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Pesquisa : C14.907.055.817 [Categoria DeCS]
Referências encontradas : 23 [refinar]
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  1 / 23 MEDLINE  
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[PMID]:27770590
[Au] Autor:Cho YH; Craig ME; Januszewski AS; Benitez-Aguirre P; Hing S; Jenkins AJ; Donaghue KC
[Ad] Endereço:Institute of Endocrinology and Diabetes, Children's Hospital at Westmead, Westmead, Australia.
[Ti] Título:Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications.
[So] Source:Diabet Med;34(4):543-550, 2017 Apr.
[Is] ISSN:1464-5491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To test the hypothesis that non-invasive skin autofluorescence, a measure of advanced glycation end products, would provide a surrogate measure of long-term glycaemia and be associated with early markers of microvascular complications in adolescents with Type 1 diabetes. METHODS: Forearm skin autofluorescence (arbitrary units) was measured in a cross-sectional study of 135 adolescents with Type 1 diabetes [mean ± sd age 15.6 ± 2.1 years, diabetes duration 8.7 ± 3.5 years, HbA 72 ± 16 mmol/mol (8.7 ± 1.5%)]. Retinopathy, assessed using seven-field stereoscopic fundal photography, was defined as ≥1 microaneurysm or haemorrhage. Cardiac autonomic function was measured by standard deviation of consecutive RR intervals on a 10-min continuous electrocardiogram recording, as a measure of heart rate variability. RESULTS: Skin autofluorescence was significantly associated with age (R = 0.15; P < 0.001). Age- and gender-adjusted skin autofluorescence was associated with concurrent HbA (R = 0.32; P < 0.001) and HbA over the previous 2.5-10 years (R = 0.34-0.43; P < 0.002). Age- and gender-adjusted mean skin autofluorescence was higher in adolescents with retinopathy vs those without retinopathy [mean 1.38 (95% CI 1.29, 1.48) vs 1.22 (95% CI 1.17, 1.26) arbitrary units; P = 0.002]. In multivariable analysis, retinopathy was significantly associated with skin autofluorescence, adjusted for duration (R = 0.19; P = 0.03). Cardiac autonomic dysfunction was also independently associated with skin autofluorescence (R = 0.11; P = 0.006). CONCLUSIONS: Higher skin autofluorescence is associated with retinopathy and cardiac autonomic dysfunction in adolescents with Type 1 diabetes. The relationship between skin autofluorescence and previous glycaemia may provide insight into metabolic memory. Longitudinal studies will determine the utility of skin autofluorescence as a non-invasive screening tool to predict future microvascular complications.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/fisiopatologia
Angiopatias Diabéticas/diagnóstico por imagem
Retinopatia Diabética/diagnóstico por imagem
Microaneurisma/diagnóstico por imagem
Hemorragia Retiniana/diagnóstico por imagem
Pele/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Doenças do Sistema Nervoso Autônomo/etiologia
Doenças do Sistema Nervoso Autônomo/fisiopatologia
Diabetes Mellitus Tipo 1/complicações
Diabetes Mellitus Tipo 1/metabolismo
Angiopatias Diabéticas/etiologia
Angiopatias Diabéticas/fisiopatologia
Retinopatia Diabética/etiologia
Retinopatia Diabética/fisiopatologia
Eletrocardiografia
Feminino
Fundo de Olho
Hemoglobina A Glicada/metabolismo
Frequência Cardíaca
Seres Humanos
Masculino
Microaneurisma/etiologia
Microaneurisma/fisiopatologia
Análise Multivariada
Imagem Óptica
Hemorragia Retiniana/etiologia
Hemorragia Retiniana/fisiopatologia
Pele/irrigação sanguínea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/dme.13280


  2 / 23 MEDLINE  
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[PMID]:28570738
[Au] Autor:López-Luppo M; Catita J; Ramos D; Navarro M; Carretero A; Mendes-Jorge L; Muñoz-Cánoves P; Rodriguez-Baeza A; Nacher V; Ruberte J
[Ad] Endereço:Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain 2Department of Animal Health and Anatomy, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
[Ti] Título:Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging.
[So] Source:Invest Ophthalmol Vis Sci;58(7):2832-2842, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several age-related diseases, has been analyzed in the old-age human retina and in the retina of a progeric mouse. Methods: Retinas were obtained from 17 nondiabetic donors and from mice deficient in Bmi1. Cellular senescence was analyzed by immunohistochemistry, senescent-associated ß-galactosidase activity assay, Sudan black B staining, conventional transmission electron microscopy, and immunoelectronmicroscopy. Results: Neurons, but not neuroglia, and blood vessels undergo cellular senescence in the old-age human retina. The canonical senescence markers p16, p53, and p21 were up-regulated and coexisted with apoptosis in old-age human microaneurysms. Senescent endothelial cells were discontinuously covered by fibronectin, and p16 colocalized with the ß1 subunit of fibronectin receptor α5ß1 integrin under the endothelial cellular membrane, suggesting anoikis as a mechanism involved in endothelial cell apoptosis. In a progeric mouse model deficient in Bmi1, where p21 was overexpressed, the retinal blood vessels displayed an aging phenotype characterized by enlarged caveolae and lipofuscin accumulation. Although mouse retina is not prone to develop microaneurysms, Bmi1-deficient mice presented abundant retinal microaneurysms. Conclusions: Together, these results uncover cellular senescence as a player during the formation of microaneurysms in old-age human retinas.
[Mh] Termos MeSH primário: Envelhecimento
Senescência Celular/fisiologia
Microaneurisma/patologia
Vasos Retinianos/ultraestrutura
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Apoptose
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Camundongos
Microscopia Eletrônica de Transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20312


  3 / 23 MEDLINE  
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[PMID]:28483496
[Au] Autor:Parravano M; De Geronimo D; Scarinci F; Querques L; Virgili G; Simonett JM; Varano M; Bandello F; Querques G
[Ad] Endereço:Fondazione G.B. Bietti-IRCCS, Rome, Italy.
[Ti] Título:Diabetic Microaneurysms Internal Reflectivity on Spectral-Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography Detection.
[So] Source:Am J Ophthalmol;179:90-96, 2017 Jul.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To correlate the appearance of microaneurysms (MAs) on structural spectral-domain optical coherence tomography (SDOCT) with their detection on OCT angiography (OCTA) in patients with nonproliferative diabetic retinopathy (NPDR). DESIGN: Interinstrument reliability study. METHODS: Sixteen patients with NPDR without macular edema underwent SDOCT and OCTA. To compare MAs seen on OCTA with those on SDOCT, we superimposed the OCTA superficial capillary plexus (SCP) vascular landmarks onto those of the near infrared. Two observers masked to patient groupings evaluated reflectivity of MAs on SDOCT scans, graded as hyporeflective, moderate, or hyperreflective, and their visualization at the level of SCP and deep capillary plexus (DCP) on OCTA. RESULTS: Among 145 MAs imaged with SDOCT, 47 (32.4%) appeared as hyperreflective, 71 (49.0%) as moderately reflective, and 27 (18.6%) as hyporeflective. After excluding 3 eyes (10 MAs) because of poor-quality OCTA scans, 135 MAs were evaluated on OCTA; 76 (56.3%) were visible only in the DCP, 9 (6.7%) only in the SCP, 29 (21.5%) were visible in both SCP and DCP; and 21 (15.6%) were not visible on OCTA. Compared with MAs with hyperreflectivity or moderate reflectivity, MAs with hyporeflectivity on structural SDOCT were significantly less likely to be detected on OCTA (odds ratio [OR]: 4.6; 95% confidence interval [CI]: 1.5-14.0, P = .008; and OR: 4.2, 95% CI: 1.2-14.2, P = .022, respectively). CONCLUSIONS: MAs that appear hyporeflective on structural SDOCT have a lower detection rate on OCTA. The results of this study may help further understand the different blood flow dynamics pattern in MAs.
[Mh] Termos MeSH primário: Retinopatia Diabética/diagnóstico
Angiofluoresceinografia/métodos
Macula Lutea/patologia
Microaneurisma/diagnóstico
Vasos Retinianos/patologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Idoso
Capilares/patologia
Retinopatia Diabética/complicações
Feminino
Fundo de Olho
Seres Humanos
Masculino
Microaneurisma/etiologia
Meia-Idade
Reprodutibilidade dos Testes
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE


  4 / 23 MEDLINE  
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[PMID]:28432113
[Au] Autor:Ehlers JP; Wang K; Vasanji A; Hu M; Srivastava SK
[Ad] Endereço:Ophthalmic Imaging Center, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
[Ti] Título:Automated quantitative characterisation of retinal vascular leakage and microaneurysms in ultra-widefield fluorescein angiography.
[So] Source:Br J Ophthalmol;101(6):696-699, 2017 Jun.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ultra-widefield fluorescein angiography (UWFA) is an emerging imaging modality used to characterise pathology in the retinal vasculature such as microaneurysms (MAs) and vascular leakage. Despite its potential value for diagnosis and disease surveillance, objective quantitative assessment of retinal pathology by UWFA is currently limited because it requires laborious manual segmentation by trained human graders. In this report, we describe a novel fully automated software platform, which segments MAs and leakage areas in native and dewarped UWFA images with retinal vascular disease. Comparison of the algorithm with human grader-generated gold standards demonstrated significant strong correlations for MA and leakage areas (intraclass correlation coefficient (ICC)=0.78-0.87 and ICC=0.70-0.86, respectively, p=2.1×10 to 3.5×10 and p=7.8×10 to 1.3×10 , respectively). These results suggest the algorithm performs similarly to human graders in MA and leakage segmentation and may be of significant utility in clinical and research settings.
[Mh] Termos MeSH primário: Angiofluoresceinografia/métodos
Microaneurisma/diagnóstico
Retina/patologia
Doenças Retinianas/diagnóstico
[Mh] Termos MeSH secundário: Algoritmos
Fundo de Olho
Seres Humanos
Vasos Retinianos/patologia
Estudos Retrospectivos
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-310047


  5 / 23 MEDLINE  
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[PMID]:28421125
[Au] Autor:Zhou W; Wu C; Chen D; Wang Z; Yi Y; Du W
[Ad] Endereço:Faculty of Robot Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China.
[Ti] Título:Automatic Microaneurysms Detection Based on Multifeature Fusion Dictionary Learning.
[So] Source:Comput Math Methods Med;2017:2483137, 2017.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recently, microaneurysm (MA) detection has attracted a lot of attention in the medical image processing community. Since MAs can be seen as the earliest lesions in diabetic retinopathy, their detection plays a critical role in diabetic retinopathy diagnosis. In this paper, we propose a novel MA detection approach named multifeature fusion dictionary learning (MFFDL). The proposed method consists of four steps: preprocessing, candidate extraction, multifeature dictionary learning, and classification. The novelty of our proposed approach lies in incorporating the semantic relationships among multifeatures and dictionary learning into a unified framework for automatic detection of MAs. We evaluate the proposed algorithm by comparing it with the state-of-the-art approaches and the experimental results validate the effectiveness of our algorithm.
[Mh] Termos MeSH primário: Algoritmos
Retinopatia Diabética/diagnóstico por imagem
Técnicas de Diagnóstico Oftalmológico
Microaneurisma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Seres Humanos
Processamento de Imagem Assistida por Computador
Aprendizagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1155/2017/2483137


  6 / 23 MEDLINE  
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[PMID]:28336057
[Au] Autor:Silva PS; El-Rami H; Barham R; Gupta A; Fleming A; van Hemert J; Cavallerano JD; Sun JK; Aiello LP
[Ad] Endereço:Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Teleophthalmology and Image Reading Center, Philippine Eye Research Institute, National Institutes of Health, University of the Philippines, Manila, Phili
[Ti] Título:Hemorrhage and/or Microaneurysm Severity and Count in Ultrawide Field Images and Early Treatment Diabetic Retinopathy Study Photography.
[So] Source:Ophthalmology;124(7):970-976, 2017 Jul.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate detection of hemorrhage and/or microaneurysm (H/Ma) using ultrawide field (UWF) retinal imaging as compared with standard Early Treatment Diabetic Retinopathy Study (ETDRS) 7-field photographs (ETDRS photos). DESIGN: Single-site comparative study of UWF images and ETDRS photos. PARTICIPANTS: One hundred twenty-six eyes of 69 patients with no diabetic retinopathy (DR) or mild or moderate nonproliferative DR (NPDR). METHODS: Stereoscopic 200° UWF images and stereoscopic 35mm 30° 7-field color photographs were acquired on the same visit. Images were graded for severity and distribution of H/Ma. H/Mas were counted in ETDRS fields 2 to 7 in both ETDRS photos and UWF images. H/Mas in the UWF peripheral fields were also counted. MAIN OUTCOME MEASURES: Kappa (κ) and weighted κ statistics for agreement. Number of H/Ma within and outside ETDRS fields identified in UWF images and ETDRS photos. RESULTS: Distribution of DR severity by ETDRS photos was 24 (19.0%) no DR, 48 (38.1%) mild NPDR, and 54 (42.9%) moderate NPDR. A total of 748 of 756 fields (98.9%) were gradable for H/Mas on ETDRS photos and UWF images. Simple κ/weighted κ statistics for severity of H/Ma: all fields 0.61/0.69, field 2 0.70/0.77, field 3 0.62/0.73, field 4 0.50/0.62, field 5 0.54/0.65, field 6 0.64/0.70, and field 7 0.58/0.63 with overall exact agreement in 81.3% and within 1 step in 97.9% of fields. A greater proportion of fields was graded a more severe H/Ma level in UWF images than in the corresponding ETDRS photos (UWF: 12.7% vs. ETDRS: 6.5%). Evaluating comparable areas in UWF images and ETDRS photos (fields 2-7), a mean of 42.8 H/Mas were identified using ETDRS photos and 48.8 in UWF images (P = 0.10). An additional mean of 21.3 H/Mas (49.8% increase, P < 0.0001) were identified in the peripheral fields of the UWF images. CONCLUSIONS: There is good to excellent agreement between UWF images and ETDRS photos in determining H/Ma severity, with excellent correlation of H/Ma counts within ETDRS photo fields. UWF peripheral fields identified 49.8% more H/Ma, suggesting a more severe H/Ma in 12.7% of eyes. Given the additional lesions detected in peripheral fields and the known risks associated with H/Ma and peripheral lesions, quantification of H/Ma using UWF images may provide a more accurate representation of DR disease activity and potential greater accuracy in predicting DR progression.
[Mh] Termos MeSH primário: Retinopatia Diabética/diagnóstico
Microaneurisma/diagnóstico
Fotografia/métodos
Retina/patologia
Hemorragia Retiniana/diagnóstico
[Mh] Termos MeSH secundário: Retinopatia Diabética/complicações
Retinopatia Diabética/terapia
Progressão da Doença
Seguimentos
Seres Humanos
Microaneurisma/etiologia
Estudos Prospectivos
Curva ROC
Hemorragia Retiniana/etiologia
Índice de Gravidade de Doença
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  7 / 23 MEDLINE  
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[PMID]:28196225
[Au] Autor:López-Luppo M; Nacher V; Ramos D; Catita J; Navarro M; Carretero A; Rodriguez-Baeza A; Mendes-Jorge L; Ruberte J
[Ad] Endereço:Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Bellaterra, Spain.
[Ti] Título:Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging.
[So] Source:Invest Ophthalmol Vis Sci;58(2):1116-1131, 2017 Feb 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Microaneurysms, considered a hallmark of retinal vascular disease, are present in aged retinas. Here, the basement membrane of human retinal microaneurysms has been analyzed during aging. Methods: Retinas were obtained from 17 nondiabetic donors. Whole mount retinas and paraffin sections were marked immunohistochemically with antibodies against the main components of the blood basement membrane. Trypsin digestion and transmission electron microscopy also were performed. Results: Small microaneurysms presented increased expression of collagen IV, laminin, fibronectin, nidogen, and perlecan, along with basement membrane thickening. Unexpectedly, crosslinked fibrils of collagen III, a type of collagen absent in retinal capillaries, were found specifically in small microaneurysms. This was parallel to enhanced lysyl oxidase-like (LOXL) 2 and 4 expression. Large microaneurysms showed diminution of protein content, as well as disorganization, in their basement membrane. This was concomitant with an increased expression of matrix-metalloproteinase (MMP)-9 and plasminogen activator inhibitor (PAI)-1. Pericyte coverage declined between small and large microaneurysms. Conclusions: Thickening of the basement membrane in small microaneurysms by accumulation of matrix proteins probably produced by recruited pericytes, together with the appearance of crosslinked collagen III fibrils probably due to the action of LOXL2 and LOXL4, could be considered as compensatory mechanisms to strengthen the vascular wall in the early phase of microaneurysm formation. Later, increased activity of MMP-9 and PAI-I, which produce disruption of the blood basement membrane and expansion of microthrombi respectively, and loss of pericytes, which produces weakening of the vascular wall, could explain the wall dilation observed in the late phase of microaneurysm formation.
[Mh] Termos MeSH primário: Envelhecimento
Membrana Basal/ultraestrutura
Microaneurisma/diagnóstico
Doenças Retinianas/diagnóstico
Vasos Retinianos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Membrana Basal/metabolismo
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Metaloproteinase 9 da Matriz/biossíntese
Microaneurisma/metabolismo
Microscopia Eletrônica de Transmissão
Meia-Idade
Inibidor 1 de Ativador de Plasminogênio/biossíntese
Doenças Retinianas/metabolismo
Doadores de Tecidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasminogen Activator Inhibitor 1); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-19998


  8 / 23 MEDLINE  
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[PMID]:28187898
[Au] Autor:Javidi M; Pourreza HR; Harati A
[Ad] Endereço:Faculty of Computer Engineering, Ferdowsi University of Mashhad, Mashhad, Iran; Machine Vision Lab, Eye Image Analysis Research Group (EIARG), Ferdowsi University of Mashhad, Mashhad, Iran.
[Ti] Título:Vessel segmentation and microaneurysm detection using discriminative dictionary learning and sparse representation.
[So] Source:Comput Methods Programs Biomed;139:93-108, 2017 Feb.
[Is] ISSN:1872-7565
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Diabetic retinopathy (DR) is a major cause of visual impairment, and the analysis of retinal image can assist patients to take action earlier when it is more likely to be effective. The accurate segmentation of blood vessels in the retinal image can diagnose DR directly. In this paper, a novel scheme for blood vessel segmentation based on discriminative dictionary learning (DDL) and sparse representation has been proposed. The proposed system yields a strong representation which contains the semantic concept of the image. To extract blood vessel, two separate dictionaries, for vessel and non-vessel, capable of providing reconstructive and discriminative information of the retinal image are learned. In the test step, an unseen retinal image is divided into overlapping patches and classified to vessel and non-vessel patches. Then, a voting scheme is applied to generate the binary vessel map. The proposed vessel segmentation method can achieve the accuracy of 95% and a sensitivity of 75% in the same range of specificity 97% on two public datasets. The results show that the proposed method can achieve comparable results to existing methods and decrease false positive vessels in abnormal retinal images with pathological regions. Microaneurysm (MA) is the earliest sign of DR that appears as a small red dot on the surface of the retina. Despite several attempts to develop automated MA detection systems, it is still a challenging problem. In this paper, a method for MA detection, which is similar to our vessel segmentation approach, is proposed. In our method, a candidate detection algorithm based on the Morlet wavelet is applied to identify all possible MA candidates. In the next step, two discriminative dictionaries with the ability to distinguish MA from non-MA object are learned. These dictionaries are then used to classify the detected candidate objects. The evaluations indicate that the proposed MA detection method achieves higher average sensitivity about 2-15%, compared to existing methods.
[Mh] Termos MeSH primário: Vasos Sanguíneos/patologia
Microaneurisma/diagnóstico
[Mh] Termos MeSH secundário: Algoritmos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


  9 / 23 MEDLINE  
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[PMID]:27927677
[Au] Autor:Soares M; Neves C; Marques IP; Pires I; Schwartz C; Costa MÂ; Santos T; Durbin M; Cunha-Vaz J
[Ad] Endereço:AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal.
[Ti] Título:Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography.
[So] Source:Br J Ophthalmol;101(1):62-68, 2017 Jan.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. METHODS: This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. RESULTS: Percentages of non-gradable images for the outline of foveal avascular zone (FAZ) in the central subfield (CSF) were 29.0% for FA, 12.0% for AngioVue and 3.0% for AngioPlex. For capillary loss, percentages of non-gradable images in the CSF were 25.0% for FA, 11% for AngioVue and 0.0% for AngioPlex. For the inner ring (IR), percentages of non-gradable images were 12.5% for FA, 11.5% for AngioVue and 0.5% for AngioPlex. Agreement between graders was substantial for outline of FAZ. For capillary loss, the agreement was fair for the CSF, and moderate for the IR. CONCLUSIONS: The OCTA allows better discrimination of the CSF and parafoveal macular microvasculature than FA, especially for FAZ disruption and capillary dropout, without the need of an intravenous injection of fluorescein. In addition, FA had also a higher number of non-gradable images. The OCTA can replace with advantage the FA, as a non-invasive and more sensitive procedure for detailed morphological evaluation of central macular vascular changes. TRIAL REGISTRATION NUMBER: NCT02391558, Pre-results.
[Mh] Termos MeSH primário: Retinopatia Diabética/patologia
Angiofluoresceinografia
Vasos Retinianos/diagnóstico por imagem
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Idoso
Capilares/diagnóstico por imagem
Estudos Transversais
Retinopatia Diabética/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Microaneurisma/diagnóstico por imagem
Meia-Idade
Vasos Retinianos/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309424


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[PMID]:27886718
[Au] Autor:Srivastava R; Duan L; Wong DWK; Liu J; Wong TY
[Ad] Endereço:Institute for Infocomm Research, Singapore 138632. Electronic address: srivastavar@i2r.a-star.edu.sg.
[Ti] Título:Detecting retinal microaneurysms and hemorrhages with robustness to the presence of blood vessels.
[So] Source:Comput Methods Programs Biomed;138:83-91, 2017 Jan.
[Is] ISSN:1872-7565
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Diabetic Retinopathy is the leading cause of blindness in developed countries in the age group 20-74 years. It is characterized by lesions on the retina and this paper focuses on detecting two of these lesions, Microaneurysms and Hemorrhages, which are also known as red lesions. This paper attempts to deal with two problems in detecting red lesions from retinal fundus images: (1) false detections on blood vessels; and (2) different size of red lesions. METHODS: To deal with false detections on blood vessels, novel filters have been proposed which can distinguish between red lesions and blood vessels. This distinction is based on the fact that vessels are elongated while red lesions are usually circular blob-like structures. The second problem of the different size of lesions is dealt with by applying the proposed filters on patches of different sizes instead of filtering the full image. These patches are obtained by dividing the original image using a grid whose size determines the patch size. Different grid sizes were used and lesion detection results for these grid sizes were combined using Multiple Kernel Learning. RESULTS: Experiments on a dataset of 143 images showed that proposed filters detected Microaneurysms and Hemorrhages successfully even when these lesions were close to blood vessels. In addition, using Multiple Kernel Learning improved the results when compared to using a grid of one size only. The areas under receiver operating characteristic curve were found to be 0.97 and 0.92 for Microaneurysms and Hemorrhages respectively which are better than the existing related works. CONCLUSIONS: Proposed filters are robust to the presence of blood vessels and surpass related works in detecting red lesions from retinal fundus images. Improved lesion detection using the proposed approach can help in automatic detection of Diabetic Retinopathy.
[Mh] Termos MeSH primário: Hemorragia/diagnóstico
Microaneurisma/diagnóstico
Vasos Retinianos/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Seres Humanos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE



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