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[PMID]:28749085
[Au] Autor:Llewellyn EA; Todd JM; Sharkey LC; Rendahl A
[Ad] Endereço:Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, 55108.
[Ti] Título:A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis.
[So] Source:J Vet Emerg Crit Care (San Antonio);27(5):569-578, 2017 Sep.
[Is] ISSN:1476-4431
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To characterize platelet indices at time of diagnosis of septic peritonitis in dogs and to assess the relationship between platelet parameter data and survival to discharge in dogs treated surgically. DESIGN: Retrospective, observational, descriptive pilot study from 2009 to 2014. SETTING: University teaching hospital. ANIMALS: Forty-eight dogs diagnosed with septic peritonitis were included in this study. Thirty-six dogs had surgical source control. Blood samples from 46 healthy control dogs were used for reference interval (RI) generation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Dogs with septic peritonitis had significantly increased mean values for mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) with increased proportions of dogs having values above the RI compared to healthy dogs. A significantly increased proportion of dogs with septic peritonitis had platelet counts above (12.5%) and below (8.3%) the RI, with no significant difference in mean platelet count compared to healthy dogs. No significant differences in the mean platelet count, MPV, PCT, or PDW were found between survivors and nonsurvivors in dogs with surgical source control; however, dogs with MPV values above the RI had significantly increased mortality compared to dogs within the RI (P = 0.025). Values outside the RI for other platelet parameters were not associated with significant differences in mortality. CONCLUSIONS: Dogs with septic peritonitis have increased frequency of thrombocytosis and thrombocytopenia with increased MPV, PCT, and PDW. An increased MPV may be a useful indicator of increased risk of mortality in dogs treated surgically.
[Mh] Termos MeSH primário: Transtornos Plaquetários/veterinária
Doenças do Cão/sangue
Peritonite/veterinária
Contagem de Plaquetas/veterinária
Sepse/veterinária
[Mh] Termos MeSH secundário: Animais
Transtornos Plaquetários/sangue
Cães
Volume Plaquetário Médio
Peritonite/sangue
Projetos Piloto
Prognóstico
Valores de Referência
Estudos Retrospectivos
Sepse/sangue
Trombocitopenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/vec.12628


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[PMID]:28612396
[Au] Autor:Sivapalaratnam S; Collins J; Gomez K
[Ad] Endereço:Department of Haematology, University of Cambridge, Cambridge, UK.
[Ti] Título:Diagnosis of inherited bleeding disorders in the genomic era.
[So] Source:Br J Haematol;179(3):363-376, 2017 Nov.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inherited bleeding disorders affect between 1 in 1000 individuals for the most common disorder, von Willebrand Disease, to only 8 reported cases worldwide of alpha-2-antiplasmin deficiency. Those with an identifiable abnormality can be divided into disorders of coagulation factors (87%), platelet count and function (8%) and the fibrinolytic system (3%). Of the patients registered in the UK with a bleeding disorder, the remaining 2% are unclassifiable. In addition to bleeding symptoms, patients with an inherited bleeding disorder can manifest other abnormalities, making an accurate and complete diagnosis that reflects the underlying molecular pathology important. Although some inherited bleeding disorders can still be easily diagnosed through a combination of careful clinical assessment and laboratory assays of varying degrees of complexity, there are many where conventional approaches are inadequate. Improvements in phenotyping assays have enhanced our diagnostic armoury but genotyping now offers the most accurate and complete diagnosis for some of these conditions. The advent of next generation sequencing technology has meant that many genes can now be analysed routinely in clinical practice. Here, we discuss the different diagnostic tools currently available for inherited bleeding disorders and suggest that genotyping should be incorporated at an early stage in the diagnostic pathway.
[Mh] Termos MeSH primário: Transtornos Herdados da Coagulação Sanguínea/diagnóstico
Genômica/métodos
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/diagnóstico
Anormalidades Múltiplas/genética
Transtornos Herdados da Coagulação Sanguínea/genética
Transtornos Plaquetários/diagnóstico
Transtornos Plaquetários/genética
Diagnóstico Diferencial
Genótipo
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Achados Incidentais
Exame Físico/métodos
Testes de Função Plaquetária/métodos
Doenças de von Willebrand/diagnóstico
Doenças de von Willebrand/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14796


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[PMID]:28575217
[Au] Autor:Perez Botero J; Warad DM; He R; Uhl CB; Tian S; Otteson GE; Barness RL; Olson MC; Gossman SC; Charlesworth JE; Nichols WL; Pruthi RK; Chen D
[Ad] Endereço:Division of Hematology.
[Ti] Título:Comprehensive Platelet Phenotypic Laboratory Testing and Bleeding History Scoring for Diagnosis of Suspected Hereditary Platelet Disorders: A Single-Institution Experience.
[So] Source:Am J Clin Pathol;148(1):23-32, 2017 Jul 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: Patients with hereditary/congenital platelet disorders (HPDs) have a broad range of clinical manifestations and laboratory phenotypes. We assessed the performance characteristics of the International Society on Thrombosis and Haemostasis bleeding assessment tool (ISTH-BAT) and clinically validated platelet laboratory tests for diagnosis of HPDs. Methods: The records of 61 patients with suspected HPDs were reviewed and ISTH-BAT scores calculated. Results: Nineteen (31%) patients had thrombocytopenia, and 46 (75%) had positive ISTH-BAT scores. Thirteen and 17 patients had prolonged PFA-100 (Dade Behring, Miami, FL) adenosine diphosphate and epinephrine closure times, respectively. Twenty-two had abnormal platelet light transmission aggregation. Twenty-four had platelet transmission electron microscopy (PTEM) abnormalities (10 dense granule deficiency, 14 other ultrastructural abnormalities). Positive ISTH-BAT scores were associated with thrombocytopenia (P < .0001) and abnormal PTEM (P = .002). Twenty-three patients had normal results. Conclusions: ISTH-BAT identified patients with suspected HPDs but lacked a robust association with laboratory abnormalities. Despite comprehensive laboratory testing, some patients may have normal results.
[Mh] Termos MeSH primário: Transtornos Plaquetários/diagnóstico
Hemorragia/diagnóstico
Agregação Plaquetária
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Transtornos Plaquetários/genética
Criança
Pré-Escolar
Feminino
Hemorragia/genética
Seres Humanos
Lactente
Masculino
Meia-Idade
Testes de Função Plaquetária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqx038


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[PMID]:28550916
[Au] Autor:Connelly CR; Yonge JD; McCully SP; Hart KD; Hilliard TC; Lape DE; Watson JJ; Rick B; Houser B; Deloughery TG; Schreiber MA; Kiraly LN
[Ad] Endereço:Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon. Electronic address: connelch@ohsu.edu.
[Ti] Título:Assessment of three point-of-care platelet function assays in adult trauma patients.
[So] Source:J Surg Res;212:260-269, 2017 May 15.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antiplatelet (AP) medication use is common among trauma patients and is associated with poor outcomes. Management options for platelet dysfunction in trauma patients are controversial, expensive, and potentially harmful. Although light transmission platelet aggregometry is considered the standard test to assess platelet function, it is cumbersome and not generally available. Currently, there are no widely accepted platelet function point-of-care tests for acute trauma. STUDY DESIGN: Prospective observational study from 2014 to 2015. Baseline Multiplate aggregometry aspirin area under the platelet aggregation curve (ASPI AUC), Thrombelastography Platelet Mapping percent inhibition of arachidonic acid (TEG-PM AA), and VerifyNow Aspirin Test (ARU) were compared for ability to detect any AP medication use (aspirin or clopidogrel), platelet dysfunction, and identify patients at risk for intracranial hemorrhage (ICH) progression by calculating the area under receiver operating characteristic curves (AUC), sensitivity, specificity, and positive and negative predictive values. Adenosine diphosphate assays were similarly evaluated. RESULTS: Sixty-four patients were enrolled, 25 were taking AP medications. AP patients were older (71.6 versus 35.0 y, P < 0.001) and received more platelet transfusions, but other baseline characteristics were similar. Median ASPI AUC (22.0 versus 53.5 P < 0.001) and VerifyNow ARU (503.5 versus 629.0, P < 0.001) were lower, whereas TEG-PM AA (51.8% versus 18.3%, P < 0.001) was higher in AP patients. Multiplate ASPI AUC, TEG-PM AA percent inhibition, and VerifyNow ARU could identify AP medication use (AUC: 0.90, 0.77, and 0.90, respectively). Adenosine diphosphate assays did not correlate with AP medication use in this population. TEG-PM AA percent inhibition and VerifyNow ARU correlated well with Multiplate ASPI AUC to identify platelet dysfunction (AUC: 0.78, 0.89, respectively). ICH occurred in 29 patients; 12 of which had progression of their injury. ASPI AUC (AUC: 0.50) and VerifyNow ARU (AUC: 0.59) did not correlate, and TEG-PM AA percent inhibition (AUC: 0.66) minimally correlated with progression. CONCLUSIONS: Multiplate, TEG-PM, and VerifyNow are useful point-of-care tests which identify AP medication use and platelet dysfunction in trauma patients. Initial TEG-PM AA percent inhibition may be associated with risk for ICH progression. However, additional large, prospective studies are needed.
[Mh] Termos MeSH primário: Transtornos Plaquetários/diagnóstico
Sistemas Automatizados de Assistência Junto ao Leito
Ferimentos e Lesões/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Transtornos Plaquetários/sangue
Transtornos Plaquetários/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Testes de Função Plaquetária
Estudos Prospectivos
Sensibilidade e Especificidade
Ferimentos e Lesões/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28534116
[Au] Autor:Hayashi Y; Harada Y; Huang G; Harada H
[Ad] Endereço:Laboratory of Oncology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
[Ti] Título:Myeloid neoplasms with germ line RUNX1 mutation.
[So] Source:Int J Hematol;106(2):183-188, 2017 Aug.
[Is] ISSN:1865-3774
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Familial platelet disorder with propensity to myeloid malignancies (FPD/AML) is an autosomal dominant disorder characterized by quantitative and/or qualitative platelet defects with a tendency to develop a variety of hematological malignancies. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML. Notably, about half of individuals in the family with germ line mutations in RUNX1 develop overt hematological malignancies. The latency is also relatively long as an average age at diagnosis is more than 30 years. Similar to what is observed in sporadic hematological malignancies, acquired additional genetic events cooperate with inherited RUNX1 mutations to progress the overt malignant phase. Reflecting recent increased awareness of hematological malignancies with germ line mutations, FPD/AML was added in the revised WHO 2016 classification. In this review, we provide an update on FPD/AML with recent clinical and experimental findings.
[Mh] Termos MeSH primário: Transtornos Herdados da Coagulação Sanguínea/genética
Transtornos Plaquetários/genética
Subunidade alfa 2 de Fator de Ligação ao Core/genética
Estudos de Associação Genética
Predisposição Genética para Doença/genética
Mutação em Linhagem Germinativa
Leucemia Mieloide Aguda/genética
[Mh] Termos MeSH secundário: Genes Dominantes/genética
Heterozigoto
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Core Binding Factor Alpha 2 Subunit); 0 (RUNX1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1007/s12185-017-2258-5


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[PMID]:28514344
[Au] Autor:Makarova EV; Tarasenko SV; Melikyan AL; Ponomarenko AV
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
[Ti] Título:[Erbium laser application for oral surgery in patients with platelet hemostatic disorders].
[Ti] Título:Primenenie érbievogo lazera pri khirurgicheskom stomatologicheskom lechenii patsientov s narusheniiami trombotsitarnogo gemostaza..
[So] Source:Stomatologiia (Mosk);96(2):29-32, 2017.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Hemostatic disorders are typically associated with prolonged bleeding after or during surgical procedures. The aim of the study was to increase the efficiency of oral surgery in these patients using erbium laser. Selected 46 patients receiving oral surgery were randomly divided in 2 groups: 43 patients with thrombocytopenia, trombocytemia and other platelet disorders treated with erbium laser and a control group of 43 patients without concomitant pathology determined for conventional surgical treatment. No postoperative bleeding was seen in group 1. Conventional procedures were associated with significantly more postoperative pain and epithelization took 1-3 days longer. Erbium laser radiation is an up-to-date method which can be successfully used for oral surgery in patients with hemostatic disorders.
[Mh] Termos MeSH primário: Transtornos Plaquetários/complicações
Lasers de Estado Sólido
Procedimentos Cirúrgicos Bucais/instrumentação
Hemorragia Pós-Operatória/etiologia
Hemorragia Pós-Operatória/prevenção & controle
[Mh] Termos MeSH secundário: Transtornos Plaquetários/patologia
Seres Humanos
Hemorragia Pós-Operatória/patologia
Trombocitopenia/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201796229-32


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[PMID]:28416505
[Au] Autor:Songdej N; Rao AK
[Ad] Endereço:Sol Sherry Thrombosis Research Center and Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
[Ti] Título:Hematopoietic transcription factor mutations: important players in inherited platelet defects.
[So] Source:Blood;129(21):2873-2881, 2017 May 25.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most patients with inherited platelet defects are unknown. There is now increasing evidence that mutations in hematopoietic TFs are an important underlying cause for defects in platelet production, morphology, and function. The hematopoietic TFs implicated in patients with impaired platelet function and number include runt-related transcription factor 1, Fli-1 proto-oncogene, E-twenty-six (ETS) transcription factor (friend leukemia integration 1), GATA-binding protein 1, growth factor independent 1B transcriptional repressor, ETS variant 6, ecotropic viral integration site 1, and homeobox A11. These TFs act in a combinatorial manner to bind sequence-specific DNA within promoter regions to regulate lineage-specific gene expression, either as activators or repressors. TF mutations induce rippling downstream effects by simultaneously altering the expression of multiple genes. Mutations involving these TFs affect diverse aspects of megakaryocyte biology, and platelet production and function, culminating in thrombocytopenia and platelet dysfunction. Some are associated with predisposition to hematologic malignancies. These TF variants may occur more frequently in patients with inherited platelet defects than generally appreciated. This review focuses on alterations in hematopoietic TFs in the pathobiology of inherited platelet defects.
[Mh] Termos MeSH primário: Transtornos Plaquetários/genética
Doenças Genéticas Inatas/genética
Hematopoese/genética
Mutação
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Transcription Factors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2016-11-709881


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[PMID]:28296756
[Au] Autor:Shi X; Lin Z; He L; Li W; Mo L; Li Y; Yang Z; Mo WN
[Ad] Endereço:Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
[Ti] Título:Transient appearance of EDTA-dependent pseudothrombocytopenia in a postoperative patient with sepsis: A case report.
[So] Source:Medicine (Baltimore);96(11):e6330, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is a rare phenomenon characterized by spuriously low platelet counts when EDTA reacts with harvested blood. However, to the best of our knowledge, only two cases involving EDTA-PTCP in postoperative patients with sepsis have been reported. Here, we describe a case of EDTA-PTCP that appeared transiently in a postoperative patient with sepsis. PATIENT CONCERNS: A 68-year-old female patient underwent laparoscopic tension-free hernioplasty for incisional hernia. Postoperatively, the patient developed very low platelet counts. The number of platelets in this patient had not improved following treatment with fresh-frozen plasma and platelet transfusions. DIAGNOSES: The diagnosis of EDTA-PTCP was confirmed from the discovery of platelet aggregation in peripheral blood smears. INTERVENTIONS: We used sodium citrate-anticoagulated blood samples for platelet counting. OUTCOMES: The patient's platelet counts returned to normal with the use of sodium citrate-anticoagulated blood samples. Furthermore, the phenomenon of EDTA-PTCP disappeared when the patient was cured. LESSONS: The phenomenon of low platelet counts in postoperative patients with sepsis should be considered as possible EDTA-PTCP. In addition, peripheral blood smears and the use of sodium citrate anticoagulant are effective and valuable methods that can help identify EDTA-PTCP.
[Mh] Termos MeSH primário: Transtornos Plaquetários/complicações
Ácido Edético/sangue
Complicações Pós-Operatórias/sangue
Sepse/complicações
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Agregação Plaquetária/fisiologia
Contagem de Plaquetas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9G34HU7RV0 (Edetic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006330


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[PMID]:28211564
[Au] Autor:Wegman-Ostrosky T; Savage SA
[Ad] Endereço:Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
[Ti] Título:The genomics of inherited bone marrow failure: from mechanism to the clinic.
[So] Source:Br J Haematol;177(4):526-542, 2017 May.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The inherited bone marrow failure syndromes (IBMFS) typically present with significant cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia, and are associated with increased risk of cancer. Although the clinical features of the IBMFS are often diagnostic, variable disease penetrance and expressivity may result in diagnostic dilemmas. The discovery of the genetic aetiology of the IBMFS has been greatly facilitated by next-generation sequencing methods. This has advanced understanding of the underlying biology of the IBMFS and been essential in improving clinical management and genetic counselling for affected patients. Herein we review the clinical features, underlying biology, and new genomic discoveries in the IBMFS, including Fanconi anaemia, dyskeratosis congenita, Diamond Blackfan anaemia, Shwachman Diamond syndrome and some disorders of the myeloid and megakaryocytic lineages.
[Mh] Termos MeSH primário: Anemia Aplástica/genética
Doenças da Medula Óssea/genética
Genômica/métodos
Hemoglobinúria Paroxística/genética
[Mh] Termos MeSH secundário: Anemia Aplástica/diagnóstico
Anemia de Diamond-Blackfan/diagnóstico
Anemia de Diamond-Blackfan/genética
Transtornos Plaquetários/diagnóstico
Transtornos Plaquetários/genética
Doenças da Medula Óssea/diagnóstico
Distúrbios no Reparo do DNA/genética
Disceratose Congênita/diagnóstico
Disceratose Congênita/genética
Insuficiência Pancreática Exócrina/diagnóstico
Insuficiência Pancreática Exócrina/genética
Anemia de Fanconi/diagnóstico
Anemia de Fanconi/genética
Aconselhamento Genético
Hemoglobinúria Paroxística/diagnóstico
Seres Humanos
Lipomatose/diagnóstico
Lipomatose/genética
Neutropenia/congênito
Neutropenia/diagnóstico
Neutropenia/genética
Ribossomos/genética
Telômero/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14535


  10 / 3433 MEDLINE  
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[PMID]:28095213
[Au] Autor:Rao AK
[Ad] Endereço:a Sol Sherry Thrombosis Research Center and Department of Medicine , Lewis Katz School of Medicine at Temple University , Philadelphia , PA , USA.
[Ti] Título:Editorial: Platelet Genomics and Disorders of Platelet Number and Function.
[So] Source:Platelets;28(1):2, 2017 Jan.
[Is] ISSN:1369-1635
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos Plaquetários/sangue
Transtornos Plaquetários/etiologia
Plaquetas/metabolismo
Genômica
Contagem de Plaquetas
Testes de Função Plaquetária
[Mh] Termos MeSH secundário: Genômica/métodos
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1080/09537104.2016.1262013



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