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[PMID]:29330562
[Au] Autor:Zhao L; Zhu H; Han B; Wang L; Sun Y; Lu X; Huang C; Tan B; Chen C; Qin L
[Ad] Endereço:Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
[Ti] Título:Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.
[So] Source:Ann Hematol;97(4):685-695, 2018 Apr.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Studies have suggested that IL-23/STAT3 and IL-12/STAT4 signaling pathways associate with aplastic anemia (AA) occurrence. Polymorphisms in pathway-related genes may contribute to AA risk. In the current study, we investigated the association between polymorphisms in genes of IL23R, STAT3, IL12B, and STAT4 and occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. In the current 164 AA cases and 211 controls study, we found T allele and TT genotype of rs7574865 were more frequent in the cases than that in the controls. In the additive model, individual carrying rs7574865 T allele demonstrated a 37% (OR (95% CI) = 1.37 (1.02-1.85), Pper = 0.036) increased AA risk. In the recessive model, carrier with rs7574865 TT genotype showed a 2.08-fold increased AA risk (OR (95% CI) = 2.08 (1.14-3.70), Pper = 0.017). Additionally, we showed that G allele and GG genotype of rs11209032 were more frequent in the 88 non-severe AA cases than that in the 76 severe AA ones. Our study also found G allele and GG genotype of rs11209032, and GG-genotype of rs744166 associated with the immunosuppressive therapy outcome in AA patients. Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China.
[Mh] Termos MeSH primário: Anemia Aplástica/genética
Anemia Aplástica/terapia
Imunossupressão
Polimorfismo de Nucleotídeo Único
Receptores de Interleucina/genética
Fator de Transcrição STAT3/genética
Fator de Transcrição STAT4/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anemia Aplástica/imunologia
Anemia Aplástica/fisiopatologia
Grupo com Ancestrais do Continente Asiático
Estudos de Casos e Controles
China
Feminino
Seguimentos
Estudos de Associação Genética
Predisposição Genética para Doença
Seres Humanos
Subunidade p40 da Interleucina-12/genética
Masculino
Meia-Idade
Estudos Retrospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (IL12B protein, human); 0 (IL23R protein, human); 0 (Interleukin-12 Subunit p40); 0 (Receptors, Interleukin); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human); 0 (STAT4 Transcription Factor); 0 (STAT4 protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-018-3227-7


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[PMID]:28452257
[Au] Autor:Boddu PC; Kadia TM
[Ad] Endereço:a Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
[Ti] Título:Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.
[So] Source:Expert Rev Hematol;10(5):433-448, 2017 05.
[Is] ISSN:1747-4094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The past decade or longer has witnessed an acceleration in our understanding of previously developed immune system and clonal evolution mechanisms, and the genesis of more novel concepts of telomere attrition. Many of these concepts are steadily finding their way into translation in various aspects of clinical practice, and provide prospects to improve AA management and inform therapeutic strategy development. In this review, we intend to discuss the pathophysiology and treatments with an emphasis on most recent developments to provide an update on our understanding of disease mechanisms. Areas covered: A literature search was undertaken addressing various aspects of pathophysiology with a focus on the role of immune system repertoire, telomeres and mutational events surrounding AA. We also reviewed upon the temporal evolution of treatment strategies in AA to the contemporary management of today and commented briefly upon the more recently investigated novel therapies and their expanding niche especially in the transplant and salvage setting. Expert commentary: Immune-mediated destruction of hematopoietic stem and progenitor cells, leading to a marrow devoid of hematopoietic elements, and peripheral pancytopenia are the hallmarks of AA. Recent studies have shed light on another facet of the disease - as a clonal disorder characterized by karyotypic abnormalities, genomic instability, telomere attrition, and recurrent somatic mutations reminiscent of myeloid malignancies. Further understanding of this underlying pathophysiology can help in improving prognostication and treatment of this disease.
[Mh] Termos MeSH primário: Anemia Aplástica
[Mh] Termos MeSH secundário: Cariótipo Anormal
Anemia Aplástica/genética
Anemia Aplástica/metabolismo
Anemia Aplástica/fisiopatologia
Anemia Aplástica/terapia
Instabilidade Genômica
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Telômero/genética
Telômero/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/17474086.2017.1313700


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[PMID]:29285764
[Au] Autor:Samarasinghe S; Veys P; Vora A; Wynn R
[Ad] Endereço:Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
[Ti] Título:Paediatric amendment to adult BSH Guidelines for aplastic anaemia.
[So] Source:Br J Haematol;180(2):201-205, 2018 01.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Anemia Aplástica/diagnóstico
Anemia Aplástica/terapia
[Mh] Termos MeSH secundário: Adulto
Anemia Aplástica/etiologia
Terapia Combinada
Gerenciamento Clínico
Transplante de Células-Tronco Hematopoéticas/métodos
Seres Humanos
Imunossupressores/farmacologia
Imunossupressores/uso terapêutico
Doadores de Tecidos
Resultado do Tratamento
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15066


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[PMID]:29382003
[Au] Autor:Shi H; Wang Z
[Ad] Endereço:MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University.
[Ti] Título:Hemoglobin Hornchurch [ß43 (CD2) Glu > Lys; HBB: c.130G > A] in a Chinese boy complicated with thrombocytopenia: A case report and literature review.
[So] Source:Medicine (Baltimore);96(47):e8862, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hemoglobin Hornchurch is regarded as an asymptomatic hemoglobinopathy with no obvious hematological or clinical abnormalities. Recently, we identified hemoglobin Hornchurch in a 13-year-old Chinese boy complicated with thrombocytopenia, which displayed instability in isopropanol precipitation test. PATIENT CONCERNS: In this case report, we reported a Chinese boy with hemoglobin Hornchurch complicated by thrombocytopenia. The patients have been misdiagnosed as aplastic anemia and myelodysplastic syndrome before. DIAGNOSES: Hemolysis tests, high-performance liquid chromatography, and HBB gene sequencing identified the E44K (G>A) mutation. Isopropanol precipitation test showed instability in hemoglobin Hornchurch. INTERVENTIONS: The patient was given immunosuppressive therapy for 3 months. OUTCOMES: His general conditions have improved along with the recovery of the hemogram index. LESSONS: Further research is needed to clarify the relation between structural abnormality and functional properties of hemoglobin Hornchurch. This second case of hemoglobin Hornchurch indicates that there might be more hemoglobin variants or their carriers in the Chinese population.
[Mh] Termos MeSH primário: Hemoglobinopatias/sangue
Hemoglobinopatias/complicações
Hemoglobinas Anormais/análise
Trombocitopenia/etiologia
[Mh] Termos MeSH secundário: Adolescente
Anemia Aplástica/diagnóstico
Seres Humanos
Masculino
Síndromes Mielodisplásicas/diagnóstico
Trombocitopenia/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hemoglobins, Abnormal); 0 (hemoglobin Hornchurch)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008862


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[PMID]:29255553
[Au] Autor:Hiddou A; Zemmrani Y; Ahroui Y; Soraa N
[Ad] Endereço:Service de Microbiologie, CHU Mohammed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.
[Ti] Título:[Bacteremia due to Kingella denitrificans in a child followed-up for bone marrow failure syndrome].
[Ti] Título:Bactériémie à Kingella denitrificans chez un enfant suivi pour un syndrome d'insuffisance médullaire..
[So] Source:Pan Afr Med J;28:83, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Kingella denitrificans is a non-pathogenic micro-organism present in oropharyngeal flora. This germ has been recently recognized as responsible for opportunistic invasive infections mainly affecting immunosuppressed patients. We here report the case of a child aged 3 years and 7 months followed-up since the age of one year for bone marrow failure syndrome associated with pancytopenia of undetermined origin who had bacteremia due to Kingella denitrificans, a group of difficult to culture gram-negative bacteria rarely described in the literature. Clinicians and microbiologists should suspect the presence of this germ especially in immunosuppressed patients. The use of blood culture bottle contributes in a significant way to the detection of this germ.
[Mh] Termos MeSH primário: Anemia Aplástica/imunologia
Bacteriemia/diagnóstico
Doenças da Medula Óssea/imunologia
Hemoglobinúria Paroxística/imunologia
Infecções por Neisseriaceae/diagnóstico
Infecções Oportunistas/diagnóstico
[Mh] Termos MeSH secundário: Bacteriemia/microbiologia
Pré-Escolar
Seres Humanos
Hospedeiro Imunocomprometido
Kingella/isolamento & purificação
Masculino
Infecções por Neisseriaceae/microbiologia
Infecções Oportunistas/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.83.13698


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[PMID]:27776731
[Au] Autor:Tu S; Zhong D; Wu X; Li Y; Song C
[Ad] Endereço:Department of Haematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
[Ti] Título:Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Posttransplant Lymphopoliferative Disorder.
[So] Source:Am J Med Sci;352(4):439-441, 2016 10.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Linfoma de Zona Marginal Tipo Células B/diagnóstico
Linfoma não Hodgkin/diagnóstico
Transtornos Linfoproliferativos/diagnóstico
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Anemia Aplástica/complicações
Anemia Aplástica/terapia
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Ciclofosfamida/administração & dosagem
Feminino
Seres Humanos
Imunossupressores/administração & dosagem
Linfoma de Zona Marginal Tipo Células B/complicações
Linfoma não Hodgkin/complicações
Transtornos Linfoproliferativos/complicações
Complicações Pós-Operatórias
Prednisona/administração & dosagem
Rituximab/administração & dosagem
Neoplasias Gástricas/complicações
Vincristina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 4F4X42SYQ6 (Rituximab); 5J49Q6B70F (Vincristine); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28801981
[Au] Autor:Giri N; Reed HD; Stratton P; Savage SA; Alter BP
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Rockville, Maryland.
[Ti] Título:Pregnancy outcomes in mothers of offspring with inherited bone marrow failure syndromes.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Children with inherited bone marrow failure syndromes (IBMFSs) may be symptomatic in utero, resulting in maternal and fetal problems during the pregnancy. Subsequent pregnancies by their mothers should be considered "high risk". METHODS: We retrospectively analyzed outcomes of 575 pregnancies in 165 unaffected mothers of offspring with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachman-Diamond syndrome (SDS) for events noted during pregnancy, labor, and delivery. We compared outcomes of pregnancies with affected and unaffected offspring within each group of mothers and with the general population. RESULTS: The rates of miscarriage (12-20%), elective abortion (5-10%), and live birth (68-78%) among mothers of all IBMFS groups were similar and comparable with general population rates but recurrent miscarriages (≥2) were significantly more common in mothers of offspring with DBA and SDS. Offspring with FA were more frequently born small for gestational age (SGA) than unaffected babies (39% vs. 4%) and had fetal malformations (46%) with 18% having three or more, often necessitating early delivery and surgery; offspring with DC had higher rates of SGA (39% vs. 8%) and fetal distress (26% vs. 3%); and offspring with DBA had fetal hypoxia (19% vs. 1%) leading to preterm and emergency cesarean deliveries (26% vs. 6%). Offspring with early-onset severe phenotypes had the most prenatal and peripartum adverse events. CONCLUSION: We identified the high-risk nature of pregnancies in mothers with IBMFS-affected fetuses, suggesting the need for prepregnancy counseling and monitoring of subsequent pregnancies by high-risk fetal-maternal specialists.
[Mh] Termos MeSH primário: Aborto Espontâneo
Anemia Aplástica
Doenças da Medula Óssea
Hemoglobinúria Paroxística
Recém-Nascido Pequeno para a Idade Gestacional
Nascimento Vivo
Período Periparto
Nascimento Prematuro/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Recém-Nascido
Meia-Idade
Gravidez
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26757


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[PMID]:29068868
[Au] Autor:Lu S; Qiao X; Xie X
[Ad] Endereço:Department of Pediatrics, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
[Ti] Título:Elevated Serum Interleukin-6 Predicts Favorable Response to Immunosuppressive Therapy in Children With Aplastic Anemia.
[So] Source:J Pediatr Hematol Oncol;39(8):614-617, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Immunosuppressive therapy (IST) is the standard treatment for aplastic anemia (AA) children who lack a sibling donor, but the clinical response rate to IST varies. Predictors of response to IST are valuable for stratifying AA patients and making clinical decisions. METHODS: The serum interleukin (IL)-6 levels of 41 AA patients were measured at the time of diagnosis and the response rate of the patients to IST was evaluated at 3, 6, and 12 months after IST. Receiver-operator characteristic (ROC) analysis was used to calculate the predictive value of initial IL-6 levels in determining response at 6 months after IST. RESULTS: The initial IL-6 levels were significant higher in responders than nonresponders at 6 months after IST (211.89 vs. 18.09 pg/mL; P=0.005), using 36.8 pg/mL as a threshold, there were 80% sensitivity and 81% specificity for discriminating responders and nonresponders to IST. Patients with initial high IL-6 level (>36.8 pg/mL) have favorable response rates than those with initial low IL-6 level (<36.8 pg/mL) at 3, 6, and 12 months after IST (P<0.01). CONCLUSION: High levels of IL-6 at the time of diagnosis predict a favorable response to IST in children with AA and this may be helpful for patient's stratification and clinical decisions.
[Mh] Termos MeSH primário: Anemia Aplástica/sangue
Anemia Aplástica/tratamento farmacológico
Imunossupressores/uso terapêutico
Interleucina-6/sangue
[Mh] Termos MeSH secundário: Adolescente
Anemia Aplástica/diagnóstico
Biomarcadores
Contagem de Células Sanguíneas
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Imunossupressores/administração & dosagem
Masculino
Curva ROC
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunosuppressive Agents); 0 (Interleukin-6)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000942


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[PMID]:28935248
[Au] Autor:Zhang HF; Huang ZD; Wu XR; Li Q; Yu ZF
[Ad] Endereço:Department of Chinese Medicine, School of Chinese Medicine Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.
[Ti] Título:Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes.
[So] Source:Life Sci;189:71-75, 2017 Nov 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: This study aims to compare the proportion of peripheral blood T lymphocyte subsets and related blood cell and bone marrow cytology indexes between patients with aplastic anemia (AA) and hypoplastic myelodysplastic syndrome (hypo-MDS), and investigate the clinical identification significance. MATERIALS AND METHODS: A total of 41 patients with AA and 46 patients with hypo-MDS were collected, and the proportions of peripheral blood T lymphocyte subsets, CD3 CD16/CD56 NK cells, CD3 CD57 T-LGL cells and CD19 B lymphocytes were detected by flow cytometry. KEY FINDINGS: The CD4 /CD8 ratio decreased in the AA and hypo-MDS groups, and the difference was statistically significant when compared with that in the control group (P<0.05). However, there was no significant difference between AA and hypo-MDS groups (P>0.05). The proportions of CD3 CD16/CD56 NK cells and CD3 CD57 T-LGL cells in the hypo-MDS group were distinctly higher than those in the AA group (P<0.05). However, the proportion of CD19 B lymphocyte was obviously lower than that in the AA group (P<0.05). Furthermore, the proportions of reticulocytes, bone marrow progenitor cells and immature red blood cells in the hypo-MDS group were significantly more than those in the AA group (P<0.05), and the proportion of mature lymphocytes in the hypo-MDS group was distinctly lower than that in the AA group (P<0.05). SIGNIFICANCE: Changes of T lymphocyte subsets and the proportions of large granular lymphocytes and B lymphocytes can be utilized as indexes in the differential diagnosis between AA and hypo-MDS.
[Mh] Termos MeSH primário: Anemia Aplástica/imunologia
Linfócitos B/imunologia
Células da Medula Óssea/citologia
Síndromes Mielodisplásicas/imunologia
Subpopulações de Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anemia Aplástica/diagnóstico
Diagnóstico Diferencial
Feminino
Citometria de Fluxo
Seres Humanos
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
Síndromes Mielodisplásicas/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


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[PMID]:28866669
[Au] Autor:Du Y; Long Z; Chen M; Han B; Hou B; Feng F
[Ad] Endereço:Department of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.
[Ti] Título:Observational Monitoring of Patients with Aplastic Anemia and Low/Intermediate-1 Risk of Myelodysplastic Syndromes Complicated with Iron Overload.
[So] Source:Acta Haematol;138(2):119-128, 2017.
[Is] ISSN:1421-9662
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study focuses on the iron overload (IOL) of patients with transfused aplastic anemia (AA) or a low/intermediate-1 risk of myelodysplastic syndrome (MDS). METHODS: Ninety-two AA or MDS patients with IOL were prospectively recruited. Clinical data were collected every 6 months, and organ magnetic resonance imaging T2* values were collected annually. Patients with IOL were chelated. RESULTS: Serum ferritin was correlated with liver T2* and pancreatic T2* in the AA and MDS groups. Transfusion amounts were correlated with serum ferritin values, liver T2*, and pancreatic T2* in the AA group. At the 6-month and 1-year evaluations, patients with sufficient chelation experienced significant decreases in serum ferritin, and those with decreased serum ferritin experienced an obvious increase in hemoglobin. At their 1-year-follow-up, patients with adequate chelation showed significant increases in hepatic T2*, cardiac T2*, and left ventricular ejection fraction (LVEF). Patients with decreased serum ferritin (including those without chelation) experienced an increase in hemoglobin, hepatic T2*, cardiac T2*, and LVEF. CONCLUSION: The transfusion amount was more reliable at predicting IOL in patients with AA than in those with MDS. Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels. A decrease in serum ferritin, even in the absence of chelation, may also benefit patients.
[Mh] Termos MeSH primário: Anemia Aplástica/complicações
Anemia Aplástica/diagnóstico
Sobrecarga de Ferro/complicações
Sobrecarga de Ferro/diagnóstico
Síndromes Mielodisplásicas/complicações
Síndromes Mielodisplásicas/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anemia Aplástica/terapia
Transfusão de Sangue
Feminino
Ferritinas/sangue
Seguimentos
Hemoglobinas/análise
Seres Humanos
Quelantes de Ferro/uso terapêutico
Sobrecarga de Ferro/tratamento farmacológico
Fígado/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Pâncreas/diagnóstico por imagem
Estudos Prospectivos
Risco
Função Ventricular Esquerda
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Iron Chelating Agents); 9007-73-2 (Ferritins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE
[do] DOI:10.1159/000479422



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