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[PMID]:29408878
[Au] Autor:Freundt-Revilla J; Heinrich F; Zoerner A; Gesell F; Beyerbach M; Shamir M; Oevermann A; Baumgärtner W; Tipold A
[Ad] Endereço:Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
[Ti] Título:The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis.
[So] Source:PLoS One;13(2):e0187197, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endocannabinoids (ECs) are involved in immunomodulation, neuroprotection and control of inflammation in the central nervous system (CNS). Activation of cannabinoid type 2 receptors (CB2) is known to diminish the release of pro-inflammatory factors and enhance the secretion of anti-inflammatory cytokines. Furthermore, the endocannabinoid 2-arachidonoyl glycerol (2-AG) has been proved to induce the migration of eosinophils in a CB2 receptor-dependent manner in peripheral blood and activate neutrophils independent of CB activation in humans. The aim of the current study was to investigate the influence of the endocannabinoid system in two different CNS inflammatory diseases of the dog, i.e. Steroid-Responsive Meningitis-Arteritis (SRMA) and Intraspinal Spirocercosis (IS). The two main endocannabinoids, anandamide (AEA) and 2-AG, were quantified by mass spectrometry in CSF and serum samples of dogs affected with Steroid- Responsive Meningitis-Arteritis in the acute phase (SRMA A), SRMA under treatment with prednisolone (SRMA Tr), intraspinal Spirocercosis and healthy dogs. Moreover, expression of the CB2 receptor was evaluated in inflammatory lesions of SRMA and IS and compared to healthy controls using immunohistochemistry (IHC). Dogs with SRMA A showed significantly higher concentrations of total AG and AEA in serum in comparison to healthy controls and in CSF compared to SRMA Tr (p<0.05). Furthermore, dogs with IS displayed the highest ECs concentrations in CSF, being significantly higher than in CSF samples of dogs with SRMA A (p<0.05). CSF samples that demonstrated an eosinophilic pleocytosis had the highest levels of ECs, exceeding those with neutrophilic pleocytosis, suggesting that ECs have a major effect on migration of eosinophils in the CSF. Furthermore, CB2 receptor expression was found in glial cells in the spinal cord of healthy dogs, whereas in dogs with SRMA and IS, CB2 was strongly expressed not only in glial cells but also on the cellular surface of infiltrating leukocytes (i.e. neutrophils, eosinophils, lymphocytes, plasma cells, and macrophages) at lesion sites. The present study revealed an upregulated endocannabinoid system in dogs with inflammatory CNS diseases, highlighting the endocannabinoid system as a potential target for treatment of inflammatory CNS diseases.
[Mh] Termos MeSH primário: Arterite/veterinária
Doenças do Cão/fisiopatologia
Endocanabinoides/fisiologia
Meningite/veterinária
Doenças da Coluna Vertebral/veterinária
Infecções por Spirurida/veterinária
[Mh] Termos MeSH secundário: Animais
Arterite/sangue
Arterite/líquido cefalorraquidiano
Arterite/fisiopatologia
Cromatografia Líquida
Doenças do Cão/sangue
Doenças do Cão/líquido cefalorraquidiano
Cães
Endocanabinoides/sangue
Endocanabinoides/líquido cefalorraquidiano
Espectrometria de Massas
Meningite/sangue
Meningite/líquido cefalorraquidiano
Meningite/fisiopatologia
Doenças da Coluna Vertebral/sangue
Doenças da Coluna Vertebral/líquido cefalorraquidiano
Doenças da Coluna Vertebral/fisiopatologia
Infecções por Spirurida/sangue
Infecções por Spirurida/líquido cefalorraquidiano
Infecções por Spirurida/fisiopatologia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endocannabinoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187197


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[PMID]:28846776
[Au] Autor:Kupersmith MJ; Sibony PA; Dave S
[Ad] Endereço:New York Eye and Ear Infirmary and Icahn School of Medicine at Mount Sinai, New York, New York, United States.
[Ti] Título:Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4286-4291, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: We hypothesized that the edema/swelling in the retina due to acute nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds (RF). We determined the pattern and frequency of folds in NAION at presentation and in follow-up, and the relationship between folds and a number of functional and structural parameters over time. Methods: We prospectively studied eyes with acute NAION by spectral-domain optic coherence tomography (SD-OCT). We used transaxial and en face views to evaluate the presence of peripapillary fluid (PPF), peripapillary wrinkles (PPW), RF, choroidal folds (CF), creases, macular edema, and vitreous traction on the optic disc. Retinal deformations were correlated with the retinal nerve fiber layer (RNFL) thickness, logMAR visual acuity (VA) and mean deviation (MD). Results: At presentation, 60 eyes had mean RNFL = 224 ± 75 µm, no vitreous traction, and similar VA and MD regardless of the retinal deformation or macular edema. There was PPF in 73%, PPW in 57%, RF in 38%, creases in 20%, and macular edema in 18% of eyes, and no CF. Eyes with retinal deformations had significantly greater RNFL thickness (P< 0.026). At 1 to 2 months, 49 eyes had reduction of the RNFL (112 ± 40 µm, P = 0.001) and unchanged VA and MD that did not correlate with fewer eyes having PPF (15%, P = 0.001), PPW (10%, P = 0.001), RF (10%, P = 0.001), creases (17%), and macular edema (0%, P = 0.007). Conclusions: RF in NAION reflect stresses and strains due to extracellular fluid without increased pressure in the retrolaminar tissue and subarachnoid space, seen with papilledema. In NAION, the deformations and their resolution do not correlate with vision loss.
[Mh] Termos MeSH primário: Edema Macular/etiologia
Neuropatia Óptica Isquêmica/complicações
Doenças Retinianas/etiologia
[Mh] Termos MeSH secundário: Doença Aguda
Arterite/complicações
Doenças da Coroide/etiologia
Doenças da Coroide/fisiopatologia
Feminino
Seres Humanos
Edema Macular/fisiopatologia
Masculino
Meia-Idade
Fibras Nervosas/patologia
Disco Óptico/patologia
Neuropatia Óptica Isquêmica/fisiopatologia
Estudos Prospectivos
Doenças Retinianas/fisiopatologia
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22140


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[PMID]:28707750
[Au] Autor:Cameron SA; White SM; Arrollo D; Shulman ST; Rowley AH
[Ad] Endereço:Department of Pediatrics/Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[Ti] Título:Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis.
[So] Source:Clin Exp Immunol;190(2):244-250, 2017 Nov.
[Is] ISSN:1365-2249
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of transcriptionally up-regulated immune genes in KD coronary arteries from the first 2 months after disease onset. We examined the coronary arteries of 12 fatal KD cases and 13 childhood controls for expression of a set of proteins whose genes were highly up-regulated in the KD coronary artery transcriptome: allograft inflammatory factor 1 (AIF1), interleukin 18 (IL-18), CD74, CD1c, CD20 (MS4A1), Toll-like receptor 7 (TLR-7) and Z-DNA binding protein 1 (ZBP1). Immunohistochemistry and immunofluorescence studies were performed to evaluate protein expression and co-localization, respectively. AIF1 was expressed transmurally in KD arteritis and localized to macrophages and myeloid dendritic cells. CD74, which interacts with major histocompatibility complex (MHC) class II on antigen-presenting cells, localized to the intima-media. CD1c, a marker of myeloid dendritic cells, was expressed in a transmural pattern, as were IL-18 and CD20. ZBP1 and TLR-7 were up-regulated compared to controls, but less highly compared to the other proteins. These findings provide evidence of antigen presentation and interferon response in KD arteritis. In combination with prior studies demonstrating T lymphocyte activation, these results demonstrate the complexity of the KD arterial immune response.
[Mh] Termos MeSH primário: Arterite/imunologia
Vasos Coronários/imunologia
Expressão Gênica
Síndrome de Linfonodos Mucocutâneos/imunologia
Síndrome de Linfonodos Mucocutâneos/metabolismo
[Mh] Termos MeSH secundário: Apresentação do Antígeno
Antígenos CD/genética
Antígenos CD1/genética
Antígenos CD20/genética
Arterite/fisiopatologia
Aneurisma Coronário/imunologia
Vasos Coronários/fisiopatologia
Proteínas de Ligação a DNA/genética
Feminino
Imunofluorescência
Perfilação da Expressão Gênica
Glicoproteínas/genética
Seres Humanos
Imuno-Histoquímica
Lactente
Interleucina-18/genética
Masculino
Síndrome de Linfonodos Mucocutâneos/complicações
Síndrome de Linfonodos Mucocutâneos/mortalidade
Sialiltransferases/genética
Receptor 7 Toll-Like/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIF1 protein, human); 0 (Antigens, CD); 0 (Antigens, CD1); 0 (Antigens, CD20); 0 (CD1C protein, human); 0 (DNA-Binding Proteins); 0 (Glycoproteins); 0 (Interleukin-18); 0 (TLR7 protein, human); 0 (Toll-Like Receptor 7); 0 (ZBP1 protein, human); EC 2.4.99.- (Sialyltransferases); EC 2.4.99.1 (ST6GAL1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1111/cei.13010


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[PMID]:28640392
[Au] Autor:Murata K; Motomura Y; Tanaka T; Kanno S; Yano T; Onimaru M; Shimoyama A; Nishio H; Sakai Y; Oh-Hora M; Hara H; Fukase K; Takada H; Masuda S; Ohga S; Yamasaki S; Hara T
[Ad] Endereço:Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease.
[So] Source:Clin Exp Immunol;190(1):54-67, 2017 Oct.
[Is] ISSN:1365-2249
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Calcineurin inhibitors (CNIs) have been used off-label for the treatment of refractory Kawasaki disease (KD). However, it remains unknown whether CNIs show protective effects against the development of coronary artery lesions in KD patients. To investigate the effects of CNIs on coronary arteries and the mechanisms of their actions on coronary arteritis in a mouse model of KD, we performed experiments with FK565, a ligand of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) in wild-type, severe combined immunodeficiency (SCID), caspase-associated recruitment domain 9 (CARD9) and myeloid differentiation primary response gene 88 (MyD88) mice. We also performed in-vitro studies with vascular and monocytic cells and vascular tissues. A histopathological analysis showed that both cyclosporin A and tacrolimus exacerbated the NOD1-mediated coronary arteritis in a dose-dependent manner. Cyclosporin A induced the exacerbation of coronary arteritis in mice only in high doses, while tacrolimus exacerbated it within the therapeutic range in humans. Similar effects were obtained in SCID and CARD9 mice but not in MyD88 mice. CNIs enhanced the expression of adhesion molecules by endothelial cells and the cytokine secretion by monocytic cells in our KD model. These data indicated that both vascular and monocytic cells were involved in the exacerbation of coronary arteritis. Activation of MyD88-dependent inflammatory signals in both vascular cells and macrophages appears to contribute to their adverse effects. Particular attention should be paid to the development of coronary artery lesions when using CNIs to treat refractory KD.
[Mh] Termos MeSH primário: Arterite/tratamento farmacológico
Inibidores de Calcineurina/uso terapêutico
Endotélio Vascular/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico
Fator 88 de Diferenciação Mieloide/metabolismo
Oligopeptídeos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Proteínas Adaptadoras de Sinalização CARD/genética
Vasos Coronários/patologia
Citocinas/metabolismo
Modelos Animais de Doenças
Endotélio Vascular/imunologia
Seres Humanos
Mediadores da Inflamação/metabolismo
Macrófagos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos SCID
Fator 88 de Diferenciação Mieloide/genética
Células RAW 264.7
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CARD Signaling Adaptor Proteins); 0 (Calcineurin Inhibitors); 0 (Card9 protein, mouse); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Myeloid Differentiation Factor 88); 0 (Oligopeptides); 79335-75-4 (FK 565)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1111/cei.13002


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[PMID]:28552872
[Au] Autor:Isahaya K; Shiraishi M; Tanaka K; Sasaki R; Kawakami T; Hasegawa Y
[Ad] Endereço:Department of Neurology, St. Marianna University School of Medicine.
[Ti] Título:Mononeuritis multiplex in a patient with cutaneous arteritis diagnosed by skin biopsy.
[So] Source:Rinsho Shinkeigaku;57(6):307-310, 2017 06 28.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 55-year-old man was admitted with paralysis of the left lower leg. He had purpura in the left lower extremity for three years, left calf pain for two years, and dysesthesia in the left plantar region and first toe for one year. A physical examination revealed livedo reticularis on the left leg and mononeuritis multiplex was diagnosed in the bilateral tibial and left peroneal nerve area. Anti-neutrophil cytoplasmic antibody was negative. A nerve conduction study showed decreased amplitude of compound muscle-action potential in the bilateral tibial and the left peroneal nerve, sensory nerve action potential in the bilateral sural nerve. A skin biopsy revealed inflammatory cells on blood vessel walls and cutaneous arteritis was diagnosed. Cyclophosphamide pulse therapy with steroid and anti-coagulation improved the neurological symptoms. A skin biopsy should be considered when patients present with mononeuritis multiplex in the lower extremities and cutaneous findings such as livedo reticularis in the symptomatic area.
[Mh] Termos MeSH primário: Arterite/complicações
Biópsia
Mononeuropatias/diagnóstico
Mononeuropatias/etiologia
Pele/irrigação sanguínea
Pele/patologia
[Mh] Termos MeSH secundário: Anticoagulantes/administração & dosagem
Arterite/tratamento farmacológico
Arterite/patologia
Ciclofosfamida/administração & dosagem
Diagnóstico Diferencial
Seres Humanos
Masculino
Metilprednisolona/administração & dosagem
Meia-Idade
Mononeuropatias/tratamento farmacológico
Mononeuropatias/patologia
Prednisolona/administração & dosagem
Pulsoterapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001013


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[PMID]:28528047
[Au] Autor:Barbu M; Lindström U; Nordborg C; Martinsson A; Dworeck C; Jeppsson A
[Ad] Endereço:Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
[Ti] Título:Sclerosing Aortic and Coronary Arteritis Due to IgG4-Related Disease.
[So] Source:Ann Thorac Surg;103(6):e487-e489, 2017 Jun.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We present the case of a 55-year-old woman admitted for a coronary artery bypass operation because of three-vessel coronary artery disease based on angiographic findings and clinical symptoms. Unexpected intraoperative findings with diffuse tissue thickening of the ascending aorta and coronary arteries indicated an alternate pathogenesis rather than coronary artery atherosclerosis. Histopathologic findings and clinical evaluation could confirm IgG4-related disease (IgG4-RD). IgG4-RD is a newly recognized fibroinflammatory condition that can present in a variety of organs and is characterized by common histopathologic features. Low disease awareness among clinicians makes this condition underdiagnosed.
[Mh] Termos MeSH primário: Doenças da Aorta/diagnóstico
Doenças da Aorta/etiologia
Arterite/diagnóstico
Arterite/etiologia
Doença da Artéria Coronariana/diagnóstico
Doença da Artéria Coronariana/etiologia
Imunoglobulina G
[Mh] Termos MeSH secundário: Doenças da Aorta/terapia
Arterite/terapia
Doença da Artéria Coronariana/terapia
Feminino
Seres Humanos
Meia-Idade
Esclerose
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


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[PMID]:28443978
[Au] Autor:Vasconcelos DIB; Mota EM; Pelajo-Machado M
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Patologia, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Characterisation of the vascular pathology in Sigmodon hispidus (Rodentia: Cricetidae) following experimental infection with Angiostrongylus costaricensis (Nematoda: Metastrongylidae).
[So] Source:Mem Inst Oswaldo Cruz;112(5):328-338, 2017 May.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Angiostrongylus costaricensis is a nematode that causes human abdominal angiostrongyliasis, a disease found mainly in Latin American countries and particularly in Brazil and Costa Rica. Its life cycle involves exploitation of both invertebrate and vertebrate hosts. Its natural reservoir is a vertebrate host, the cotton rat Sigmodon hispidus. The adult worms live in the ileo-colic branches of the upper mesenteric artery of S. hispidus, causing periarteritis. However, there is a lack of data on the development of vasculitis in the course of infection. OBJECTIVE: To describe the histopathology of vascular lesions in S. hispidus following infection with A. costaricensis. METHODS: Twenty-one S. hispidus were euthanised at 30, 50, 90 and 114 days post-infection (dpi), and guts and mesentery (including the cecal artery) were collected. Tissues were fixed in Carson's Millonig formalin, histologically processed for paraffin embedding, sectioned with a rotary microtome, and stained with hematoxylin-eosin, resorcin-fuchsin, Perls, Sirius Red (pH = 10.2), Congo Red, and Azan trichrome for brightfield microscopy analysis. FINDINGS: At 30 and 50 dpi, live eggs and larvae were present inside the vasa vasorum of the cecal artery, leading to eosinophil infiltrates throughout the vessel adventitia and promoting centripetal vasculitis with disruption of the elastic layers. Disease severity increased at 90 and 114 dpi, when many worms had died and the intensity of the vascular lesions was greatest, with intimal alterations, thrombus formation, iron accumulation, and atherosclerosis. CONCLUSION: In addition to abdominal angiostrongyliasis, our data suggest that this model could be very useful for autoimune vasculitis and atherosclerosis studies.
[Mh] Termos MeSH primário: Angiostrongylus
Arterite/parasitologia
Aterosclerose/parasitologia
Infecções por Strongylida/complicações
[Mh] Termos MeSH secundário: Animais
Arterite/patologia
Aterosclerose/patologia
Modelos Animais de Doenças
Roedores
Sigmodontinae
Infecções por Strongylida/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28336558
[Au] Autor:Bernelot Moens SJ; Verweij SL; Schnitzler JG; Stiekema LCA; Bos M; Langsted A; Kuijk C; Bekkering S; Voermans C; Verberne HJ; Nordestgaard BG; Stroes ESG; Kroon J
[Ad] Endereço:From the Departments of Vascular Medicine (S.J.B.M., S.L.V., L.C.A.S., M.B., S.B., E.S.G.S., J.K.), Experimental Vascular Medicine (J.G.S.), and Nuclear Medicine (H.J.V.), AMC, Amsterdam, The Netherlands; The Copenhagen General Population Study (A.L., B.G.N.) and Department of Clinical Biochemistry
[Ti] Título:Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans.
[So] Source:Arterioscler Thromb Vasc Biol;37(5):969-975, 2017 May.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). APPROACH AND RESULTS: Arterial wall inflammation and bone marrow activity were measured using F-FDG PET/CT. Monocyte phenotype was assessed with flow cytometry. The correlation between remnant levels and hematopoietic activity was validated in the CGPS (Copenhagen General Population Study). We found a 1.2-fold increase of F-FDG uptake in the arterial wall in patients with FD (n=17, age 60±8 years, remnant cholesterol: 3.26 [2.07-5.71]) compared with controls (n=17, age 61±8 years, remnant cholesterol 0.29 [0.27-0.40]; <0.001). Monocytes from patients with FD showed increased lipid accumulation (lipid-positive monocytes: Patients with FD 92% [86-95], controls 76% [66-81], =0.001, with an increase in lipid droplets per monocyte), and a higher expression of surface integrins (CD11b, CD11c, and CD18). Patients with FD also exhibited monocytosis and leukocytosis, accompanied by a 1.2-fold increase of F-FDG uptake in bone marrow. In addition, we found a strong correlation between remnant levels and leukocyte counts in the CGPS (n=103 953, for trend 5×10-276). In vitro experiments substantiated that remnant cholesterol accumulates in human hematopoietic stem and progenitor cells coinciding with myeloid skewing. CONCLUSIONS: Patients with FD have increased arterial wall and cellular inflammation. These findings imply an important inflammatory component to the atherogenicity of remnant cholesterol, contributing to the increased cardiovascular disease risk in patients with FD.
[Mh] Termos MeSH primário: Artérias/imunologia
Arterite/imunologia
Colesterol/imunologia
Hiperlipoproteinemia Tipo III/imunologia
Imunidade Celular
Lipoproteínas/imunologia
Triglicerídeos/imunologia
[Mh] Termos MeSH secundário: Idoso
Artérias/diagnóstico por imagem
Artérias/metabolismo
Arterite/sangue
Arterite/diagnóstico por imagem
Células da Medula Óssea/imunologia
Células da Medula Óssea/metabolismo
Estudos de Casos e Controles
Células Cultivadas
Colesterol/sangue
Dinamarca
Feminino
Fluordesoxiglucose F18
Células-Tronco Hematopoéticas/imunologia
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Hiperlipoproteinemia Tipo III/sangue
Hiperlipoproteinemia Tipo III/diagnóstico por imagem
Integrinas/imunologia
Integrinas/metabolismo
Lipoproteínas/sangue
Masculino
Meia-Idade
Monócitos/imunologia
Monócitos/metabolismo
Fenótipo
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
Transdução de Sinais
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Integrins); 0 (Lipoproteins); 0 (Radiopharmaceuticals); 0 (Triglycerides); 0 (remnant-like particle cholesterol); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.116.308834


  9 / 3559 MEDLINE  
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[PMID]:28288999
[Au] Autor:Santos RP; Resende CI; Vieira AP; Brito C
[Ad] Endereço:Department of Dermatology, Hospital de Braga, Braga, Portugal.
[Ti] Título:Cannabis arteritis: ever more important to consider.
[So] Source:BMJ Case Rep;2017, 2017 Mar 13.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cannabis arteritis (CA) is a major and underdiagnosed cause of peripheral arterial disease in young patients. A 34-year-old man, daily smoker of 20 cigarettes and two cannabis cigarettes for 14 years, presented with a necrotic plaque of left hallux for 3 weeks. The Doppler ultrasound and angiography were compatible with severe Buerger's disease. Submitted to a revascularisation procedure and hypocoagulation with rivaroxaban. He had ceased smoking but maintained consumption of cannabis. Owing to the persistence of distal necrosis, amputation of the hallux was performed with good evolution. CA is a subtype of Buerger's disease. It is poorly known but increasingly prevalent and manifests in cannabis users regardless of tobacco use. The drug is considered at least a cofactor of the arteriopathy. The most effective treatment is cessation of consumption. Being cannabis one of the most consumed drugs, its mandatory to ask about its use in all young patients with arteriopathy.
[Mh] Termos MeSH primário: Arterite/induzido quimicamente
Arterite/diagnóstico
Cannabis
Hálux/patologia
Abuso de Maconha/complicações
[Mh] Termos MeSH secundário: Adulto
Amputação
Angiografia/métodos
Arterite/terapia
Diagnóstico Diferencial
Diagnóstico por Imagem
Hálux/cirurgia
Seres Humanos
Perna (Membro)/irrigação sanguínea
Perna (Membro)/cirurgia
Masculino
Necrose
Fumar/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  10 / 3559 MEDLINE  
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[PMID]:28209139
[Au] Autor:Shan K; Guo W
[Ad] Endereço:Emergency Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
[Ti] Título:Stroke caused by an inflammatory thrombus: a case report.
[So] Source:BMC Neurol;17(1):33, 2017 Feb 16.
[Is] ISSN:1471-2377
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through increased susceptibility or direct induction. CASE PRESENTATION: A 46-year-old Chinese male initially presented with fever, headache, and impaired memory and developed disturbance of consciousness after admission. A clinical diagnosis of Staphylococcus aureus sepsis, massive cerebral infarction and haemorrhagic transformation (left internal carotid arterial system, inflammatory thrombus) were made based on brain radiography, blood culture and postoperative pathological examinations. These symptoms improved following antibiotic therapy with vancomycin and conventional treatments for stroke. CONCLUSION: For stroke patients without traditional cerebrovascular risk factors but with signs of infection, infectious causes should be considered.
[Mh] Termos MeSH primário: Arterite/complicações
Trombose das Artérias Carótidas/complicações
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Infarto Cerebral/complicações
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1186/s12883-017-0816-3



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