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[PMID]:28551786
[Au] Autor:Consolini AE; Ragone MI; Bonazzola P; Colareda GA
[Ad] Endereço:Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, 1900, Buenos Aires, Argentina. dinamia@biol.unlp.edu.ar.
[Ti] Título:Mitochondrial Bioenergetics During Ischemia and Reperfusion.
[So] Source:Adv Exp Med Biol;982:141-167, 2017.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During ischemia and reperfusion (I/R) mitochondria suffer a deficiency to supply the cardiomyocyte with chemical energy, but also contribute to the cytosolic ionic alterations especially of Ca . Their free calcium concentration ([Ca ]m) mainly depends on mitochondrial entrance through the uniporter (UCam) and extrusion in exchange with Na (mNCX) driven by the electrochemical gradient (ΔΨm). Cardiac energetic is frequently estimated by the oxygen consumption, which determines metabolism coupled to ATP production and to the maintaining of ΔΨm. Nevertheless, a better estimation of heart energy consumption is the total heat release associated to ATP hydrolysis, metabolism, and binding reactions, which is measurable either in the presence or the absence of oxygenation or perfusion. Consequently, a mechano-calorimetrical approach on isolated hearts gives a tool to evaluate muscle economy. The mitochondrial role during I/R depends on the injury degree. We investigated the role of the mitochondrial Ca transporters in the energetic of hearts stunned by a model of no-flow I/R in rat hearts. This chapter explores an integrated view of previous and new results which give evidences to the mitochondrial role in cardiac stunning by ischemia o hypoxia, and the influence of thyroid alterations and cardioprotective strategies, such as cardioplegic solutions (high K-low Ca, pyruvate) and the phytoestrogen genistein in both sex. Rat ventricles were perfused in a flow-calorimeter at either 30 °C or 37 °C to continuously measure the left ventricular pressure (LVP) and total heat rate (Ht). A pharmacological treatment was done before exposing to no-flow I and R. The post-ischemic contractile (PICR as %) and energetical (Ht) recovery and muscle economy (Eco: P/Ht) were determined during stunning. The functional interaction between mitochondria (Mit) and sarcoplasmic reticulum (SR) was evaluated with selective mitochondrial inhibitors in hearts reperfused with Krebs-10 mM caffeine-36 mM Na . The caffeine induced contracture (CIC) was due to SR Ca release, while relaxation mainly depends on mitochondrial Ca uptake since neither SL-NCX nor SERCA are functional under this media. The ratio of area-under-curves over ischemic values (AUC-ΔHt/AUC-ΔLVP) estimates the energetical consumption (EC) to maintain CIC. Relaxation of CIC was accelerated by inhibition of mNCX or by adding the aerobic substrate pyruvate, while both increased EC. Contrarily, relaxation was slowed by cardioplegia (high K-low Ca Krebs) and by inhibition of UCam. Thus, Mit regulate the cytosolic [Ca ] and SR Ca content. Both, hyperthyroidism (HpT) and hypothyroidism (HypoT) reduced the peak of CIC but increased EC, in spite of improving PICR. Both, CIC and PICR in HpT were also sensitive to inhibition of mNCX or UCam, suggesting that Mit contribute to regulate the SR store and Ca release. The interaction between mitochondria and SR and the energetic consequences were also analyzed for the effects of genistein in hearts exposed to I/R, and for the hypoxia/reoxygenation process. Our results give evidence about the mitochondrial regulation of both PICR and energetic consumption during stunning, through the Ca movement.
[Mh] Termos MeSH primário: Metabolismo Energético
Mitocôndrias Cardíacas/metabolismo
Contração Miocárdica
Traumatismo por Reperfusão Miocárdica/metabolismo
Reperfusão Miocárdica/efeitos adversos
Miocárdio Atordoado/metabolismo
Miócitos Cardíacos/metabolismo
[Mh] Termos MeSH secundário: Animais
Sinalização do Cálcio
Circulação Coronária
Seres Humanos
Mitocôndrias Cardíacas/ultraestrutura
Traumatismo por Reperfusão Miocárdica/etiologia
Traumatismo por Reperfusão Miocárdica/patologia
Traumatismo por Reperfusão Miocárdica/fisiopatologia
Miocárdio Atordoado/etiologia
Miocárdio Atordoado/patologia
Miocárdio Atordoado/fisiopatologia
Miócitos Cardíacos/ultraestrutura
Fatores de Risco
Retículo Sarcoplasmático/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-55330-6_8


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[PMID]:28120237
[Au] Autor:Hussein AA; Niekoop M; Dilsizian V; Ghzally Y; Abdulghani M; Asoglu R; Chen W; Smith M; See V; Shorofsky SR; Dickfeld TM; Maryland Arrhythmia and Cardiology Imaging Group (MACIG)
[Ad] Endereço:Section of Cardiac Pacing and Electrophysiology, Cleveland Clinic, Cleveland, OH, USA.
[Ti] Título:Hibernating substrate of ventricular tachycardia: a three-dimensional metabolic and electro-anatomic assessment.
[So] Source:J Interv Card Electrophysiol;48(3):247-254, 2017 Apr.
[Is] ISSN:1572-8595
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Hibernating myocardium (HM) is associated with sudden cardiac death (SCD). Little is known about the electrophysiological properties of HM and the basis of its association with SCD. We aimed to electrophysiologically characterize HM in patients with ventricular tachycardia (VT). METHODS: Endocardial voltage mapping, metabolic FDG-positron emission tomography (PET) and perfusion Rb, Tl, or Tc scans were performed in 61 ischemic heart disease patients with VT. Hibernating areas were identified which was followed by three-dimensional PET reconstructions and integration with voltage maps to allow hybrid metabolic-electro-anatomic assessment of the arrhythmogenic substrate. RESULTS: Of 61 patients with ischemic heart disease and refractory VT, 7 were found to have hibernating myocardium (13%). A total of 303 voltage points were obtained within hibernating myocardium (8.2 points per 10 cm ) and displayed abnormal voltage in 48.5 and 78.3% of bipolar and unipolar recordings, respectively, with significant heterogeneity of bipolar (p < 0.0001) and unipolar voltage measurements (p = 0.0004). Hibernating areas in 6 of 7 patients contained all three categories of bipolar voltage-defined scar (<0.5 mV), border zone (0.5-1.5 mV), and normal myocardium (>1.5 mV). The characteristics of local electrograms were also assessed and found abnormal in most recordings (76.6, 10.2% fractionated, 5.3% isolated potentials). Exit sites of clinical VTs were determined in 6 patients, of which 3 were located within hibernating myocardium. CONCLUSIONS: Hibernating myocardium displays abnormal and heterogeneous electrical properties and seems to contribute to the substrate of VT. These observations may underlie the vulnerability to reentry and SCD in patients with hypoperfused yet viable myocardium.
[Mh] Termos MeSH primário: Mapeamento Potencial de Superfície Corporal/métodos
Fluordesoxiglucose F18/farmacocinética
Sistema de Condução Cardíaco/fisiopatologia
Imagem Tridimensional/métodos
Miocárdio Atordoado/fisiopatologia
Taquicardia Ventricular/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Sistema de Condução Cardíaco/diagnóstico por imagem
Seres Humanos
Masculino
Miocárdio Atordoado/complicações
Miocárdio Atordoado/diagnóstico por imagem
Tomografia por Emissão de Pósitrons/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Taquicardia Ventricular/complicações
Taquicardia Ventricular/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1007/s10840-016-0219-1


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[PMID]:28081822
[Au] Autor:Hinkel R; Howe A; Renner S; Ng J; Lee S; Klett K; Kaczmarek V; Moretti A; Laugwitz KL; Skroblin P; Mayr M; Milting H; Dendorfer A; Reichart B; Wolf E; Kupatt C
[Ad] Endereço:I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, Technical University of Munich, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institute for Cardiovascular Prevention, Klinikum der Universität München,
[Ti] Título:Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.
[So] Source:J Am Coll Cardiol;69(2):131-143, 2017 Jan 17.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus causes microcirculatory rarefaction and may impair the responsiveness of ischemic myocardium to proangiogenic factors. OBJECTIVES: This study sought to determine whether microvascular destabilization affects organ function and therapeutic neovascularization in diabetes mellitus. METHODS: The authors obtained myocardial samples from patients with end-stage heart failure at time of transplant, with or without diabetes mellitus. Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function. Chronic ischemia was induced percutaneously (day 0) in the circumflex artery. At day 28, recombinant adeno-associated virus (rAAV) (5 × 10 viral particles encoding vascular endothelial growth factor-A [VEGF-A] or thymosin beta 4 [Tß4]) was applied regionally. CD31+ capillaries per high power field (c/hpf) and NG2+ pericyte coverage were analyzed. Global myocardial function (ejection fraction [EF] and left ventricular end-diastolic pressure) was assessed at days 28 and 56. RESULTS: Diabetic human myocardial explants revealed capillary rarefaction and pericyte loss compared to nondiabetic explants. Hyperglycemia in db pigs, even without ischemia, induced capillary rarefaction in the myocardium (163 ± 14 c/hpf in db vs. 234 ± 8 c/hpf in wt hearts; p < 0.005), concomitant with a distinct loss of EF (44.9% vs. 53.4% in nondiabetic controls; p < 0.05). Capillary density further decreased in chronic ischemic hearts, as did EF (both p < 0.05). Treatment with rAAV.Tß4 enhanced capillary density and maturation in db hearts less efficiently than in wt hearts, similar to collateral growth. rAAV.VEGF-A, though stimulating angiogenesis, induced neither pericyte recruitment nor collateral growth. As a result, rAAV.Tß4 but not rAAV.VEGF-A improved EF in db hearts (34.5 ± 1.4%), but less so than in wt hearts (44.8 ± 1.5%). CONCLUSIONS: Diabetes mellitus destabilized microvascular vessels of the heart, affecting the amplitude of therapeutic neovascularization via rAAV.Tß4 in a translational large animal model of hibernating myocardium.
[Mh] Termos MeSH primário: Doença das Coronárias/diagnóstico
Doença das Coronárias/fisiopatologia
Vasos Coronários/fisiopatologia
Angiopatias Diabéticas/diagnóstico
Angiopatias Diabéticas/fisiopatologia
Microvasos/fisiopatologia
Miocárdio
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/diagnóstico
Diabetes Mellitus Experimental/fisiopatologia
Terapia Genética
Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/fisiopatologia
Transplante de Coração
Seres Humanos
Miocárdio Atordoado/tratamento farmacológico
Miocárdio Atordoado/fisiopatologia
Neovascularização Fisiológica/efeitos dos fármacos
Volume Sistólico/efeitos dos fármacos
Volume Sistólico/fisiologia
Suínos
Timosina/administração & dosagem
Pesquisa Médica Translacional
Fator A de Crescimento do Endotélio Vascular/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vascular Endothelial Growth Factor A); 549LM7U24W (thymosin beta(4)); 61512-21-8 (Thymosin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


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[PMID]:27837689
[Au] Autor:Kerro A; Woods T; Chang JJ
[Ad] Endereço:Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.
[Ti] Título:Neurogenic stunned myocardium in subarachnoid hemorrhage.
[So] Source:J Crit Care;38:27-34, 2017 Apr.
[Is] ISSN:1557-8615
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:"Stunned myocardium," characterized by reversible left ventricular dysfunction, was first described via animal models using transient coronary artery occlusion. However, this phenomenon has also been noted with neurologic pathologies and collectively been labeled "neurogenic stunned myocardium" (NSM). Neurogenic stunned myocardium resulting from subarachnoid hemorrhage (SAH) is a challenging pathology due to its diagnostic uncertainty. Traditional diagnostic criteria for NSM after SAH focus on electrocardiographic and echocardiographic abnormalities and troponemia. However, tremendous heterogeneity still exists. Traditional pathophysiological mechanisms for NSM encompassed hypothalamic and myocardial perivascular lesions. More recently, research on pathophysiology has centered on myocardial microvascular dysfunction and genetic polymorphisms. Catecholamine surging as a mechanism has also gained attention with particular focus placed on the role of adrenergic blockade in both the prehospital and acute settings. Management remains largely supportive with case reports acknowledging the utility of inotropes such as dobutamine and milrinone and intra-aortic balloon pump when NSM is accompanied by cardiogenic shock. Neurogenic stunned myocardium that follows SAH can result in many complications such as arrhythmias, pulmonary edema, and prolonged intubation, which can negatively impact long-term recovery from SAH and increase morbidity and mortality. This necessitates the need to accurately diagnose and treat NSM.
[Mh] Termos MeSH primário: Miocárdio Atordoado/terapia
Hemorragia Subaracnóidea/complicações
Disfunção Ventricular Esquerda/terapia
[Mh] Termos MeSH secundário: Cuidados Críticos
Eletrocardiografia
Seres Humanos
Miocárdio Atordoado/complicações
Miocárdio Atordoado/diagnóstico
Disfunção Ventricular Esquerda/complicações
Disfunção Ventricular Esquerda/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


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[PMID]:27147609
[Au] Autor:McDiarmid AK; Pellicori P; Cleland JG; Plein S
[Ad] Endereço:Multidisciplinary Cardiovascular Research Centre & Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.
[Ti] Título:Taxonomy of segmental myocardial systolic dysfunction.
[So] Source:Eur Heart J;38(13):942-954, 2017 Apr 01.
[Is] ISSN:1522-9645
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The terms used to describe different states of myocardial health and disease are poorly defined. Imprecision and inconsistency in nomenclature can lead to difficulty in interpreting and applying trial outcomes to clinical practice. In particular, the terms 'viable' and 'hibernating' are commonly applied interchangeably and incorrectly to myocardium that exhibits chronic contractile dysfunction in patients with ischaemic heart disease. The range of inherent differences amongst imaging modalities used to define myocardial health and disease add further challenges to consistent definitions. The results of several large trials have led to renewed discussion about the classification of dysfunctional myocardial segments. This article aims to describe the diverse myocardial pathologies that may affect the myocardium in ischaemic heart disease and cardiomyopathy, and how they may be assessed with non-invasive imaging techniques in order to provide a taxonomy of myocardial dysfunction.
[Mh] Termos MeSH primário: Cardiomiopatia Dilatada/patologia
Cardiomiopatia Hipertrófica/patologia
Isquemia Miocárdica/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Técnicas de Imagem Cardíaca/métodos
Cardiomiopatia Dilatada/classificação
Cardiomiopatia Dilatada/metabolismo
Cardiomiopatia Hipertrófica/classificação
Cardiomiopatia Hipertrófica/metabolismo
Doença Crônica
Coração/fisiologia
Insuficiência Cardíaca Diastólica/classificação
Insuficiência Cardíaca Diastólica/metabolismo
Insuficiência Cardíaca Diastólica/patologia
Seres Humanos
Infarto do Miocárdio/classificação
Infarto do Miocárdio/metabolismo
Infarto do Miocárdio/patologia
Isquemia Miocárdica/classificação
Isquemia Miocárdica/metabolismo
Miocárdio Atordoado/classificação
Miocárdio Atordoado/metabolismo
Miocárdio Atordoado/patologia
Miocárdio/patologia
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/fisiologia
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1093/eurheartj/ehw140


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[PMID]:26560191
[Au] Autor:De Pauw M; Mubagwa K; Hodeige D; Borgers M; Flameng W; Van de Voorde J; Heyndrickx GR
[Ad] Endereço:The Department of Cardiology, Ghent University Hospital, Ghent, Belgium.
[Ti] Título:Response to exercise and mechanical efficiency in non-ischaemic stunning, induced by short-term rapid pacing in dogs: a role for calcium?
[So] Source:Acta Physiol (Oxf);219(4):768-780, 2017 Apr.
[Is] ISSN:1748-1716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Rapid pacing (RP) is a regularly used model to induce heart failure in dogs. The aim of the study was to evaluate Ca handling, left ventricular (LV) contractile response during Ca administration compared to exercise, as well as oxygen consumption and mechanical efficiency after 48 h of RP. METHODS: Fifty-three mongrel dogs were instrumented to measure LV pressure, LV fractional shortening, regional wall thickening and coronary blood flow. Contractile reserve was measured with isoproterenol and intravenous (IV) Ca administration. To assess the function of the sarcoplasmic reticulum (SR), post-extrasystolic potentiation (PESP) and SR Ca uptake were measured. A graded treadmill test was performed in baseline and after RP (n = 14). In a separate group of animals (n = 5), myocardial performance and oxygen consumption were measured using a wide range of loading conditions. RESULTS: Left ventricular contractility was significantly decreased upon cessation of pacing. The contractile response to isoproterenol was blunted compared to a preserved response to IV Ca . Post-extrasystolic potentiation was slightly increased after RP. Maximal velocity (V ) of SR Ca uptake was unchanged. Contractile response during exercise is attenuated after RP. External work is reduced, whereas oxygen consumption is preserved, provoking a reduced mechanical efficiency. CONCLUSION: Forty-eight-hours RP provokes a reversible LV dysfunction, while the SR function and response to exogenous Ca are preserved. This is compatible with an intracellular functional remodelling to counteract Ca overload provoked by RP. Left ventricular dysfunction is accompanied by a reduced contractile reserve, but an unchanged oxygen consumption, illustrating an alteration in oxygen utilization.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Insuficiência Cardíaca/fisiopatologia
Miocárdio Atordoado/fisiopatologia
Condicionamento Físico Animal
Disfunção Ventricular Esquerda/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Estimulação Cardíaca Artificial
Modelos Animais de Doenças
Cães
Insuficiência Cardíaca/metabolismo
Miocárdio Atordoado/metabolismo
Retículo Sarcoplasmático/metabolismo
Disfunção Ventricular Esquerda/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE
[do] DOI:10.1111/apha.12629


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[PMID]:27751318
[Au] Autor:Bhagwat AR; Mukhedkar SM
[Ad] Endereço:Division of Cardiology, Kamalnayan Bajaj Hospital & MMRI, Gut 43, Beed Bypass Road, Aurangabad 431005, India. Electronic address: drajitbhagwat@gmail.com.
[Ti] Título:Instantaneous unmasking of myocardial hibernation induced by microvascular obstruction.
[So] Source:Indian Heart J;68 Suppl 2:S288, 2016 Sep.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Circulação Coronária
Oclusão Coronária/complicações
Vasos Coronários/fisiopatologia
Microcirculação/fisiologia
Miocárdio Atordoado/etiologia
[Mh] Termos MeSH secundário: Angiografia Coronária
Oclusão Coronária/diagnóstico
Oclusão Coronária/fisiopatologia
Vasos Coronários/diagnóstico por imagem
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
Miocárdio Atordoado/diagnóstico
Miocárdio Atordoado/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27741040
[Au] Autor:Hyldebrandt JA; Støttrup NB; Frederiksen CA; Heiberg J; Dupont Birkler RI; Johannsen M; Schmidt MR; Ravn HB
[Ad] Endereço:1Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Skejby, Denmark.2Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.3Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.4Department of Cardiology, Randers Regional Hospital, Randers, Denmark.5Department Thoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Denmark.6Section for Forensic Chemistry, Department of Forensic Medicine, Aarhus University, Aarhus, Denmark.7The Heart Center, Department of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen, Denmark.
[Ti] Título:Citric Acid Cycle Metabolites Predict the Severity of Myocardial Stunning and Mortality in Newborn Pigs.
[So] Source:Pediatr Crit Care Med;17(12):e567-e574, 2016 Dec.
[Is] ISSN:1529-7535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Myocardial infarction and chronic heart failure induce specific metabolic changes in the neonatal myocardium that are closely correlated to outcome. The aim of this study was to examine the metabolic responses to noninfarct heart failure and inotropic treatments in the newborn heart, which so far are undetermined. DESIGN: A total of 28 newborn pigs were instrumented with a microdialysis catheter in the right ventricle, and intercellular citric acid cycle intermediates and adenosine metabolite concentrations were determined at 20-minute intervals. Stunning was induced by 10 cycles of 3 minutes of ischemia, which was performed by occluding the right coronary artery, followed by 3 minutes of reperfusion. Animals were randomized for treatment with epinephrine + milrinone, dopamine + milrinone, dobutamine, or saline. SETTING: University hospital animal laboratory. MAIN RESULTS: Ischemia-reperfusion induced right ventricular stunning and increased the concentrations of pyruvate lactate, succinate, malate, hypoxanthine, and xanthine (all, p < 0.01). During inotrope infusion, no differences in metabolite concentrations were detected between the treatment groups. In nonsurviving animals (n = 8), concentrations of succinate (p < 0.0001), malate (p = 0.009), and hypoxanthine (p = 0.04) increased compared with survivors, while contractility was significantly reduced (p = 0.03). CONCLUSIONS: Accumulation of citric acid cycle intermediates and adenosine metabolites reflects the presence of myocardial stunning and predicts mortality in acute noninfarct right ventricular heart failure in newborn pigs. This phenomenon occurs independently of the type of inotrope, suggesting that citric acid cycle intermediates represent potential markers of acute noninfarct heart failure.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Ciclo do Ácido Cítrico
Insuficiência Cardíaca/diagnóstico
Miocárdio Atordoado/diagnóstico
[Mh] Termos MeSH secundário: Animais
Cardiotônicos/uso terapêutico
Cromatografia Líquida
Dobutamina/uso terapêutico
Quimioterapia Combinada
Epinefrina/uso terapêutico
Feminino
Insuficiência Cardíaca/tratamento farmacológico
Insuficiência Cardíaca/metabolismo
Insuficiência Cardíaca/mortalidade
Microdiálise
Milrinona/uso terapêutico
Miocárdio Atordoado/tratamento farmacológico
Miocárdio Atordoado/metabolismo
Miocárdio Atordoado/mortalidade
Distribuição Aleatória
Índice de Gravidade de Doença
Cloreto de Sódio/uso terapêutico
Espectrometria de Massas por Ionização por Electrospray
Suínos
Espectrometria de Massas em Tandem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cardiotonic Agents); 3S12J47372 (Dobutamine); 451W47IQ8X (Sodium Chloride); JU9YAX04C7 (Milrinone); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE


  9 / 2151 MEDLINE  
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[PMID]:27627221
[Au] Autor:Ozkan H; Binici S; Tenekecioglu E; Ari H; Bozat T
[Ad] Endereço:Department of Cardiology, Faculty of Medicine, Bahcesehir University, Istanbul, Turquia.
[Ti] Título:Atrial Strain and Strain Rate: A Novel Method for the Evaluation of Atrial Stunning.
[So] Source:Arq Bras Cardiol;107(4):305-313, 2016 Oct.
[Is] ISSN:1678-4170
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia seen in adults. Atrial stunning is defined as the temporary mechanical dysfunction of the atrial appendage developing after AF has returned to sinus rhythm (SR). OBJECTIVES: We aimed to evaluate atrial contractile functions by strain and strain rate in patients with AF, following pharmacological and electrical cardioversion and to compare it with conventional methods. METHODS: This study included 41 patients with persistent AF and 35 age-matched control cases with SR. All the AF patients included in the study had transthoracic and transesophageal echocardiography performed before and after. Septum (SEPsSR), left atrium (LAsSR) and right atrium peak systolic strain rate (RAsSR) were defined as the maximum negative value during atrial contraction and septum (SEPε), left atrium (LAε) and right atrium peak systolic strain (RAε) was defined as the percentage of change. Parameters of two groups were compared. RESULTS: In the AF group, 1st hour and 24th hour LAε, RAε, SEPε, LAsSR, RAsSR, SEPsSR found to be significantly lower than in the control group (LAε: 2.61%±0.13, 3.06%±0.19 vs 6.45%±0.27, p<0.0001; RAε: 4.03%±0.38, 4.50%±0.47 vs 10.12%±0.64, p<0.0001; SEPε: 3.0%±0.22, 3.19%±0.15 vs 6.23%±0.49, p<0.0001; LAsSR: 0.61±0.04s-1, 0.75±0.04s- 1 vs 1.35±0.04s-1, p<0.0001; RAsSR: 1.13±0.06s-1, 1.23±0.07s-1 vs 2.10±0.08s- 1, p<0.0001; SEPsSR: 0.76±0.04s- 1, 0.78±0.04s- 1 vs 1.42±0.06 s- 1, p<0.0001). CONCLUSION: Atrial strain and strain rate parameters are superior to conventional echocardiographic parameters for the evaluation of atrial stunning in AF cases where SR has been achieved.
[Mh] Termos MeSH primário: Apêndice Atrial/fisiopatologia
Fibrilação Atrial/complicações
Fibrilação Atrial/fisiopatologia
Função Atrial/fisiologia
Miocárdio Atordoado/fisiopatologia
[Mh] Termos MeSH secundário: Apêndice Atrial/diagnóstico por imagem
Fibrilação Atrial/diagnóstico por imagem
Ecocardiografia
Cardioversão Elétrica/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Miocárdio Atordoado/diagnóstico por imagem
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Volume Sistólico/fisiologia
Sístole/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE


  10 / 2151 MEDLINE  
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[PMID]:27566477
[Au] Autor:Ieva R; Casavecchia G; Gravina M; Totaro A; Ferraretti A; Macarini L; Di Biase M; Brunetti ND
[Ad] Endereço:Cardiology Department, Ospedali Riuniti University Hospital, University of Foggia, Foggia, Italy.
[Ti] Título:Prolonged QT and myocardium recovery after primary PCI: a cMRI study.
[So] Source:Eur J Clin Invest;46(10):873-9, 2016 Oct.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The presence of viable stunned myocardium recovering after primary angioplasty is not easy to identify in the early phase of acute myocardial infarction (AMI) by noninvasive bed-side methods. We therefore aimed to assess whether a simple electrocardiogram parameter may be of help in identifying the presence of stunned viable myocardium recovering after reperfusion with primary angioplasty. MATERIALS AND METHODS: A total of 14 consecutive patients with ST-elevation AMI (STEMI) were enrolled in the study and underwent QT duration assessment after admission: the difference between QT corrected (QTc) in the ischaemic areas and QTc values in nonischaemic areas was therefore calculated and compared with the presence and the extension of viable stunned myocardium, assessed by comparing akinetic/dyskinetic areas at admission echocardiography with akinetic/dyskinetic areas and extension of scar at 6-month cardiac magnetic resonance imaging (cMRI). RESULTS: In subjects with viable recovering myocardium, 75% had a QTc max > 440 ms (vs. 17%, P = 0·03); higher differential QTc values and smaller scar areas were found (33 ms vs. -17 ms, 14% vs. 27%, P = 0·03, 0·06 respectively). Differential QTc values > 0 were able to identify the presence of viable myocardium with an odds ratio of 35 (P < 0·05, sensitivity 88%, specificity 83%, positive predictive power 88%, negative predictive power of 83%). Differential QTc values were related to the extension of viable recovering myocardium (P < 0·001). CONCLUSION: Viable myocardium recovering after primary angioplasty in STEMI may be predicted by the presence of increased QTc values in ischaemic areas in comparison with nonischaemic areas.
[Mh] Termos MeSH primário: Síndrome do QT Longo/etiologia
Miocárdio Atordoado/etiologia
Intervenção Coronária Percutânea
Infarto do Miocárdio com Supradesnível do Segmento ST/cirurgia
[Mh] Termos MeSH secundário: Cicatriz/etiologia
Cicatriz/fisiopatologia
Eletrocardiografia
Seres Humanos
Síndrome do QT Longo/fisiopatologia
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Miocárdio Atordoado/fisiopatologia
Recuperação de Função Fisiológica/fisiologia
Infarto do Miocárdio com Supradesnível do Segmento ST/fisiopatologia
Volume Sistólico/fisiologia
Disfunção Ventricular Esquerda/etiologia
Disfunção Ventricular Esquerda/fisiopatologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12670



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