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[PMID]:29297639
[Au] Autor:Tikhonova IV; Kosyakova NI; Tankanag AV; Chemeris NK
[Ti] Título:Effects of the Airway Obstruction on the Skin Microcirculation in Patients with Bronchial Asthma.
[So] Source:Vestn Ross Akad Med Nauk;71(3):233-9, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Background: Pulmonary hemodynamic disorders depend on the inflammatory phases and severity of the obstructive syndrome. However, the effect of asthma bronchial obstruction on the state of peripheral hemodynamics remains insufficiently known. Aims: To study the effects of airway obstruction on skin blood flow parameters and its regulatory systems in patients with persistent atopic bronchial asthma in the remission state. Materials and Methods: A comparative study of the skin peripheral blood flow in patients with bronchial asthma with severe airway obstruction (1st group) and without obstruction (2nd group) was conducted. 20 patients with confirmed diagnosis of atopic asthma of 50­74 years old participated in the study. All patients received basic therapy in a constant dosing of high doses of inhaled glucocorticosteroids/long-acting beta-2-agonists. The control group included 20 healthy volunteers without evidence of bronchial obstruction. The study lasted for 3 months. The forced expiratory volume in 1 s (FEV1) was used to evaluate the bronchial obstruction by spirometry technique. Skin blood perfusion changes were recorded by laser Doppler flowmetry at rest and in response to short-term local ischemia. Registered peripheral blood flow signals were examined using the amplitude temporal filtering in five frequency intervals to identify the functional features of the peripheral blood flow regulation systems. Results: Consistent two-fold decrease of the oscillation amplitudes was found in the neurogenic interval at rest (p=0.031), as well as in the myogenic (p=0.043; p=0.031) and endothelial intervals (p=0.037; p≤0.001) both at rest and during the postocclusive reactive hyperemia respectively in the 1st group of patients with bronchial obstruction (FEV1 <80%) compared with the control group. No significant changes were revealed for skin blood flow parameters in the 2nd patient group (without obstruction, FEV1 >80%) in comparison to control subjects. Conclusions: The presence of bronchial obstruction has a significant impact on the changes of the amplitudes of skin blood flow oscillations in patients with bronchial asthma in the myogenic, neurogenic and endothelial intervals.
[Mh] Termos MeSH primário: Obstrução das Vias Respiratórias
Asma/fisiopatologia
Microcirculação
Pele
[Mh] Termos MeSH secundário: Idoso
Obstrução das Vias Respiratórias/diagnóstico
Obstrução das Vias Respiratórias/etiologia
Obstrução das Vias Respiratórias/fisiopatologia
Asma/complicações
Feminino
Seres Humanos
Hiperemia/diagnóstico
Fluxometria por Laser-Doppler/métodos
Masculino
Meia-Idade
Pele/irrigação sanguínea
Pele/fisiopatologia
Espirometria/métodos
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn661


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[PMID]:27860477
[Au] Autor:Mlcáková E; Mlcák P; Karhanová M; Langová K; Maresová K
[Ti] Título:[Ocular Surface Evaluation in Patients Treated with Prostaglandin Analogues Considering Preservative Agent].
[Ti] Título:Hodnocení ocního povrchu u pacientu lécených analogy prostaglandinu s ohledem na obsazenou konzervacní látku..
[So] Source:Cesk Slov Oftalmol;72(4):120-127, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:PURPOSE: The aim of this study was to evaluate the ocular surface in patients treated with prostaglandin analogues considering contained preservative agent. METHODS: 60 patients with glaucoma or ocular hypertension treated with prostaglandin analogue monotherapy were enrolled in this observational study. 20 patients with glaucoma suspect or ocular hypertension without local or systemic glaucoma medication formed the control group. Demographic data and medical history were recorded for each participant. Patients filled in the Ocular surface disease index© (OSDI) questionnaire and underwent an ophthalmological examination including assessment of conjunctival hyperaemia according to Efron, tear film break up time (BUT) and fluorescein staining according to the Oxford grading scheme. Treated participants were divided into 3 groups according to the preservative contained in the currently used prostaglandin analogue: the preservative-free group (18 patients), the polyquaternium group (17 patients) and the benzalkonium chloride (BAK) group (25 patients). RESULTS: The control group had significantly lower fluorescein staining than the preservative-free group (p=0.001), the polyquaternium group (p=0.007) and the BAK group (p=0.002). The conjunctival hyperaemia was significantly lower in the preservative-free group compared to the polyquaternium group (p=0.011). There was no significant difference among the other groups. The difference neither in the OSDI score nor in the BUT was statistically important. CONCLUSION: This study confirmed that the ocular surface is worse in patients treated with prostaglandin analogue monotherapy than in people without glaucoma medication. A significant difference among treated patients depending on a preservative agent was not proved.Key words: benzalkonium chloride, glaucoma, ocular surface disease, preservatives, prostaglandin analogues.
[Mh] Termos MeSH primário: Anti-Hipertensivos/administração & dosagem
Doenças da Túnica Conjuntiva/prevenção & controle
Glaucoma de Ângulo Aberto/tratamento farmacológico
Hiperemia/prevenção & controle
Conservantes Farmacêuticos/administração & dosagem
Prostaglandinas F Sintéticas/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Idoso
Compostos de Benzalcônio/administração & dosagem
Compostos de Benzalcônio/efeitos adversos
Doenças da Túnica Conjuntiva/induzido quimicamente
Feminino
Fluorofotometria
Seres Humanos
Hiperemia/induzido quimicamente
Pressão Intraocular/efeitos dos fármacos
Masculino
Meia-Idade
Hipertensão Ocular/tratamento farmacológico
Soluções Oftálmicas
Polímeros/administração & dosagem
Polímeros/efeitos adversos
Conservantes Farmacêuticos/efeitos adversos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Benzalkonium Compounds); 0 (Ophthalmic Solutions); 0 (Polymers); 0 (Preservatives, Pharmaceutical); 0 (Prostaglandins F, Synthetic); 75345-27-6 (polyquaternium 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:28922226
[Au] Autor:Larsen MHH; Ekeloef S; Kokotovic D; Schou-Pedersen AM; Lykkesfeldt J; Gögenür I
[Ad] Endereço:From the *Department of Surgery, Center for Surgical Science, Zealand University Hospital, Koege, Denmark; and †Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
[Ti] Título:Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study.
[So] Source:Anesth Analg;125(5):1793-1796, 2017 Nov.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, -0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.
[Mh] Termos MeSH primário: Endotélio Vascular/efeitos dos fármacos
Antebraço/irrigação sanguínea
Inalação
Oxigenoterapia
Oxigênio/administração & dosagem
Vasodilatação/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Biomarcadores/sangue
Estudos Cross-Over
Dinamarca
Endotélio Vascular/metabolismo
Endotélio Vascular/fisiopatologia
Voluntários Saudáveis
Seres Humanos
Hiperemia/fisiopatologia
Masculino
Manometria
Projetos Piloto
Valor Preditivo dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002357


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[PMID]:28860792
[Au] Autor:Igari K; Kudo T; Toyofuku T; Inoue Y
[Ad] Endereço:Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
[Ti] Título:Endothelial dysfunction in patients with Buerger disease.
[So] Source:Vasc Health Risk Manag;13:317-323, 2017.
[Is] ISSN:1178-2048
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group. While the reactive hyperemia index was not significantly different between these two groups, the ankle brachial pressure index was significantly different (1.12 versus 0.83, =0.003). Furthermore, the reactive hyperemia index was significantly correlated with the ankle brachial pressure index value in the patients in the lumbar sympathectomy group ( =0.848, =0.005). Given that patients with Buerger disease show impairment of the sympathetic nervous system, we should consider the after-effects of such an impaired system on the condition of these patients. The patients treated with lumbar sympathectomy might be more appropriate to evaluate their endothelial function by a peripheral arterial tonometry test.
[Mh] Termos MeSH primário: Endotélio Vascular/fisiopatologia
Doença Arterial Periférica/fisiopatologia
Tromboangiite Obliterante/fisiopatologia
[Mh] Termos MeSH secundário: Índice Tornozelo-Braço
Endotélio Vascular/inervação
Feminino
Seres Humanos
Hiperemia/fisiopatologia
Vértebras Lombares/inervação
Masculino
Manometria
Meia-Idade
Doença Arterial Periférica/diagnóstico
Doença Arterial Periférica/cirurgia
Valor Preditivo dos Testes
Estudos Retrospectivos
Simpatectomia
Sistema Nervoso Simpático/fisiopatologia
Sistema Nervoso Simpático/cirurgia
Tromboangiite Obliterante/diagnóstico
Tromboangiite Obliterante/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.2147/VHRM.S139892


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[PMID]:28851731
[Au] Autor:Lee JM; Hwang D; Park J; Zhang J; Tong Y; Kim CH; Bang JI; Suh M; Paeng JC; Cheon GJ; Koo BK
[Ad] Endereço:From Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.M.L.); Department of Internal Medicine and Cardiovascular Center (D.H., J.P., J.Z., C.H.K., B.-K.K.) and Department of Nu
[Ti] Título:Exploring Coronary Circulatory Response to Stenosis and Its Association With Invasive Physiologic Indexes Using Absolute Myocardial Blood Flow and Coronary Pressure.
[So] Source:Circulation;136(19):1798-1808, 2017 Nov 07.
[Is] ISSN:1524-4539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although invasive physiological assessment for coronary stenosis has become a standard practice to guide treatment strategy, coronary circulatory response and changes in invasive physiological indexes, according to different anatomic and hemodynamic lesion severity, have not been fully demonstrated in patients with coronary artery disease. METHODS: One hundred fifteen patients with left anterior descending artery stenosis who underwent both N-ammonia positron emission tomography and invasive physiological measurement were analyzed. Myocardial blood flow (MBF) measured with positron emission tomography and invasively measured coronary pressures were used to calculate microvascular resistance and stenosis resistance. RESULTS: With progressive worsening of angiographic stenosis severity, both resting and hyperemic transstenotic pressure gradient and stenosis resistance increased ( <0.001 for all) and hyperemic MBF ( <0.001) and resting microvascular resistance ( =0.012) decreased. Resting MBF ( =0.383) and hyperemic microvascular resistance ( =0.431) were not changed and maintained stable. Both fractional flow reserve and instantaneous wave-free ratio decreased as angiographic stenosis severity, stenosis resistance, and transstenotic pressure gradient increased and hyperemic MBF decreased (all <0.001). When the presence of myocardial ischemia was defined by both low hyperemic MBF and low coronary flow reserve, the diagnostic accuracy of fractional flow reserve and instantaneous wave-free ratio did not differ, regardless of cutoff values of hyperemic MBF and coronary flow reserve. CONCLUSIONS: This study demonstrated how the coronary circulation changes in response to increasing coronary stenosis severity using N-ammonium positron emission tomography-derived MBF and invasively measured pressure data. Currently used resting and hyperemic pressure-derived invasive physiological indexes have similar patterns of relationships to the different anatomic and hemodynamic lesion severities. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01366404.
[Mh] Termos MeSH primário: Pressão Sanguínea
Cateterismo Cardíaco
Circulação Coronária
Estenose Coronária/diagnóstico
Vasos Coronários/diagnóstico por imagem
Vasos Coronários/fisiopatologia
Imagem de Perfusão do Miocárdio/métodos
Radioisótopos de Nitrogênio/administração & dosagem
Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Velocidade do Fluxo Sanguíneo
Angiografia Coronária
Estenose Coronária/diagnóstico por imagem
Estenose Coronária/fisiopatologia
Feminino
Seres Humanos
Hiperemia/fisiopatologia
Masculino
Microcirculação
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Sistema de Registros
Reprodutibilidade dos Testes
República da Coreia
Índice de Gravidade de Doença
Resistência Vascular
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Radioisotopes); 0 (Radiopharmaceuticals)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1161/CIRCULATIONAHA.117.029911


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[PMID]:28837695
[Au] Autor:Chen HJ; Wright GA
[Ad] Endereço:Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles.
[So] Source:PLoS One;12(8):e0183259, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral arterial disease (PAD), we present a physiological model incorporating oxygen transport, tissue metabolism, and vascular regulation mechanisms. The model demonstrated distinct effects between arterial stenoses and microvascular dysfunction on reactive hyperemia, and indicated a higher sensitivity of 2-minute thigh cuffing to microvascular dysfunction than 5-minute cuffing. The recorded perfusion responses in PAD patients (n = 9) were better differentiated from the normal subjects (n = 7) using the model-based analysis rather than characterization using the apparent peak and time-to-peak of the responses. The analysis results suggested different amounts of microvascular disease within the patient group. Overall, this work demonstrates a novel analysis method and facilitates understanding of the physiology involved in ASL reactive hyperemia. ASL reactive hyperemia with model-based analysis may be used as a noninvasive microvascular assessment in the presence of arterial stenoses, allowing us to look beyond the macrovascular disease in PAD. A subgroup who will have a poor prognosis after revascularization in the patients with critical limb ischemia may be associated with more severe microvascular diseases, which may potentially be identified using ASL reactive hyperemia.
[Mh] Termos MeSH primário: Artérias/fisiopatologia
Hiperemia/fisiopatologia
Músculo Esquelético/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Seres Humanos
Modelos Teóricos
Músculo Esquelético/irrigação sanguínea
Doença Arterial Periférica/fisiopatologia
Marcadores de Spin
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Spin Labels)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183259


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[PMID]:28834489
[Au] Autor:Wang WL
[Ad] Endereço:Taipei Medical University Hospital, Taipei, Taiwan luckyweilin@hotmail.com.
[Ti] Título:Venous Congestion in Ischemic Bowel.
[So] Source:N Engl J Med;377(8):e10, 2017 Aug 24.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperemia/patologia
Íleo/irrigação sanguínea
Jejuno/irrigação sanguínea
Isquemia Mesentérica/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Íleo/patologia
Jejuno/patologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1610862


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[PMID]:28604572
[Au] Autor:Rodgin SG
[Ad] Endereço:*OD, MAc, FAAO Veterans Administration Medical Center, Boston, Massachusetts; Private Practice, Wayland, Massachusetts; and Adjunct Faculty, New England College of Optometry, Boston, Massachusetts.
[Ti] Título:Food-Induced Red Eye.
[So] Source:Optom Vis Sci;94(7):775-780, 2017 Jul.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This article addresses the etiology of red eyes and a novel case of food-induced red eye. CASE REPORT: An 82-year-old white male patient reported 50 years of episodes of severe unilateral bulbar injection in either eye following ingestion of certain foods. Thinned scleras in this particular patient made the injection in his eyes more observable. Photodocumentation of this reaction after he ingested these foods is shown. CONCLUSIONS: It is hypothesized that this is a new explanation for an intermittent, unilateral, self-limited red eye-a food-induced red eye.
[Mh] Termos MeSH primário: Conjuntivite Alérgica/etiologia
Hipersensibilidade Alimentar/etiologia
Alimentos/efeitos adversos
Hiperemia/etiologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000001088


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[PMID]:28600353
[Au] Autor:Menyhárt Á; Zölei-Szénási D; Puskás T; Makra P; Bari F; Farkas E
[Ad] Endereço:Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
[Ti] Título:Age or ischemia uncouples the blood flow response, tissue acidosis, and direct current potential signature of spreading depolarization in the rat brain.
[So] Source:Am J Physiol Heart Circ Physiol;313(2):H328-H337, 2017 Aug 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spreading depolarization (SD) events contribute to lesion maturation in the acutely injured human brain. Neurodegeneration related to SD is thought to be caused by the insufficiency of the cerebral blood flow (CBF) response; yet the mediators of the CBF response, or their deficiency in the aged or ischemic cerebral cortex, remain the target of intensive research. Here, we postulated that tissue pH effectively modulates the magnitude of hyperemia in response to SD, the coupling of which is prone to be dysfunctional in the aged or ischemic cerebral cortex. To test this hypothesis, we conducted systematic correlation analysis between the direct current (DC) potential signature of SD, SD-associated tissue acidosis, and hyperemic element of the CBF response in the isoflurane-anesthetized, young or old, and intact or ischemic rat cerebral cortex. The data demonstrate that the amplitude of the SD-related DC potential shift, tissue acidosis, and hyperemia are tightly coupled in the young intact cortex; ischemia and old age uncouples the amplitude of hyperemia from the amplitude of the DC potential shift and acidosis; the duration of the DC potential shift, hyperemia and acidosis positively correlate under ischemia alone; and old age disproportionally elongates the duration of acidosis with respect to the DC potential shift and hyperemia under ischemia. The coincidence of the variables supports the view that local CBF regulation with SD must have an effective metabolic component, which becomes dysfunctional with age or under ischemia. Finally, the known age-related acceleration of ischemic neurodegeneration may be promoted by exaggerated tissue acidosis. The hyperemic element of the cerebral blood flow response to spreading depolarization is effectively modulated by tissue pH in the young intact rat cerebral cortex. This coupling becomes dysfunctional with age or under ischemia, and tissue acidosis lasts disproportionally longer in the aged cortex, making the tissue increasingly more vulnerable.
[Mh] Termos MeSH primário: Acidose/fisiopatologia
Envelhecimento
Isquemia Encefálica/fisiopatologia
Ondas Encefálicas
Córtex Cerebral/irrigação sanguínea
Córtex Cerebral/fisiopatologia
Circulação Cerebrovascular
Depressão Alastrante da Atividade Elétrica Cortical
Hiperemia/fisiopatologia
[Mh] Termos MeSH secundário: Acidose/metabolismo
Acidose/patologia
Fatores Etários
Envelhecimento/metabolismo
Envelhecimento/patologia
Animais
Isquemia Encefálica/metabolismo
Isquemia Encefálica/patologia
Córtex Cerebral/metabolismo
Modelos Animais de Doenças
Metabolismo Energético
Concentração de Íons de Hidrogênio
Hiperemia/metabolismo
Hiperemia/patologia
Masculino
Degeneração Neural
Ratos Sprague-Dawley
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00222.2017


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[PMID]:28572043
[Au] Autor:Altindas M; Arslan H; Bingöl UA; Demiröz A
[Ad] Endereço:Plastic, Reconstructive and Aesthetic Surgery Department, Private Office, Istanbul, Turkey. Electronic address: hakanarsln93@gmail.com.
[Ti] Título:Prelaminated extended temporoparietal fascia flap without tissue expansion for hemifacial reconstruction.
[So] Source:J Plast Reconstr Aesthet Surg;70(10):1457-1463, 2017 Oct.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Disfigurement of the face caused by postburn scars, resected congenital nevi and vascular malformations has both functional and psychological consequences. Ideal reconstruction of the facial components requires producing not only function but also the better appearance of the face. The skin of the neck, supraclavicular or cervicothoracic regions are the most commonly used and the most likely source of skin for facial reconstruction in those techniques which prefabrications with tissue expansion are used. This retrospective cohort study describes the two staged prelaminated temporoparietal fascia flap which eliminates the usage of tissue expansion by using skin graft harvested from the neck and occipital region and the application of this flap for the lower three-fourths of the face. METHOD: 5 patients received prelaminated temporoparietal fascia flap without tissue expansion for facial resurfacing. The mean age at surgery was 39, 2 years (range, 17-60 years). The average follow up was 21.6 months (range, 10-48 months). RESULT: The size of the raised prelaminated temporoparietal fascia flaps ranged from 9 × 8 cm to 14 × 10 cm. All flaps survived after second stage. Varied degrees of venous congestion were observed after flap insets in all cases but none required any further treatment for the congestion. The entire lesion could not be resected due to the large size of the lesion in all patients. CONCLUSION: Two stage prelaminated temporoparietal fascia flap with skin graft is an effective technique for the reconstruction of partial facial defects in selected patients. It is simple, quick, safe and reliable, and requires no expansion of skin or no microsurgery.
[Mh] Termos MeSH primário: Cicatriz
Traumatismos Faciais
Fáscia/transplante
Hiperemia
Complicações Pós-Operatórias/prevenção & controle
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cicatriz/etiologia
Cicatriz/cirurgia
Traumatismos Faciais/etiologia
Traumatismos Faciais/cirurgia
Feminino
Seres Humanos
Hiperemia/etiologia
Hiperemia/prevenção & controle
Masculino
Meia-Idade
Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos
Procedimentos Cirúrgicos Reconstrutivos/métodos
Estudos Retrospectivos
Transplante de Pele/efeitos adversos
Transplante de Pele/métodos
Retalhos Cirúrgicos/irrigação sanguínea
Expansão de Tecido/métodos
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE



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