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[PMID]:28931619
[Au] Autor:Buchman AS; Leurgans SE; Nag S; VanderHorst VGJM; Kapasi A; Schneider JA; Bennett DA
[Ad] Endereço:From the Rush Alzheimer's Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel
[Ti] Título:Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism.
[So] Source:Stroke;48(10):2792-2798, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: There are few studies of spinal microvascular pathologies in older adults. We characterized spinal cord microvascular pathologies and examined their associations with other spinal and brain postmortem indices and parkinsonism in older adults. METHODS: We documented 3 features of microvascular pathologies in spinal cord and brain specimens from 165 deceased older participants. We also measured spinal white matter pallor. Parkinsonian signs were assessed with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale. We examined the associations of spinal arteriolosclerosis with other spinal and brain postmortem indices and parkinsonism proximate to death using regression models which controlled for age and sex. RESULTS: Microinfarcts and cerebral amyloid angiopathy were not observed within the spinal cord parenchyma. Spinal arteriolosclerosis was observed at all spinal levels (C7, T7, L4, S4) examined and was more severe posteriorly than anteriorly (posterior: 4.3, SD=0.72 versus anterior: 3.9, SD=0.74; =14.58; <0.001). Arteriolosclerosis was more severe in the spinal cord than in the brain (cord: 4.10, SD=0.70; brain: 3.5, SD=0.98; =10.39; <0.001). The severity of spinal arteriolosclerosis was associated with spinal white matter pallor ( =0.47; <0.001). Spinal arteriolosclerosis accounted for ≈3% of the variation in parkinsonism in models controlling for age, sex, brain arteriolosclerosis, and cerebrovascular disease pathologies. Further models showed that the association of spinal arteriolosclerosis and parkinsonism was not mediated via spinal white matter pallor. CONCLUSIONS: Although the regional distribution of microvascular pathologies varies within the central nervous system, spinal arteriolosclerosis is common and may contribute to the severity of spinal white matter pallor and parkinsonism in older adults.
[Mh] Termos MeSH primário: Envelhecimento/patologia
Arteriolosclerose/patologia
Microvasos/patologia
Transtornos Parkinsonianos/patologia
Medula Espinal/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Arteriolosclerose/mortalidade
Encéfalo/irrigação sanguínea
Encéfalo/patologia
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Masculino
Transtornos Parkinsonianos/mortalidade
Medula Espinal/irrigação sanguínea
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017643


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[PMID]:28224671
[Au] Autor:Abner EL; Kryscio RJ; Schmitt FA; Fardo DW; Moga DC; Ighodaro ET; Jicha GA; Yu L; Dodge HH; Xiong C; Woltjer RL; Schneider JA; Cairns NJ; Bennett DA; Nelson PT
[Ad] Endereço:Department of Epidemiology, University of Kentucky, Lexington, KY.
[Ti] Título:Outcomes after diagnosis of mild cognitive impairment in a large autopsy series.
[So] Source:Ann Neurol;81(4):549-559, 2017 Apr.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine clinical and neuropathological outcomes following a clinical diagnosis of mild cognitive impairment (MCI). METHODS: Data were drawn from a large autopsy series (N = 1,337) of individuals followed longitudinally from normal or MCI status to death, derived from 4 Alzheimer Disease (AD) Centers in the United States. RESULTS: Mean follow-up was 7.9 years. Of the 874 individuals ever diagnosed with MCI, final clinical diagnoses were varied: 39.2% died with an MCI diagnosis, 46.8% with a dementia diagnosis, and 13.9% with a diagnosis of intact cognition. The latter group had pathological features resembling those with a final clinical diagnosis of MCI. In terms of non-AD pathologies, both primary age-related tauopathy (p < 0.05) and brain arteriolosclerosis pathology (p < 0.001) were more severe in MCI than cognitively intact controls. Among the group that remained MCI until death, mixed AD neuropathologic changes (ADNC; ≥1 comorbid pathology) were more frequent than "pure" ADNC pathology (55% vs 22%); suspected non-Alzheimer pathology comprised the remaining 22% of cases. A majority (74%) of subjects who died with MCI were without "high"-level ADNC, Lewy body disease, or hippocampal sclerosis pathologies; this group was enriched in cerebrovascular pathologies. Subjects who died with dementia and were without severe neurodegenerative pathologies tended to have cerebrovascular pathology and carry the MCI diagnosis for a longer interval. INTERPRETATION: MCI diagnosis usually was associated with comorbid neuropathologies; less than one-quarter of MCI cases showed "pure" AD at autopsy. Ann Neurol 2017;81:549-559.
[Mh] Termos MeSH primário: Arteriolosclerose/patologia
Disfunção Cognitiva/patologia
Demência/patologia
Arteriosclerose Intracraniana/patologia
Tauopatias/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/patologia
Arteriolosclerose/classificação
Autopsia
Disfunção Cognitiva/classificação
Demência/classificação
Feminino
Seguimentos
Seres Humanos
Arteriosclerose Intracraniana/classificação
Masculino
Tauopatias/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24903


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[PMID]:27979431
[Au] Autor:Ye Z; Zhang Z; Zhang H; Hao Y; Zhang J; Liu W; Xu G; Liu X
[Ad] Endereço:Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu, China; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Título:Prognostic Value of C-Reactive Protein and Homocysteine in Large-Artery Atherosclerotic Stroke: a Prospective Observational Study.
[So] Source:J Stroke Cerebrovasc Dis;26(3):618-626, 2017 Mar.
[Is] ISSN:1532-8511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our objective is to investigate whether C-reactive protein (CRP) and homocysteine (Hcy) levels in the acute phase of large-artery atherosclerotic stroke predict long-term functional disability and recurrent vascular events. METHODS: Patients with first-ever large-artery atherosclerotic ischemic stroke were prospectively registered in the Nanjing Stroke Registry Program between January 2012 and June 2014. Venous blood samples were collected within 2 weeks after the index stroke. Patients were followed up for 1 year. The Kaplan-Meier method was performed in survival analysis. Multiple logistic regression analysis and Cox proportional hazard model were applied to identify predictors of functional disability and recurrent vascular events, respectively. RESULTS: A total of 625 eligible patients (458 males) were evaluated. During the 1-year follow-up period, 63 patients suffered recurrent vascular events. An elevated CRP level is an independent predictor of poor functional disability at 1 year (P for trend = .002), in both males (P for trend = .017) and females (P for trend = .042). Hcy showed no relationship with functional disability. No significant relationship between CRP and Hcy levels and recurrent vascular events was found in total patients in multiple models. Stratified by sex, high Hcy levels were associated with recurrent vascular events in females (P for trend = .036) but not in males. CONCLUSIONS: Elevated CRP levels are associated with poor functional disability in patients with large-artery atherosclerotic stroke at 1 year, and Hcy is a relatively moderate predictor of recurrent vascular events in female patients with large-artery atherosclerotic stroke at 1 year.
[Mh] Termos MeSH primário: Arteriolosclerose/complicações
Proteína C-Reativa/metabolismo
Homocisteína/sangue
Acidente Vascular Cerebral/sangue
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Estudos Prospectivos
Análise de Regressão
Estudos Retrospectivos
Estatísticas não Paramétricas
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0LVT1QZ0BA (Homocysteine); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:26738751
[Au] Autor:Ighodaro ET; Abner EL; Fardo DW; Lin AL; Katsumata Y; Schmitt FA; Kryscio RJ; Jicha GA; Neltner JH; Monsell SE; Kukull WA; Moser DK; Appiah F; Bachstetter AD; Van Eldik LJ; Nelson PT; Alzheimer's Disease Neuroimaging Initiative (ADNI)
[Ad] Endereço:Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA.
[Ti] Título:Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.
[So] Source:J Cereb Blood Flow Metab;37(1):201-216, 2017 Jan.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the "oldest-old" compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death: < 80 years (n = 1008) and ≥80 years (n = 1382). In both age groups, severe brain arteriolosclerosis was associated with worse performances on global cognition tests. Hypertension (but not diabetes) was a brain arteriolosclerosis risk factor in the younger group. In the ≥ 80 years age at death group, an ABCC9 gene variant (rs704180), previously associated with aging-related hippocampal sclerosis, was also associated with brain arteriolosclerosis. A post-hoc arterial spin labeling neuroimaging experiment indicated that ABCC9 genotype is associated with cerebral blood flow impairment; in a convenience sample from Alzheimer's Disease Neuroimaging Initiative (n = 15, homozygous individuals), non-risk genotype carriers showed higher global cerebral blood flow compared to risk genotype carriers. We conclude that brain arteriolosclerosis is associated with altered cognitive status and a novel vascular genetic risk factor.
[Mh] Termos MeSH primário: Envelhecimento/psicologia
Arteriolosclerose/etiologia
Arteriolosclerose/psicologia
Cognição
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Arteriolosclerose/genética
Encéfalo/patologia
Encéfalo/fisiopatologia
Circulação Cerebrovascular/genética
Bases de Dados Factuais
Variação Genética
Seres Humanos
Hipertensão/complicações
Fatores de Risco
Receptores Sulfonilureia/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABCC9 protein, human); 0 (Sulfonylurea Receptors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


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[PMID]:27694152
[Au] Autor:James BD; Wilson RS; Boyle PA; Trojanowski JQ; Bennett DA; Schneider JA
[Ad] Endereço:Rush Alzheimer's Disease Center, Rush University Medical Center, Department of Internal Medicine, 600 s. Paulina Street, Chicago, IL 60612, USA.
[Ti] Título:TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia.
[So] Source:Brain;139(11):2983-2993, 2016 Nov 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hyperphosphorylated transactive response DNA-binding protein 43 (TDP-43, encoded by TARDBP ) proteinopathy has recently been described in ageing and in association with cognitive impairment, especially in the context of Alzheimer's disease pathology. To explore the role of mixed Alzheimer's disease and TDP-43 pathologies in clinical Alzheimer's-type dementia, we performed a comprehensive investigation of TDP-43, mixed pathologies, and clinical Alzheimer's-type dementia in a large cohort of community-dwelling older subjects. We tested the hypotheses that TDP-43 with Alzheimer's disease pathology is a common mixed pathology; is related to increased likelihood of expressing clinical Alzheimer's-type dementia; and that TDP-43 pathologic stage is an important determinant of clinical Alzheimer's-type dementia. Data came from 946 older adults with ( n = 398) and without dementia ( n = 548) from the Rush Memory and Aging Project and Religious Orders Study. TDP-43 proteinopathy (cytoplasmic inclusions) was present in 496 (52%) subjects, and the pattern of deposition was classified as stage 0 (none; 48%), stage 1 (amygdala; 18%), stage 2 (extension to hippocampus/entorhinal; 21%), or stage 3 (extension to neocortex; 14%). TDP-43 pathology combined with a pathologic diagnosis of Alzheimer's disease was a common mixed pathology (37% of all participants), and the proportion of subjects with clinical Alzheimer's-type dementia formerly labelled 'pure pathologic diagnosis of Alzheimer's disease' was halved when TDP-43 was considered. In logistic regression models adjusted for age, sex, and education, TDP-43 pathology was associated with clinical Alzheimer's-type dementia (odds ratio = 1.51, 95% confidence interval = 1.11, 2.05) independent of pathological Alzheimer's disease (odds ratio = 4.30, 95% confidence interval = 3.08, 6.01) or other pathologies (infarcts, arteriolosclerosis, Lewy bodies, and hippocampal sclerosis). Mixed Alzheimer's disease and TDP-43 pathologies were associated with higher odds of clinical Alzheimer's-type dementia (odds ratio = 6.73, 95% confidence interval = 4.18, 10.85) than pathologic Alzheimer's disease alone (odds ratio = 4.62, 95% confidence interval = 2.84, 7.52). In models examining TDP-43 stage, a dose-response relationship with clinical Alzheimer's-type dementia was observed, and a significant association was observed starting at stage 2, extension beyond the amygdala. In this large sample from almost 1000 community participants, we observed that TDP-43 proteinopathy was very common, frequently mixed with pathological Alzheimer's disease, and associated with a higher likelihood of the clinical expression of clinical Alzheimer's-type dementia but only when extended beyond the amygdala.
[Mh] Termos MeSH primário: Doença de Alzheimer/metabolismo
Doença de Alzheimer/patologia
Encéfalo/metabolismo
Encéfalo/patologia
Proteínas de Ligação a DNA/metabolismo
Proteinopatias TDP-43/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Arteriolosclerose/etiologia
Arteriolosclerose/metabolismo
Arteriolosclerose/patologia
Autopsia
Infarto Encefálico/etiologia
Infarto Encefálico/metabolismo
Infarto Encefálico/patologia
Estudos de Coortes
Feminino
Seres Humanos
Vida Independente
Masculino
Escalas de Graduação Psiquiátrica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (TDP-43 protein, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1093/brain/aww224


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[PMID]:27327274
[Au] Autor:Kono K; Fujii H; Nakai K; Goto S; Watanabe S; Watanabe K; Nishi S
[Ad] Endereço:Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.
[Ti] Título:Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease.
[So] Source:Kidney Blood Press Res;41(4):374-83, 2016.
[Is] ISSN:1423-0143
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Hypertension (HT) is a common complication in patients with chronic kidney disease (CKD). However, the relationship between circadian rhythm disorder of blood pressure (BP) and intra-renal damage remains unclear. METHODS: Ninety patients with chronic glomerular disease (CGD) were included in the present study. On the basis of the clinic BP (CBP) and 24 h-ambulatory BP (ABP) measurements, the patients were divided into the following groups; normotension (NT), white coat HT (WHT), masked HT (MHT), and sustained HT (SHT). For renal histopathological assessment, we evaluated each biopsy specimen for sclerotic glomeruli (SG), interstitial fibrosis (IF), intimal thickening of intra-lobular arteries (ILA), and arteriolar hyalinosis (AH). RESULTS: The prevalence of NT, WHT, MHT and SHT was 60.0%, 3.3%, 23.3%, and 13.4%, respectively. Compared with circadian BP pattern, all-day HT was most prevalent in the SHT group, whereas nighttime HT was most prevalent in the MHT group. The results of histological analysis showed that the SHT group had more severe SG and IF and the MHT group had more severe IF compared to the NT group. As for renal arteriolosclerosis, the MHT and SHT groups had more severe AH compared with the NT group, whereas ILA was comparable among all four groups. Furthermore, multivariate analysis revealed that ILA was significantly correlated only with age, whereas AH was significantly correlated with age and HT based on ABP, but not HT based on CBP. CONCLUSIONS: Our findings suggest that renal AH was severe not only in the SHT group, but also in the MHT group. Careful ABP monitoring should be recommended in patients with CGD.
[Mh] Termos MeSH primário: Arteriolosclerose/fisiopatologia
Monitorização Ambulatorial da Pressão Arterial
Hipertensão/classificação
Insuficiência Renal Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hipertensão Renal
Glomérulos Renais/irrigação sanguínea
Glomérulos Renais/fisiopatologia
Masculino
Hipertensão Mascarada
Meia-Idade
Hipertensão do Jaleco Branco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE
[do] DOI:10.1159/000443440


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[PMID]:27121159
[Au] Autor:Ranjbar K; Rahmani-Nia F; Shahabpour E
[Ad] Endereço:Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran.
[Ti] Título:Aerobic training and l-arginine supplementation promotes rat heart and hindleg muscles arteriogenesis after myocardial infarction.
[So] Source:J Physiol Biochem;72(3):393-404, 2016 Sep.
[Is] ISSN:1877-8755
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Arteriogenesis is a main defense mechanism to prevent heart and local tissues dysfunction in occlusive artery disease. TGF-ß and angiostatin have a pivotal role in arteriogenesis. We tested the hypothesis that aerobic training and l-arginine supplementation promotes cardiac and skeletal muscles arteriogenesis after myocardial infarction (MI) parallel to upregulation of TGF-ß and downregulation of angiostatin. For this purpose, 4 weeks after LAD occlusion, 50 male Wistar rats were randomly distributed into five groups: (1) sham surgery without MI (sham, n = 10), (2) control-MI (Con-MI, n = 10), (3) l-arginine-MI (La-MI, n = 10), (4) exercise training-MI (Ex-MI, n = 10), and (5) exercise and l-arginine-MI (Ex + La-MI). Exercise training groups running on a treadmill for 10 weeks with moderate intensity. Rats in the l-arginine-treated groups drank water containing 4 % l-arginine. Arteriolar density with different diameters (11-25, 26-50, 51-75, and 76-150 µm), TGF-ß, and angiostatin gene expression were measured in cardiac (area at risk) and skeletal (soleus and gastrocnemius) muscles. Smaller arterioles decreased in cardiac after MI. Aerobic training and l-arginine increased the number of cardiac arterioles with 11-25 and 26-50 µm diameters parallel to TGF-ß overexpression. In gastrocnemius muscle, the number of arterioles/mm(2) was only increased in the 11 to 25 µm in response to training with and without l-arginine parallel to angiostatin downregulation. Soleus arteriolar density with different size was not different between experimental groups. Results showed that 10 weeks aerobic exercise training and l-arginine supplementation promotes arteriogenesis of heart and gastrocnemius muscles parallel to overexpression of TGF-ß and downregulation of angiostatin in MI rats.
[Mh] Termos MeSH primário: Arginina/uso terapêutico
Vasos Coronários/fisiopatologia
Suplementos Nutricionais
Músculo Esquelético/irrigação sanguínea
Infarto do Miocárdio/reabilitação
Neovascularização Fisiológica
Condicionamento Físico Animal
[Mh] Termos MeSH secundário: Indutores da Angiogênese/uso terapêutico
Angiostatinas/antagonistas & inibidores
Angiostatinas/genética
Angiostatinas/metabolismo
Animais
Arteríolas/fisiopatologia
Arteriolosclerose/dietoterapia
Arteriolosclerose/fisiopatologia
Arteriolosclerose/terapia
Terapia Combinada
Regulação da Expressão Gênica
Coração/fisiopatologia
Membro Posterior
Masculino
Atividade Motora
Músculo Esquelético/metabolismo
Músculo Esquelético/fisiopatologia
Infarto do Miocárdio/etiologia
Infarto do Miocárdio/metabolismo
Infarto do Miocárdio/fisiopatologia
Miocárdio/metabolismo
Distribuição Aleatória
Ratos Wistar
Fator de Crescimento Transformador beta/agonistas
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inducing Agents); 0 (Transforming Growth Factor beta); 86090-08-6 (Angiostatins); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1007/s13105-016-0480-x


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[PMID]:27091839
[Au] Autor:Gigante A; Barbano B; Di Mario F; Rosato E; Simonelli M; Rocca AR; Conti F; Ceccarelli F; Giannakakis K; Valesini G; Cianci R
[Ad] Endereço:Department of Clinical Medicine, Sapienza University of Rome, Italy antonietta_gigante@yahoo.it.
[Ti] Título:Renal parenchymal resistance in patients with biopsy proven glomerulonephritis: Correlation with histological findings.
[So] Source:Int J Immunopathol Pharmacol;29(3):469-74, 2016 Sep.
[Is] ISSN:2058-7384
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Renal Doppler ultrasound is increasingly used in nephrology for the evaluation of renovascular disease, allograft dysfunction, and chronic nephropathies. We compared intrarenal hemodynamic parameters to biopsy findings of glomerular sclerosis, tubular atrophy, interstitial fibrosis, crescents, arteriolosclerosis, and clinical variables in 100 patients. A positive correlation exists between renal function and percentage of glomerular sclerosis (P <0.01, r = 0.26), conversely a negative correlation exists between glomerular filtrate rate and percentage of glomerular sclerosis(P <0.0001, r = -0.35). The percentage of glomerular sclerosis correlate positively with pulsatile index (PI) (P <0.05, r = 0.21) and renal resistive index (RI) (P <0.05, r = 0.20). The percentage of crescents correlates positively with PI(P <0.05, r = 0.21) and RI (P <0.05, r = 0.20). Classifying arteriolosclerosis in four groups according to a severity scale, from absence to severe, PI (P <0.05) and RI (P <0.01) were significantly different. In the post hoc analysis, the median values of PI and RI are significantly different in patients with severe arteriolosclerosis than others. Ultrasound examination is a non-invasive diagnostic technique used on patients with suspected or established renal disease. Our study shows a close correlation between kidney function, ultrasound parameters, and histological findings. Measurement of renal parenchymal resistance by ultrasound could be used in association with biopsy and glomerular function for the evaluation of renal damage in patients with glomerulonephritis.
[Mh] Termos MeSH primário: Glomerulonefrite/patologia
Rim/patologia
[Mh] Termos MeSH secundário: Arteriolosclerose/patologia
Biópsia
Feminino
Taxa de Filtração Glomerular/fisiologia
Seres Humanos
Falência Renal Crônica/patologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1177/0394632016645590


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[PMID]:26768207
[Au] Autor:Lim AS; Yu L; Schneider JA; Bennett DA; Buchman AS
[Ad] Endereço:From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chi
[Ti] Título:Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People.
[So] Source:Stroke;47(2):516-8, 2016 Feb.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Although several forms of sleep disruption are associated with stroke, few studies have examined the relationship between sleep and histopathologic measures of cerebrovascular disease. We tested the hypothesis that greater sleep fragmentation is associated with a higher burden of cerebral vessel and infarct pathology at autopsy. METHODS: We used ordinal logistic regression models to relate sleep fragmentation measured by actigraphy to the severity of arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy, and the number of macroscopic and microscopic infarcts assessed by structured brain autopsy in 315 participants from the Rush Memory and Aging Project. RESULTS: Greater sleep fragmentation was associated with more severe arteriolosclerosis (odds ratio, 1.27; 95% confidence interval, 1.02-1.59; P=0.03 per 1 SD greater sleep fragmentation) and more subcortical macroscopic infarcts (odds ratio, 1.31; 95% confidence interval, 1.01-1.68; P=0.04). These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities. CONCLUSIONS: Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults.
[Mh] Termos MeSH primário: Arteriolosclerose/epidemiologia
Angiopatia Amiloide Cerebral/epidemiologia
Infarto Cerebral/epidemiologia
Arteriosclerose Intracraniana/epidemiologia
Privação do Sono/epidemiologia
[Mh] Termos MeSH secundário: Actigrafia
Idoso de 80 Anos ou mais
Arteriolosclerose/patologia
Autopsia
Infarto Encefálico/epidemiologia
Infarto Encefálico/patologia
Angiopatia Amiloide Cerebral/patologia
Infarto Cerebral/patologia
Feminino
Seres Humanos
Vida Independente
Arteriosclerose Intracraniana/patologia
Modelos Logísticos
Masculino
Razão de Chances
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.115.011608


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[PMID]:26661292
[Au] Autor:Matos AC; Câmara NO; REQUIãO-Moura LR; Tonato EJ; Filiponi TC; Souza-DURãO M; Malheiros DM; Fregonesi M; Borrelli M; Pacheco-Silva A
[Ad] Endereço:Renal Transplant Division, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil. accmatos@einstein.br.
[Ti] Título:Presence of arteriolar hyalinosis in post-reperfusion biopsies represents an additional risk to ischaemic injury in renal transplant.
[So] Source:Nephrology (Carlton);21(11):923-929, 2016 Nov.
[Is] ISSN:1440-1797
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:AIM: The role of post-reperfusion biopsy findings as a predictor of early and long-term graft function and survival is still a target of research. METHODS: We analyzed data from 136 post-reperfusion biopsies performed in deceased donor renal transplanted patients from November 2008 to May 2012. We analyzed the presence of acute tubular necrosis (ATN), arteriolar hyalinosis (AH), intimal thickness (IT), interstitial fibrosis (IF) and glomerulosclerosis (GS). We also analyzed the impact of donor features on the following outcomes: delayed graft function (DGF) and chronic allograft dysfunction defined as eGFR < 60 mL/min at 1 year. RESULTS: The mean donor age was 41 years, 26% of whom were extended criteria donors (ECD), 33% had hypertension and 50% had cerebral vascular accident (CVA) as the cause of death. ATN was present in 87% of these biopsies, AH in 31%, IF in 21%, IT in 27% and GS in 32%. DGF occurred in 80% and chronic allograft dysfunction was present in 53%. AH was the only histological finding associated with DGF and chronic allograft dysfunction at 1 year. Patients with AH had a lower eGFR at 1 year than patients without it (49.8 mL/min × 64.5 mL/min, P = 0.02). In the multivariate analysis, risk variables for development of chronic graft dysfunction were male sex (odds ratio [OR] = 3.159 [CI: 1.22-8.16]; P = 0.018), acute rejection (OR = 8.91 [CI: 2.21-35.92]; P = 0.002), donor hypertension (OR = 2.94 [CI: 1.10-7.84]; P = 0.031), AH (OR = 3.96 [CI: 1.46-10.70]; P = 0.007) and eGFR at discharge (OR = 0.96 [CI: 0.93-0.98]; P = 0.005). In multivariate analysis, risk factors for AH were donor age ≥ 50 years (OR = 2.46 [CI: 1.10-5.44]; P = 0.027) and CVA as the cause of donor death (OR = 2.33 [CI: 1.05-5.15]; P = 0.007). CONCLUSION: The presence of AH in post-reperfusion biopsies is a marker of ageing and vascular disease and was associated with DGF and a one year poorer renal function. AH in donor biopsies superimposed to long ischaemic time is a predictor of renal function. The management of immunosuppression based on the presence of AH in post-reperfusion biopsy could be useful to improve long term graft function.
[Mh] Termos MeSH primário: Arteriolosclerose
Função Retardada do Enxerto
Necrose Tubular Aguda
[Mh] Termos MeSH secundário: Adulto
Arteriolosclerose/metabolismo
Arteriolosclerose/patologia
Biópsia/métodos
Função Retardada do Enxerto/etiologia
Função Retardada do Enxerto/patologia
Função Retardada do Enxerto/fisiopatologia
Função Retardada do Enxerto/prevenção & controle
Feminino
Taxa de Filtração Glomerular
Sobrevivência de Enxerto
Seres Humanos
Hialina/metabolismo
Imunossupressão/métodos
Transplante de Rim/efeitos adversos
Transplante de Rim/métodos
Necrose Tubular Aguda/complicações
Necrose Tubular Aguda/patologia
Necrose Tubular Aguda/fisiopatologia
Masculino
Traumatismo por Reperfusão/fisiopatologia
Traumatismo por Reperfusão/prevenção & controle
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1111/nep.12699



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