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[PMID]:29246081
[Au] Autor:Garriboli L; Jannello AM
[Ad] Endereço:1 Department of Vascular Surgery, H. Sacro Cuore Don Calabria, Negrar VR, Italy.
[Ti] Título:Uncovered Chimney Stent Graft for Renal Arteries With the Nellix Endovascular Aneurysm Sealing Technique.
[So] Source:Vasc Endovascular Surg;52(2):148-153, 2018 Feb.
[Is] ISSN:1938-9116
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the application of uncovered chimney stent grafts with the Nellix endovascular aneurysm sealing technique (ChEVAS) for juxtarenal abdominal aortic aneurysms (JAAAs). CASE REPORT: Two patients with JAAA and multiple comorbidities were considered unfit for open surgery and were selected for an endovascular approach. Fenestrated and branched endografts were too expensive, and a chimney endovascular approach was considered inappropriate for the relatively high incidence of proximal type I endoleak and graft migration. ChEVAS was performed successfully with the novel addition of uncovered chimney stents to further reduce costs and possibly improve target vessel patency. JAAA exclusion and visceral vessel patency was confirmed at 18-month follow-up. CONCLUSION: ChEVAS with bare chimney stents is technically less complex, potentially reduces access complications and procedural costs, and may improve long-term patency compared to alternative techniques. Results at 18 months seem promising, but strict follow-up is necessary as the long-term durability is unknown.
[Mh] Termos MeSH primário: Aorta Abdominal/cirurgia
Aneurisma da Aorta Abdominal/cirurgia
Implante de Prótese Vascular/instrumentação
Prótese Vascular
Procedimentos Endovasculares/instrumentação
Artéria Renal/cirurgia
Stents
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Aorta Abdominal/diagnóstico por imagem
Aneurisma da Aorta Abdominal/diagnóstico por imagem
Aortografia/métodos
Angiografia por Tomografia Computadorizada
Seres Humanos
Masculino
Meia-Idade
Desenho de Prótese
Artéria Renal/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1177/1538574417747175


  2 / 16441 MEDLINE  
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[PMID]:29443753
[Au] Autor:Lee M; Ryu JS; Suh CH; Hyun IY
[Ad] Endereço:Departments of Nuclear Medicine.
[Ti] Título:Intense 18F-FDG activity in aortoiliac bypass graft mimicking infection: A case report.
[So] Source:Medicine (Baltimore);97(7):e9876, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) has the potential to become an important imaging tool for the diagnosis of suspected aortoiliac bypass graft infection (AGI). PATIENT CONCERNS: A 76-year-old man presented with incidental findings of intense F-FDG activity in previous operation site of aortobiiliac bypass graft in the initial staging of small cell lung cancer (SCLC). DIAGNOSES: Based on F-FDG PET/CT examination, preliminary differential diagnosis was AGI. INTERVENTIONS: We performed laboratory tests and Galliun-citrate (Ga) single photon emission computed tomography/computed tomography (SPECT/CT). OUTCOMES: He had no constitutional symptoms and abnormal laboratory test results suggesting AGI. CT scan of the abdomen and pelvis showed no abnormal findings. Also, Ga planar scintigraphy and SPECT/CT imaging of the abdomen and pelvis failed to show abnormal Ga uptake in the same site of aortobiiliac bypass graft with F-FDG uptake. LESSONS: We present a case with postoperative inflammatory aortobiiliac bypass graft which was misdiagnosed as AGI based on intense F-FDG activity seen at PET/CT imaging.
[Mh] Termos MeSH primário: Fluordesoxiglucose F18/uso terapêutico
Neoplasias Pulmonares/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Infecções Relacionadas à Prótese/diagnóstico
Carcinoma de Pequenas Células do Pulmão/patologia
Enxerto Vascular
[Mh] Termos MeSH secundário: Idoso
Aorta Abdominal/diagnóstico por imagem
Aorta Abdominal/cirurgia
Aneurisma da Aorta Abdominal/cirurgia
Diagnóstico Diferencial
Seres Humanos
Artéria Ilíaca/diagnóstico por imagem
Artéria Ilíaca/cirurgia
Achados Incidentais
Masculino
Estadiamento de Neoplasias
Compostos Radiofarmacêuticos/uso terapêutico
Reprodutibilidade dos Testes
Enxerto Vascular/efeitos adversos
Enxerto Vascular/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009876


  3 / 16441 MEDLINE  
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[PMID]:29346401
[Au] Autor:van Puijvelde GHM; Foks AC; van Bochove RE; Bot I; Habets KLL; de Jager SC; Ter Borg MND; van Osch P; Boon L; Vos M; de Waard V; Kuiper J
[Ad] Endereço:Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
[Ti] Título:CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice.
[So] Source:PLoS One;13(1):e0190962, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (Ang II). We demonstrate that a deficiency in CD1d dependent NKT cells under hyperlipidemic conditions (LDLr-/-CD1d-/- mice) results in a strong decline in the severity of angiotensin II induced aneurysm formation when compared with LDLr-/- mice. In addition, we show that Ang II amplifies the activation of NKT cells both in vivo and in vitro. We also provide evidence that type I NKT cells contribute to AAA development by inducing the expression of matrix degrading enzymes in vSMCs and macrophages, and by cytokine dependently decreasing vSMC viability. Altogether, these data prove that CD1d-dependent NKT cells contribute to AAA development in the Ang II-mediated aneurysm model by enhancing aortic degradation, establishing that therapeutic applications which target NKT cells can be a successful way to prevent AAA development.
[Mh] Termos MeSH primário: Antígenos CD1d/genética
Aneurisma da Aorta Abdominal/prevenção & controle
Receptores de LDL/genética
[Mh] Termos MeSH secundário: Angiotensina II/administração & dosagem
Animais
Apoptose/imunologia
Citometria de Fluxo
Ativação Linfocitária
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Músculo Liso Vascular/imunologia
Músculo Liso Vascular/patologia
Células NIH 3T3
Células T Matadoras Naturais/imunologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD1d); 0 (Cd1d1 protein, mouse); 0 (Receptors, LDL); 11128-99-7 (Angiotensin II)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190962


  4 / 16441 MEDLINE  
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[PMID]:29350897
[Au] Autor:Tomic A; Milovic N; Marjanovic I; Lekovic; Bjelanovic Z; Sarac M; Vavic N; Ignjatovic L; Stamenkovic D; Mickovic S
[Ti] Título:Aortobifemoral reconstruction and renal transplantation in a patient with abdominal aortic aneurysm and occlusion of iliac arteries: A case report.
[So] Source:Vojnosanit Pregl;74(1):81-4, 2017 Jan.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Aortoiliac occlusive disease and abdominal aortic aneurysm in patients with renal insufficiency on hemodialysis can significantly influence the success of renal transplantation. In the recent past, advanced atherosclerosis was considered as contraindication for renal transplantation. Complicated creation of vascular anastomoses and progression of occlusive or aneurysmal disease were the main reasons. Case report: We presented a 52-year-old man with a 5-year history of end-stage renal disease on haemodialysis. The patient was previously excluded from renal transplantation program because of severe aortoiliac atherosclerosis and abdominal aortic aneurysm. Resection of abdominal aortic aneurysm with occlusion of the iliac arteries and reconstruction with aortobifemoral synthetic grafts was performed and followed by cadaveric renal transplantation. Conclusion: Advanced atherosclerotic disease in aortoiliac segment requires elective vascular surgical reconstruction, as part of preparation for renal transplantation in patients with end-stage renal disease.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/cirurgia
Arteriopatias Oclusivas/cirurgia
Implante de Prótese Vascular/métodos
Artéria Femoral/cirurgia
Artéria Ilíaca/cirurgia
Falência Renal Crônica/cirurgia
Transplante de Rim
[Mh] Termos MeSH secundário: Aneurisma da Aorta Abdominal/complicações
Aneurisma da Aorta Abdominal/diagnóstico por imagem
Aortografia/métodos
Arteriopatias Oclusivas/complicações
Arteriopatias Oclusivas/diagnóstico por imagem
Prótese Vascular
Implante de Prótese Vascular/instrumentação
Angiografia por Tomografia Computadorizada
Artéria Femoral/diagnóstico por imagem
Seres Humanos
Artéria Ilíaca/diagnóstico por imagem
Falência Renal Crônica/complicações
Falência Renal Crônica/diagnóstico
Masculino
Meia-Idade
Polietilenotereftalatos
Desenho de Prótese
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyethylene Terephthalates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.2298/VSP140609139T


  5 / 16441 MEDLINE  
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[PMID]:29314796
[Au] Autor:Sarac M; Marjanovic I; Bezmarevic M; Sarac S; Milic R; Obradovic S; Tomic A
[Ti] Título:Influence of open surgical and endovascular abdominal aortic aneurysm repair on clot quality assessed by ROTEM® test.
[So] Source:Vojnosanit Pregl;73(7):643-50, 2016 Jul.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction/Aim: The disturbances in hemostasis are often in open surgical repair (OR) and endovascular repair (EVAR) of an abdominal aortic aneurysm (AAA). These changes may influence the perioperative and early postoperative period inducing serious complications. The aim of this study was to compare the impact of OR and EVAR of AAA on clot quality assessed by rotational thromboelastometry (ROTEM®) tests. Methods: The study included 40 patients who underwent elective AAA surgery and were devided into two groups (the OR and the EVAR group - 20 patients in each group). The ROTEM ® test was performed in 4 points: point 1 - 10 min before starting anesthesia in both groups; point 2 - 10 min after aortic clapming in the OR group and 10 min after the stent-graft trunk release in the EVAR group; point 3 - 10 min after the releasing of aortic clamp in the OR group and 10 min after stentgraft placement and releasing the femoral clamp in the EVAR group; point 4 - one hour after the procedure in both groups. Three ROTEM® tests were performed as: extrinsically activated assay with tissue factor (EXTEM), intrinsically activated test using kaolin (INTEM), and extrinsically activated test with tissue factor and the platelet inhibitor cytochalasin D (FIBTEM). All tests included the assessment of the maximum clot firmness (MCF) and the platelet component of clot strength was presented as maximal clot elasticity (MCE). Results: No significant difference in age, gender and diameter of AAA between groups was found. The time required for the procedure was significantly longer and loss of blood was greater in the OR group than in the EVAR group (p < 0.001). The significant deviation of MCF values in EXTEM test was found mainly in the point 3 (p ≤ 0.004) with significant difference between groups (p < 0.001). A significant difference of MCF values in INTEM test between groups was found in the points 3 and 4 (p < 0.001), which were dose-dependent by heparin sulfate. The MCF values in FIBTEM test were more prominent in the OR group than in the EVAR group without significant difference. The significant changes of MCF values in the FIBTEM test were found during time in both groups (p < 0.001). The values of MCE were lower in both groups, but without significant changes and difference between groups (p = 0.105). Conclusion: The disorders of hemostatic parameters assessed by ROTEM® tests are present in both the OR and the EVAR groups being more prominent in OR of AAA. Vigilant monitoring of hemostatic parameters evaluated by ROTEM® tests could help in administration of the adequate and target therapy in patients who underwent EVAR or OR of AAA.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/sangue
Aneurisma da Aorta Abdominal/cirurgia
Coagulação Sanguínea
Procedimentos Endovasculares
[Mh] Termos MeSH secundário: Idoso
Transtornos da Coagulação Sanguínea/etiologia
Testes de Coagulação Sanguínea
Procedimentos Endovasculares/efeitos adversos
Feminino
Seres Humanos
Masculino
Complicações Pós-Operatórias
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150510123S


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[PMID]:29296021
[Au] Autor:Li T; Yu B; Liu Z; Li J; Ma M; Wang Y; Zhu M; Yin H; Wang X; Fu Y; Yu F; Wang X; Fang X; Sun J; Kong W
[Ad] Endereço:Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
[Ti] Título:Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.
[So] Source:Nat Commun;9(1):11, 2018 01 02.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However, the mechanism underlying HHcy-aggravated vascular injury remains unclear. Here we show that the aggravation of abdominal aortic aneurysm by HHcy is abolished in mice with genetic deletion of the angiotensin II type 1 (AT1) receptor and in mice treated with an AT1 blocker. We find that homocysteine directly activates AT1 receptor signalling. Homocysteine displaces angiotensin II and limits its binding to AT1 receptor. Bioluminescence resonance energy transfer analysis reveals distinct conformational changes of AT1 receptor upon binding to angiotensin II and homocysteine. Molecular dynamics and site-directed mutagenesis experiments suggest that homocysteine regulates the conformation of the AT1 receptor both orthosterically and allosterically by forming a salt bridge and a disulfide bond with its Arg and Cys residues, respectively. Together, these findings suggest that strategies aimed at blocking the AT1 receptor may mitigate HHcy-associated aneurysmal vascular injuries.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/metabolismo
Homocisteína/metabolismo
Receptor Tipo 1 de Angiotensina/metabolismo
[Mh] Termos MeSH secundário: Regulação Alostérica
Angiotensina I/metabolismo
Angiotensina II/metabolismo
Animais
Células HEK293
Seres Humanos
Masculino
Camundongos Endogâmicos C57BL
Simulação de Dinâmica Molecular
Mutagênese Sítio-Dirigida
Conformação Proteica
Lesões do Sistema Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptor, Angiotensin, Type 1); 0LVT1QZ0BA (Homocysteine); 11128-99-7 (Angiotensin II); 9041-90-1 (Angiotensin I)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02401-7


  7 / 16441 MEDLINE  
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[PMID]:29225168
[Au] Autor:Chai H; Tao Z; Chen W; Xu Y; Huang F; Su C; Chen X
[Ad] Endereço:The Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Changle Road 68, Nanjing 210006, Jiangsu, People's Republic of China.
[Ti] Título:Cortistatin attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the ERK1/2 signaling pathways.
[So] Source:Biochem Biophys Res Commun;495(2):1801-1806, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abdominal aortic aneurysm (AAA) is a fatal disease that is associated with chronic inflammation in the vessel wall. Cortistatin is implicated in inflammation, vascular smooth muscle cell migration and other cardiovascular pathologies. But, the hypothetical effect of cortistatin on AAA remains uncertain. We investigated the effect of cortistatin administration to angiotensin (Ang) II-induced AAA formation in apolipoprotein E deficient (Apoe ) mice. We showed that cortistatin administration significantly suppresses incidence and severity of AAA in Apoe mice. A significant increase in macrophage infiltration, excretion of inflammatory cytokines, activities and expression levels of MMP2 and MMP9, reactive oxygen species levels and cell apoptosis in aneurysmal aortic wall of Apoe mice infused with Ang-II, and these events were significantly alleviated by co-treatment with cortistatin. Mechanistic studies showed that the protective effects of cortistatin were related to the blocking of ERK1/2 signaling pathways, while does not was not actually affect JNK, P38 phosphorylation. In conclusion, cortistatin appears to play an essential role in the formation of AAA and indicate cortistatin may as novel therapeutic option for AAA.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/prevenção & controle
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Neuropeptídeos/administração & dosagem
[Mh] Termos MeSH secundário: Angiotensina II/administração & dosagem
Animais
Aorta Abdominal/efeitos dos fármacos
Aorta Abdominal/metabolismo
Aorta Abdominal/patologia
Aneurisma da Aorta Abdominal/etiologia
Aneurisma da Aorta Abdominal/metabolismo
Apoptose/efeitos dos fármacos
Linhagem Celular
Modelos Animais de Doenças
Elastina/metabolismo
Masculino
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Camundongos
Camundongos Knockout para ApoE
Miócitos de Músculo Liso/efeitos dos fármacos
Miócitos de Músculo Liso/patologia
Proteólise/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Neuropeptides); 0 (Reactive Oxygen Species); 0 (cortistatin); 11128-99-7 (Angiotensin II); 9007-58-3 (Elastin); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.24 (Mmp2 protein, mouse); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  8 / 16441 MEDLINE  
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[PMID]:27773830
[Au] Autor:Stefanov F; McGloughlin T; Morris L
[Ad] Endereço:Galway Medical Technologies Centre, Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
[Ti] Título:A computational assessment of the hemodynamic effects of crossed and non-crossed bifurcated stent-graft devices for the treatment of abdominal aortic aneurysms.
[So] Source:Med Eng Phys;38(12):1458-1473, 2016 12.
[Is] ISSN:1873-4030
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are several issues attributed with abdominal aortic aneurysm endovascular repair. The positioning of bifurcated stent-grafts (SG) may affect SG hemodynamics. The hemodynamics and geometrical parameters of crossing or non-crossing graft limbs have not being totally accessed. Eight patient-specific SG devices and four pre-operative cases were computationally simulated, assessing the hemodynamic and geometrical effects for crossed (n= 4) and non-crossed (n= 4) configurations. SGs eliminated the occurrence of significant recirculations within the sac prior treatment. Dean's number predicted secondary flow locations with the greatest recirculations occurring at the outlets especially during the deceleration phase. Peak drag force varied from 3.9 to 8.7N, with greatest contribution occurring along the axial and anterior/posterior directions. Average resultant drag force was 20% smaller for the crossed configurations. Maximum drag force orientation varied from 1.4° to 51°. Drag force angle varied from 1° to 5° during one cardiac cycle. 44% to 62% of the resultant force acted along the proximal centerline where SG migration is most likely to occur. The clinician's decision for SG positioning may be a critical parameter, and should be considered prior to surgery. All crossed SG devices had an increased spiral flow effect along the distal legs with reductions in drag forces.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/fisiopatologia
Aneurisma da Aorta Abdominal/terapia
Hemodinâmica
Medicina de Precisão/instrumentação
Stents
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 16441 MEDLINE  
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[PMID]:28454907
[Au] Autor:Ruiz de Galarreta S; Antón R; Cazón A; Finol EA
[Ad] Endereço:Department of Mechanical Engineering, Tecnun, University of Navarra, Paseo Manuel de Lardizabal, 13, 20018 San Sebastián, Spain.
[Ti] Título:A methodology for developing anisotropic AAA phantoms via additive manufacturing.
[So] Source:J Biomech;57:161-166, 2017 05 24.
[Is] ISSN:1873-2380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An Abdominal Aortic Aneurysm (AAA) is a permanent focal dilatation of the abdominal aorta at least 1.5 times its normal diameter. The criterion of maximum diameter is still used in clinical practice, although numerical studies have demonstrated the importance of biomechanical factors for rupture risk assessment. AAA phantoms could be used for experimental validation of the numerical studies and for pre-intervention testing of endovascular grafts. We have applied multi-material 3D printing technology to manufacture idealized AAA phantoms with anisotropic mechanical behavior. Different composites were fabricated and the phantom specimens were characterized by biaxial tensile tests while using a constitutive model to fit the experimental data. One composite was chosen to manufacture the phantom based on having the same mechanical properties as those reported in the literature for human AAA tissue; the strain energy and anisotropic index were compared to make this choice. The materials for the matrix and fibers of the selected composite are, respectively, the digital materials FLX9940 and FLX9960 developed by Stratasys. The fiber proportion for the composite is equal to 0.15. The differences between the composite behavior and the AAA tissue are small, with a small difference in the strain energy (0.4%) and a maximum difference of 12.4% in the peak Green strain ratio. This work represents a step forward in the application of 3D printing technology for the manufacturing of AAA phantoms with anisotropic mechanical behavior.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal
Imagens de Fantasmas
[Mh] Termos MeSH secundário: Anisotropia
Aorta Abdominal
Ruptura Aórtica
Fenômenos Biomecânicos
Seres Humanos
Impressão Tridimensional
Medição de Risco
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180120
[Lr] Data última revisão:
180120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  10 / 16441 MEDLINE  
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[PMID]:29265406
[Au] Autor:Oliver-Williams C; Sweeting MJ; Turton G; Parkin D; Cooper D; Rodd C; Thompson SG; Earnshaw JJ; Gloucestershire and Swindon Abdominal Aortic Aneurysm Screening Programme
[Ad] Endereço:Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, Cambridge, UK.
[Ti] Título:Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme.
[So] Source:Br J Surg;105(1):68-74, 2018 Jan.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to assess how the prevalence and growth rates of small and medium abdominal aortic aneurysms (AAAs) (3·0-5·4 cm) have changed over time in men aged 65 years, and to evaluate long-term outcomes in men whose aortic diameter is 2·6-2·9 cm (subaneurysmal), and below the standard threshold for most surveillance programmes. METHODS: The Gloucestershire Aneurysm Screening Programme (GASP) started in 1990. Men aged 65 years with an aortic diameter of 2·6-5·4 cm, measured by ultrasonography using the inner to inner wall method, were included in surveillance. Aortic diameter growth rates were estimated separately for men who initially had a subaneurysmal aorta, and those who had a small or medium AAA, using mixed-effects models. RESULTS: Since 1990, 81 150 men had ultrasound screening for AAA (uptake 80·7 per cent), of whom 2795 had an aortic diameter of 2·6-5·4 cm. The prevalence of screen-detected AAA of 3·0 cm or larger decreased from 5·0 per cent in 1991 to 1·3 per cent in 2015. There was no evidence of a change in AAA growth rates during this time. Of men who initially had a subaneurysmal aorta, 57·6 (95 per cent c.i. 54·4 to 60·7) per cent were estimated to develop an AAA of 3·0 cm or larger within 5 years of the initial scan, and 28·0 (24·2 to 31·8) per cent to develop a large AAA (at least 5·5 cm) within 15 years. CONCLUSION: The prevalence of screen-detected small and medium AAAs has decreased over the past 25 years, but growth rates have remained similar. Men with a subaneurysmal aorta at age 65 years have a substantial risk of developing a large AAA by the age of 80 years.
[Mh] Termos MeSH primário: Aneurisma da Aorta Abdominal/diagnóstico por imagem
Aneurisma da Aorta Abdominal/epidemiologia
Programas de Rastreamento
[Mh] Termos MeSH secundário: Idoso
Aneurisma da Aorta Abdominal/patologia
Progressão da Doença
Seguimentos
Seres Humanos
Masculino
Modelos Estatísticos
Prevalência
Ultrassonografia
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10715



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