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[PMID]:29214791
[Au] Autor:Ahn MJ; Yu JE; Jeong J; Sim DW; Koh YI
[Ad] Endereço:Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
[Ti] Título:A Case of Schnitzler's Syndrome without Monoclonal Gammopathy-Associated Chronic Urticaria Treated with Anakinra.
[So] Source:Yonsei Med J;59(1):154-157, 2018 Jan.
[Is] ISSN:1976-2437
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Chronic urticaria may often be associated with interleukin (IL)-1-mediated autoinflammatory disease, which should be suspected if systemic inflammation signs are present. Here, we report a case of Schnitzler's syndrome without monoclonal gammopathy treated successfully with the IL-1 receptor antagonist anakinra. A 69-year-old man suffered from a pruritic urticarial rash for 12 years. It became aggravated episodically and was accompanied by high fever, arthralgia, leukocytosis, and an elevated C-reactive protein and erythrocyte sedimentation rate. The episodes each lasted for over one week. Neutrophilic and eosinophilic inflammation was found on skin biopsy. However, serum and urine electrophoresis showed no evidence of monoclonal gammopathy. The cutaneous lesions were unresponsive to various kinds of anti-histamines, systemic glucocorticoids, colchicine, cyclosporine, dapsone, and methotrexate, which were administered over a span of 3 years immediately preceding successful treatment. A dramatic response, however, was observed after a daily administration of anakinra. This observation suggests that the correct diagnosis of this case is Schnitzler's syndrome without monoclonal gammopathy. For an adult patient with refractory chronic urticaria and systemic inflammation, Schnitzler's syndrome could be considered as a possible differential diagnosis. Although the typical form of Schnitzler's syndrome exhibits the presence of monoclonal gammopathy as a diagnostic criterion, monoclonal gammopathy may be absent in an atypical form. In such a situation, an IL-1 antagonist should be effective for the management of chronic urticaria.
[Mh] Termos MeSH primário: Proteína Antagonista do Receptor de Interleucina 1/uso terapêutico
Paraproteinemias/complicações
Síndrome de Schnitzler/tratamento farmacológico
Urticária/complicações
[Mh] Termos MeSH secundário: Idoso
Sedimentação Sanguínea
Proteína C-Reativa/metabolismo
Doença Crônica
Seres Humanos
Leucócitos/metabolismo
Masculino
Síndrome de Schnitzler/sangue
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Interleukin 1 Receptor Antagonist Protein); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.3349/ymj.2018.59.1.154


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[PMID]:29390260
[Au] Autor:Chiang HH; Wieland RS; Rogers TS; Gibson PC; Atweh G; McCormick G
[Ad] Endereço:University of Vermont College of Medicine.
[Ti] Título:Paraproteinemic keratopathy in monoclonal gammopathy of undetermined significance treated with primary keratoprosthesis: Case report, histopathologic findings, and world literature review.
[So] Source:Medicine (Baltimore);96(50):e8649, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report a case of paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance, treated with keratoprosthesis as a primary penetrating procedure. Histopathological findings and a world literature review are presented. PATIENT CONCERNS: A 74 year old female recently diagnosed with monoclonal gammopathy undetermined significance presented with progressive blurry vision bilaterally. DIAGNOSES: Examination revealed corneal opacities consistent with paraproteinemic keratopathy. INTERVENTIONS: Corneal transplantation with the Boston Type I keratoprosthesis was performed on the right and, a year later, on the left. OUTCOMES: Visual outcomes were good. Histopathological staining of host corneal buttons were consistent with monoclonality, and electron microscopy revealed fibrillar extracellular aggregates within intervening normal stroma. LESSONS: Corneal deposits may be the only manifestation of monoclonal gammopathy of undetermined significance in patients who are otherwise systemically asymptomatic. Ophthalmologists who encounter corneal opacities may order the appropriate diagnostic studies to determine the presence of occult systemic disease. Risk of graft failure after penetrating keratoplasty from recurring opacities is high, so keratoprosthesis as a primary penetrating procedure may afford superior long-term outcomes. Host corneal buttons retrieved from penetrating keratoplasty or corneal biopsy may be sent for histopathological examination to confirm the diagnosis.
[Mh] Termos MeSH primário: Doenças da Córnea/etiologia
Opacidade da Córnea/etiologia
Gamopatia Monoclonal de Significância Indeterminada/complicações
Paraproteinemias/complicações
[Mh] Termos MeSH secundário: Idoso
Doenças da Córnea/cirurgia
Opacidade da Córnea/cirurgia
Transplante de Córnea
Feminino
Seres Humanos
Transtornos da Visão/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008649


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[PMID]:28858963
[Au] Autor:Derzko-Dzulynsky L
[Ad] Endereço:University of Toronto, Department of Ophthalmology and Vision Sciences, Canada.
[Ti] Título:IgG4-related disease in the eye and ocular adnexa.
[So] Source:Curr Opin Ophthalmol;28(6):617-622, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: IgG4-related disease is a multi-organ fibro-inflammatory disease with characteristic histopathology showing lymphoplasmacytic infiltration, increased IgG4+ plasma cells and elevated IgG4/IgG ratios (>40%). The lacrimal gland is the most common ocular site of involvement. Scleritis and intraocular involvement in IgG4-related ophthalmic disease (IgG4-ROD) have recently been reported. The purpose of this review is to describe orbital and intraocular IgG4-ROD with a focus on publications since 2016. RECENT FINDINGS: Case reports of scleritis and uveitis in IgG4-ROD have been described since 2012. Systemic prednisone is recommended as the first-line treatment, but immunosuppressive therapy may be required for steroid-sparing or in steroid-resistant cases. High rates of systemic IgG4-RD involvement exist in patients with bilateral IgG4-ROD or if the lacrimal gland is involved. Rituximab is the most specific immune targeted therapy available with high rates of remission. SUMMARY: IgG4-ROD is an emerging cause of scleritis and uveitis and should be considered in any patient with multisystem inflammatory disease. New targeted immune therapies may improve outcomes and lead to clinical remission.
[Mh] Termos MeSH primário: Oftalmopatias/imunologia
Imunoglobulina G
Paraproteinemias/imunologia
[Mh] Termos MeSH secundário: Dacriocistite/diagnóstico
Dacriocistite/tratamento farmacológico
Dacriocistite/imunologia
Oftalmopatias/diagnóstico
Oftalmopatias/tratamento farmacológico
Glucocorticoides/uso terapêutico
Seres Humanos
Imunoglobulina G/imunologia
Imunossupressores/uso terapêutico
Pseudotumor Orbitário/diagnóstico
Pseudotumor Orbitário/tratamento farmacológico
Pseudotumor Orbitário/imunologia
Paraproteinemias/diagnóstico
Paraproteinemias/tratamento farmacológico
Esclerite/diagnóstico
Esclerite/tratamento farmacológico
Esclerite/imunologia
Uveíte/diagnóstico
Uveíte/tratamento farmacológico
Uveíte/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunoglobulin G); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000427


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[PMID]:28817638
[Au] Autor:Valor LM; Rodríguez-Bayona B; Ramos-Amaya AB; Brieva JA; Campos-Caro A
[Ad] Endereço:Unidad de Investigación, Hospital Universitario Puerta del Mar and Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, Spain.
[Ti] Título:The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies.
[So] Source:PLoS One;12(8):e0183264, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC, transcriptomes from human naïve BC were compared to those of three functionally-different subsets of human in vivo-generated PC: i) tonsil PC, mainly consisting of early PC; ii) PC released to the blood after a potent booster-immunization (mostly cycling plasmablasts); and, iii) bone marrow CD138+ PC that represent highly mature PC and include the long-lived PC compartment. This transcriptional transition involves subsets of genes related to key processes for PC maturation: the already known protein processing, apoptosis and homeostasis, and of new discovery including histones, macromolecule assembly, zinc-finger transcription factors and neuromodulation. This human PC signature is partially reproduced in vitro and is conserved in mouse. Moreover, the present study identifies genes that define PC subtypes (e.g., proliferation-associated genes for circulating PC and transcriptional-related genes for tonsil and bone marrow PC) and proposes some putative transcriptional regulators of the human PC signatures (e.g., OCT/POU, XBP1/CREB, E2F, among others). Finally, we also identified a restricted imbalance of the present PC transcriptional program in monoclonal gammopathies that correlated with PC malignancy.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Paraproteinemias/genética
Plasmócitos/imunologia
Transcrição Genética
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Análise de Sequência com Séries de Oligonucleotídeos
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183264


  5 / 4424 MEDLINE  
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[PMID]:28679988
[Au] Autor:Oka T; Kobayashi M; Komori T; Nakamine H; Kitano T; Hishizawa M; Kondoh T; Yamashita K; Takaori-Kondo A
[Ad] Endereço:Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University.
[Ti] Título:Follicular lymphoma with plasmacytic differentiation accompanied by monoclonal IgG gammopathy.
[So] Source:Rinsho Ketsueki;58(6):595-600, 2017.
[Is] ISSN:0485-1439
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 59-year-old woman presented with high serum total protein, detected on a screening examination. Laboratory tests revealed high plasma levels of M-protein (IgG-λ), and FDG-PET/CT revealed systemic lymph node swelling and a large tumorous mass in the abdominal cavity. Bone marrow aspirates contained 8.4% plasma cells and approximately 30% abnormal small lymphocytes. A biopsy of the left supraclavicular lymph node was initially interpreted as lymphoplasmacytic lymphoma (LPL). However, chromosomal analysis of the lymph node demonstrated an unusual karyotype with t (14;18) (q32;q21). FISH analysis for the IgH-BCL2 fusion gene was positive. Furthermore, the MYD88 L265P mutation was not detected in tumor cells. Based on these findings, this case was determined to be a type of follicular lymphoma with plasmacytic differentiation. We considered that this case was an important example emphasizing the importance of karyotypic examination for lymphoma classification.
[Mh] Termos MeSH primário: Imunoglobulina G/imunologia
Linfoma Folicular/complicações
Paraproteinemias/imunologia
[Mh] Termos MeSH secundário: Diferenciação Celular
Cromossomos Humanos Par 14
Cromossomos Humanos Par 18
Feminino
Seres Humanos
Meia-Idade
Paraproteinemias/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.11406/rinketsu.58.595


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[PMID]:28653323
[Au] Autor:McIlroy G; Mytton J; Evison F; Yadav P; Drayson MT; Cook M; Pratt G; Cockwell P; Pinney JH
[Ad] Endereço:Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[Ti] Título:Increased fracture risk in plasma cell dyscrasias is associated with poorer overall survival.
[So] Source:Br J Haematol;179(1):61-65, 2017 Oct.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pathological fractures are a common complication of plasma cell dyscrasias (PCD) and are associated with significant morbidity. Routine use of bisphosphonates over the past decade has aimed to reduce the risk of fractures in patients with multiple myeloma, but despite this, fractures continue to represent a significant burden of disease. In this study we report the fracture rate of hospital in-patients with PCD in England. Data from the national registry Hospital Episode Statistics between 2001 and 2015 were used to determine fracture rate and its effect on overall survival. Fracture rates were 17·8 times higher than the general population in the first year after admission with PCD, and remained elevated for up to 10 years after first admission. The increased fracture risk preceded the first admission with PCD and, conversely, the incidence of PCD increased after admission with one or more fractures. Overall survival is improving with PCD, however poorer survival is found in patients with a preceding fracture (Hazard ratio 1·20). Despite widespread bisphosphonate use, fractures remain common in PCD, and are associated with poorer outcomes.
[Mh] Termos MeSH primário: Fraturas Ósseas/etiologia
Fraturas Espontâneas/etiologia
Paraproteinemias/complicações
Paraproteinemias/mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Fraturas Ósseas/epidemiologia
Fraturas Espontâneas/epidemiologia
Seres Humanos
Lactente
Recém-Nascido
Estimativa de Kaplan-Meier
Masculino
Paraproteinemias/epidemiologia
Vigilância da População
Modelos de Riscos Proporcionais
Risco
Análise de Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14815


  7 / 4424 MEDLINE  
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[PMID]:28602874
[Au] Autor:Pineton de Chambrun M; Gousseff M; Mauhin W; Lega JC; Lambert M; Rivière S; Dossier A; Ruivard M; Lhote F; Blaison G; Alric L; Agard C; Saadoun D; Graveleau J; Soubrier M; Lucchini-Lecomte MJ; Christides C; Bosseray A; Levesque H; Viallard JF; Tieulie N; Lovey PY; Le Moal S; Bibes B; Malizia G; Abgueguen P; Lifermann F; Ninet J; Hatron PY; Amoura Z; EurêClark Study Group
[Ad] Endereço:Service de médecine interne 2, CHU La Pitié-Salpêtrière, APHP, Université Paris 6, France; Service de réanimation médicale, CHU La Pitié-Salpêtrière, APHP, Université Paris 6, France.
[Ti] Título:Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome.
[So] Source:Am J Med;130(10):1219.e19-1219.e27, 2017 Oct.
[Is] ISSN:1555-7162
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Monoclonal gammopathy-associated systemic capillary-leak syndrome, also known as Clarkson disease, is a rare condition characterized by recurrent life-threatening episodes of capillary hyperpermeability in the context of a monoclonal gammopathy. This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome. METHODS: We conducted a cohort analysis of all patients included in the European Clarkson disease (EurêClark) registry between January 1997 and March 2016. From diagnosis to last follow-up, studied outcomes (eg, the frequency and severity of attacks, death, and evolution toward multiple myeloma) and the type of preventive treatments administered were monitored every 6 months. RESULTS: Sixty-nine patients (M/F sex ratio 1:1; mean ± SD age at disease onset 52 ± 12 years) were included in the study. All patients had monoclonal gammopathy of immunoglobulin G type, with kappa light chains in 47 (68%). Median (interquartile range) follow-up duration was 5.1 (2.5-9.7) years. Twenty-four patients (35%) died after 3.3 (0.9-8) years. Fifty-seven (86%) patients received at least one preventive treatment, including intravenous immunoglobulins (IVIg) n = 48 (73.8%), theophylline n = 22 (33.8%), terbutaline n = 22 (33.8%), and thalidomide n = 5 (7.7%). In the 65 patients with follow-up, 5- and 10-year survival rates were 78% (n = 35) and 69% (n = 17), respectively. Multivariate analysis found preventive treatment with IVIg (hazard ratio 0.27; 95% confidence interval, 0.10-0.70; P = .007) and terbutaline (hazard ratio 0.35; 95% confidence interval, 0.13-0.96; P = .041) to be independent predictors of mortality. CONCLUSIONS: We describe the largest cohort to date of patients with well-defined monoclonal gammopathy-associated systemic capillary-leak syndrome. Preventive treatment with IVIg was the strongest factor associated with survival, suggesting the use of IVIg as the first line in prevention therapy.
[Mh] Termos MeSH primário: Síndrome de Vazamento Capilar/tratamento farmacológico
Imunoglobulinas Intravenosas/uso terapêutico
Paraproteinemias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Síndrome de Vazamento Capilar/etiologia
Síndrome de Vazamento Capilar/mortalidade
Síndrome de Vazamento Capilar/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Paraproteinemias/complicações
Paraproteinemias/mortalidade
Paraproteinemias/patologia
Análise de Sobrevida
Terbutalina/uso terapêutico
Teofilina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); C137DTR5RG (Theophylline); N8ONU3L3PG (Terbutaline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28591989
[Au] Autor:Zhang X; Niu K; Xu J; Cheng M; Wang H; Ren YL; Chai LJ; Wang SX
[Ti] Título:[Clinicopathologic characteristics of light chain proximal tubulopathy].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(6):411-412, 2017 Jun 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Cadeias kappa de Imunoglobulina
Nefropatias/patologia
Túbulos Renais Proximais/patologia
Paraproteinemias/patologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin kappa-Chains)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.06.009


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[PMID]:28591035
[Au] Autor:Zdziarski P; Gamian A; Dworacki G
[Ad] Endereço:aDepartment of Clinical Immunology, Lower Silesian Center for Cellular Transplantation bL Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw cDepartment of Immunology, Poznan University of Medical Sciences, Poznan, Poland.
[Ti] Título:A case report of lymphoid intestitial pneumonia in common variable immunodeficiency: Oligoclonal expansion of effector lymphocytes with preferential cytomegalovirus-specific immune response and lymphoproliferative disease promotion.
[So] Source:Medicine (Baltimore);96(23):e7031, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Lymphoid interstitial pneumonia (LIP) is a rare disease with lymphocytic infiltration of the alveolar interstitial and air spaces, sometimes classified as a clonal lymphoproliferative disease (LPD) with high prevalence in patients with immunodysregulation. Although association of mucosa-associated lymphoid tissue (MALT) lymphoma development with infectious agents has been well described, it is not so in the case of LIP. Attempts to demonstrate an infective cause by direct microbe detection have failed, but association with atypical specific immune response to opportunistic infectious agent has not been studied. PATIENT CONCERNS AND DIAGNOSES: We performed clinical, biochemical, and immunologic analysis of patients LIP that arises primarily from the common variable immune deficiency (CVID) with normal immunoglobulin class M (IgM) level and mild infectious course as a result of immunodysregulation. At the age of 13 multiple nodules, areas of consolidation were observed and LIP was confirmed by histological examination. The progression of the disease with massive splenomegaly (17→27 cm), lymphadenopathy soft tissue infiltration coincides with high standardized uptake value (SUV was 3.1-5.2), regulatory T cells decrease (CD4+25FoxP3+ level -0.02%, i.e., 8 cells per 100 µL), oligoclonal gammapathy: very high IgM (3340 mg/dL) and ß2-microglobulin (18.8 mg/L) level observed 10 years later.Immune response polarization was observed in humoral and cellular compartment -Th and Tc-dependent: 10.8% of lymphocytes are CD8high+CMV pp65-pentamer positive cells (Epstein-Barr virus-specific not observed). Specific immune response polarization correlates with negative immunofixation, light chains κ/λ = 2.84 and narrow, but non-monoclonal T cell receptor (TCR)/ B cell receptor (BCR) repertoire. LESSONS: Taking everything into account, this case report shows that LIP is a consequence of immune-dysregulation in CVID, that is, Treg deficiency, narrow lymphocyte repertoire, and abnormal ability to respond to cytomegalovirus (CMV) antigens. It may be visualized by positron emission tomography (PET) and monitored by CMV-specific immune response, ß2-microglobulin level, and IgM paraproteinaemia, but not by immunofixation and κ/λ ratio.
[Mh] Termos MeSH primário: Imunodeficiência de Variável Comum/complicações
Doenças Pulmonares Intersticiais/etiologia
Transtornos Linfoproliferativos/complicações
[Mh] Termos MeSH secundário: Adolescente
Antígenos Virais/metabolismo
Imunodeficiência de Variável Comum/imunologia
Citomegalovirus/imunologia
Feminino
Seres Humanos
Imunoglobulina M/metabolismo
Doenças Pulmonares Intersticiais/imunologia
Linfócitos/imunologia
Transtornos Linfoproliferativos/imunologia
Bandas Oligoclonais
Paraproteinemias/etiologia
Paraproteinemias/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (Immunoglobulin M); 0 (Oligoclonal Bands)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007031


  10 / 4424 MEDLINE  
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[PMID]:28575180
[Au] Autor:Messiaen AS; De Sloovere MMW; Claus PE; Vercammen M; Van Hoovels L; Heylen O; Debrabandere J; Vanpoucke H; De Smet D
[Ad] Endereço:From the Department of Laboratory Medicine, AZ Delta Roeselare-Menen, Roeselare, Belgium.
[Ti] Título:Performance Evaluation of Serum Free Light Chain Analysis: Nephelometry vs Turbidimetry, Monoclonal vs Polyclonal Reagents.
[So] Source:Am J Clin Pathol;147(6):611-622, 2017 Jun 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: Free light chain (FLC) measurement gained a lot of interest for diagnostic workup of monoclonal gammopathy. Methods: We evaluated the performance of turbidimetric polyclonal Freelite (The Binding Site, Birmingham, UK) assays on Cobas 6000 (Roche Diagnostics, Rotkreuz, Switzerland) and nephelometric monoclonal N Latex (Siemens Healthcare Diagnostics, Marburg, Germany) assays on BN ProSpec (Dade Behring, Deerfield, IL) vs established nephelometric Freelite assays on BN ProSpec. Results: Analytical performance was acceptable. Method comparison (n = 118) showed significant proportional FLC differences for N Latex assays. However, good correlation and clinical concordance were shown. Recovery study in the low concentration range demonstrated consistent over- and underrecovery for Freelite reagents, hampering future research on prognostic value of suppressed noninvolved FLC. Antigen excess detection was successful for κ FLC in three-fourths of cases with Freelite reagents and in all cases with N Latex reagents. However, the latter resulted in underestimated κ FLC concentrations. Conclusions: FLC analysis requires continuous awareness of analytical limitations. Monitoring of disease response requires FLC analysis on the same platform using the same reagents.
[Mh] Termos MeSH primário: Cadeias Leves de Imunoglobulina/sangue
Cadeias kappa de Imunoglobulina/sangue
Cadeias lambda de Imunoglobulina/sangue
Nefelometria e Turbidimetria/métodos
Paraproteinemias/diagnóstico
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/imunologia
Seres Humanos
Cadeias Leves de Imunoglobulina/imunologia
Cadeias kappa de Imunoglobulina/imunologia
Cadeias lambda de Imunoglobulina/imunologia
Paraproteinemias/imunologia
Prognóstico
Kit de Reagentes para Diagnóstico
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Immunoglobulin Light Chains); 0 (Immunoglobulin kappa-Chains); 0 (Immunoglobulin lambda-Chains); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqx037



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