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[PMID]:29252646
[Au] Autor:Buckley PS; Kane J; Ciccotti MG
[Ad] Endereço:Department of Orthopaedic Surgery, Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
[Ti] Título:Immunoglobulin G Deficiency-Associated Septic Arthritis Identified Following Corticosteroid Injection and Knee Arthroscopy: A Case Report.
[So] Source:JBJS Case Connect;6(3):e69, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: We present the case of a patient who had worsening pain following intra-articular knee corticosteroid injection and who subsequently underwent arthroscopic partial meniscectomy with positive intraoperative cultures for Staphylococcus lugdunensis. He was treated with multiple irrigation and debridements, and subsequent work-up yielded a diagnosis of immunoglobulin G (IgG) deficiency. We believe that it is critical to maintain a high index of suspicion for underlying immune deficiency when faced with atypical presentations of infections or atypical bacteria in otherwise healthy patients. CONCLUSION: Knee arthroscopy for the treatment of meniscal tears is one of the most common procedures performed by orthopaedic surgeons in the United States. Patients with an antibody deficiency may have a limited or reduced immune response when presented with a pathogen foreign to the body. This may place the patient at an increased risk of infection and should be addressed through referral to the appropriate subspecialists when recurrent or atypical infection presents to the orthopaedic surgeon.
[Mh] Termos MeSH primário: Artrite Infecciosa/imunologia
Deficiência de IgG/complicações
Injeções Intra-Articulares/efeitos adversos
Meniscectomia/efeitos adversos
Complicações Pós-Operatórias/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.15.00254


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[PMID]:28422000
[Au] Autor:Barton JC; Bertoli LF; Barton JC; Acton RT
[Ad] Endereço:Department of Medicine, Brookwood Medical Center, Birmingham, AL; Southern Iron Disorders Center, Birmingham, AL; and Department of Medicine, University of Alabama at Birmingham, AL, USA. ironmd@isp.com.
[Ti] Título:Fibromyalgia in 300 adult index patients with primary immunodeficiency.
[So] Source:Clin Exp Rheumatol;35 Suppl 105(3):68-73, 2017 May-Jun.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We sought to determine the prevalence and clinical and laboratory associations of fibromyalgia in adults with primary immunodeficiency (immunoglobulin (Ig) G subclass deficiency (IgGSD) and common variable immunodeficiency (CVID). METHODS: We performed a retrospective analysis of these observations in 300 non-Hispanic white adult index patients with recurrent/severe respiratory tract infections and IgGSD or CVID: age; sex; IgGSD; fibromyalgia; chronic fatigue; autoimmune conditions (ACs); interstitial cystitis (IC); diabetes; body mass index; serum Ig isotypes; blood lymphocytes and subsets; and human leukocyte antigen (HLA)-A and -B types and haplotypes. We performed univariate comparisons, logistic multivariable regressions, and an analysis of covariance. RESULTS: Mean age was 49 ± 12 (standard deviation) y. There were 246 women (82.0%). IgGSD was diagnosed in 276 patients (92.0%). Fifty-six patients had fibromyalgia (18.7%; female:male 13:1). Other characteristics included: chronic fatigue, 63.0%; aggregate ACs, 35.3%; Sjögren's syndrome, 8.0%; IC, 3.0%; diabetes, 10.3%; and HLA-A*29, B*44 positivity, 9.7%. Prevalences of female sex; chronic fatigue; IC; and HLA-A*29, B*44 positivity were greater in patients with fibromyalgia. Logistic regression on fibromyalgia revealed three positive associations: chronic fatigue (p=0.0149; odds ratio 2.6 [95% confidence interval 1.2, 5.6]); Sjögren's syndrome (p=0.0004; 5.2 [2.1, 13.2]); and IC (p=0.0232; 5.7 [1.3, 25.7]). In an analysis of covariance, there were significant interactions of chronic fatigue, Sjögren's syndrome, and interstitial cystitis on fibromyalgia. CONCLUSIONS: Fibromyalgia is common in non-Hispanic white adult index patients with primary immunodeficiency, especially women. Chronic fatigue, Sjögren's syndrome, and IC are significantly associated with fibromyalgia after adjustment for other independent variables.
[Mh] Termos MeSH primário: Imunodeficiência de Variável Comum/epidemiologia
Fibromialgia/epidemiologia
Deficiência de IgG/epidemiologia
Síndrome de Sjogren/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Doenças Autoimunes/epidemiologia
Imunodeficiência de Variável Comum/genética
Cistite Intersticial/epidemiologia
Síndrome de Fadiga Crônica/epidemiologia
Feminino
Fibromialgia/genética
Antígenos HLA-A/genética
Antígeno HLA-B44/genética
Haplótipos
Seres Humanos
Deficiência de IgG/genética
Síndromes de Imunodeficiência/epidemiologia
Síndromes de Imunodeficiência/genética
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Prevalência
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-A Antigens); 0 (HLA-A29 antigen); 0 (HLA-B44 Antigen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:27634199
[Au] Autor:Bogaert DJ; De Bruyne M; Debacker V; Depuydt P; De Preter K; Bonroy C; Philippé J; Bordon V; Lambrecht BN; Kerre T; Cerutti A; Vermaelen KY; Haerynck F; Dullaers M
[Ad] Endereço:Clinical Immunology Research Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Belgium.
[Ti] Título:The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives.
[So] Source:Haematologica;102(1):192-202, 2017 Jan.
[Is] ISSN:1592-8721
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The etiology of primary antibody deficiencies is largely unknown. Beside rare monogenic forms, the majority of cases seem to have a more complex genetic basis. Whereas common variable immunodeficiency has been investigated in depth, there are only a few reports on milder primary antibody deficiencies such as idiopathic primary hypogammaglobulinemia and IgG subclass deficiency. We performed flow cytometric immunophenotyping in 33 patients with common variable immunodeficiency, 23 with idiopathic primary hypogammaglobulinemia and 21 with IgG subclass deficiency, as well as in 47 asymptomatic first-degree family members of patients and 101 unrelated healthy controls. All three groups of patients showed decreased memory B- and naïve T-cell subsets and decreased B-cell activating factor receptor expression. In contrast, circulating follicular helper T-cell frequency and expression of inducible T-cell co-stimulator and chemokine receptors were only significantly altered in patients with common variable immunodeficiency. Asymptomatic first-degree family members of patients demonstrated similar, albeit intermediate, alterations in naïve and memory B- and T-cell subsets. About 13% of asymptomatic relatives had an abnormal peripheral B-cell composition. Furthermore, asymptomatic relatives showed decreased levels of CD4 recent thymic emigrants and increased central memory T cells. Serum IgG and IgM levels were also significantly lower in asymptomatic relatives than in healthy controls. We conclude that, in our cohort, the immunophenotypic landscape of primary antibody deficiencies comprises a spectrum, in which some alterations are shared between all primary antibody deficiencies whereas others are only associated with common variable immunodeficiency. Importantly, asymptomatic first-degree family members of patients were found to have an intermediate phenotype for peripheral B- and T-cell subsets.
[Mh] Termos MeSH primário: Agamaglobulinemia/diagnóstico
Doenças Assintomáticas
Imunodeficiência de Variável Comum/diagnóstico
Família
Deficiência de IgG/diagnóstico
Imunofenotipagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Agamaglobulinemia/sangue
Idoso
Idoso de 80 Anos ou mais
Subpopulações de Linfócitos B/imunologia
Subpopulações de Linfócitos B/metabolismo
Biomarcadores
Estudos de Casos e Controles
Criança
Pré-Escolar
Análise por Conglomerados
Imunodeficiência de Variável Comum/sangue
Células Dendríticas/imunologia
Células Dendríticas/metabolismo
Feminino
Seres Humanos
Deficiência de IgG/sangue
Imunoglobulinas/sangue
Imunofenotipagem/métodos
Masculino
Meia-Idade
Fenótipo
Subpopulações de Linfócitos T/imunologia
Subpopulações de Linfócitos T/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunoglobulins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.3324/haematol.2016.149112


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[PMID]:27550483
[Au] Autor:Kim JH; Park S; Hwang YI; Jang SH; Jung KS; Sim YS; Kim CH; Kim C; Kim DG
[Ad] Endereço:Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Medical Center, Anyang, Korea.
[Ti] Título:Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
[So] Source:J Korean Med Sci;31(10):1560-5, 2016 Oct.
[Is] ISSN:1598-6357
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Immunoglobulin G subclass deficiency (IgGSCD) is a relatively common primary immunodeficiency disease (PI) in adults. The biological significance of IgGSCD in patients with chronic airway diseases is controversial. We conducted a retrospective study to characterize the clinical features of IgGSCD in this population. This study examined the medical charts from 59 adult patients with IgGSCD who had bronchial asthma or chronic obstructive pulmonary disease (COPD) from January 2007 to December 2012. Subjects were classified according to the 10 warning signs developed by the Jeffrey Modell Foundation (JMF) and divided into two patient groups: group I (n = 17) met ≥ two JMF criteria, whereas group II (n = 42) met none. IgG3 deficiency was the most common subclass deficiency (88.1%), followed by IgG4 (15.3%). The most common infectious complication was pneumonia, followed by recurrent bronchitis, and rhinosinusitis. The numbers of infections, hospitalizations, and exacerbations of asthma or COPD per year were significantly higher in group I than in group II (P < 0.001, P = 0.012, and P < 0.001, respectively). The follow-up mean forced expiratory volume (FEV1) level in group I was significantly lower than it was at baseline despite treatment of asthma or COPD (P = 0.036). In conclusion, IgGSCD is an important PI in the subset of patients with chronic airway diseases who had recurrent upper and lower respiratory infections as they presented with exacerbation-prone phenotypes, decline in lung function, and subsequently poor prognosis.
[Mh] Termos MeSH primário: Asma/diagnóstico
Deficiência de IgG/diagnóstico
Doença Pulmonar Obstrutiva Crônica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Asma/complicações
Feminino
Volume Expiratório Forçado
Seres Humanos
Deficiência de IgG/complicações
Imunoglobulina G/classificação
Klebsiella/isolamento & purificação
Masculino
Meia-Idade
Moraxella (Branhamella) catarrhalis/isolamento & purificação
Pseudomonas aeruginosa/isolamento & purificação
Doença Pulmonar Obstrutiva Crônica/complicações
Testes de Função Respiratória
Infecções Respiratórias/complicações
Infecções Respiratórias/microbiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.3346/jkms.2016.31.10.1560


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[PMID]:27484815
[Au] Autor:Schatorjé E; van der Flier M; Seppänen M; Browning M; Morsheimer M; Henriet S; Neves JF; Vinh DC; Alsina L; Grumach A; Soler-Palacin P; Boyce T; Celmeli F; Goudouris E; Hayman G; Herriot R; Förster-Waldl E; Seidel M; Simons A; de Vries E
[Ad] Endereço:Department Pediatrics, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands.
[Ti] Título:Primary immunodeficiency associated with chromosomal aberration - an ESID survey.
[So] Source:Orphanet J Rare Dis;11(1):110, 2016 08 02.
[Is] ISSN:1750-1172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with syndromic features frequently suffer from recurrent respiratory infections, but little is known about the spectrum of immunological abnormalities associated with their underlying chromosomal aberrations outside the well-known examples of Down and DiGeorge syndromes. Therefore, we performed this retrospective, observational survey study. METHODS: All members of the European Society for Immunodeficiencies (ESID) were invited to participate by reporting their patients with chromosomal aberration (excluding Down and DiGeorge syndromes) in combination with one or more identified immunological abnormalities potentially relating to primary immunodeficiency. An online questionnaire was used to collect the patient data. RESULTS: Forty-six patients were included from 16 centers (24 males, 22 females; median age 10.4 years [range 1.0-69.2 years]; 36 pediatric, 10 adult patients). A variety of chromosomal aberrations associated with immunological abnormalities potentially relating to primary immune deficiency was reported. The most important clinical presentation prompting the immunological evaluation was 'recurrent ear-nose-throat (ENT) and airway infections'. Immunoglobulin isotype and/or IgG-subclass deficiencies were the most prevalent immunological abnormalities reported. CONCLUSIONS: Our survey yielded a wide variety of chromosomal aberrations associated with immunological abnormalities potentially relating to primary immunodeficiency. Although respiratory tract infections can often also be ascribed to other causes (e.g. aspiration or structural abnormalities), we show that a significant proportion of patients also have an antibody deficiency requiring specific treatment (e.g. immunoglobulin replacement, antibiotic prophylaxis). Therefore, it is important to perform immunological investigations in patients with chromosomal aberrations and recurrent ENT or airway infections, to identify potential immunodeficiency that can be specifically treated.
[Mh] Termos MeSH primário: Aberrações Cromossômicas
Síndromes de Imunodeficiência/diagnóstico
Síndromes de Imunodeficiência/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Seres Humanos
Deficiência de IgG/diagnóstico
Deficiência de IgG/genética
Lactente
Deficiência Intelectual/genética
Masculino
Meia-Idade
Estudos Retrospectivos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1186/s13023-016-0492-1


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[PMID]:27302695
[Au] Autor:Ohnishi H; Kawamoto N; Kaneko H; Kasahara K; Ohara O; Kato Z; Fukao T
[Ad] Endereço:Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan. Electronic address: ohnishih@gifu-u.ac.jp.
[Ti] Título:A case of selective IgG subclass deficiency with STAT3 mutation.
[So] Source:Allergol Int;65(4):495-497, 2016 Oct.
[Is] ISSN:1440-1592
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Deficiência de IgG/genética
Deficiência de IgG/imunologia
Imunoglobulina G/sangue
Mutação
Fator de Transcrição STAT3/genética
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Deficiência de IgG/diagnóstico
Isotipos de Imunoglobulinas/sangue
Contagem de Leucócitos
Subpopulações de Linfócitos T/imunologia
Subpopulações de Linfócitos T/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Immunoglobulin Isotypes); 0 (STAT3 Transcription Factor)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE


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Andrade, Luís Eduardo C
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[PMID]:27274095
[Au] Autor:Perazzio SF; Granados Á; Salomão R; Silva NP; Carneiro-Sampaio M; Andrade LE
[Ad] Endereço:Division of Rheumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Division of Research and Development, Fleury Group.
[Ti] Título:High frequency of immunodeficiency-like states in systemic lupus erythematosus: a cross-sectional study in 300 consecutive patients.
[So] Source:Rheumatology (Oxford);55(9):1647-55, 2016 Sep.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the frequency of immunodeficiency-like states in SLE and related clinical features. METHODS: Three hundred and fifteen SLE patients and 301 controls were evaluated for C4A and C4B gene copy number, immunoglobulin isotypes, IgG subclasses, total haemolytic complement (CH50), C2, C3 and neutrophil oxidative burst. C2 and C3 genes were sequenced in cases of low C2 or C3 levels. Those presenting abnormal CH50 with normal C2 and C3 underwent C1q-C9 determination. Patients with active SLE and abnormal results were re-tested after the flare or were excluded if no remission was attained. Fifteen patients were excluded on this basis. Persistent abnormal results characterized an immunodeficiency-like state. RESULTS: A significantly higher percentage of SLE patients presented an immunodeficiency-like state compared with controls (28.7% vs 3.3%; P < 0.001), especially low immunoglobulin serum levels. Rigorous testing confirmed only two cases of C2 deficiency carriers among the SLE patients. There were significantly more SLE patients with less than two C4A copies compared with controls. SLE patients had higher frequency of low IgG2, IgG3, IgG4 and IgM levels compared with controls. Patients with low IgG3 or IgG4 presented higher frequency of lupus nephropathy. Patients with low IgM had longer disease duration, older age at SLE onset and lower frequency of oral ulcers. CONCLUSION: An immunodeficiency-like state is present in a sizable fraction of SLE patients. Further studies are warranted to determine the impact of these immunodeficiency states and whether they are a primary condition or are secondary to confounding factors, including SLE itself.
[Mh] Termos MeSH primário: Síndromes de Imunodeficiência/etiologia
Lúpus Eritematoso Sistêmico/imunologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Complemento C3/genética
Complemento C4a/genética
Complemento C4b/genética
Estudos Transversais
Feminino
Dosagem de Genes/genética
Seres Humanos
Deficiência de IgG
Nefrite Lúpica/imunologia
Masculino
Fagócitos/metabolismo
Explosão Respiratória/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complement C3); 80295-49-4 (Complement C4a); 80295-50-7 (Complement C4b)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kew227


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[PMID]:27123464
[Au] Autor:Barton JC; Bertoli LF; Barton JC; Acton RT
[Ad] Endereço:Department of Medicine, Brookwood Medical Center, Birmingham, AL 35209, USA; Southern Iron Disorders Center, Birmingham, AL 35209, USA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35209, USA.
[Ti] Título:Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections.
[So] Source:J Immunol Res;2016:1405950, 2016.
[Is] ISSN:2314-7156
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:We characterized 54 adult index patients with reports of frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG1. Mean age was 50 ± 13 (SD) y; 87.0% were women. Associated disorders included the following: autoimmune conditions 50.0%; hypothyroidism 24.1%; atopy 38.9%; and other allergy 31.5%. In 35.5%, proportions of protective S. pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination (PPPV). Blood lymphocyte subset levels were within reference limits in most patients. Regressions on IgG1 and IgG3 revealed no significant association with age, sex, autoimmune conditions, hypothyroidism, atopy, other allergy, corticosteroid therapy, or lymphocyte subsets. Regression on IgG2 revealed significant associations with PPPV response (negative) and CD19+ lymphocytes (positive). Regression on IgG4 revealed significant positive associations with episodic corticosteroid use and IgA. Regression on IgA revealed positive associations with IgG2 and IgG4. Regression on IgM revealed negative associations with CD56+/CD16+ lymphocytes. Regressions on categories of infection revealed a negative association of urinary tract infections and IgG1. HLA-A(⁎)03, HLA-B(⁎)55 and HLA-A(⁎)24, HLA-B(⁎)35 haplotype frequencies were greater in 38 patients than 751 controls. We conclude that nonprotective S. pneumoniae IgG levels and atopy contribute to increased susceptibility to respiratory tract infections in patients with selective subnormal IgG1.
[Mh] Termos MeSH primário: Deficiência de IgG/imunologia
Imunoglobulina G/sangue
Infecções Respiratórias/imunologia
Streptococcus pneumoniae/imunologia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Idoso
Antígenos CD19/imunologia
Doenças Autoimunes/complicações
Doenças Autoimunes/imunologia
Suscetibilidade a Doenças
Feminino
Antígenos HLA-A/genética
Antígenos HLA-B/genética
Haplótipos
Seres Humanos
Hipersensibilidade/complicações
Hipersensibilidade/imunologia
Hipotireoidismo/complicações
Hipotireoidismo/imunologia
Deficiência de IgG/complicações
Imunoglobulina A/sangue
Imunoglobulina M/sangue
Subpopulações de Linfócitos
Masculino
Meia-Idade
Vacinas Pneumocócicas/administração & dosagem
Vacinas Pneumocócicas/efeitos adversos
Infecções Respiratórias/complicações
Infecções Respiratórias/genética
Infecções Respiratórias/microbiologia
Estudos Retrospectivos
Infecções Urinárias/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD19); 0 (HLA-A Antigens); 0 (HLA-B Antigens); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (Pneumococcal Vaccines)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1155/2016/1405950


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[PMID]:26846287
[Au] Autor:Schatorjé EJ; de Jong E; van Hout RW; García Vivas Y; de Vries E
[Ad] Endereço:Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
[Ti] Título:The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.
[So] Source:J Clin Immunol;36(2):141-8, 2016 Feb.
[Is] ISSN:1573-2592
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Immunoglobulin(Ig)G-subclass deficiency and specific polysaccharide antibody deficiency (SPAD) are among the most frequent causes of recurrent respiratory infections in children. Little is known about their prevalence, clinical presentation and prognosis. No study has been published in a Western-European nor in a mainly non-tertiary cohort until now. Therefore, we performed this observational cohort study in children recruited from secondary and tertiary pediatric practices all over The Netherlands. METHODS: Dutch pediatricians were monthly asked to report patients with IgG-subclass deficiency and/or SPAD. Demographic, clinical and laboratory characteristics were collected. Separate informed consent was asked from parents and children (≥ 12 years of age) for annual update of the medical status. RESULTS: 49 children with confirmed IgG-subclass deficiency and/or SPAD were included. The majority of children (69%) was reported by four (out of 12) secondary hospitals with a pediatric immunologist in the staff. 45 children had ≥ 1 low IgG-subclass level and 11 had SPAD. IgG2 deficiency was the most prevalent IgG-subclass deficiency (37/49;76%). 10% of these children already showed bronchiectasis. Two-thirds were male (33/49;67%, p = 0.015). From 10 years of age, only boys were left and only boys showed progressive immunodeficiency during follow-up (11/24; 46%). CONCLUSIONS: This is the first Western-European mainly non-tertiary cohort of children with IgG-subclass deficiency and/or SPAD. The disease course is not always benign, especially in boys. Most children were reported and managed in secondary hospitals with a pediatric immunologist in the staff. To identify more patients, the awareness of these diseases among general pediatricians should increase.
[Mh] Termos MeSH primário: Deficiência de IgG/imunologia
Imunoglobulina G/imunologia
Polissacarídeos/imunologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Seres Humanos
Deficiência de IgG/sangue
Deficiência de IgG/diagnóstico
Imunoglobulina G/sangue
Isotipos de Imunoglobulinas/sangue
Isotipos de Imunoglobulinas/imunologia
Masculino
Países Baixos
Fenótipo
Polissacarídeos Bacterianos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Immunoglobulin Isotypes); 0 (Polysaccharides); 0 (Polysaccharides, Bacterial)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1007/s10875-016-0236-y


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[PMID]:26164024
[Au] Autor:Bilal J; Riaz IB; Hill JL; Zangeneh TT
[Ad] Endereço:Department of Internal Medicine, University of Arizona, Tucson, AZ.
[Ti] Título:Intravenous Immunoglobulin-Induced Pulmonary Embolism: It Is Time to Act!
[So] Source:Am J Ther;23(4):e1074-7, 2016 Jul-Aug.
[Is] ISSN:1536-3686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary embolism (PE) is a common clinical problem affecting 600,000 patients per year in the United States. Although the diagnosis can be easily confirmed by imaging techniques, such as computed tomographic angiography of the chest, the identification of underlying mechanism leading to PE is important for appropriate duration of anticoagulation, and prevention of subsequent episodes. The differential diagnosis of underlying mechanism is broad and must include careful review of medication history. Drug-related thromboembolic disease can be easily missed and may have catastrophic consequences. The identification of the culprit drug is important for prevention of subsequent episodes and choosing appropriate duration of anticoagulation. We report a case of a middle-aged man who developed PE after administration of intravenous immunoglobulin.
[Mh] Termos MeSH primário: Deficiência de IgG/tratamento farmacológico
Imunoglobulinas Intravenosas/efeitos adversos
Embolia Pulmonar/induzido quimicamente
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Imunoglobulinas Intravenosas/uso terapêutico
Masculino
Meia-Idade
Embolia Pulmonar/diagnóstico
Embolia Pulmonar/diagnóstico por imagem
Trombose Venosa/induzido quimicamente
Trombose Venosa/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150713
[St] Status:MEDLINE
[do] DOI:10.1097/MJT.0000000000000288



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