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[PMID]: 29225169 [Au] Autor: Yu BX; Yuan JN; Zhang FR; Liu YY; Zhang TT; Li K; Lv XF; Zhou JG; Huang LY; Shang JY; Liang SJ [Ad] Endereço: Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Guangzhou, China; Center for Translational Medicine, The First Affiliated Hospital, Guangzhou, China. [Ti] Título: Inhibition of Orai1-mediated Ca entry limits endothelial cell inflammation by suppressing calcineurin-NFATc4 signaling pathway. [So] Source: Biochem Biophys Res Commun;495(2):1864-1870, 2018 01 08. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Orai1-dependent Ca entry plays an essential role in inflammatory response through regulating T cell and macrophage activation and neutrophil infiltration. However, whether Orai1 Ca entry contributes to endothelial activation, one of the early steps of vascular inflammation, remains elusive. In the present study, we observed that knockdown of Orai1 reduced, whereas overexpression of Orai1 potentiated, TNFα-induced expression of adhesion molecules such as ICAM-1 and VCAM-1 in HUVECs, and subsequently blocked adhesion of monocyte to HUVECs. In vivo, Orai1 downregulation attenuated TNFα-induced ICAM-1 and VCAM-1 expression in mouse aorta and the levels of pro-inflammatory cytokines in the serum. In addition, Orai1 knockdown also dramatically decreased the expression of pro-inflammatory cytokines and neutrophil infiltration in the lung after TNFα treatment, and thus protected lung tissue injury. Notably, among all isoforms of nuclear factor of activated T cells (NFATs), TNFα only triggered NFATc4 nuclear accumulation in HUVECs. Knockdown of Orai1 or inhibition of calcineurin prevented TNFα-induced NFATc4 nuclear translocation and reduced ICAM-1 and VCAM-1 expression in HUVECs. Overexpression of NFATc4 further enhanced ICAM-1 and VCAM-1 expression induced by TNFα. Our study demonstrates that Orai1-Ca -calcineurin-NFATc4 signaling is an essential inflammatory pathway required for TNFα-induced endothelial cell activation and vascular inflammation. Therefore, Orai1 may be a potential therapeutic target for treatment of inflammatory diseases. [Mh] Termos MeSH primário: Aortite/imunologia Calcineurina/imunologia Cálcio/imunologia Moléculas de Adesão Celular/imunologia Endotélio Vascular/imunologia Fatores de Transcrição NFATC/imunologia Proteína ORAI1/imunologia [Mh] Termos MeSH secundário: Animais Aortite/patologia Células Cultivadas Regulação para Baixo/imunologia Seres Humanos Mediadores da Inflamação/imunologia Redes e Vias Metabólicas/imunologia Camundongos Camundongos Endogâmicos C57BL [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Cell Adhesion Molecules); 0 (Inflammation Mediators); 0 (NFATC Transcription Factors); 0 (Nfatc4 protein, mouse); 0 (ORAI1 Protein); 0 (Orai1 protein, mouse); EC 3.1.3.16 (Calcineurin); SY7Q814VUP (Calcium) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171212 [St] Status: MEDLINE

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[PMID]: 29273506 [Au] Autor: Yan A; Yue T; Li L; Li W; Li Q; Li J [Ad] Endereço: Department of Geriatrics, Zibo Center Hospital, Zibo, Shandong 255036, China. [Ti] Título: Bromodomain-containing protein 7 deficiency augments atherosclerotic lesions in ApoE mice. [So] Source: Biochem Biophys Res Commun;495(3):2202-2208, 2018 01 15. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Atherosclerotic plaque formation is characterized by the persistence of lipid-laden macrophages on the inner walls of arteries. Chronic inflammation and imbalanced macrophage function are likely to play a critical role. Herein, we investigated whether bromodomain-containing protein 7 (Brd7), a member of the bromodomain-containing protein family, regulates atherosclerosis, and if so, which mechanisms are responsible for the process. We found that Brd7 is expressed in mouse atherosclerotic plaques, and mostly in macrophages. Inhibition of Brd7 accelerates atherosclerotic lesion formation in ApoE mice by promoting NF-κB-mediated inflammation. Furthermore, Brd7 inhibition alters the phenotype of macrophages and promotes plaque instability, at least partly via STAT6 signaling. Our data define a previously undescribed role of Brd7 in the development of atherosclerosis. [Mh] Termos MeSH primário: Aortite/imunologia Aterosclerose/imunologia Proteínas Cromossômicas não Histona/imunologia Macrófagos/imunologia Macrófagos/patologia NF-kappa B/imunologia [Mh] Termos MeSH secundário: Animais Aortite/patologia Apolipoproteínas E/genética Aterosclerose/patologia Proteínas Cromossômicas não Histona/deficiência Masculino Camundongos Camundongos Knockout [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Apolipoproteins E); 0 (Brd7 protein, mouse); 0 (Chromosomal Proteins, Non-Histone); 0 (NF-kappa B) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171224 [St] Status: MEDLINE

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[PMID]: 28747159 [Au] Autor: Spaltenstein M; Humbert F; Vu DL; Uçkay I; John G [Ad] Endereço: Division of Internal Medicine, Hôpital Neuchâtelois, La Chaux-de-Fonds, Switzerland. [Ti] Título: A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis. [So] Source: BMC Infect Dis;17(1):520, 2017 07 26. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused by a peripheral arterial embolism diagnosed by CT. CASE PRESENTATION: We present a young man with sudden abdominal pain and flank tenderness without fever. Blood tests showed acute kidney failure. Computed tomography showed a right renal infarct and a non-circular thickening of the descending thoracic aortic wall with intra-luminal thrombus. Serology confirmed the diagnosis of syphilis. Treatment with anticoagulant and penicillin resulted in a good outcome. Follow-up PET-MRI showed resolution of the thrombus with a metabolically inactive atheromatous plaque. CONCLUSION: Technologies, such as CT, PET-CT and PET-MRI, that were not present during the pre-antibiotic era, can provide new insights into rare presentations of tertiary syphilis such as aortitis. These imaging modalities show promise for early radiological diagnosis of aortitis in syphilis and may be useful for determining the response to treatment in specific cases. [Mh] Termos MeSH primário: Aortite/diagnóstico por imagem Aortite/microbiologia Infarto/diagnóstico por imagem Sífilis Cardiovascular/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Antibacterianos/uso terapêutico Aortite/tratamento farmacológico Seres Humanos Infarto/tratamento farmacológico Infarto/microbiologia Rim/irrigação sanguínea Rim/diagnóstico por imagem Imagem por Ressonância Magnética Masculino Penicilinas/uso terapêutico Tomografia por Emissão de Pósitrons Sífilis/diagnóstico por imagem Sífilis/tratamento farmacológico Sífilis Cardiovascular/tratamento farmacológico Sífilis Cardiovascular/patologia Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Penicillins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180120 [Lr] Data última revisão: 180120 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2624-1

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[PMID]: 28882868 [Au] Autor: Nakao T; Horie T; Baba O; Nishiga M; Nishino T; Izuhara M; Kuwabara Y; Nishi H; Usami S; Nakazeki F; Ide Y; Koyama S; Kimura M; Sowa N; Ohno S; Aoki H; Hasegawa K; Sakamoto K; Minatoya K; Kimura T; Ono K [Ad] Endereço: From the Departments of Cardiovascular Medicine (T.N., T.H., O.B., M.N., T.N., M.I., Y.K., H.N., S.U., F.N., Y.I., S.K., M.K., N.S., T.K., K.O.) and Cardiovascular Surgery (K.S., K.M.), Graduate School of Medicine, Kyoto University, Japan; The Cardiovascular Research Institute, Kurume University, Ja [Ti] Título: Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways. [So] Source: Arterioscler Thromb Vasc Biol;37(11):2161-2170, 2017 Nov. [Is] ISSN: 1524-4636 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Abdominal aortic aneurysm (AAA) is an increasingly prevalent and ultimately fatal disease with no effective pharmacological treatment. Because matrix degradation induced by vascular inflammation is the major pathophysiology of AAA, attenuation of this inflammation may improve its outcome. Previous studies suggested that miR-33 (microRNA-33) inhibition and genetic ablation of miR-33 increased serum high-density lipoprotein cholesterol and attenuated atherosclerosis. APPROACH AND RESULTS: MiR-33a-5p expression in central zone of human AAA was higher than marginal zone. MiR-33 deletion attenuated AAA formation in both mouse models of angiotensin II- and calcium chloride-induced AAA. Reduced macrophage accumulation and monocyte chemotactic protein-1 expression were observed in calcium chloride-induced AAA walls in miR-33 mice. In vitro experiments revealed that peritoneal macrophages from miR-33 mice showed reduced matrix metalloproteinase 9 expression levels via c-Jun N-terminal kinase inactivation. Primary aortic vascular smooth muscle cells from miR-33 mice showed reduced monocyte chemotactic protein-1 expression by p38 mitogen-activated protein kinase attenuation. Both of the inactivation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase were possibly because of the increase of ATP-binding cassette transporter A1 that is a well-known target of miR-33. Moreover, high-density lipoprotein cholesterol derived from miR-33 mice reduced expression of matrix metalloproteinase 9 in macrophages and monocyte chemotactic protein-1 in vascular smooth muscle cells. Bone marrow transplantation experiments indicated that miR-33-deficient bone marrow cells ameliorated AAA formation in wild-type recipients. MiR-33 deficiency in recipient mice was also shown to contribute the inhibition of AAA formation. CONCLUSIONS: These data strongly suggest that inhibition of miR-33 will be effective as a novel strategy for treating AAA. [Mh] Termos MeSH primário: Aorta Abdominal/metabolismo Aneurisma da Aorta Abdominal/prevenção & controle Aortite/prevenção & controle Mediadores da Inflamação/metabolismo MicroRNAs/metabolismo [Mh] Termos MeSH secundário: Angiotensina II Animais Aorta Abdominal/patologia Aneurisma da Aorta Abdominal/induzido quimicamente Aneurisma da Aorta Abdominal/genética Aneurisma da Aorta Abdominal/metabolismo Aortite/induzido quimicamente Aortite/genética Aortite/metabolismo Apolipoproteínas E/deficiência Apolipoproteínas E/genética Transplante de Medula Óssea Cloreto de Cálcio Linhagem Celular Quimiocina CCL2/metabolismo HDL-Colesterol/sangue Dilatação Patológica Modelos Animais de Doenças Feminino Predisposição Genética para Doença Seres Humanos Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo Macrófagos Peritoneais/metabolismo Macrófagos Peritoneais/patologia Masculino Metaloproteinase 9 da Matriz/metabolismo Camundongos Endogâmicos C57BL Camundongos Knockout MicroRNAs/genética Músculo Liso Vascular/metabolismo Músculo Liso Vascular/patologia Miócitos de Músculo Liso/metabolismo Miócitos de Músculo Liso/patologia Fenótipo Transdução de Sinais Fatores de Tempo Transfecção Remodelação Vascular Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Apolipoproteins E); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Cholesterol, HDL); 0 (Inflammation Mediators); 0 (MIRN33 microRNA, human); 0 (MicroRNAs); 0 (Mirn33 microRNA, mouse); 11128-99-7 (Angiotensin II); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse); M4I0D6VV5M (Calcium Chloride) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170909 [St] Status: MEDLINE [do] DOI: 10.1161/ATVBAHA.117.309768

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[PMID]: 28859604 [Au] Autor: Skeik N; Ostertag-Hill CA; Garberich RF; Alden PB; Alexander JQ; Cragg AH; Manunga JM; Stephenson EJ; Titus JM; Sullivan TM [Ad] Endereço: 1 Vascular Medicine, Minneapolis Heart Institute, Minneapolis, MN, USA. [Ti] Título: Diagnosis, Management, and Outcome of Aortitis at a Single Center. [So] Source: Vasc Endovascular Surg;51(7):470-479, 2017 Oct. [Is] ISSN: 1938-9116 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Aortitis is a rare condition with inflammatory or infectious etiology that can be difficult to diagnose due to the highly variable clinical presentation and nonspecific symptoms. However, current literature on the diagnosis, management, and prognosis of aortitis is extremely scarce. METHODS: We retrospectively reviewed all patients' charts who were diagnosed with giant cell arteritis, Takayasu arteritis, or noninfectious aortitis presenting at a single center between January 1, 2009, and April 17, 2015. Data collected included demographics, medical history, comorbidities, laboratory and imaging data, management, and outcome. RESULTS: Among the included 15 patients presenting with aortitis at our center, 53% were diagnosed with Takayasu arteritis, 33% with idiopathic inflammatory aortitis, and 13% with giant cell arteritis. All patients received steroid treatment, 67% received adjunctive immunosuppressants or immunomodulators, and 33% underwent interventional procedures. Based on clinical presentation and laboratory and imaging findings at the last follow-up visit for each patient, 67% showed improvement, 27% had no change in disease activity, and 7% had a progression of the disease. CONCLUSIONS: Takayasu arteritis was found to be more common than idiopathic inflammatory aortitis and giant cell arteritis among our 15 cases diagnosed with aortitis. All patients received medical therapy and 33% received interventional procedures, leading to 67% improvement of disease activity or related complications. This article also offers a comprehensive review of the diagnosis, management, and outcome of aortitis, supplementing the very limited literature on this disease. [Mh] Termos MeSH primário: Aortite/diagnóstico por imagem Aortite/terapia Procedimentos Endovasculares Arterite de Células Gigantes/diagnóstico por imagem Arterite de Células Gigantes/terapia Imunossupressores/uso terapêutico Esteroides/uso terapêutico Arterite de Takayasu/tratamento farmacológico Arterite de Takayasu/terapia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Aortite/epidemiologia Progressão da Doença Procedimentos Endovasculares/efeitos adversos Feminino Arterite de Células Gigantes/epidemiologia Seres Humanos Imunossupressores/efeitos adversos Masculino Meia-Idade Minnesota/epidemiologia Indução de Remissão Estudos Retrospectivos Esteroides/efeitos adversos Arterite de Takayasu/epidemiologia Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Immunosuppressive Agents); 0 (Steroids) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170902 [St] Status: MEDLINE [do] DOI: 10.1177/1538574417704296

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[PMID]: 28635612 [Au] Autor: Kaprinay B; Sotnikova R; Frimmel K; Krizak J; Bernatova I; Navarova J; Okruhlicova L [Ad] Endereço: Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia. barbara.kaprinay@savba.sk. [Ti] Título: Consequences of lipopolysaccharide and n-3 polyunsaturated fatty acid administration on aortic function of spontaneously hypertensive rats. [So] Source: Gen Physiol Biophys;36(3):353-359, 2017 Jul. [Is] ISSN: 0231-5882 [Cp] País de publicação: Slovakia [La] Idioma: eng [Ab] Resumo: The aim of the work was to study the delayed effect of lipopolysaccharide (LPS) administration on endothelial function of the aorta of rats with genetic hypertension. Further, the possibility to ameliorate LPS-induced changes by n-3 polyunsaturated fatty acids (n-3 PUFA) was tested. Rats received a bolus of 1 mg/kg LPS i.p.; n-3 PUFA were administered in the dose of 30 mg/kg daily for 10 days p.o.. Ten days after receiving of LPS, the body weight gain of rats was statistically lower compared to control rats (p < 0.05). n-3 PUFA administration to LPS rats had no effect on this parameter. The TBARS and NAGA concentrations in plasma were significantly increased in the LPS group (p < 0.05) and n-3 PUFA administration returned them to control values. In functional studies, phenylephrine (PE, 1 µmol/l) evoked contraction of aortas which was not statistically different among experimental groups. However, endothelium-dependent relaxation was depressed in the LPS group (p < 0.05) and n-3 PUFA slightly recovered it to control values. In conclusion, oxidative stress seems to be responsible for aortic endothelial dysfunction detected 10 days after administration of LPS to rats. n-3 PUFA slightly improved the function of the endothelium injured by LPS, probably thanks to their antioxidant properties. Prolonged administration of higher doses of n-3 PUFA should defend the vascular endothelium against detrimental effect of bacterial inflammation. [Mh] Termos MeSH primário: Aorta/efeitos dos fármacos Aorta/imunologia Aortite/induzido quimicamente Aortite/imunologia Ácidos Graxos Ômega-3/administração & dosagem Lipopolissacarídeos [Mh] Termos MeSH secundário: Animais Aortite/prevenção & controle Interações Medicamentosas Hipertensão/imunologia Masculino Ratos Ratos Endogâmicos SHR [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Fatty Acids, Omega-3); 0 (Lipopolysaccharides) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170912 [Lr] Data última revisão: 170912 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170622 [St] Status: MEDLINE [do] DOI: 10.4149/gpb_2016054

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[PMID]: 28496085 [Au] Autor: Yada M; Yamanaka K; Miwa S; Hirose K; Sakaguchi H; Yoshida Y; Onga Y; Tara Y [Ad] Endereço: Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Japan. [Ti] Título: [Graft Pseudoaneurysm after Ascending to Abdominal Aorta Bypass for Atypical Coarctation Due to Aortitis Syndrome;Report of a Case]. [So] Source: Kyobu Geka;70(5):377-380, 2017 May. [Is] ISSN: 0021-5252 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: We present a case of a 44-year-old woman, with pseudoaneurysm formation at the middle of the prosthetic graft, 60 mm in diameter. She had been diagnosed with atypical coarctation due to aortitis 27 years before, and had undergone a bypass operation with 14 mm-diameter Cooley double velour graft from the ascending aorta to the abdominal aorta. This time, endovascular aortic repair was performed to prevent rupture of the pseudoaneurysm. Though a knitted Dacron graft has a risk of psuedaneurysm formation long patency could be obtained when used in ascending aorta-abdominal aorta bypass. [Mh] Termos MeSH primário: Falso Aneurisma/cirurgia Aorta Abdominal/cirurgia Aorta/cirurgia Aortite/complicações [Mh] Termos MeSH secundário: Adulto Falso Aneurisma/diagnóstico por imagem Falso Aneurisma/etiologia Feminino Seres Humanos Imagem Tridimensional Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171013 [Lr] Data última revisão: 171013 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170513 [St] Status: MEDLINE

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[PMID]: 28375417 [Au] Autor: Marketkar S; LeGolvan M [Ad] Endereço: Resident in Pathology, Rhode Island Hospital/ Alpert Medical School of Brown University, Providence, RI. [Ti] Título: IgG4 Aortitis: A Case Report. [So] Source: R I Med J (2013);100(4):29-32, 2017 Apr 03. [Is] ISSN: 2327-2228 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: IgG4 aortitis is one of the entities seen in the spectrum of IgG4-related disease (IgG4-RD). It is characterized by serologic (elevated serum IgG4) and histologic features including a lymphoplasmacytic infiltrate with increased numbers of IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis. Some studies have described a correlation between infections and IgG4 aortitis. We describe a patient with an aneurysm of the infrarenal descending abdominal aorta with features of IgG4-RD, as well as culture evidence of Streptococcus sanguis. [Full article available at http://rimed.org/rimedicaljournal-2017-04.asp]. [Mh] Termos MeSH primário: Aneurisma Dissecante/diagnóstico Aortite/diagnóstico Imunoglobulina G/análise Plasmócitos/imunologia [Mh] Termos MeSH secundário: Aneurisma Dissecante/imunologia Aneurisma Dissecante/patologia Aortite/imunologia Aortite/patologia Biomarcadores/análise Seres Humanos Imunoglobulina G/sangue Imuno-Histoquímica Masculino Meia-Idade Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Immunoglobulin G) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170531 [Lr] Data última revisão: 170531 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170405 [St] Status: MEDLINE

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[PMID]: 28261753 [Au] Autor: Wills S [Ad] Endereço: Forensic Science SA, GPO Box 2790, Adelaide, SA, 5001, Australia. stephen.wills@sa.gov.au. [Ti] Título: Incidental necrotizing aortitis in a child. [So] Source: Forensic Sci Med Pathol;13(2):252-254, 2017 Jun. [Is] ISSN: 1556-2891 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Aortite/patologia Achados Incidentais [Mh] Termos MeSH secundário: Acidentes de Trânsito Criança Seres Humanos Masculino Traumatismo Múltiplo/etiologia Necrose [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170307 [St] Status: MEDLINE [do] DOI: 10.1007/s12024-017-9842-0

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[PMID]: 28254396 [Au] Autor: Delaval L; Goulenok T; Achouh P; Saadoun D; Gaudric J; Pellenc Q; Kahn JE; Pasi N; van Gysel D; Bruneval P; Papo T; Sacre K [Ad] Endereço: Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France. [Ti] Título: New insights on tuberculous aortitis. [So] Source: J Vasc Surg;66(1):209-215, 2017 Jul. [Is] ISSN: 1097-6809 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Aortitis is an exceedingly rare manifestation of tuberculosis. We describe 11 patients with tuberculous aortitis (TA). METHODS: Multicenter medical charts of patients hospitalized between 2003 and 2015 with TA in Paris, France, were reviewed. Demographic, medical history, laboratory, imaging, pathologic findings, treatment, and follow-up data were extracted from medical records. TA was considered when aortitis was diagnosed in a patient with active tuberculosis. RESULTS: Eleven patients (8 women; median age, 44.6 years) with TA were identified during this 12-year period. No patient had human immunodeficiency virus infection. Tuberculosis was active in all cases, with a median delay of 18 months between the first symptoms and diagnosis. At disease onset, vascular signs were mainly claudication, asymmetric blood pressure, and diminished distal pulses. Constitutional symptoms or extravascular signs were present in all patients at some point. Aortic pseudoaneurysm was the most frequent lesion, but three patients had isolated inflammatory aortic stenosis. TA appeared as extension from a contiguous infection in only three cases. Tuberculosis was considered because of clinical features, tuberculin skin or QuantiFERON-TB Gold (Quest Diagnostics, Madison, NJ) test results, pathologic findings, and improvement on antituberculosis therapy. A definite Mycobacterium tuberculosis identification was made in only three cases. All patients received antituberculosis therapy for 6 to 12 months. Surgery including Bentall procedures, aortic bypass, and open abdominal aneurysm repair was performed at diagnosis in eight patients. Seven patients received steroids as an adjunct therapy. All patients clinically improved under treatment. No patients died for a median follow-up duration of 4 years. CONCLUSIONS: TA may result in aneurysms contiguous to regional adenitis but also in isolated inflammatory aortic stenosis. Steroids may be associated with antituberculosis therapy for inflammatory stenotic lesions. Surgery is indicated for aneurysms and in case of worsening stenotic lesions despite anti-inflammatory drugs. No patient died after such combined treatment strategy. [Mh] Termos MeSH primário: Falso Aneurisma Aneurisma Infectado Aneurisma Aórtico Aortite Arteriopatias Oclusivas Tuberculose Cardiovascular [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Falso Aneurisma/diagnóstico Falso Aneurisma/microbiologia Falso Aneurisma/terapia Aneurisma Infectado/diagnóstico Aneurisma Infectado/microbiologia Aneurisma Infectado/terapia Antituberculosos/uso terapêutico Aneurisma Aórtico/diagnóstico Aneurisma Aórtico/microbiologia Aneurisma Aórtico/terapia Aortite/diagnóstico Aortite/microbiologia Aortite/terapia Aortografia/métodos Arteriopatias Oclusivas/diagnóstico Arteriopatias Oclusivas/microbiologia Arteriopatias Oclusivas/terapia Biópsia Angiografia por Tomografia Computadorizada Feminino França Seres Humanos Testes de Liberação de Interferon-gama Masculino Registros Médicos Meia-Idade Valor Preditivo dos Testes Estudos Retrospectivos Esteroides/uso terapêutico Fatores de Tempo Resultado do Tratamento Teste Tuberculínico Tuberculose Cardiovascular/diagnóstico Tuberculose Cardiovascular/microbiologia Tuberculose Cardiovascular/terapia Procedimentos Cirúrgicos Vasculares Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY [Nm] Nome de substância: 0 (Antitubercular Agents); 0 (Steroids) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170304 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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