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Referências encontradas : 154 [refinar]
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[PMID]:29384193
[Au] Autor:Sibson KR; Biss TT; Furness CL; Grainger JD; Hough RE; Macartney C; Payne JH; Chalmers EA; British Society for Haematology
[Ad] Endereço:Department of Haematology, Great Ormond Street Hospital, London, UK.
[Ti] Título:BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy.
[So] Source:Br J Haematol;180(4):511-525, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos Hemostáticos/diagnóstico
Transtornos Hemostáticos/etiologia
Transtornos Hemostáticos/terapia
Neoplasias/complicações
Trombose/diagnóstico
Trombose/etiologia
Trombose/terapia
[Mh] Termos MeSH secundário: Tomada de Decisão Clínica
Gerenciamento Clínico
Seres Humanos
Neoplasias/terapia
Pediatria
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15112


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Moraes, Roberto Henrique Pinto
Texto completo SciELO Brasil
[PMID]:28443942
[Au] Autor:Sano-Martins IS; Duarte AC; Guerrero B; Moraes RHP; Barros EJG; Arocha-Piñango CL
[Ad] Endereço:Instituto Butantan, Laboratório de Fisiopatologia, São Paulo, São Paulo, Brazil.
[Ti] Título:Hemostatic disorders induced by skin contact with Lonomia obliqua (Lepidoptera, Saturniidae) caterpillars.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e24, 2017 Apr 20.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Patients envenomed by Lonomia sp caterpillars initially experience a mild burning pain, headache, nausea, vomiting, and skin and mucosal hemorrhages. Some patients can rapidly progress to a severe coagulopathy that presents as visceral or intracerebral hemorrhaging. We studied the hemostatic alterations that occurred in 14 patients who were envenomed by Lonomia obliqua in Southern Brazil and presented at the Hospital São Vicente de Paulo (Passo Fundo, RS), Brazil during the summers of 1993 and 1994 when Lonomia antivenom was not yet available for treatment. The patients were classified into to 4 clinical groups: 0 (two patients), I (eight patients), II (two patients), and III (two patients). The patients were admitted to the hospital between 4 hours and five days after contact with the caterpillars. In this study, the coagulation parameters of the patients were followed up for up to 172 hours after the accidents. The patients received no treatment with the exceptions of two patients who received blood transfusions and antifibrinolytic treatment. The observed abnormalities related to blood coagulation and fibrinolytic factors were similar regardless of the severity of the bleeding symptoms. These findings suggest that alterations in hemostatic parameters without thrombocytopenia are not predictors of the seriousness of such accidents. Thus, consumptive disorder and reactive fibrinolysis are not proportional to mild coagulopathy. Furthermore, these patients recovered. The hemostatic parameters of most of the patients normalized between 96 and 120 h after the accident.
[Mh] Termos MeSH primário: Antivenenos/administração & dosagem
Venenos de Artrópodes/envenenamento
Transtornos Hemostáticos/induzido quimicamente
Lepidópteros/classificação
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Criança
Pré-Escolar
Feminino
Transtornos Hemostáticos/prevenção & controle
Seres Humanos
Masculino
Meia-Idade
Índice de Gravidade de Doença
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antivenins); 0 (Arthropod Venoms)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28190865
[Au] Autor:Ogawa Y; Yanagisawa K; Ishizaki T; Shimizu H; Mitsui T; Ichinose A; Nojima Y; Handa H
[Ad] Endereço:Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine.
[Ti] Título:Late-onset neutropenia after rituximab therapy in patients with autoimmune thrombotic and hemostatic disorders: a single center analysis.
[So] Source:Rinsho Ketsueki;58(1):42-46, 2017.
[Is] ISSN:0485-1439
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Autoimmune thrombotic and hemostatic disorders, caused by autoantibodies against various factors regulating thrombosis and hemostasis, are rare. Rituximab (RTX) is on occasion used for treating these disorders. Late-onset neutropenia (LON) has been described as a side effect of RTX treatment for patients with hemato-oncological and/or rheumatological diseases but not for those with autoimmune thrombotic and hemostatic disorders. Eleven patients with autoimmune thrombotic and hemostatic disorders received RTX in our institution. Four of these 11 cases (36.4%) developed LON after a median 72.6 days of RTX administration (range 43-122). Three cases required G-CSF, but no severe infections developed.
[Mh] Termos MeSH primário: Doenças Autoimunes/tratamento farmacológico
Transtornos Hemostáticos/tratamento farmacológico
Neutropenia/induzido quimicamente
Rituximab/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Estudos Retrospectivos
Rituximab/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.11406/rinketsu.58.42


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[PMID]:28034472
[Au] Autor:Webster CR
[Ad] Endereço:Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address: Cynthia.Leveille-Webster@tufts.edu.
[Ti] Título:Hemostatic Disorders Associated with Hepatobiliary Disease.
[So] Source:Vet Clin North Am Small Anim Pract;47(3):601-615, 2017 May.
[Is] ISSN:1878-1306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The liver plays a crucial role in all aspects of coagulation because most factors that regulate procoagulation, anticoagulation, and fibrinolysis are produced, cleared, and/or activated in the liver. Establishing the coagulation status of an individual patient with hepatobiliary disease can therefore be challenging. Although, classically, patients with hepatobiliary disease were thought of as potentially hypocoagulable, hypercoagulability also occurs. The article summarizes the breadth of coagulation abnormalities that have been reported in dogs and cats with hepatobiliary disease and provides strategies to respond to bleeding and thrombotic risk.
[Mh] Termos MeSH primário: Doenças Biliares/veterinária
Doenças do Gato/sangue
Doenças do Cão/sangue
Transtornos Hemostáticos/veterinária
Hepatopatias/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças Biliares/sangue
Doenças Biliares/diagnóstico
Doenças Biliares/terapia
Fatores de Coagulação Sanguínea
Doenças do Gato/diagnóstico
Doenças do Gato/terapia
Gatos
Doenças do Cão/diagnóstico
Doenças do Cão/terapia
Cães
Transtornos Hemostáticos/sangue
Transtornos Hemostáticos/diagnóstico
Transtornos Hemostáticos/terapia
Seres Humanos
Hepatopatias/sangue
Hepatopatias/diagnóstico
Hepatopatias/terapia
Inibidores da Agregação de Plaquetas/uso terapêutico
Tempo de Protrombina/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Coagulation Factors); 0 (Platelet Aggregation Inhibitors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27762165
[Au] Autor:Hacioglu S; Karabulut A; Sari I; Keskin A
[Ad] Endereço:a Department of Hematology , Pamukkale University, Faculty of Medicine , Denizli , Turkey.
[Ti] Título:Haemostatic disorders in reproductive age women with menorrhagia and effects on quality of life.
[So] Source:J Obstet Gynaecol;36(8):1041-1045, 2016 Nov.
[Is] ISSN:1364-6893
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine the frequency of haemostatic abnormalities in women with menorrhagia and to evaluate their effect on quality of life (QoL). The study population was composed of patients with menorrhagia seen in the outpatient clinic, having a score of >185 with a pictorial blood assessment chart. Structured questionnaires were used in the assessment of demographic characteristics and QoL, and patients were tested for bleeding disorders. Ninety women were recruited for the study. Bleeding disorders were detected in 40% of them: 11.1% had von Willebrand disease, 2.2% had low von Willebrand factor and 26.7% had platelet function disorders (PFD). In 22 (91.6%) cases with PFD the, defect was non-specific and impaired aggregation response to ristocetine (37.5%) was the most commonly detected problem. Bleeding disorders were not associated with any significant reduction in QoL (p > .05). Hereditary bleeding disorders may be the cause of unexplained menorrhagia even in the middle-aged women, but they had no prominent effect on QoL.
[Mh] Termos MeSH primário: Transtornos Plaquetários/psicologia
Transtornos Hemostáticos/psicologia
Menorragia/psicologia
Qualidade de Vida
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Menorragia/etiologia
Meia-Idade
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27706533
[Au] Autor:Hanmod SS; Jesudas R; Kulkarni R; Chitlur M
[Ad] Endereço:Department of Pediatrics and Human Development, MSU Center for Bleeding and Clotting Disorders, Michigan State University, East Lansing, Michigan.
[Ti] Título:Neonatal Hemostatic Disorders: Issues and Challenges.
[So] Source:Semin Thromb Hemost;42(7):741-751, 2016 Oct.
[Is] ISSN:1098-9064
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neonates form a unique cohort with distinct features associated with the hemostatic system compared with older children and adults. The development of the human hemostatic system begins around 10 weeks in utero and continues to evolve during childhood. This dynamic period termed developmental hemostasis should be taken into consideration when diagnosing a neonate with disorders of bleeding or thrombosis.
[Mh] Termos MeSH primário: Hemorragia
Transtornos Hemostáticos
Doenças do Recém-Nascido
Trombose
[Mh] Termos MeSH secundário: Adulto
Feminino
Hemorragia/sangue
Hemorragia/diagnóstico
Hemorragia/etiologia
Hemorragia/terapia
Transtornos Hemostáticos/sangue
Transtornos Hemostáticos/complicações
Transtornos Hemostáticos/diagnóstico
Transtornos Hemostáticos/terapia
Seres Humanos
Recém-Nascido
Doenças do Recém-Nascido/sangue
Doenças do Recém-Nascido/diagnóstico
Doenças do Recém-Nascido/terapia
Masculino
Trombose/sangue
Trombose/diagnóstico
Trombose/etiologia
Trombose/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


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[PMID]:27369959
[Au] Autor:Bonhomme F; Boehlen F; Clergue F; de Moerloose P
[Ad] Endereço:Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland. fanny.bonhomme@hcuge.ch.
[Ti] Título:Preoperative hemostatic assessment: a new and simple bleeding questionnaire.
[Ti] Título:Évaluation préopératoire de l'hémostase: un nouveau questionnaire simple sur le saignement..
[So] Source:Can J Anaesth;63(9):1007-15, 2016 Sep.
[Is] ISSN:1496-8975
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Current recommendations for the assessment of the risk of perioperative bleeding limit coagulation testing to patients with a personal and/or family history of bleeding. As no simple preoperative screening questionnaire is currently available, we assessed the performance of a novel screening questionnaire for its ability to detect bleeding disorders. METHODS: A dichotomized, seven-point questionnaire named HEMSTOP (Hematoma, hEmorrhage, Menorrhagia, Surgery, Tooth extraction, Obstetrics, Parents) was applied to three groups of subjects: patients referred to hemostasis specialists for bleeding symptoms for whom any kind of perioperative hemostatic precautions were subsequently recommended (n = 38); patients referred to hemostasis specialists for whom precautions were not required (n = 75); healthy volunteers (n = 70). We calculated the sensitivity and specificity of HEMSTOP scores and compared them with the discriminative performances of standard blood coagulation assays (prothrombin time, activated partial thromboplastin time). RESULTS: Patients requiring perioperative hemostatic precautions had greater median [interquartile range] HEMSTOP scores (2 [2-3]) than patients not requiring precautions (1 [1-2]) and healthy controls (0 [0-0]); P < 0.001. A HEMSTOP score ≥ 2 had a specificity of 98.6% [95% confidence interval (CI), 92.3 to 100] and a sensitivity of 89.5% (95% CI, 75.2 to 97.1). The 26.3% (95% CI, 13.4 to 43.1) sensitivity of the standard coagulation times was much lower. CONCLUSION: The HEMSTOP score discriminates patients at an elevated risk for bleeding with recommended perioperative precautions from those without such recommendations as well as from healthy participants. Further evaluation of the HEMSTOP score is required for a better evaluation of its definitive usefulness to predict the risk of perioperative bleeding.
[Mh] Termos MeSH primário: Transtornos Hemostáticos/diagnóstico
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adulto
Testes de Coagulação Sanguínea
Perda Sanguínea Cirúrgica/prevenção & controle
Feminino
Hemostasia
Seres Humanos
Complicações Intraoperatórias/epidemiologia
Complicações Intraoperatórias/prevenção & controle
Masculino
Assistência Perioperatória
Reprodutibilidade dos Testes
Medição de Risco
Tempo de Coagulação do Sangue Total
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; VALIDATION STUDIES
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160703
[St] Status:MEDLINE
[do] DOI:10.1007/s12630-016-0688-9


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[PMID]:27341813
[Au] Autor:Ranucci M
[Ad] Endereço:Department of Cardiothoracic and Vascular Anesthesia and ICU, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, Milan, Italy. cardioanestesia@virgilio.it.
[Ti] Título:Detection of inherited and acquired hemostatic disorders in surgical patients.
[Ti] Título:Le dépistage des troubles de l'hémostase héréditaires ou acquis chez les patients chirurgicaux..
[So] Source:Can J Anaesth;63(9):1003-6, 2016 09.
[Is] ISSN:1496-8975
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemostasia
Transtornos Hemostáticos
[Mh] Termos MeSH secundário: Hemostáticos
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Nm] Nome de substância:
0 (Hemostatics)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160626
[St] Status:MEDLINE
[do] DOI:10.1007/s12630-016-0687-x


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PubMed Central Texto completo
Texto completo
[PMID]:27251655
[Au] Autor:Adekwu A; Adoga AS; Gav TA
[Ad] Endereço:Department of Surgery, College of Health Sciences, Benue State University, Makurdi, Nigeria.
[Ti] Título:Our experience with pre-operative haemostatic assessment of paediatric patients undergoing adenotonsillectomy at Federal Medical Centre, Makurdi.
[So] Source:Afr J Paediatr Surg;13(2):69-72, 2016 Apr-Jun.
[Is] ISSN:0974-5998
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In 2-4% of all patients requiring adenoidectomy, tonsillectomy or adenotonsillectomy, pre-operative screening tests for coagulation disorders are indicated to detect surgical bleeding complications. However, because of cost effect on the patients, the usefulness of these tests is being challenged. We therefore highlight our experience in paediatric patients undergoing adenoidectomy, tonsillectomy or both in our centre. PATIENTS AND METHODS: This is a 3½-year analysis of the data of 165 paediatric patients who had adenoidectomy, tonsillectomy or both over the study period. The data collected included age, sex, procedure done and detailed clinical bleeding history. RESULTS: A total of 165 children had either adenoidectomy or tonsillectomy, or both. There were 76 males and 89 females giving a male to female ratio of 1:1.2. Their ages ranged from 10 months to 18 years. Eighty-five (51.5%) patients had adenotonsillectomy, 48 (29.1%) and 32 (19.4%) had only tonsillectomies and adenoidectomies, respectively. Only 11 (6.7%) families volunteered the history of either prolonged bleeding with minor injury on the skin or occasional slight nose bleeding. Six (3.6%) patients including 3 of the children with positive family history had posttonsillectomy bleed, out of which 4 (66.7%) were moderate whereas the remaining 2 (33.3%) were severe bleeding, which was not statistically significant (P = 0.041). The two cases of severe bleeding had fresh whole blood transfused whereas the rest that had no bleeding issues were discharged home 48 h postoperatively. CONCLUSION: Our experience in this study suggests that detailed bleeding history is necessary as well as pre-operative haemostatic assessment, if available and affordable for paediatric patients undergoing adenotonsillectomy.
[Mh] Termos MeSH primário: Adenoidectomia/efeitos adversos
Transtornos Hemostáticos/diagnóstico
Hemorragia Pós-Operatória/etiologia
Tonsilectomia/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Testes Hematológicos
Transtornos Hemostáticos/complicações
Seres Humanos
Lactente
Masculino
Nigéria
Cuidados Pré-Operatórios
Estudos Retrospectivos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.4103/0189-6725.182559


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[PMID]:27206953
[Au] Autor:Wang T; Xu B; Fan R; Liu Z; Gong D
[Ad] Endereço:National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
[Ti] Título:Asparaginase-associated concurrence of hyperlipidemia, hyperglobulinemia, and thrombocytosis was successfully treated by centrifuge/membrane hybrid double-filtration plasmapheresis.
[So] Source:J Clin Lipidol;10(3):646-9, 2016 May-Jun.
[Is] ISSN:1933-2874
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asparaginase-associated concurrence of hyperlipidemia, hyperglobulinemia, and thrombocytosis is a rare complication requiring aggressive lipoprotein apheresis, but no one of currently available lipoprotein apheresis methods can simultaneously resolve the 3 abnormalities. Herein, we reported a construction of double-filtration plasmapheresis (DFPP) using a combination of centrifugal/membranous plasma separation techniques to successfully treat a patient with hyperlipidemia, hyperglobulinemia, and thrombocytosis. A male presented with severe hyperlipidemia, hyperglobulinemia, and thrombocytosis during asparaginase treatment for NK/T-cell lymphoblastic lymphoma and was scheduled to receive lipoprotein apheresis. To simultaneously remove lipoproteins, immunoglobulin, and deplete platelets from blood, a centrifuge/membrane hybrid DFPP was constructed as following steps: plasma and part of platelets were separated first from whole blood by centrifugal technique and then divided by a fraction plasma separator into 2 parts: platelets and plasma components with large size, which were discarded; and those containing albumin, which were returned to blood with a supplement of extrinsic albumin solution. DFPP lasted 240 minutes uneventfully, processing 5450-mL plasma. The concentrations of plasma components before DFPP were as follows: triglycerides 38.22 mmol/L, total cholesterols 22.98 mmol/L, immunoglobulin A (IgA) 15.7 g/L, IgG 12.7 g/L, and IgM 14.3 g/L; whereas after treatment were 5.69 mmol/L, 2.38 mmol/L, 2.5 g/L, 7.7 g/L, and 0.4 g/L, respectively. The respective reduction ratio was 85.1%, 89.6%, 83.9%, 39.4%, and 96.9%. Platelet count decreased by 40.4% (from 612 × 10(9)/L to 365 × 10(9)/L). Centrifuge/membrane hybrid DFPP can simultaneously remove lipoproteins, immunoglobulin, and deplete platelets, with a success in treatment of asparaginase treatment-induced hyperlipidemia, hyperglobulinemia, and thrombocytosis, and may be useful for patients requiring DFPP but with particular situations.
[Mh] Termos MeSH primário: Asparaginase/metabolismo
Centrifugação
Transtornos Hemostáticos/complicações
Hiperlipidemias/terapia
Membranas Artificiais
Plasmaferese/métodos
Trombocitose/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Hiperlipidemias/complicações
Hiperlipidemias/metabolismo
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membranes, Artificial); EC 3.5.1.1 (Asparaginase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE



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