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[PMID]:29241772
[Au] Autor:St John J; Vedak P; Garza-Mayers AC; Hoang MP; Nigwekar SU; Kroshinsky D
[Ad] Endereço:Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts.
[Ti] Título:Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement.
[So] Source:J Am Acad Dermatol;78(1):115-120, 2018 Jan.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis. OBJECTIVE: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a predictor of significant renal involvement at the time of the skin biopsy and the months following. METHODS: A retrospective study on renal function from 72 adult patients with skin-biopsy proven HSP. Longitudinal renal data were analyzed after HSP diagnosis by using baseline renal function for comparison. RESULTS: Statistical analysis adjusted for sex, age, and baseline creatinine revealed a trend between HSP lesions only on the upper and lower extremities and long-term renal involvement (4.767, P = .067). Moreover, in another analysis adjusted for age and baseline creatinine, lesions located only on the upper and lower extremities significantly increased the odds of having long-term significant renal involvement (6.55, P = .049) in men. LIMITATIONS: This retrospective study used patient information that was subject to selection bias. CONCLUSION: In patients with HSP, skin lesion distribution on the extremities might be predictive of significant long-term renal involvement and might be critical for risk stratification and development of personalized diagnostics and therapeutics.
[Mh] Termos MeSH primário: Nefropatias/etiologia
Nefropatias/patologia
Púrpura de Schoenlein-Henoch/complicações
Púrpura de Schoenlein-Henoch/patologia
[Mh] Termos MeSH secundário: Abdome/fisiopatologia
Centros Médicos Acadêmicos
Adulto
Fatores Etários
Biópsia por Agulha
Estudos de Coortes
Bases de Dados Factuais
Feminino
Técnica Direta de Fluorescência para Anticorpo/métodos
Seguimentos
Seres Humanos
Imuno-Histoquímica
Testes de Função Renal
Estudos Longitudinais
Extremidade Inferior/fisiopatologia
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Retrospectivos
Medição de Risco
Índice de Gravidade de Doença
Fatores Sexuais
Extremidade Superior/fisiopatologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:29190714
[Au] Autor:Pillebout E; Jamin A; Ayari H; Housset P; Pierre M; Sauvaget V; Viglietti D; Deschenes G; Monteiro RC; Berthelot L; HSPrognosis group
[Ad] Endereço:INSERM 1149, Center of Research on Inflammation (CRI), Paris, France.
[Ti] Título:Biomarkers of IgA vasculitis nephritis in children.
[So] Source:PLoS One;12(11):e0188718, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Henoch-Schönlein purpura is a systemic vasculitis characterized by IgA deposits, which target the skin, joints, and kidneys, among other organs. In children, prognosis is often good but little is known about biomarkers of pediatric nephritis. We hypothesized that biological markers, including cytokines, immunoglobulins, IgA-immune complexes, IgA glycosylation and neutrophil gelatinase-associated lipocalin (NGAL), may discriminate IgA vasculitis (IgAV) pediatric patients with renal involvement from those without renal involvement. Fifty children at the time of IgAV rash between 2010 and 2015 were prospectively enrolled and compared to 21 controls. All patients were assessed for clinical and biological parameters at the time of diagnosis, including the levels of cytokines, immunoglobulins, immune complexes, IgA glycosylation and NGAL in serum and urine. Among IgAV patients, 33 patients exhibited nephritis (IgAV-N) and 17 children were without nephritis (IgAV-woN). The serum level of galactose-deficient (Gd)-IgA1 (p<0.01) and the urinary concentrations of IgA, IgG, IgM, IL-6, IL-8, IL-10, IgA-IgG complexes and IgA-sCD89 complexes (p<0.001 for all) were higher in the IgAV-N patients than in the IgAV-woN patients. Among those markers, urinary IgA and IgM had the highest AUC (0.86 and 0.87 respectively, p<0.0001). This prospective cohort study furthers our understanding of the pathophysiology of IgAV. We identified biomarkers that are able to distinguish patients initially with or without nephritis. To conclude, serum Gd-IgA1 and urinary IgA, IgG, IgM, IL-6, IL-8, IL-10, and IgA-IgG and IgA-sCD89 complexes could identify IgAV pediatric patients with renal involvement at the time of diagnosis.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Imunoglobulina A/sangue
Púrpura de Schoenlein-Henoch/sangue
[Mh] Termos MeSH secundário: Complexo Antígeno-Anticorpo/sangue
Criança
Citocinas/urina
Ensaio de Imunoadsorção Enzimática
Feminino
Glicosilação
Seres Humanos
Imunoglobulina A/imunologia
Masculino
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigen-Antibody Complex); 0 (Biomarkers); 0 (Cytokines); 0 (Immunoglobulin A)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188718


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[PMID]:28850963
[Au] Autor:Fleischmann C; Herrmann A; Felber J; Stallmach A
[Ad] Endereço:Institut für Allgemeinmedizin, Universitätsklinikum Jena.
[Ti] Título:[Multiple Hemorrhagic Skin Lesions in a 52-Year-Old Patient with Liver Cirrhosis].
[Ti] Título:52-jähriger Patient mit Leberzirrhose und multiplen hämorrhagischen Hautbefunden..
[So] Source:Dtsch Med Wochenschr;142(17):1273-1275, 2017 Sep.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Cirrose Hepática/complicações
Púrpura de Schoenlein-Henoch
[Mh] Termos MeSH secundário: Mãos/patologia
Seres Humanos
Perna (Membro)/patologia
Masculino
Meia-Idade
Pele/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-112234


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[PMID]:28761605
[Au] Autor:Karakayali B; Yilmaz S; Çakir D; Günes PG; Güven S; Islek I
[Ad] Endereço:University of Health Sciences, Umraniye Research and Training Hospital, Department of Pediatrics, Istanbul, Turkey.
[Ti] Título:Henoch-Schonlein purpura associated with primary active Epstein-Barr virus infection: a case report.
[So] Source:Pan Afr Med J;27:29, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Herein we present HSP patient possibly caused by EBV infection. A 8-year old boy was admitted to our department with fever, rashes on legs and arms and intermittent mild abdominal pain. Multiple purpuric rashes were on his extremities, abdomen and buttock. Laboratory investigations revealed that monospot test was positive, EBV serology tests; Anti-EA-D Ig G: 3+, Anti-VCA gp125 Ig G: 3+, Anti-VCA p19 Ig M: 2+, Anti EBNA-1 Ig M: negative, Anti EBNA-1 Ig M: negative, Anti EBNA-1 Ig G: negative. The patient was interpreted as the primary active acute EBV infection. A skin biopsy showed leucocytoclastic vasculitis. The other viral and bacterial investigations were negative. The patient was diagnosed as HSP vasculitis according to EULAR criteria and treated with intravenous hydration and ibuprofen. He was discharged after 15 days with normal laboratory findings and physical examination. We think that EBV infection may be stimulant factor for autoimmune reactions and may cause HSP vasculitis. Hence, it may be useful to investigate the EBV infection in etiology of HSP cases.
[Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/complicações
Púrpura de Schoenlein-Henoch/diagnóstico
Vasculite Leucocitoclástica Cutânea/diagnóstico
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Biópsia
Criança
Infecções por Vírus Epstein-Barr/diagnóstico
Antígenos Nucleares do Vírus Epstein-Barr/imunologia
Seres Humanos
Masculino
Púrpura de Schoenlein-Henoch/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (EBV-encoded nuclear antigen 1); 0 (Epstein-Barr Virus Nuclear Antigens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.29.10481


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[PMID]:28697834
[Au] Autor:Fan L; Liu H; Wang YC; Chen L; Zhou JJ; Cui YX
[Ad] Endereço:Department of Pediatrics, Guizhou Provincial People's Hospital, Guiyang 550002, China. cuiyuxia1969@163.com.
[Ti] Título:[Association of serum vitamin D level with severity and treatment in children with Henoch-Schönlein purpura].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(7):796-799, 2017 Jul.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the association of serum vitamin D [25-(OH)D ] level with the severity and treatment in children with Henoch-Schönlein purpura (HSP). METHODS: A total of 50 children with newly-diagnosed HSP between January and December, 2015 were enrolled as HSP group, and 49 healthy children were enrolled as control group. Fasting serum samples were collected, and ELISA was used to measure serum 25-(OH)D level. According to the serum 25-(OH)D level, the HSP group were further divided into normal group (>20 ng/mL) (n=9), insufficiency group (15-20 ng/mL) (n=15), deficiency group (≤15 ng/mL) (n=25), and severe deficiency group (≤5 ng/mL) (n=1). The general data, clinical manifestations, hormone therapy, course of disease before admission, and length of hospital stay were compared between groups. RESULTS: The HSP group had a significantly lower serum 25-(OH)D level than the control group (16±6 ng/mL vs 29±5 ng/mL; P<0.01). Compared with the normal and insufficiency groups, the deficiency and severe deficiency groups had significant increases in the incidence rate of renal involvement, rate of hormone application, and median length of hospital stay (P<0.05), while there was no significant difference in course of disease before admission (P>0.05). CONCLUSIONS: Children with HSP have a low serum 25-(OH)D level, and such children may have a high risk of renal involvement, a high rate of hormone application, and a prolonged length of hospital stay. However, further studies are needed to investigate whether vitamin D supplementation is helpful to the treatment of HSP and can shorten the course of disease in children with HSP.
[Mh] Termos MeSH primário: Púrpura de Schoenlein-Henoch/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Tempo de Internação
Masculino
Púrpura de Schoenlein-Henoch/complicações
Púrpura de Schoenlein-Henoch/tratamento farmacológico
Índice de Gravidade de Doença
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28609516
[Au] Autor:Chalhoub NE; Kaw D; Nagaraja V
[Ad] Endereço:Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio.
[Ti] Título:A Man With a Nonblanchable Purpuric Rash.
[So] Source:JAMA;317(22):2329-2330, 2017 Jun 13.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Imunoglobulina A
Púrpura de Schoenlein-Henoch/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Exantema/patologia
Seres Humanos
Dermatoses da Perna/patologia
Masculino
Púrpura/patologia
Púrpura de Schoenlein-Henoch/imunologia
Púrpura de Schoenlein-Henoch/patologia
Recidiva
Tronco
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Immunoglobulin A)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.4954


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[PMID]:28605168
[Au] Autor:Audemard-Verger A; Terrier B; Dechartres A; Chanal J; Amoura Z; Le Gouellec N; Cacoub P; Jourde-Chiche N; Urbanski G; Augusto JF; Moulis G; Raffray L; Deroux A; Hummel A; Lioger B; Catroux M; Faguer S; Goutte J; Martis N; Maurier F; Rivière E; Sanges S; Baldolli A; Costedoat-Chalumeau N; Roriz M; Puéchal X; André M; Lavigne C; Bienvenu B; Mekinian A; Zagdoun E; Girard C; Bérezné A; Guillevin L; Thervet E; Pillebout E; French Vasculitis Study Group
[Ad] Endereço:Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France.
[Ti] Título:Characteristics and Management of IgA Vasculitis (Henoch-Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey.
[So] Source:Arthritis Rheumatol;69(9):1862-1870, 2017 Sep.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Data on adult IgA vasculitis (Henoch-Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy of treatments in a French patient population. METHODS: Data on clinical characteristics, histologic features, and treatment response from 260 patients with IgAV included in a French multicenter retrospective survey were analyzed. Efficacy data were compared using different statistical models. RESULTS: The mean ± SD age of the patients with IgAV at diagnosis was 50.1 ± 18 years, and 63% of patients were male. Baseline manifestations included purpura (100%), arthralgias/arthritis/myalgia (61%), glomerulonephritis (70%), and/or gastrointestinal involvement (53%). Thirty percent of patients showed renal failure at baseline. In univariate analysis, the response to therapy was 80% (64 of 80) in patients treated with corticosteroids (CS) alone, compared to 77% (23 of 30) in patients treated with CS plus cyclophosphamide (CYC) and 59% (10 of 17) in patients treated with colchicine (P = 0.17). Multivariable analysis showed that treatment with CS or CS plus CYC was more effective than colchicine in achieving a response. Efficacy differences were demonstrated using different statistical models: in the multivariable logistic regression model, odds ratio (OR) 3.68, 95% confidence interval (95% CI) 1.10-12.33 (P = 0.03); in the inverse probability weighting on propensity score model, OR 3.75, 95% CI 1.28-10.99 (P = 0.02). The efficacy of CS plus CYC as compared to CS alone was discordant according to the analytic method used. Analysis with the multivariable logistic regression model did not demonstrate a difference between CS plus CYC and CS alone (OR 0.88, 95% CI 0.29-2.67; P = 0.82). In contrast, inverse probability weighting on propensity score showed that CS plus CYC was more effective than CS alone (OR 1.79, 95% CI 1.00-3.20; P = 0.049). CONCLUSION: This series constitutes the largest series of adults with IgAV reported in the literature so far. It provides data on clinical and histologic presentation and therapeutic efficacy, suggesting that CS alone appears to be a reasonable first-line therapy in patients with IgAV, while the benefit of adding CYC to CS remains uncertain.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Púrpura de Schoenlein-Henoch/tratamento farmacológico
Púrpura de Schoenlein-Henoch/patologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Adulto
Idoso
Artralgia/epidemiologia
Artralgia/etiologia
Colchicina/uso terapêutico
Ciclofosfamida/uso terapêutico
Quimioterapia Combinada
Feminino
França/epidemiologia
Gastroenteropatias/epidemiologia
Gastroenteropatias/etiologia
Glomerulonefrite por IGA/epidemiologia
Glomerulonefrite por IGA/etiologia
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Pontuação de Propensão
Púrpura de Schoenlein-Henoch/complicações
Estudos Retrospectivos
Inquéritos e Questionários
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Antirheumatic Agents); 8N3DW7272P (Cyclophosphamide); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1002/art.40178


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[PMID]:28591051
[Au] Autor:Xu H; Li W; Mao JH; Pan YX
[Ad] Endereço:aDepartment of Clinical Laboratory bDepartment of Nephrology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
[Ti] Título:Association between red blood cell distribution width and Henoch-Schonlein purpura nephritis.
[So] Source:Medicine (Baltimore);96(23):e7091, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate whether red blood cell distribution width (RDW) is a marker of the risk of Henoch-Schonlein purpura (HSP) nephritis (HSPN), a total of 669 HSP patients and 168 healthy controls were included in this retrospective study. Two hundred fifty-six (38.3%) of the patients had kidney involvement. Compared with the HSP group, RDW was significantly higher in the HSPN group (P < .001). Binary logistic regression identified that HSPN was independently associated with age, RDW, platelet, and total cholesterol (odds ratio = 1.409, 1.353, 0.996, and 2.019, respectively). In addition, RDW values of HSPN patients with crescents on histopathology (classes III, IV, and V) were higher compared with those of HSPN without crescents (classes I and II) (P = .019). The receiver-operating characteristic curve analysis showed that the RDW at a cut-off point of 13.25 has 61% sensitivity and 79% specificity in predicting the presence of crescents on histopathology. It was first shown that RDW levels in HSPN are significantly higher than those in HSP without nephritis and healthy controls. RDW can be an independent predictor of HSPN and its levels greater than 13.25 were useful in the predicting the presence of crescents on histopathology.
[Mh] Termos MeSH primário: Índices de Eritrócitos
Nefrite/sangue
Púrpura de Schoenlein-Henoch/sangue
[Mh] Termos MeSH secundário: Fatores Etários
Biomarcadores/sangue
Criança
Colesterol/sangue
Eritrócitos/patologia
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Análise Multivariada
Razão de Chances
Prognóstico
Curva ROC
Estudos Retrospectivos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007091


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[PMID]:28533861
[Au] Autor:Aounallah A; Arouss A; Ghariani N; Saidi W; Sriha B; Denguezli M; Belajouza C; Nouira R
[Ad] Endereço:Université du Centre, Tunisie.
[Ti] Título:[Cutaneous leukocytoclastic vasculitis: about 85 cases].
[Ti] Título:Vascularites cutanées leucocytoclasiques: à propos de 85 cas..
[So] Source:Pan Afr Med J;26:138, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Clinical manifestation, etiology and outcome of leukocytoclastic vasculitis are little studied. The aim of our study was to examine epidemiological, clinical etiological, and evolutionary characteristics of this entity. We conducted a cross-sectional data collection from medical records of 85 patients with leukocytoclastic vasculitis in the Department of Dermatology at the Farhat Hached University Hospital, Sousse between January 2000 and December 2013. Epidemiological, clinical, paraclinical, etiological data sheets had been completed for each patient. The average age of patients was 47.65 years, ranging between 10 and 78 years. Fifty-three women and 32 men were registered (sex ratio = 0.6). Cutaneous manifestations were dominated by vascular purpura (88.2%). The most common causes of leukocytoclastic vasculitis were systemic diseases (51%), infection (20%) and neutrophilic dermatoses (14.5%). Other causes were drugs (9.1%) and hematologic malignancies (5.4%). The cause of leukocytoclastic vasculitis was not detected in 30 patients (35, 3%). Two predictive factors associated with the acute outcome were retained: the presence of a recent infection (p= 0.014) and drug intake before the rash (p= 0.013). Chronic evolution was positively correlated with antinuclear antibodies (p= 0.009) and cryoglobulinemia (p=0.025). Our study highlights the multitude of causes of leukocytoclastic vasculitis. The search for an underlying disease is an imperative in order to ensure better therapeutic management.
[Mh] Termos MeSH primário: Anticorpos Antinucleares/análise
Crioglobulinemia/epidemiologia
Púrpura de Schoenlein-Henoch/etiologia
Vasculite Leucocitoclástica Cutânea/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Estudos Transversais
Crioglobulinemia/etiologia
Feminino
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Púrpura de Schoenlein-Henoch/epidemiologia
Estudos Retrospectivos
Vasculite Leucocitoclástica Cutânea/epidemiologia
Vasculite Leucocitoclástica Cutânea/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.26.138.9721


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[PMID]:28489991
[Au] Autor:Miloslavsky EM; Stone JH; Moy AP
[Ad] Endereço:From the Departments of Medicine (E.M.M., J.H.S.) and Pathology (A.P.M.), Massachusetts General Hospital, and the Departments of Medicine (E.M.M., J.H.S.) and Pathology (A.P.M.), Harvard Medical School - both in Boston.
[Ti] Título:Case 14-2017 - A 20-Year-Old Man with Pain and Swelling of the Left Calf and a Purpuric Rash
[So] Source:N Engl J Med;376(19):1868-1877, 2017 05 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Púrpura de Schoenlein-Henoch/diagnóstico
Pele/patologia
Vasculite/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Doença de Crohn/complicações
Diagnóstico Diferencial
Edema/etiologia
Exantema/etiologia
Seres Humanos
Masculino
Dor/etiologia
Púrpura/etiologia
Púrpura de Schoenlein-Henoch/complicações
Púrpura de Schoenlein-Henoch/patologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1616397



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