| [PMID]: | 23147353 |
| [Au] Autor: | Pham CM; Syed AA; Siddiqui HA; Keller RA; Kowalewski C |
| [Ad] Endereço: | Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. |
| [Ti] Título: | Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. |
| [So] Source: | Am J Dermatopathol;35(2):e34-6, 2013 Apr. |
| [Is] ISSN: | 1533-0311 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | BACKGROUND: While basal cell carcinoma (BCC) remains the most common skin cancer, the incidence of metastasis is rare. Most cases of metastatic BCC have been to regional lymph nodes. Metastasis to bone marrow with myelophthisic anemia is especially rare. To our knowledge, there have been only 5 reported cases in literature. We report a sixth case. OBSERVATIONS: A 46-year-old male patient presented with an 8 × 7-cm ulcerated plaque on his chest, found to be morpheaform basal cell on pathology. Laboratory findings were notable for normocytic anemia, thrombocytopenia, and elevated LDH. Further work up with bone marrow biopsy revealed tumor cells staining positive for CK AE1/AE3, BerEP4, CK7, CD56, and PIN-4. This confirmed the diagnosis of metastatic BCC (MBCC) to bone marrow. CONCLUSIONS: Although the rate of metastasis for BCC is rare, once it occurs, prognosis is poor. MBCC remains a challenge to treat. Therefore, it is critical to resolve the primary BCC and obtain vigilant follow-up, especially in patients with multiple risk factors for MBCC. |
| [Mh] Termos MeSH primário: |
Anemia Mielopática/etiologia
Neoplasias da Medula Óssea/complicações
Neoplasias da Medula Óssea/secundário
Carcinoma Basocelular/secundário
Neoplasias Cutâneas/patologia
|
| [Mh] Termos MeSH secundário: |
Seres Humanos
Masculino
Meia-Idade
|
| [Pt] Tipo de publicação: | CASE REPORTS; JOURNAL ARTICLE |
| [Em] Mês de entrada: | 1309 |
| [Cu] Atualização por classe: | 130401 |
[Lr] Data última revisão:
| 130401 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 121114 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1097/DAD.0b013e3182761362 |
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