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  1 / 3809 MEDLINE  
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[PMID]:29489690
[Au] Autor:Yang L; Ma G; Yu T; Gao H; Wang Y; Wu Y
[Ad] Endereço:Department of Cardiology, Beijing Friendship Hospital.
[Ti] Título:A case report of Brugada-like ST-segment elevation probably due to coronary vasospasm.
[So] Source:Medicine (Baltimore);97(9):e9900, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, with transient ST-segment elevation on electrocardiography. Brugada Syndrome is an inherited arrhythmogenic cardiac disorder with a diagnostic electrocardiography characterized by coved-type ST-segment elevation in right precordial leads (V1-V3). Those two diseases usually have no correlation. In this report, we discuss an interesting case of a patient who was diagnosed as vasospastic angina according to his coronary angiography, but his electrocardiography showed a Brugada-like ST-segment elevation. PATIENT CONCERNS: Our patient had a 9-month history of temporary but progressive substernal burning sensation with acid bilges of shoulders and arms, as well as profuse sweating at night. DIAGNOSES: Although he had no abnormal laboratory test result, no dysfunctional recorded echocardiogram or documented arrhythmia after being admitted to the hospital, his electrocardiography showed a Brugada-like ST-segment elevation. The coronary angiography result confirmed a diagnosis of vasospastic angina. INTERVENTIONS: The patient was prescribed diltiazem, aspirin, isosorbide mononitrate and rosuvastatin and was strongly advised to quit cigarettes and alcohol. OUTCOMES: Follow-up at half a year turned out well. LESSONS: This case links Brugada syndrome to coronary vasospasm. They may share similar mechanisms. Provocation test and gene test needs to be ran to distinguish both. Long-term follow-up is essential for it may bring a warning sign for life threatening ventricular arrhythmias.
[Mh] Termos MeSH primário: Angina Pectoris/complicações
Síndrome de Brugada/etiologia
Vasoespasmo Coronário/complicações
[Mh] Termos MeSH secundário: Idoso
Angina Pectoris/diagnóstico por imagem
Síndrome de Brugada/diagnóstico por imagem
Angiografia Coronária
Vasoespasmo Coronário/diagnóstico por imagem
Eletrocardiografia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009900


  2 / 3809 MEDLINE  
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[PMID]:29096805
[Au] Autor:Aziz A; Hansen HS; Sechtem U; Prescott E; Ong P
[Ad] Endereço:Department of Cardiology, Robert Bosch Krankenhaus, Stuttgart, Germany; Department of Cardiology, Odense University Hospital, Odense, Denmark. Electronic address: Ahmed.Aziz@rsyd.dk.
[Ti] Título:Sex-Related Differences in Vasomotor Function in Patients With Angina and Unobstructed Coronary Arteries.
[So] Source:J Am Coll Cardiol;70(19):2349-2358, 2017 Nov 07.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coronary vasomotor dysfunction is an important mechanism for angina in patients with unobstructed coronary arteries. OBJECTIVES: The purpose of this study was to determine sex differences in the prevalence and clinical presentation of vasomotor dysfunction in a European population and to examine sex differences in the dose of acetylcholine leading to a positive acetylcholine provocation test (ACH test). METHODS: Between 2007 and 2014, we included 1,379 consecutive patients with stable angina, unobstructed coronaries and ACH test performed for epicardial vasospasm or coronary microvascular dysfunction (CMD) due to microvascular spasm. The predictive value of sex, risk factors, symptoms, and noninvasive test results was analyzed by means of logistic regression. RESULTS: The mean patient age was 62 years, and 42% were male. There were 813 patients (59%) with a pathological ACH test, 33% for CMD and 26% for epicardial vasospasm. A pathological test was more common in females (70% vs. 43%; p < 0.001). In a multivariable logistic regression model the sex difference was statistically significant with a female-male odds ratio for CMD and epicardial vasospasm of 4.2 (95% confidence interval: 3.1 to 5.5; p < 0.001) and 2.3 (95% confidence interval: 1.7 to 3.1; p < 0.001), respectively. Effort-related symptoms, but neither risk factors nor noninvasive stress tests, contributed to predicting a pathological test. Female patients were more sensitive to acetylcholine with vasomotor dysfunction occurring at lower ACH doses compared with male patients. CONCLUSIONS: Vasomotor dysfunction is frequent in patients with angina and unobstructed coronaries in a European population. Female patients have a higher prevalence of vasomotor dysfunction (especially CMD) compared with male patients. A pathological ACH test was observed at lower ACH doses in women compared with men.
[Mh] Termos MeSH primário: Angina Pectoris/fisiopatologia
Vasoespasmo Coronário/fisiopatologia
Vasos Coronários/fisiologia
Caracteres Sexuais
Vasodilatadores/farmacologia
Sistema Vasomotor/fisiologia
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Idoso
Angina Pectoris/epidemiologia
Vasoespasmo Coronário/induzido quimicamente
Vasoespasmo Coronário/epidemiologia
Vasos Coronários/efeitos dos fármacos
Relação Dose-Resposta a Droga
Europa (Continente)/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Sistema Vasomotor/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  3 / 3809 MEDLINE  
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[PMID]:29046002
[Au] Autor:Ong P; Sechtem U
[Ti] Título:[Optimal Diagnostics and Therapy for Microvascular Angina Pectoris].
[Ti] Título:Optimale Diagnostik und Therapie der mikrovaskulären Angina pectoris..
[So] Source:Dtsch Med Wochenschr;142(21):1586-1593, 2017 Oct.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Patients with microvascular angina are characterized by angina pectoris with proof of myocardial ischemia in the absence of any relevant epicardial stenosis and without myocardial disease (type 1 coronary microvascular dysfunction according to Crea and Camici). Structural and functional alterations of the coronary microvessels (diameter < 500 µm) are the reason for this phenomenon. Frequently such alterations are associated with cardiovascular risk factors. Patients with angina pectoris without epicardial stenoses represent for 10 - 50 % of all patients undergoing coronary angiography depending on the clinical presentation. Diagnostic approaches include non-invasive (e. g. combination of coronary CT-angiography and positron emission tomography/echo Doppler-based coronary flow reserve measurements) as well as invasive procedures (coronary flow reserve measurements in response to adenosine, intracoronary acetylcholine testing). Pharmacological treatment of these patients is often challenging and should be based on the characterization of the underlying mechanisms. Moreover, strict risk factor control and individually titrated combinations of antianginal substances (e. g. beta blockers, calcium channel blockers, nitrates, ranolazine, ivabradine etc.) are recommended.
[Mh] Termos MeSH primário: Angina Microvascular/diagnóstico
Angina Microvascular/terapia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/uso terapêutico
Bloqueadores dos Canais de Cálcio/uso terapêutico
Fármacos Cardiovasculares/uso terapêutico
Vasoespasmo Coronário/complicações
Vasos Coronários/fisiopatologia
Seres Humanos
Neuroestimuladores Implantáveis
Angina Microvascular/fisiopatologia
Isquemia Miocárdica/complicações
Condicionamento Físico Humano
Fatores de Risco
Bloqueadores dos Canais de Sódio/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Calcium Channel Blockers); 0 (Cardiovascular Agents); 0 (Sodium Channel Blockers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104469


  4 / 3809 MEDLINE  
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[PMID]:28984779
[Au] Autor:Hung MJ; Ko T; Liang CY; Kao YC
[Ad] Endereço:aSection of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung bChang Gung University College of Medicine, Taoyuan, Taiwan.
[Ti] Título:Two-dimensional myocardial deformation in coronary vasospasm-related Takotsubo cardiomyopathy: A case report of a serial echocardiographic study.
[So] Source:Medicine (Baltimore);96(40):e8232, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Although transient reduction in the left ventricular ejection fraction is characteristic of Takotsubo cardiomyopathy, little is known about the time-course changes of myocardial deformation in coronary vasospasm-related Takotsubo cardiomyopathy. PATIENT CONCERNS: We retrospectively analyzed the time-course changes in left ventricle, right ventricle, and left atrium strain values in a patient with coronary vasospasm-related Takotsubo cardiomyopathy. We found that not only left ventricular strain but also left atrial strain was abnormal during acute Takotsubo cardiomyopathy due to coronary vasospasm. Right ventricular free wall strain was normal. DIAGNOSES: Coronary vasospasm-related Takotsubo cardiomyopathy. INTERVENTIONS: A serial echocardiographic study. OUTCOMES: The left ventricular strain was still subnormal despite a normalized left ventricular ejection fraction 2 months later. The left atrial strain was normal when the left ventricular ejection fraction normalized. LESSONS: From this limited experience, it is suggested that echocardiographic myocardial deformation analysis can provide more information than the standard ejection fraction in evaluating myocardial contractile function.
[Mh] Termos MeSH primário: Vasoespasmo Coronário/diagnóstico por imagem
Ecocardiografia/métodos
Cardiomiopatia de Takotsubo/diagnóstico por imagem
Disfunção Ventricular Esquerda/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Função do Átrio Esquerdo/fisiologia
Vasoespasmo Coronário/complicações
Vasoespasmo Coronário/fisiopatologia
Feminino
Coração/diagnóstico por imagem
Coração/fisiopatologia
Seres Humanos
Estudos Retrospectivos
Volume Sistólico
Cardiomiopatia de Takotsubo/etiologia
Cardiomiopatia de Takotsubo/fisiopatologia
Disfunção Ventricular Esquerda/etiologia
Disfunção Ventricular Esquerda/fisiopatologia
Função Ventricular Esquerda/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008232


  5 / 3809 MEDLINE  
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[PMID]:28694411
[Au] Autor:Kounis NG; Koniari I; Velissaris D; Patsuras N; Hahalis G
[Ad] Endereço:Department of Cardiology, University of Patras Medical School, Rion, Patras, Achaia, Greece. ngkounis@otenet.gr.
[Ti] Título:Amoxicillin/clavulanate allergic reaction, implantable defibrillator shock, and Kounis syndrome: Pathophysiological considerations.
[So] Source:Turk Kardiyol Dern Ars;45(5):490-492, 2017 07.
[Is] ISSN:1308-4488
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Mh] Termos MeSH primário: Combinação Amoxicilina e Clavulanato de Potássio
Desfibriladores Implantáveis
[Mh] Termos MeSH secundário: Vasoespasmo Coronário
Quimioterapia Combinada
Seres Humanos
Hipersensibilidade
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.5543/tkda.2017.00671


  6 / 3809 MEDLINE  
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[PMID]:28692363
[Au] Autor:Patel P; Yau C; Kurian J
[Ad] Endereço:Cardiology Registrar and Clinical Research Fellow, Department of Cardiology, Leeds General Infirmary, Leeds LS1 3EX.
[Ti] Título:ST elevation myocardial infarction after coronary artery spasm with no clear trigger.
[So] Source:Br J Hosp Med (Lond);78(7):412-413, 2017 Jul 02.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Arritmias Cardíacas/etiologia
Vasoespasmo Coronário/complicações
Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia
[Mh] Termos MeSH secundário: Anlodipino/uso terapêutico
Arritmias Cardíacas/terapia
Reanimação Cardiopulmonar
Angiografia Coronária
Vasoespasmo Coronário/diagnóstico
Vasoespasmo Coronário/tratamento farmacológico
Morte Súbita Cardíaca/prevenção & controle
Desfibriladores Implantáveis
Eletrocardiografia
Seres Humanos
Dinitrato de Isossorbida/análogos & derivados
Dinitrato de Isossorbida/uso terapêutico
Masculino
Meia-Idade
Nitroglicerina/uso terapêutico
Recidiva
Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); 1J444QC288 (Amlodipine); G59M7S0WS3 (Nitroglycerin); IA7306519N (Isosorbide Dinitrate); LX1OH63030 (isosorbide-5-mononitrate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.12968/hmed.2017.78.7.412


  7 / 3809 MEDLINE  
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[PMID]:28658116
[Au] Autor:Sun J; Feng L; Li F; Zhang Y; Dong J
[Ad] Endereço:Department of Cardiology, Zhongshan Hospital of Sun Yat-sen University, Guangdong, China.
[Ti] Título:An interesting implantable cardioverter defibrillator treatment for lethal ventricular arrhythmias caused by coronary artery spasm: A case report.
[So] Source:Medicine (Baltimore);96(26):e7251, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Coronary artery spasm (CAS) could cause serious lethal ventricular arrhythmias. While implantable cardioverter defibrillators (ICDs) have been recommend for secondary prevention of sudden cardiac death related to lethal ventricular arrhythmias. However, in resuscitated sudden cardiac death caused by CAS, the effect of ICD is still not well clear. PATIENT CONCERNS: A 60-year-old male presented with 2 episodes of syncope. Coronary angiography showed normal coronary arteries. Twenty-four hour Holter electrocardiograms revealed that there were repeatedly transient marked ST segment elevation in the all leads except avR lead, junctional rhythm, and subsequently nonsustained ventricular tachycardia. DIAGNOSES: Ischemic-induced lethal ventricular arrhythmias caused by CAS. INTERVENTIONS: Both calcium channel blocker (diltiazem, 180 mg twice daily) and nitrate (isosorbide dinitrate 40 mg twice daily) were initially administrated, and ICD was subsequently implanted as a secondary prevention. OUTCOMES: In the early stage of CAS, ICD therapy terminated the lethal ventricular arrhythmias. Conversely, after the administration of epinephrine, ICD therapy, even combined with external defibrillation, failed in resuscitating sudden cardiac death. LESSONS: For the sudden cardiac death related to lethal ventricular arrhythmias caused by CAS, ICD therapy is an efficient secondary prevention base on administrating coronary vasodilators. Furthermore, administration of epinephrine should be avoided during cardiorespiratory resuscitation of sudden cardiac death caused by CAS.
[Mh] Termos MeSH primário: Arritmias Cardíacas/etiologia
Arritmias Cardíacas/terapia
Vasoespasmo Coronário/complicações
Desfibriladores Implantáveis
[Mh] Termos MeSH secundário: Fármacos Cardiovasculares/uso terapêutico
Vasoespasmo Coronário/terapia
Morte Súbita Cardíaca
Evolução Fatal
Seres Humanos
Masculino
Meia-Idade
Isquemia Miocárdica/etiologia
Isquemia Miocárdica/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiovascular Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007251


  8 / 3809 MEDLINE  
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[PMID]:28636863
[Au] Autor:Kondo T; Terada K
[Ad] Endereço:Chiba University Hospital, Chiba, Japan reds_liverpool_2005@yahoo.co.jp.
[Ti] Título:Coronary-Artery Vasospasm.
[So] Source:N Engl J Med;376(25):e52, 2017 Jun 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vasoespasmo Coronário/diagnóstico por imagem
[Mh] Termos MeSH secundário: Dor no Peito/etiologia
Angiografia Coronária
Vasoespasmo Coronário/complicações
Vasoespasmo Coronário/tratamento farmacológico
Seres Humanos
Masculino
Meia-Idade
Nitroglicerina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
G59M7S0WS3 (Nitroglycerin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1614640


  9 / 3809 MEDLINE  
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[PMID]:28539572
[Au] Autor:Oumi T; Nozato T; Sakakibara A; Nomoto H; Ohno M; Takahashi Y; Ashikaga T; Satoh Y; Isobe M
[Ad] Endereço:Department of Cardiology, National Hospital Organization, Disaster Medical Center.
[Ti] Título:Malondialdehyde-Modified Low Density Lipoprotein as Oxidative-Stress Marker in Vasospastic Angina Patients.
[So] Source:Int Heart J;58(3):335-343, 2017 May 31.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Vasospastic angina (VSA) is caused by endothelial dysfunction and hypercontraction of vascular smooth muscle cells. Although oxidative-stress can induce endothelial dysfunction, the relationship of VSA and the oxidative-stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL) remains unclear. PURPOSE: Serum MDA-LDL was evaluated in candidate VSA patients.The subjects were 84 patients admitted to our hospital because of chest pain at rest. We stratified the patients into 3 groups; definite VSA, suspected VSA, and unlikely VSA according to a Japanese Circulation Society (JCS) guideline. The patients classified as definite VSA or suspected VSA were considered as "clinical VSA".Forty cases were classified as definite VSA, 35 as suspected VSA, and 9 as unlikely VSA. Thus, clinical VSA was the diagnosis in 75 cases. The patient characteristics showed that the average age of the patients was 60.2 years old (men, 61%). The serum MDA-LDL level of the clinical VSA group (126.3 ± 38.0 U/L) was significantly higher than the unlikely VSA group (98.7 ± 31.1 U/L). Serum MDA-LDL was positively correlated with total cholesterol (T-Chol), lowdensity lipoprotein cholesterol (LDL-C), triglycerides, and fasting blood glucose. Multivariate analysis showed that serum MDA-LDL was the most predictive marker for making a diagnosis of clinical VSA (Odds ratio 1.064, 95% confidence interval 1.014-1.145, P = 0.008). In a population with positive or borderline ECG change, the positive rate in the acetylcholine provocation test was significantly higher in the MDA-LDL higher group compared to the MDA-LDL lower group (81% versus 37%, P = 0.032).: Serum MDA-LDL might be a useful biomarker of VSA and have additional value for the diagnosis of clinical VSA.
[Mh] Termos MeSH primário: Vasoespasmo Coronário/sangue
Lipoproteínas LDL/sangue
Malondialdeído/análogos & derivados
Estresse Oxidativo
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Angiografia Coronária
Vasoespasmo Coronário/diagnóstico
Diagnóstico Diferencial
Eletrocardiografia
Feminino
Seguimentos
Seres Humanos
Masculino
Malondialdeído/sangue
Meia-Idade
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Lipoproteins, LDL); 0 (malondialdehyde-low density lipoprotein, human); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-455


  10 / 3809 MEDLINE  
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[PMID]:28511332
[Au] Autor:Guo JJ; Liu JY; Wang SL
[Ti] Título:[Kounis sysdrome secondary to crucian allergy:a case report].
[So] Source:Zhonghua Xin Xue Guan Bing Za Zhi;45(5):438-439, 2017 May 24.
[Is] ISSN:0253-3758
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Vasoespasmo Coronário
[Mh] Termos MeSH secundário: Seres Humanos
Hipersensibilidade/complicações
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3758.2017.05.015



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