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[PMID]:29431320
[Au] Autor:Kudaeva IV; Dyakovich OA; Masnavieva LB; Popkova OV; Abramatets EA
[Ti] Título:[Features of the lipid exchange in workers employed in aluminium productions].
[So] Source:Gig Sanit;95(9):857-60, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Aluminum production can be referred to the category of industries of the increased health hazard for the workers. During technological process of receiving aluminum the air of a working zone is polluted by a large number of harmful substances. Workers are exposed to the complex of toxicants possessing a polytropic impact on the body. The most significant consequences are violations of different types of metabolism in the organism, including lipid metabolism. The purpose of the study is the investigation of the state of lipid metabolism in persons working in the production of aluminum. The object of research was 108 male workers of aluminum production suffering from occupational pathology of airways. The group of comparison was consisted of 103 men, apparently healthy, not exposed to toxicants. There was determined the content of the total cholesterol (TC), high and low density lipoprotein cholesterol (HDLC and LDLC), triglycerides (TG), phospholipids (PL), atherogenic index (AI). Statistical processing was performed with the use of software «Statistica 6.0¼. There were established statistically significant differences of indices of lipid exchange in the persons occupied in aluminum production when related to the group of comparison. IA values in persons from the study group proved to be higher than in the comparison group, due to elevated levels of TC and LDLC. The TG and PL level was also higher. The values of IA, TC and TG in workers of aluminum production in more than 50% cases exceeded the reference values. The average concentration of HDL cholesterol in both groups did not differ, and was above the lower reference boundary. Established features of lipid metabolism in workers of aluminum allow us to suggest the distinction in mechanisms of developing proatherogenic disorders from previously established ones for workers exposed to other chemicals. One of the causes of the shaping of these disorders can be oxidative stress, which in turn serves as a response to the exposure of complex of toxic substances to workers.
[Mh] Termos MeSH primário: Alumínio
Aterosclerose
Metabolismo dos Lipídeos/efeitos dos fármacos
Doenças Profissionais
Exposição Ocupacional
Local de Trabalho/normas
[Mh] Termos MeSH secundário: Adulto
Alumínio/efeitos adversos
Alumínio/análise
Aterosclerose/epidemiologia
Aterosclerose/etiologia
Aterosclerose/prevenção & controle
Seres Humanos
Masculino
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador/normas
Avaliação de Resultados (Cuidados de Saúde)
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 27167 MEDLINE  
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[PMID]:29203734
[Au] Autor:Skochko OV; Kaidashev IP
[Ad] Endereço:Department Of Internal Medicine No 3 With Phthisiology, Higher State Educational Establishment Of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
[Ti] Título:Effect of pioglitazone on insulin resistance, progression of atherosclerosis and clinical course of coronary heart disease.
[So] Source:Wiad Lek;70(5):881-890, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ). Activation of receptor PPAR-γ regulates carbohydrate and lipid metabolism, immune and inflammatory responses in heart tissues. THE AIM: Our aim was to study the effect of pioglitazone on insulin resistance, the clinical course of atherosclerosis and coronary heart disease (CHD). MATERIALS AND METHODS: The study included 43 patients with coronary artery disease. Patients were divided into the main group - 20 patients, in whom pioglitazone (Pioglar, Ranbaxy, India) was included in the combined therapy at a dose of 15 mg 1 time per day in the morning, and the comparison group - 23 patients receiving standard complex drug therapy over 6 months. Patients underwent clinical examination, ultrasound of neck vessels, study of carbohydrate and lipid metabolism. RESULTS: Joining pioglitazone to standard therapy resulted in the reduction of systolic (p<0.05) and diastolic (p<0.05) blood pressure; decrease in the duration of pain attacks (p<0.05); reduction in the frequency of angina attacks (p<0.05); regression of atherosclerosis of the carotid vessels (p<0.05), decrease in the thickness of the intima-media complex (p<0.05). The decline in oral glucose tolerance test (p<0.05), hyperglycemic factor (p<0.05), total cholesterol (p<0.05), and low density lipoproteins (p<0.05) were observed, as well as increased high-density lipoprotein (p<0.05). CONCLUSION: Long-term treatment with pioglitazone at low doses against the background of standard therapy contributes to functional and clinical condition of patients, promotes the prevention of atherosclerosis and reduction of insulin resistance, thereby improving the clinical manifestations of coronary heart disease.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Resistência à Insulina
Tiazolidinedionas/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Aterosclerose/diagnóstico por imagem
Fármacos Cardiovasculares/administração & dosagem
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cardiovascular Agents); 0 (Hypoglycemic Agents); 0 (Thiazolidinediones); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  3 / 27167 MEDLINE  
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[PMID]:29292899
[Au] Autor:Jonasson L; Hansson G
[Ad] Endereço:Universitetssjukhuset i Linköping Kardiologiska kliniken - Linköping, Sweden - Linköping, Sweden.
[Ti] Título:Inflammation och ateroskleros ­ sista pusselbiten är på plats - Inflammation är en aktör vid ateroskleros: nya fynd kan ge ny måltavla för effektiv läkemedelsterapi..
[So] Source:Lakartidningen;114, 2017 Oct 30.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Ab] Resumo:Inflammation and atherosclerosis - last piece of the puzzle has fallen into place Inflammation is a major component of atherosclerotic lesions and inflammatory biomarkers can be used to predict cardiovascular disease. Still, it has been unclear whether inflammation is a driving force in atherosclerosis, or merely an epiphenomenon. The recently published results of the CANTOS trial shows that treatment with canacinumab, a monoclonal antibody to the proinflammatory cytokine interleukin-1ß, led to a significantly lower rate of recurrent cardiovascular events, compared to placebo. Thus, it establishes beyond doubt that inflammation is a treatable pathogenetic mechanism in atherosclerosis.
[Mh] Termos MeSH primário: Aterosclerose/patologia
Inflamação/patologia
[Mh] Termos MeSH secundário: Anti-Inflamatórios/administração & dosagem
Anticorpos Monoclonais/administração & dosagem
Aterosclerose/tratamento farmacológico
Doenças Cardiovasculares/prevenção & controle
LDL-Colesterol/sangue
Seres Humanos
Inflamação/tratamento farmacológico
Interleucina-1beta/antagonistas & inibidores
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antibodies, Monoclonal); 0 (Cholesterol, LDL); 0 (Interleukin-1beta); 37CQ2C7X93 (canakinumab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


  4 / 27167 MEDLINE  
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[PMID]:28463859
[Au] Autor:Katsiki N; Mantzoros C; Mikhailidis DP
[Ad] Endereço:aSecond Department of Propaedeutic Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece bDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA cDepartment of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
[Ti] Título:Adiponectin, lipids and atherosclerosis.
[So] Source:Curr Opin Lipidol;28(4):347-354, 2017 Aug.
[Is] ISSN:1473-6535
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. RECENT FINDINGS: This narrative review discusses the associations of adiponectin with obesity-related metabolic disorders (metabolic syndrome, nonalcoholic fatty liver disease, hyperuricaemia and type 2 diabetes mellitus). We also focus on the links between adiponectin and lipid disorders and with coronary heart disease and noncardiac vascular diseases (i.e. stroke, peripheral artery disease, carotid artery disease, atherosclerotic renal artery stenosis, abdominal aortic aneurysms and chronic kidney disease). Further, the effects of lifestyle interventions and drug therapy on adiponectin levels are briefly reviewed. SUMMARY: Based on available data, adiponectin represents a multifaceted biomarker that may beneficially affect atherosclerosis, inflammation and insulin resistance pathways. However, there are conflicting results with regard to the associations between adiponectin levels and the prevalence and outcomes of cardiometabolic diseases. Further research on the potential clinical implications of adiponectin in the diagnosis and treatment of such diseases is needed.
[Mh] Termos MeSH primário: Adiponectina/metabolismo
Aterosclerose/metabolismo
Metabolismo dos Lipídeos
[Mh] Termos MeSH secundário: Aterosclerose/complicações
Aterosclerose/cirurgia
Cirurgia Bariátrica
Seres Humanos
Estilo de Vida
Obesidade/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adiponectin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1097/MOL.0000000000000431


  5 / 27167 MEDLINE  
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[PMID]:29419394
[Au] Autor:Morley RL; Sharma A; Horsch AD; Hinchliffe RJ
[Ad] Endereço:North Bristol NHS Trust, Bristol, Bristol, UK.
[Ti] Título:Peripheral artery disease.
[So] Source:BMJ;360:j5842, 2018 02 01.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Aterosclerose/complicações
Transtornos Cerebrovasculares/complicações
Isquemia Miocárdica/complicações
Doença Arterial Periférica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Aterosclerose/patologia
Transtornos Cerebrovasculares/epidemiologia
Complicações do Diabetes
Diagnóstico Diferencial
Inglaterra/epidemiologia
Seres Humanos
Meia-Idade
Isquemia Miocárdica/epidemiologia
Doença Arterial Periférica/complicações
Doença Arterial Periférica/epidemiologia
Doença Arterial Periférica/fisiopatologia
Guias de Prática Clínica como Assunto
Atenção Primária à Saúde/normas
Medição de Risco
Fatores de Risco
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5842


  6 / 27167 MEDLINE  
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[PMID]:28450656
[Au] Autor:Amin HZ; Sasaki N; Hirata KI
[Ad] Endereço:Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan. Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. hilman_amin@yahoo.co.id.
[Ti] Título:Regulatory T Cell Immunity in Atherosclerosis.
[So] Source:Acta Med Indones;49(1):63-68, 2017 Jan.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:Atherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated. In this review, we discuss recent advances in our understanding of the roles of Tregs and Teffs in experimental atherosclerosis, as well as human coronary artery disease.
[Mh] Termos MeSH primário: Aterosclerose/imunologia
Linfócitos T Reguladores/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Inflamação/imunologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  7 / 27167 MEDLINE  
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[PMID]:29406052
[Au] Autor:Hegde R; Li S; Gupta N; Cohen S
[Ad] Endereço:Department of Radiology, Bridgeport Hospital-Yal`e New Haven Health System, Bridgeport, Connecticut. Electronic address: rahulhegde@gmail.com.
[Ti] Título:Aortic Intramural Hemorrhage Secondary to Penetrating Atherosclerotic Ulcers.
[So] Source:Am J Med Sci;355(2):e5-e6, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aorta Torácica/diagnóstico por imagem
Aortografia
Aterosclerose/diagnóstico por imagem
Hemorragia/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  8 / 27167 MEDLINE  
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[PMID]:29406041
[Au] Autor:Mamudu HM; Jones A; Paul T; Subedi P; Wang L; Alamian A; Alamin AE; Blackwell G; Budoff M
[Ad] Endereço:Department of Health Services Management and Policy, College of Public Health, East Tennessee State University, Johnson City, Tennessee. Electronic address: mamudu@etsu.edu.
[Ti] Título:Geographic and Individual Correlates of Subclinical Atherosclerosis in an Asymptomatic Rural Appalachian Population.
[So] Source:Am J Med Sci;355(2):140-148, 2018 02.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to examine the association between subclinical atherosclerosis (ascertained as coronary artery calcium [CAC]) in asymptomatic individuals in the Central Appalachian region of the United States and individual- and geographic-level factors. MATERIALS AND METHODS: Data were obtained from participants in CAC screening between 2012 and 2016. CAC score was assessed as CAC = 0 (no plaque), 1 ≤ CAC ≤ 99 (mild plaque), 100 ≤ CAC ≤ 399 (moderate plaque) and CAC ≥ 400 (severe plaque). Additionally, data on demographics (age, sex and race), medical conditions, lifestyle factors and family history of coronary artery disease were obtained. Further, zip codes of place of residence for participants were used to generate geographic-level data. Descriptive statistics were used to estimate the prevalence of CAC, and multinomial logistic regression models were used to delineate significant factors. RESULTS: Of 1,512 participants, 57.6% had CAC > 0. The prevalence of mild, moderate and severe plaques was 31.6%, 16.3% and 9.7%, respectively. Demographics (age and sex), medical conditions, lifestyle factors and family history of coronary artery disease were associated with increased risk for subclinical atherosclerosis. Further, the proportion of minority residents significantly increased the risk for severe plaque (relative risk ratio = 1.06, P = 0.04) and the proportion of residents on government assistance significantly decreased the risk for mild plaque (relative risk ratio = 0.93, P = 0.03). CONCLUSIONS: The results imply that the proportion of minority residents in a geographic area is associated with increased relative risk for subclinical atherosclerosis, while the proportion of residents on government assistance decreased such risk. However, future geographic or neighborhood-level studies with a larger sample size are needed to delineate further the consistency of these results in the Central Appalachian population.
[Mh] Termos MeSH primário: Aterosclerose/epidemiologia
Placa Aterosclerótica/epidemiologia
População Rural
[Mh] Termos MeSH secundário: Região dos Apalaches/epidemiologia
Aterosclerose/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Placa Aterosclerótica/fisiopatologia
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  9 / 27167 MEDLINE  
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[PMID]:28471688
[Au] Autor:Dobiásová M
[Ad] Endereço:Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. milada.dobiasova@fgu.cas.cz.
[Ti] Título:Atherogenic impact of lecithin-cholesterol acyltransferase and its relation to cholesterol esterification rate in HDL (FER(HDL)) and AIP [log(TG/HDL-C)] biomarkers: the butterfly effect?
[So] Source:Physiol Res;66(2):193-203, 2017 May 04.
[Is] ISSN:1802-9973
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins. The functionality of LCAT substantially depends on its mass together with the composition of the phospholipid bilayer as well as the saturation and the length of fatty acyls and other effectors about which we know yet nothing. Over the years, LCAT puzzle has been significantly supplemented but yet not so satisfactory as to enable how to manipulate LCAT in order to prevent cardiometabolic events. It reminds the butterfly effect when only a moderate change in the process of transformation free cholesterol to cholesteryl esters may cause a crucial turn in the intended target. On the other hand, two biomarkers - FER(HDL) (fractional esterification rate in HDL) and AIP [log(TG/HDL-C)] can offer a benefit to identify the risk of cardiovascular disease (CVD). They both reflect the rate of cholesterol esterification by LCAT and the composition of lipoprotein subpopulations that controls this rate. In clinical practice, AIP can be calculated from the routine lipid profile with help of AIP calculator www.biomed.cas.cz/fgu/aip/calculator.php.
[Mh] Termos MeSH primário: Aterosclerose/metabolismo
Biomarcadores/metabolismo
Colesterol/metabolismo
Ácidos Graxos/metabolismo
Lipoproteínas HDL/metabolismo
Fosfatidilcolina-Esterol O-Aciltransferase/metabolismo
[Mh] Termos MeSH secundário: Animais
Aterosclerose/sangue
Esterificação
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Fatty Acids); 0 (Lipoproteins, HDL); 97C5T2UQ7J (Cholesterol); EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  10 / 27167 MEDLINE  
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[PMID]:28460767
[Au] Autor:Verma I; Syngle A; Krishan P
[Ad] Endereço:Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
[Ti] Título:Predictors of endothelial dysfunction and atherosclerosis in rheumatoid arthritis in Indian population.
[So] Source:Indian Heart J;69(2):200-206, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Cardiovascular (CV) disease is leading cause of mortality in rheumatoid arthritis (RA). Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with atherosclerosis and is therefore an early feature in atherogenesis. Biomarkers for rapid evolution of CV complications would be highly desirable for risk stratification. Finally, predictive biomarkers for cardiovascular risk would allow tailoring therapy to the individual. We assessed endothelial function and atherosclerosis utilizing carotid intima-media thickness (CIMT) in RA in context of clinical and laboratory markers in Indian RA population. METHODS: We performed a prospective study of 35 consecutive RA patients and 25 age- and sex matched healthy controls. Patients with traditional CV risk factors were excluded. Flow mediated dilatation (FMD) as measures of endothelial function and CIMT as measures of atherosclerosis were assessed. Disease-specific measures, inflammatory measures, serum cytokines, serum nitrite, lipids and endothelial progenitor cells (EPCs) were estimated. RESULTS: FMD was significantly lower in RA (6.53%±1.81%) compared to controls (10.77%±0.53%; p<0.001). CIMT (mm) was significantly increased in RA (0.62±0.17) vs. controls (0.043±0.07; p=0.003). In RA patients, FMD% inversely correlated with CIMT, CRP, DAS-28, TNF-α, serum nitrite and positively correlated with EPC. CIMT correlated with age, DAS-28, IL-6, HDL, LDL, and inversely correlated with EPC. CONCLUSIONS: In the present study, FMD and CIMT were impaired in RA, indicating endothelial dysfunction and accelerated atherosclerosis respectively. CRP, TNF-α, serum nitrite, DAS-28 and depleted EPC population predicted endothelial dysfunction. Age, IL-6, HDL, LDL and depleted EPC population predicted accelerated atherosclerosis.
[Mh] Termos MeSH primário: Artrite Reumatoide/complicações
Aterosclerose/etiologia
Endotélio Vascular/fisiopatologia
Vasodilatação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Artrite Reumatoide/epidemiologia
Aterosclerose/epidemiologia
Aterosclerose/fisiopatologia
Feminino
Seres Humanos
Incidência
Índia/epidemiologia
Masculino
Meia-Idade
Prognóstico
Estudos Prospectivos
Medição de Risco
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE



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