Base de dados : MEDLINE
Pesquisa : C14.907.137.126 [Categoria DeCS]
Referências encontradas : 49324 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 4933 ir para página                         

  1 / 49324 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28796785
[Au] Autor:Lipska-Zietkiewicz BS; Gellermann J; Boyer O; Gribouval O; Zietkiewicz S; Kari JA; Shalaby MA; Ozaltin F; Dusek J; Melk A; Bayazit AK; Massella L; Hyla-Klekot L; Habbig S; Godron A; Szczepanska M; Bienias B; Drozdz D; Odeh R; Jarmuzek W; Zachwieja K; Trautmann A; Antignac C; Schaefer F; PodoNet Consortium
[Ad] Endereço:Department of Biology and Medical Genetics, Clinical Genetics Unit, Medical University of Gdansk, Gdansk, Poland.
[Ti] Título:Low renal but high extrarenal phenotype variability in Schimke immuno-osseous dysplasia.
[So] Source:PLoS One;12(8):e0180926, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schimke immuno-osseous dysplasia (SIOD) is a rare multisystem disorder with early mortality and steroid-resistant nephrotic syndrome (SRNS) progressing to end-stage kidney disease. We hypothesized that next-generation gene panel sequencing may unsurface oligosymptomatic cases of SIOD with potentially milder disease courses. We analyzed the renal and extrarenal phenotypic spectrum and genotype-phenotype associations in 34 patients from 28 families, the largest SMARCAL1-associated nephropathy cohort to date. In 11 patients the diagnosis was made unsuspectedly through SRNS gene panel testing. Renal disease first manifested at median age 4.5 yrs, with focal segmental glmerulosclerosis or minimal change nephropathy on biopsy and rapid progression to end-stage kidney disease (ESKD) at median age 8.7 yrs. Whereas patients diagnosed by phenotype more frequently developed severe extrarenal complications (cerebral ischemic events, septicemia) and were more likely to die before age 10 years than patients identified by SRNS-gene panel screening (88 vs. 40%), the subgroups did not differ with respect to age at proteinuria onset and progression to ESKD. Also, 10 of 11 children diagnosed unsuspectedly by Next Generation Sequencing were small at diagnosis and all showed progressive growth failure. Severe phenotypes were usually associated with biallelic truncating mutations and milder phenotypes with biallelic missense mutations. However, no genotype-phenotype correlation was observed for the renal disease course. In conclusion, while short stature is a reliable clue to SIOD in children with SRNS, other systemic features are highly variable. Our findings support routine SMARCAL1 testing also in non-syndromic SRNS.
[Mh] Termos MeSH primário: Arteriosclerose/genética
Arteriosclerose/patologia
Síndromes de Imunodeficiência/genética
Síndromes de Imunodeficiência/patologia
Rim/patologia
Síndrome Nefrótica/genética
Síndrome Nefrótica/patologia
Osteocondrodisplasias/genética
Osteocondrodisplasias/patologia
Embolia Pulmonar/genética
Embolia Pulmonar/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Arteriosclerose/diagnóstico
Criança
Pré-Escolar
Estudos de Coortes
DNA Helicases/genética
Testes Genéticos
Genótipo
Seres Humanos
Síndromes de Imunodeficiência/diagnóstico
Lactente
Mutação
Síndrome Nefrótica/diagnóstico
Osteocondrodisplasias/diagnóstico
Fenótipo
Embolia Pulmonar/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.- (SMARCAL1 protein, human); EC 3.6.4.- (DNA Helicases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180926


  2 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28661316
[Au] Autor:Richter CK; Skulas-Ray AC; Fleming JA; Link CJ; Mukherjea R; Krul ES; Kris-Etherton PM
[Ad] Endereço:1Department of Nutritional Sciences,1177 E. 4th St.,University of Arizona,Tucson,AZ 85716,USA.
[Ti] Título:Effects of isoflavone-containing soya protein on ex vivo cholesterol efflux, vascular function and blood markers of CVD risk in adults with moderately elevated blood pressure: a dose-response randomised controlled trial.
[So] Source:Br J Nutr;117(10):1403-1413, 2017 May.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Emerging CVD risk factors (e.g. HDL function and central haemodynamics) may account for residual CVD risk experienced by individuals who meet LDL-cholesterol and blood pressure (BP) targets. Recent evidence suggests that these emerging risk factors can be modified by polyphenol-rich interventions such as soya, but additional research is needed. This study was designed to investigate the effects of an isoflavone-containing soya protein isolate (delivering 25 and 50 g/d soya protein) on HDL function (i.e. ex vivo cholesterol efflux), macrovascular function and blood markers of CVD risk. Middle-aged adults (n 20; mean age=51·6 (sem 6·6) years) with moderately elevated brachial BP (mean systolic BP=129 (sem 9) mmHg; mean diastolic BP=82·5 (sem 8·4) mmHg) consumed 0 (control), 25 and 50 g/d soya protein in a randomised cross-over design. Soya and control powders were consumed for 6 weeks each with a 2-week compliance break between treatment periods. Blood samples and vascular function measures were obtained at baseline and following each supplementation period. Supplementation with 50 g/d soya protein significantly reduced brachial diastolic BP (-2·3 mmHg) compared with 25 g/d soya protein (Tukey-adjusted P=0·03) but not the control. Soya supplementation did not improve ex vivo cholesterol efflux, macrovascular function or other blood markers of CVD risk compared with the carbohydrate-matched control. Additional research is needed to clarify whether effects on these CVD risk factors depend on the relative health of participants and/or equol producing capacity.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/sangue
Colesterol/metabolismo
Hipertensão/sangue
Isoflavonas/química
Proteínas de Soja/farmacologia
[Mh] Termos MeSH secundário: Adulto
Arteriosclerose/tratamento farmacológico
Biomarcadores
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Proteínas de Soja/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Isoflavones); 0 (Soybean Proteins); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451700143X


  3 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28321055
[Au] Autor:Ryuzaki M; Morimoto S; Niiyama M; Seki Y; Yoshida N; Oshima Y; Mizuguchi Y; Watanabe D; Ando T; Ichihara A
[Ad] Endereço:Department of Medicine II, Endocrinology and Hypertension, Tokyo Women's Medical University, Japan.
[Ti] Título:The Relationships between the Differences in the Central Blood Pressure and Brachial Blood Pressure and Other Factors in Patients with Essential Hypertension.
[So] Source:Intern Med;56(6):587-596, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Objective The management of blood pressure (BP) in hypertensive patients is the key to preventing a progression of organ damage. The brachial BP (bBP) has been used as the representative method for measuring the BP. The central BP (cBP), which is, different from the bBP due to the propagation and the reflection of the pulse wave in the arterial system, has recently received attention because it can now be estimated non-invasively. We examined the relationships between the difference in the central systolic BP (csBP) and the brachial systolic BP (bsBP) (Δ) and other factors in hypertensive patients. Methods The bsBP and csBP were measured in patients with essential hypertension and the relationships between the bsBP, csBP, or Δ and background factors including age, the brain natriuretic peptide (BNP) level, the estimated glomerular filtration rate (eGFR), flow-mediated vasodilation (an index of vascular endothelial function), the cardio-ankle vascular index (CAVI, an index of arteriosclerosis), and the carotid intima-media thickness (an index of atherosis) were investigated. Results The data of 191 patients were analyzed. Although there was no significant correlation between the CAVI and the bsBP; positive correlations were observed between the CAVI and the csBP (r=0.249, p=0.001). The Δ value showed significant positive correlations with age, and the BNP, eGFR, and CAVI values. Conclusion The csBP is more strongly associated with arteriosclerosis than the bsBP. Moreover, the Δ value is more strongly associated with cardiac function, renal function, and arteriosclerosis than the bsBP or csBP. These data suggested that the Δ value may have a greater prognostic value than the bsBP or csBP and may be worth calculating in the clinical setting.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Hipertensão/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Índice Tornozelo-Braço
Arteriosclerose/fisiopatologia
Determinação da Pressão Arterial
Espessura Intima-Media Carotídea
Hipertensão Essencial
Feminino
Taxa de Filtração Glomerular
Frequência Cardíaca
Seres Humanos
Masculino
Meia-Idade
Peptídeo Natriurético Encefálico/sangue
Vasodilatação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
114471-18-0 (Natriuretic Peptide, Brain)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7597


  4 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28287291
[Au] Autor:Simon K; Wittmann I
[Ad] Endereço:Belgyógyászati Osztály, Siófoki Kórház-Rendelointézet Siófok, Semmelweis u. 1., 8600.
[Ti] Título:[The blood glucose value not necessarily indicates correctly the cellular metabolic state].
[Ti] Título:A vércukorértékek nem feltétlenül jellemzik megfeleloen a sejtanyagcsere-állapotot..
[So] Source:Orv Hetil;158(11):409-417, 2017 Mar.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:In clinical recommendations the normalized blood glucose level is declared as the main target in therapy of diabetes mellitus, i.e. the achievement of euglycemia is the main therapeutic goal. This approach suggests, that the normal blood glucose value is the marker of the normal carbohydrate metabolism (eumetabolism), and vice versa: hyperglycemia is associated with abnormal metabolism (dysmetabolism). However the question arises, whether identical blood glucose values do reflect the same intracellular biochemical mechanisms? On the basis of data published in the literature authors try to answer these questions by studying the relations between the short/longterm blood glucose level and the cellular metabolism in different clinical settings characterized by divergent pathophysiological parameters. The correlations between blood glucose level and cellular metabolism in development of micro-, and macroangiopathy, in the breakthrough phenomenon, as well as during administration of metabolic promoters, the discrepancies of relation between blood glucose values and cellular metabolism in type 1, and type 2 diabetes mellitus, furthermore association between blood glucose value and myocardial metabolism in acute and chronic stress were analyzed. Authors conclude, that the actual blood glucose values reveal the actual cellular metabolism in a very variable manner: neither euglycemia does mandatorily indicate eumetabolism (balance of cellular energy production), nor hyperglycemia is necessarily a marker of abnormal metabolic state (dept of cellular energy production). Moreover, at the same actual blood glucose level both the metabolic efficacy of the same organ may sharply vary, and the intracellular biochemical machinery could also be very different. In case of the very same longterm blood glucose level the metabolic state of the different organs could be very variable: some organs show an energetically balanced metabolism, while others produce a significant deficit. These inconsistencies between blood glucose level and cellular metabolism can be explained by the fact, that blood glucose value is a transport parameter, reflecting the actual steady state of glucose transport from the carbohydrate pools into the blood, and that from the blood into the tissues. Without knowing the speed of these transports of opposite direction, the blood glucose value per se can not reveal the quantitative and qualitative characteristics of cellular metabolism. Orv. Hetil., 2017, 158(11), 409-417.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Obesidade/metabolismo
[Mh] Termos MeSH secundário: Arteriosclerose/metabolismo
Seres Humanos
Hiperlipidemias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30681


  5 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28287021
[Au] Autor:Shinno H; Kurose S; Yamanaka Y; Higurashi K; Fukushima Y; Tsutsumi H; Kimura Y
[Ad] Endereço:a Department of Health Science , Graduate School of Medicine, Kansai Medical University , Osaka , Japan.
[Ti] Título:Evaluation of a static stretching intervention on vascular endothelial function and arterial stiffness.
[So] Source:Eur J Sport Sci;17(5):586-592, 2017 Jun.
[Is] ISSN:1536-7290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Maintenance and enhancement of vascular endothelial function contribute to the prevention of cardiovascular disease and prolong a healthy life expectancy. Given the reversible nature of vascular endothelial function, interventions to improve this function might prevent arteriosclerosis. Accordingly, we studied the effects of a 6-month static stretching intervention on vascular endothelial function (reactive hyperaemia peripheral arterial tonometry index: RH-PAT index) and arterial stiffness (brachial-ankle pulse wave velocity: baPWV) and investigated the reversibility of these effects after a 6-month detraining period following intervention completion. METHODS: The study evaluated 22 healthy, non-smoking, premenopausal women aged ≥40 years. Subjects were randomly assigned to the full-intervention (n = 11; mean age: 48.6 ± 2.8 years) or a half-intervention that included a control period (n = 11; mean age: 46.9 ± 3.6 years). RESULTS: Body flexibility and vascular endothelial function improved significantly after 3 months of static stretching. In addition to these improvements, arterial stiffness improved significantly after a 6-month intervention. However, after a 6-month detraining period, vascular endothelial function, flexibility, and arterial stiffness all returned to preintervention conditions, demonstrating the reversibility of the obtained effects. CONCLUSION: A 3-month static stretching intervention was found to improve vascular endothelial function, and an additional 3-month intervention also improved arterial stiffness. However, these effects were reversed by detraining.
[Mh] Termos MeSH primário: Endotélio Vascular/fisiologia
Exercícios de Alongamento Muscular
Rigidez Vascular
[Mh] Termos MeSH secundário: Adulto
Índice Tornozelo-Braço
Artérias/fisiologia
Arteriosclerose/prevenção & controle
Feminino
Seres Humanos
Meia-Idade
Análise de Onda de Pulso
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1080/17461391.2017.1284267


  6 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28207318
[Au] Autor:Martinez MP; Cianciolo RE; Foster JD; Lees GE
[Ti] Título:Pathology in Practice.
[So] Source:J Am Vet Med Assoc;250(5):515-517, 2017 Mar 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Arteriosclerose/veterinária
Doenças do Cão/patologia
Glomerulonefrite/veterinária
[Mh] Termos MeSH secundário: Animais
Arteriosclerose/complicações
Doenças do Cão/etiologia
Cães
Glomerulonefrite/diagnóstico
Glomerulonefrite/patologia
Túbulos Renais/patologia
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.5.515


  7 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Brandt, Carlos Teixeira
Texto completo SciELO Brasil
[PMID]:28146208
[Au] Autor:Godoi ET; Brandt CT; Lacerda HR; Godoi JT; Oliveira DC; Costa GF; Santos Junior GG; Leite KM; Godoi JT; Vasconcelos AF
[Ad] Endereço:Universidade Federal de Pernambuco, Recife, PE, Brazil.
[Ti] Título:Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals.
[So] Source:Arq Bras Cardiol;108(1):3-11, 2017 Jan.
[Is] ISSN:1678-4170
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:BACKGROUND: The prevalence of atherosclerosis is higher in HIV-positive people, who also experience it earlier than the general population. OBJECTIVES: To assess and compare the prevalence of atherosclerosis evaluated by the intima-media thickness of carotid and femoral arteries, and by the ankle-brachial pressure index (ABPI) in HIV patients treated or not treated with protease inhibitors (PIs) and controls. METHODS: Eighty HIV+ subjects (40 using PIs and 40 not using PIs) and 65 controls were included in the study. Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. Classical risk factors for atherosclerosis and HIV were compared between the groups by statistical tests. A p ≤ 0.05 was considered significant. RESULTS: An IMT > P75 or the presence of plaque was higher in the HIV+ than in the control group (37.5% vs 19%, p = 0.04). Comparative analysis showed a significant difference (p=0.014) in carotid IMT between HIV+ with PIs (0.71 ± 0.28 mm), without PIs 0.63 ± 0.11 mm and, and controls (0.59 ± 0.11 mm). There was no significant difference in femoral IMT between the groups or in ABPI between HIV+ subjects and controls. However, a significant difference (p=0.015) was found between HIV+ patients not treated with PIs (1.17 [1.08 - 1.23]), and controls 1.08 [1.07 - 1.17]). CONCLUSION: In HIV patients, atherosclerosis is more prevalent and seems to occur earlier with particular characteristics compared with HIV-negative subjects.
[Mh] Termos MeSH primário: Síndrome de Imunodeficiência Adquirida/epidemiologia
Arteriosclerose/diagnóstico por imagem
Arteriosclerose/epidemiologia
Doenças das Artérias Carótidas/diagnóstico por imagem
Doenças das Artérias Carótidas/epidemiologia
Espessura Intima-Media Carotídea
Artéria Femoral/diagnóstico por imagem
[Mh] Termos MeSH secundário: Síndrome de Imunodeficiência Adquirida/complicações
Síndrome de Imunodeficiência Adquirida/tratamento farmacológico
Adulto
Índice Tornozelo-Braço
Terapia Antirretroviral de Alta Atividade
Arteriosclerose/etiologia
Brasil/epidemiologia
Contagem de Linfócito CD4
Doenças das Artérias Carótidas/etiologia
Doenças das Artérias Carótidas/patologia
Estudos de Casos e Controles
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estudos Prospectivos
Valores de Referência
Fatores de Risco
Sensibilidade e Especificidade
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE


  8 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28099511
[Au] Autor:Kim EJ; Choi MJ; Lee JH; Oh JE; Seo JW; Lee YK; Yoon JW; Kim HJ; Noh JW; Koo JR
[Ad] Endereço:Department of Internal Medicine, Hallym Kidney Research Institute, College of Medicine, Hallym University, Chuncheon, Korea.
[Ti] Título:Extracellular Fluid/Intracellular Fluid Volume Ratio as a Novel Risk Indicator for All-Cause Mortality and Cardiovascular Disease in Hemodialysis Patients.
[So] Source:PLoS One;12(1):e0170272, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In hemodialysis patients, fluid overload and malnutrition are accompanied by extracellular fluid (ECF) expansion and intracellular fluid (ICF) depletion, respectively. We investigated the relationship between ECF/ICF ratio (as an integrated marker reflecting both fluid overload and malnutrition) and survival and cardiovascular disease (CVD) in the context of malnutrition-inflammation-arteriosclerosis (MIA) complex. METHODS: Seventy-seven patients from a single hemodialysis unit were prospectively enrolled. The ECF/ICF volume was measured by segmental multi-frequency bioimpedance analysis. MIA and volume status were measured by serum albumin, C-reactive protein (CRP), pulse wave velocity (PWV) and plasma B-type natriuretic peptide (BNP), respectively. RESULTS: The mean ECF/ICF ratio was 0.56±0.06 and the cut-off value for maximum discrimination of survival was 0.57. Compared with the low ECF/ICF group, the high ECF/ICF group (ratio≥0.57, 42%) had higher all-cause mortality, CVD, CRP, PWV, and BNP, but lower serum albumin. During the 5-year follow-up, 24 all-cause mortality and 38 CVD occurred (18 and 24, respectively, in the high ECF/ICF group versus 6 and 14 respectively in the low ECF/ICF group, P<0.001). In the adjusted Cox analysis, the ECF/ICF ratio nullifies the effects of the MIA and volume status on survival and CVD and was an independent predictor of all-cause mortality and CVD: hazard ratio (95% confidence interval); 1.12 (1.01-1.25) and 1.09 (1.01-1.18) for a 0.01 increase in the ECF/ICF ratio. The degree of malnutrition (albumin), inflammation (CRP), arteriosclerosis (PWV), and fluid overload (BNP) were correlated well with the ECF/ICF ratio. CONCLUSIONS: Hemodialysis patients with high ECF/ICF ratio are not only fluid overloaded, but malnourished and have stiff artery with more inflammation. The ECF/ICF ratio is highly related to the MIA complex, and is a major risk indicator for all-cause mortality and CVD.
[Mh] Termos MeSH primário: Arteriosclerose/patologia
Líquido Extracelular/metabolismo
Inflamação/patologia
Líquido Intracelular/metabolismo
Desnutrição/patologia
Diálise Renal/mortalidade
[Mh] Termos MeSH secundário: Proteína C-Reativa/análise
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Peptídeo Natriurético Encefálico/sangue
Estudos Prospectivos
Análise de Onda de Pulso
Fatores de Risco
Albumina Sérica/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Serum Albumin); 114471-18-0 (Natriuretic Peptide, Brain); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170272


  9 / 49324 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28087255
[Au] Autor:Wzgarda A; Kleszcz R; Prokop M; Regulska K; Regulski M; Paluszczak J; Stanisz BJ
[Ad] Endereço:Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, ul. Grunwaldzka 6, 60-780 Poznan, Poland. Electronic address: annawzgarda@ump.edu.pl.
[Ti] Título:Unknown face of known drugs - what else can we expect from angiotensin converting enzyme inhibitors?
[So] Source:Eur J Pharmacol;797:9-19, 2017 Feb 15.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The renin-angiotensin system (RAS) is one of important systems among homeostatic mechanisms that control the function of cardiovascular, renal and adrenal systems. As RAS has a very complex nature, it has been also found as related to the control of cell migration and apoptosis. Angiotensin-converting enzyme inhibitors (ACEI) are drugs most commonly used in the modulation of RAS activity. ACEI have been extensively described as effective in the treatment of hypertension among adults, but also as drugs delaying progression in diabetic nephropathy and reducing mortality in left ventricular dysfunction and congestive heart failure. What is less obvious, ACEI are also widely used in pediatric nephrology and cardiology. Moreover, there are more and more reports showing evidence that ACEI can be beneficial in the treatment of many other diseases and the pleiotropic activity of ACEI is mainly based on their antioxidant properties. In this paper we focus on the less obvious possibilities of the clinical use of ACEI in neurological or oncological patients, discuss the role of ACE gene polymorphism and show the perspectives of potentially new applications of ACEI in contemporary pharmacotherapy.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/farmacologia
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Animais
Arteriosclerose/tratamento farmacológico
Seres Humanos
Neoplasias/tratamento farmacológico
Neurologia
Pediatria
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


  10 / 49324 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28060190
[Au] Autor:van Twist DJ; Houben AJ; de Haan MW; de Leeuw PW; Kroon AA
[Ad] Endereço:aDepartment of Internal Medicine bCardiovascular Research Institute Maastricht (CARIM) cDepartment of Radiology, Maastricht University Medical Center (MUMC+), Maastricht dDepartment of Internal Medicine, Zuyderland Medical Center, Sittard, The Netherlands.
[Ti] Título:Pathophysiological differences between multifocal fibromuscular dysplasia and atherosclerotic renal artery stenosis.
[So] Source:J Hypertens;35(4):845-852, 2017 Apr.
[Is] ISSN:1473-5598
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secretion. However, given the differences in the blood pressure (BP)-lowering effect of revascularization between patients with ARAS and FMD, we questioned whether this is true. METHODS: We measured renal blood flow (Xenon washout method) and renin secretion per kidney and their relationship to BP in a cohort of 64 patients with multifocal FMD and 110 patients with ARAS (off medication, prior to revascularization). RESULTS: We found that renal blood flow is significantly higher in FMD as compared with ARAS. In patients with unilateral ARAS, renin secretion was increased in the affected kidney as compared with the unaffected kidney. This lateralization in renin secretion, however, was not found in unilateral FMD. After correction for differences in baseline characteristics, we found that systemic renin levels and local renin secretion was lower in FMD as compared with ARAS. Moreover, the relationship between BP and renin secretion in FMD was inverse to that in ARAS. CONCLUSION: These findings argue against the hypothesis that FMD induces hypertension via similar pathophysiological mechanism as in ARAS.
[Mh] Termos MeSH primário: Displasia Fibromuscular/fisiopatologia
Hipertensão Renovascular/fisiopatologia
Obstrução da Artéria Renal/fisiopatologia
Circulação Renal
Renina/secreção
[Mh] Termos MeSH secundário: Adulto
Idoso
Arteriosclerose/complicações
Pressão Sanguínea
Feminino
Displasia Fibromuscular/complicações
Seres Humanos
Hipertensão Renovascular/etiologia
Rim/fisiopatologia
Masculino
Meia-Idade
Estudos Prospectivos
Obstrução da Artéria Renal/etiologia
Renina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.23.15 (Renin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1097/HJH.0000000000001243



página 1 de 4933 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde