ranolazina/uso terapêutico
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Serviço Hospitalar de Emergência
Feminino
Coração/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
A6IEZ5M406 (Ranolazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


  6 / 973 MEDLINE  
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[PMID]:28068419
[Au] Autor:Lutfi MF
[Ad] Endereço:Department of Physiology - Faculty of Medicine and Health Sciences - Al-Neelain University, Khartoum, Sudan.
[Ti] Título:Anxiety Level and Cardiac Autonomic Modulations in Coronary Artery Disease and Cardiac Syndrome X Patients.
[So] Source:PLoS One;12(1):e0170086, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Anxiety and cardiac autonomic modulations (CAM) were thoroughly investigated in coronary artery disease (CAD) and cardiac syndrome X (CSX) patients worldwide, but not among Sudanese with similar pathology. AIMS: To compare levels of anxiety and CAM between Sudanese patients with CSX and CAD. MATERIALS AND METHODS: Anxiety was evaluated in 51 CAD and 26 CSX patients using Taylor Manifest anxiety score (TMAS) questionnaire while heart rate variability derived indices were used to assess CAM, namely natural logarithm of low frequency (LnLF), high frequency (LnHF) and LF/HF ratio (LnLF/HF). RESULTS: Low anxiety levels were achieved by 6 (23.1%) and 9 (17.6%) patients with CSX and CAD respectively. High anxiety level was achieved by only one (3.8%) patient, who was suffering from CSX. TMAS was significantly higher in CSX (31.27 (21.97)) compared to CAD (21.86 (12.97), P = 0.021). However, abnormally increased anxiety was not associated with higher risk of CSX. LnLF, LnHF and LnLF/HF were comparable in CAD and CSX patients. CONCLUSION: CSX and CAD patients showed comparable CAM. Although anxiety levels were higher in CSX compared to CAD, TMAS ≥ 35 failed to show significant association with CSX.
[Mh] Termos MeSH primário: Ansiedade
Sistema Nervoso Autônomo/fisiopatologia
Doença da Artéria Coronariana/fisiopatologia
Doença da Artéria Coronariana/psicologia
Angina Microvascular/fisiopatologia
Angina Microvascular/psicologia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/diagnóstico
Pressão Sanguínea
Comorbidade
Feminino
Frequência Cardíaca
Seres Humanos
Masculino
Meia-Idade
Sudão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170086


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[PMID]:27870973
[Au] Autor:Michelsen MM; Mygind ND; Pena A; Olsen RH; Christensen TE; Ghotbi AA; Hasbak P; Kjaer A; Gustafsson I; Hansen PR; Hansen HS; Høst N; Kastrup J; Prescott E
[Ad] Endereço:Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: marie.mide.michelsen@regionh.dk.
[Ti] Título:Transthoracic Doppler echocardiography compared with positron emission tomography for assessment of coronary microvascular dysfunction: The iPOWER study.
[So] Source:Int J Cardiol;228:435-443, 2017 Feb 01.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coronary microvascular function can be assessed by transthoracic Doppler echocardiography as a coronary flow velocity reserve (TTDE CFVR) and by positron emission tomography as a myocardial blood flow reserve (PET MBFR). PET MBFR is regarded the noninvasive reference standard for measuring coronary microvascular function but has limited availability. We compared TTDE CFVR with PET MBFR in women with angina pectoris and no obstructive coronary artery disease and assessed repeatability of TTDE CFVR. METHODS: From a cohort of women with angina and no obstructive coronary artery stenosis at invasive coronary angiography, TTDE CFVR by dipyridamole induced stress and MBFR by rubidium-82 PET with adenosine was successfully measured in 107 subjects. Repeatability of TTDE CFVR was assessed in 10 symptomatic women and in 10 healthy individuals. RESULTS: MBFR was systematically higher than CFVR. Median MBFR (interquartile range, IQR) was 2.68 (2.29-3.10) and CFVR (IQR) was 2.31 (1.89-2.72). Pearson's correlation coefficient was 0.36 (p<0.01). Limits of agreement (2·standard deviation) assessed by the Bland-Altman (confidence interval, CI) method was 1.49 (1.29;1.69) and unaffected by time-interval between examinations. Results were similar when adjusting for rate pressure product or focusing on perfusion of the left anterior descending artery region. Limits of agreement (CI) for repeated CFVR in 10 healthy individuals and in 10 women with angina was 0.44 (0.21;0.68) and 0.48 (0.22; 0.74), respectively. CONCLUSION: CFVR had a good repeatability, but the agreement between CFVR and MBFR was modest. Divergence could be due to methodology differences; TTDE estimates flow velocities whereas PET estimates myocardial blood flow.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Circulação Coronária/fisiologia
Vasos Coronários/diagnóstico por imagem
Ecocardiografia Doppler em Cores/métodos
Angina Microvascular/diagnóstico
Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Angiografia Coronária
Vasos Coronários/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Angina Microvascular/fisiopatologia
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


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[PMID]:27848160
[Au] Autor:Cho SG; Park KS; Kim J; Kang SR; Song HC; Kim JH; Cho JY; Hong YJ; Jabin Z; Park HJ; Jeong GC; Kwon SY; Paeng JC; Kim HS; Min JJ; Garcia EV; Bom HH
[Ad] Endereço:Department of Nuclear Medicine, Chonnam National University Hospital, Gwang-ju, South Korea.
[Ti] Título:Coronary flow reserve and relative flow reserve measured by N-13 ammonia PET for characterization of coronary artery disease.
[So] Source:Ann Nucl Med;31(2):144-152, 2017 Feb.
[Is] ISSN:1864-6433
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS: Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVR ) were measured by N-13 ammonia PET. The presence of significant stenosis (SS) and diffuse atherosclerosis (DA) was evaluated on CCTA and CAG. Functional parameters measured by PET were compared among arteries with and without SS and DA. RESULTS: Arteries with SS and those with DA showed significantly lower stress MBF, as compared to those without. RFR was significantly lower in arteries with SS as compared to those without, while CFR was not. CFR was significantly lower in arteries with DA as compared to those without, while RFR was not. Among arteries without SS, CFR was significantly lower in those with DA as compared to those without. However, among arteries with SS, CFR was similar between those with and without DA. In contrast, RFR was significantly lower in arteries with SS, regardless of the presence of DA. CFR and RFR showed a weak positive correlation (r = 0.269) with discordance in 24 cases (35%). Among the arteries with CFR-RFR discordance, the prevalence of DA was significantly higher in those with low CFR but preserved RFR, as compared to those with preserved CFR but low RFR (75 vs 25%, p = 0.028). CVR was significantly higher in arteries with DA, implicating a correlation of DA with underlying microvascular disease. CONCLUSIONS: CFR and RFR measured by myocardial perfusion PET could provide a comprehensive information for characterization of epicardial CAD.
[Mh] Termos MeSH primário: Amônia
Doença da Artéria Coronariana/diagnóstico por imagem
Reserva Fracionada de Fluxo Miocárdico
Radioisótopos de Nitrogênio
Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos
[Mh] Termos MeSH secundário: Angina Estável/diagnóstico por imagem
Angina Estável/fisiopatologia
Doença da Artéria Coronariana/fisiopatologia
Estenose Coronária/diagnóstico por imagem
Feminino
Hemodinâmica
Seres Humanos
Masculino
Angina Microvascular/diagnóstico por imagem
Angina Microvascular/fisiopatologia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Radioisotopes); 0 (Radiopharmaceuticals); 7664-41-7 (Ammonia)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1007/s12149-016-1138-z


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[PMID]:27440799
[Au] Autor:Yi JE; Youn HJ
[Ad] Endereço:1 Department of Cardiology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
[Ti] Título:Hemorheological abnormalities and their associations with coronary blood flow in patients with cardiac syndrome X: a comparison between males and females.
[So] Source:Perfusion;32(1):57-67, 2017 Jan.
[Is] ISSN:1477-111X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: The role of elevated whole blood viscosity (WBV) in the pathogenesis of atherosclerosis is well known. We sought to investigate the gender differences in the association between WBV, coronary blood flow and tissue oxygen delivery index (TODI) in cardiac syndrome X (CSX). METHODS: Forty-six CSX patients and 14 healthy volunteers were enrolled. The coronary flow parameters were obtained with transthoracic Doppler echocardiography and WBV was measured (at high-shear and low-shear rates of 300s and 5s , respectively) using a scanning capillary tube viscometer. TODI was determined from the ratio of hematocrit to WBV measured at a low-shear rate of 5s . RESULTS: In male patients, the mean diastolic coronary flow velocity (CFV) and diastolic velocity time integral (VTI) were significantly decreased compared to control group (all p<0.05) and the WBV showed significant negative correlation with peak systolic CFV (r = -0.559 at 300s , r = -0.438 at 5s ), mean systolic CFV (r = -0.577 at 300s , r = -0.488 at 5s ), systolic VTI (r = -0.576 at 300s , r = -0.530 at 5s ) and diastolic VTI (r = -0.553 at 300s , r = -0.551 at 5s ) (all p<0.01). Meanwhile, although female patients showed no significant relationships between WBV and coronary flow parameters, TODI were significantly decreased compared to the control group (3.64 ± 0.34 vs. 4.07 ± 0.38%/centipoises (cP), respectively, p=0.008). CONCLUSION: Our study suggests that there are gender-related differences in the pathogenesis of microvascular angina and gender-specific approaches for CSX patients might be needed.
[Mh] Termos MeSH primário: Circulação Coronária
Coração/fisiopatologia
Hemorreologia
Angina Microvascular/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Velocidade do Fluxo Sanguíneo
Viscosidade Sanguínea
Estudos Transversais
Ecocardiografia
Feminino
Hematócrito
Seres Humanos
Masculino
Angina Microvascular/sangue
Angina Microvascular/diagnóstico por imagem
Angina Microvascular/epidemiologia
Meia-Idade
Estudos Prospectivos
Fatores Sexuais
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1177/0267659116661052


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[PMID]:26657083
[Au] Autor:Anchisi C; Marti G; Bellacosa I; Mary D; Vacca G; Marino P; Grossini E
[Ad] Endereço:aCardiology Clinic bLaboratory of Physiology and Experimental Surgery, Department of Translational Medicine, Università del Piemonte Orientale 'A. Avogadro,' AOU 'Maggiore della Carità', Novara, Italy.
[Ti] Título:Coronary flow reserve/diastolic function relationship in angina-suffering patients with normal coronary angiography.
[So] Source:J Cardiovasc Med (Hagerstown);18(5):325-331, 2017 May.
[Is] ISSN:1558-2035
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Coronary blood flow and diastolic function are well known to interfere with each other through mechanical and metabolic mechanisms. We aimed to assess the relationship between coronary flow reserve (CFR) and diastolic dysfunction in patients suffering from angina but with normal coronary angiography. METHODS: In 16 patients with chest pain and angiographically normal coronary arteries, CFR was measured using transthoracic echo-Doppler by inducing hyperemia through dipyridamole infusion. Diastolic function (E/A, deceleration time, isovolumetric relaxation time [IVRT], propagation velocity [Vp]) and left ventricular mass were evaluated by means of two-dimensional transthoracic echocardiography. RESULTS: The patients were initially divided into two groups on the grounds of CFR only (ACFR: altered CFR, n = 9; NACFR: unaltered CFR, n = 7). Thereafter they were divided into four groups on the grounds of CFR and diastolic function (NN: normal; AA: altered CFR/diastole; AN: altered CFR/normal diastole; NA: normal CFR/altered diastole). Most of the subjects were scheduled in AA (n = 8) or NA (n = 5) groups, which were taken into consideration for further analysis. Patients were not different regarding various risk factors. ACFR and AA patients were older with normal body weight in comparison with NACFR and NA patients (P < 0.05). In the AA group, CFR and diastolic variables were found to be related to each other. CONCLUSION: Diastolic dysfunction and reduced CFR were correlated in patients with concomitant alterations of those variables only. Because most risk factors were shared with patients with altered diastolic properties only, our findings could represent a direct relationship between altered CFR and diastole.
[Mh] Termos MeSH primário: Angiografia Coronária
Vasos Coronários/diagnóstico por imagem
Ecocardiografia Doppler
Reserva Fracionada de Fluxo Miocárdico
Microcirculação
Angina Microvascular/diagnóstico por imagem
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Idoso
Fenômenos Biomecânicos
Velocidade do Fluxo Sanguíneo
Vasos Coronários/fisiopatologia
Diástole
Dipiridamol/administração & dosagem
Feminino
Seres Humanos
Hiperemia/fisiopatologia
Masculino
Angina Microvascular/fisiopatologia
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Fatores de Risco
Vasodilatadores/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); 64ALC7F90C (Dipyridamole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.2459/JCM.0000000000000344



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