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[PMID]: 28667718 [Au] Autor: Masavkar SS; Mauskar A; Patwardhan G; Bhat V; Manglani MV [Ad] Endereço: Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. Correspondence to: Dr Sanjeevani Satish Masavkar, Associate Professor, 242/9458, Kannamwar Nagar 2, Vikhroli E, Mumbai 400 083, India. nagotkar.leena@gmail.com. [Ti] Título: Acquired Methemoglobinemia - A Sporadic Holi Disaster. [So] Source: Indian Pediatr;54(6):473-475, 2017 Jun 15. [Is] ISSN: 0974-7559 [Cp] País de publicação: India [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To study clinical profile and outcome in patients with methemoglobinemia following exposure to toxic colors during Holi festival. METHODS: This retrospective study included 112 children (5 to 12 years) admitted with methemoglobinemia after playing Holi. Clinical and treatment details were reviewed. RESULTS: The common symptoms were giddiness, vomiting and headache. Treatment included thorough skin wash, intravenous fluid and methylene blue in 111 children. Age 7-9 and > 11 years, vomiting, giddiness, cyanosis, PaO2 < 80 mm Hg and oxygen saturation < 95% were associated with higher need for methylene blue. All children had a good outcome. CONCLUSION: Timely diagnosis and management of acquired methemoglobinemia can save lives. [Mh] Termos MeSH primário: Corantes/toxicidade Férias e Feriados Metemoglobinemia [Mh] Termos MeSH secundário: Criança Pré-Escolar Cianose Inibidores Enzimáticos/administração & dosagem Inibidores Enzimáticos/uso terapêutico Feminino Hinduísmo Seres Humanos Índia Masculino Metemoglobinemia/induzido quimicamente Metemoglobinemia/diagnóstico Metemoglobinemia/tratamento farmacológico Metemoglobinemia/fisiopatologia Azul de Metileno/administração & dosagem Azul de Metileno/uso terapêutico Estudos Retrospectivos Vômito [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Coloring Agents); 0 (Enzyme Inhibitors); T42P99266K (Methylene Blue) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170702 [St] Status: MEDLINE

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[PMID]: 28440745 [Au] Autor: Vieira JL; Ferreira MES; Ferreira MVD; Gomes MM [Ad] Endereço: Pharmacy Faculty, Para Federal University, Belem, Brazil. [Ti] Título: Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due to in the Brazilian Amazon Basin. [So] Source: Am J Trop Med Hyg;96(5):1171-1175, 2017 May. [Is] ISSN: 1476-1645 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: AbstractPrimaquine is the only licensed drug available for the elimination of hypnozoites. Methemoglobinemia is currently reported in the course of treatment. There is evidence that metabolites of primaquine formed by the cytochrome pathway are responsible for methemoglobin formation; a genetic polymorphism of cytochrome isoforms; and a potential influence of gender in the activities of these enzymes requiring the establishment of dose × response curves profiles in different population groups. Concentrations of primaquine in plasma and methemoglobin levels were investigated in 54 patients with malaria due to during the course of the standard regimen of chloroquine with primaquine (0.25 mg/kg/day for 14 days). All study subjects lived in an endemic area of the Brazilian Amazon Basin. The blood samples were collected before initiation of treatment and 3 hours (range 2-4 hours) after the administration of antimalarial drugs on days 2, 7, and 14. Plasma primaquine concentrations were similar in both genders (males: range = 164-191 ng/mL, females: range = 193-212 ng/mL). Methemoglobin levels ranged from 3.3% to 5.9% in males and from 3.1% to 6.5% in females. There were no significant correlations between the plasma primaquine concentrations or total dose and methemoglobin levels, suggesting that unidentified metabolites rather than parent drug were likely responsible for changes in methemoglobin levels. There was no significant influence of gender on primaquine concentrations in plasma or methemoglobin levels. [Mh] Termos MeSH primário: Antimaláricos/sangue Cloroquina/uso terapêutico Malária Vivax/tratamento farmacológico Metemoglobina/metabolismo Primaquina/sangue [Mh] Termos MeSH secundário: Adolescente Adulto Antimaláricos/farmacocinética Brasil Esquema de Medicação Quimioterapia Combinada Feminino Seres Humanos Malária Vivax/sangue Malária Vivax/parasitologia Masculino Metemoglobinemia/sangue Metemoglobinemia/induzido quimicamente Meia-Idade Plasmodium vivax/efeitos dos fármacos Plasmodium vivax/fisiologia Primaquina/farmacocinética Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antimalarials); 886U3H6UFF (Chloroquine); 9008-37-1 (Methemoglobin); MVR3634GX1 (Primaquine) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170803 [Lr] Data última revisão: 170803 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170426 [St] Status: MEDLINE [do] DOI: 10.4269/ajtmh.15-0368

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[PMID]: 28117232 [Au] Autor: Bairy L; Hardy G; Di Gregorio M; Bihin B [Ad] Endereço: Service d'anesthésie, CHU UcL Namur, 1, avenue du Docteur-Gaston-Therasse, 5530 Yvoir, Belgique. Electronic address: laurent.bairy@uclouvain.be. [Ti] Título: [Evolution of the carboxyhemoglobinemia and methemoglobinemia during endoscopic resection: An observational study]. [Ti] Título: Évolution de la carboxyhémoglobinémie et de la méthémoglobinémie lors de résections endoscopiques : une étude observationnelle.. [So] Source: Prog Urol;27(2):98-102, 2017 Feb. [Is] ISSN: 1166-7087 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: AIM OF THE STUDY: Combustion of organic tissues due to endoscopic resection could induce methemoglobin (MetHb) and carboxyhemoglobin (COHb) formation. The aim of this study is to evaluate MetHb and COHb formation in patients undergoing prostatic or bladder endoscopic procedures. METHODS: COHb and MetHb measurements were performed in 44 patients at the beginning and end of the procedure. A third measurement was done in patients who stayed more than one hour in the recovery room. Means were compared using Student t-test, simple regressions were used for quantitative variables and ANOVA for categorical variables. Multiple linear regressions were used for multivariate analysis. RESULTS: COHb increased by 0.5±0.9 % (95 % CI: 0.2 to 0.7 % P=0.001). MetHb increase was 0.0±0.4 % (95 % CI: -0.1 to 0.2 % P=0.552). In univariate analysis, the variables associated with COHb increase are the length of surgery, the amount of irrigation fluid and location (prostate or bladder) of the procedure. In the multivariate model, COHb increase is associated with the amount of liquid and the location. CONCLUSION: MetHb did not increase during endoscopic surgery. In contrast, COHb increases, and can, in some patients, exceed 2-4 %. This could be responsible for a decreased angina threshold in patients with ischemic heart disease. LEVEL OF EVIDENCE: 4. [Mh] Termos MeSH primário: Carboxihemoglobina/análise Cistoscopia Metemoglobina/análise Ressecção Transuretral da Próstata [Mh] Termos MeSH secundário: Idoso Carboxihemoglobina/biossíntese Seres Humanos Metemoglobina/biossíntese Metemoglobinemia/sangue Período Perioperatório [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 9008-37-1 (Methemoglobin); 9061-29-4 (Carboxyhemoglobin) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170816 [Lr] Data última revisão: 170816 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170125 [St] Status: MEDLINE

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[PMID]: 27919469 [Au] Autor: Pain S; Chavant F; Fauconneau B; Guenezan J; Marjanovic N; Lardeur JY; Brunet B; Perault-Pochat MC [Ad] Endereço: Centre d'addictovigilance CEIP-A de Poitiers, service de pharmacologie clinique et vigilances, Pavillon R.-Le-Blaye, CHU de Poitiers, rue de la Milétrie, BP 577, 86021 Poitiers, France. Electronic address: stephanie.pain@univ-poitiers.fr. [Ti] Título: Dangerous intoxication after oral ingestion of poppers (alkyl nitrites): Two case reports. [So] Source: Therapie;72(3):397-399, 2017 Jun. [Is] ISSN: 0040-5957 [Cp] País de publicação: France [La] Idioma: eng [Mh] Termos MeSH primário: Nitrito de Amila/efeitos adversos Metemoglobinemia/induzido quimicamente Transtornos Relacionados ao Uso de Substâncias/complicações Vasodilatadores/efeitos adversos [Mh] Termos MeSH secundário: Administração Oral Adulto Overdose de Drogas Feminino Seres Humanos Masculino [Pt] Tipo de publicação: CASE REPORTS; LETTER [Nm] Nome de substância: 0 (Vasodilator Agents); 8017-89-8 (Amyl Nitrite) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161207 [St] Status: MEDLINE

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[PMID]: 27879543 [Au] Autor: Burtseva TE; Ammosova TN; Protopopova NN; Yakovleva SY; Slobodchikova MP [Ad] Endereço: *Yakut Science Centre of Complex Medical Problems ‡The Consultation Polyclinic of the Pediatric Center, Yakutsk §Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia †Center for Sickle Cell Disease, Howard University, Washington, DC. [Ti] Título: Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). [So] Source: J Pediatr Hematol Oncol;39(1):42-45, 2017 Jan. [Is] ISSN: 1536-3678 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Type I congenital methemoglobinemia is an autosomal recessive disorder. A high frequency of congenital methemoglobinemia has been reported among Native Americans inhabiting the Yukon-Kuskokwim Delta. Other rare cases of congenital methemoglobinemia of types I and II have been reported in Japan and other countries. In Russia-namely, in Yakutia-a high frequency of type I congenital methemoglobinemia has been reported. In 2009, the Consultation Polyclinic of the Pediatric Center in Yakutsk city established a registry of children with congenital methemoglobinemia. In total, 43 patients were registered between 2005 and 2009. The median methemoglobin level was 13.5% (ranging between 4.2% and 33.9%) and physical examination revealed cyanosis of the skin and mucus membranes. There were significant positive relationships between percentage of methemoglobin and erythrocyte count, hemoglobin concentration, and hematocrit among male patients, consistent with an upregulation of the hypoxic response. The prevalence per 100,000 children ranged from 12.7 to 47.0 in 3 geographic regions of Yakutia. Further research is needed to clarify the clinical consequences of congenital methemoglobinemia in the children of Yakutia and the reasons for the high variability in the prevalence of the condition. [Mh] Termos MeSH primário: Citocromo-B(5) Redutase/deficiência Metemoglobinemia/genética [Mh] Termos MeSH secundário: Adolescente Processamento Alternativo Criança Pré-Escolar Citocromo-B(5) Redutase/sangue Citocromo-B(5) Redutase/genética Contagem de Eritrócitos Grupos Étnicos/genética Feminino Hemoglobinas/análise Seres Humanos Lactente Masculino Metemoglobina/análise Metemoglobinemia/sangue Metemoglobinemia/epidemiologia Prevalência Estudos Retrospectivos Fatores Sexuais Sibéria/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins); 9008-37-1 (Methemoglobin); EC 1.6.2.2 (Cytochrome-B(5) Reductase) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170904 [Lr] Data última revisão: 170904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161124 [St] Status: MEDLINE

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[PMID]: 27879542 [Au] Autor: Sharma S; Srinivasaraghavan R; Krishnamurthy S [Ad] Endereço: Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. [Ti] Título: Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency. [So] Source: J Pediatr Hematol Oncol;39(1):e27-e28, 2017 Jan. [Is] ISSN: 1536-3678 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The authors herein report a 5-year-old child who presented with massive hemolysis, irritability, and cyanosis. The final diagnosis was glucose-6-phosphate dehydrogenase deficiency with associated central nervous system symptoms probably because of concomitantly acquired methemoglobinemia following oxidant drug exposure. The associated acute-onset anemia would have contributed to the development of cerebral anoxia-related seizures and encephalopathy. [Mh] Termos MeSH primário: Deficiência de Glucosefosfato Desidrogenase/complicações Humor Irritável Metemoglobinemia/etiologia Norfloxacino/efeitos adversos Oxidantes/efeitos adversos Convulsões/etiologia [Mh] Termos MeSH secundário: Doença Aguda Pré-Escolar Consanguinidade Cianose/etiologia Deficiência de Glucosefosfato Desidrogenase/diagnóstico Deficiência de Glucosefosfato Desidrogenase/genética Seres Humanos Masculino Metemoglobinemia/induzido quimicamente Metemoglobinemia/psicologia Metemoglobinemia/urina Norfloxacino/uso terapêutico Oxidantes/uso terapêutico Recidiva [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Oxidants); N0F8P22L1P (Norfloxacin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170904 [Lr] Data última revisão: 170904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161124 [St] Status: MEDLINE

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[PMID]: 27876251 [Au] Autor: Genere L; Pecciarini N; Peretti N; Villard F; Lachaux A [Ad] Endereço: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France. [Ti] Título: [Food protein-induced enterocolitis syndrome: A case report of diarrhea with hypovolemic shock and methemoglobinemia]. [Ti] Título: Syndrome d'entérocolite induite par les protéines alimentaires (SEIPA) : à propos d'une observation de diarrhée avec choc hypovolémique et méthémoglobinémie.. [So] Source: Arch Pediatr;24(1):28-32, 2017 Jan. [Is] ISSN: 1769-664X [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: We report on the case of a young infant with chronic diarrhea that worsened and turned into hypovolemic shock with methemoglobinemia. We underline and discuss the main features of food protein-induced enterocolitis syndrome (FPIES). FPIES is a non-IgE-mediated food allergy involving tumor necrosis factor-alpha (TNF-α). Many triggering foods exist but cow's milk, as in the case reported herein, is one of the most frequent. It can start early or be delayed and start around the average age of 5 months. Symptoms are nonspecific with diarrhea and vomiting, but in the presence of methemoglobinemia, the diagnosis must be seriously considered. The oral food challenge remains the gold standard to confirm the diagnosis if there is still a doubt. Treatment of FPIES associates emergency treatment of acute dehydration with the prevention of relapses by avoiding the suspected protein. [Mh] Termos MeSH primário: Enterocolite/etiologia Hipersensibilidade Alimentar/complicações Proteínas do Leite/efeitos adversos [Mh] Termos MeSH secundário: Diarreia/etiologia Feminino Seres Humanos Lactente Metemoglobinemia/etiologia Choque/etiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Milk Proteins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161124 [St] Status: MEDLINE

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[PMID]: 27863456 [Au] Autor: Kedar P; Desai A; Warang P; Colah R [Ad] Endereço: a National Institute of Immunohematology (Indian Council of Medical Research) , Mumbai , India. [Ti] Título: A microplate reader-based method to quantify NADH-cytochrome b5 reductase activity for diagnosis of recessive congenital methaemoglobinemia. [So] Source: Hematology;22(4):252-257, 2017 May. [Is] ISSN: 1607-8454 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Congenital methemoglobinemia due to NADH-cytochrome b5 reductase 3 (CYB5R3) deficiencies is an autosomal recessive disorder that occurs sporadically worldwide, A sensitive, accurate, and rapid analysis of NADH-CYB5R enzyme concentrations is necessary for the diagnosis of RCM. Here we present an alternative microplate method that is based on a standard 96-well microplate format and microplate reader that simplify the quantification of NADH-CYB5R activity. METHODS: TECAN (Infinite 200 PRO series) microplate reader with Tecan's proven Magellan™ software measured the NADH-CYB5R enzyme activity in 250 normal controls and previously diagnosed 25 cases of RCM due to NADH-CYB5R deficiency in the Indian population using 96-well microplates using 200 µl of total reaction mixture and also compared with standard spectrophotometric assay. We have also studied stability of the hemolysate stored at 4 and -20°C temperature. RESULTS AND DISCUSSION: Enzyme activity in all 25 samples ranged from 6.09 to 10.07 IU/g Hb (mean ± SD: 8.08 ± 1.99 IU/g Hb) where as normal control ranged (n = 250) between 13.42 and 21.58 IU/g Hb) (mean ± SD: 17.5 ± 4.08 IU/g of Hb). Data obtained from the microplate reader were compared with standard spectrophotometer method and found 100% concordance using both methods. Microplate method allows differentiating between normal, deficient and intermediate enzyme activity. It was observed that samples had significant loss of activity when stored at 4°C and retained stable activity at -20°C for 1 week time. CONCLUSION: Our new method, incorporating a whole process of enzyme assay into a microplate format is readily applicable and allows rapid monitoring of enzyme assay. It is readily applicable to quantitative assay on pediatric sample as well as large number of samples for population screening. [Mh] Termos MeSH primário: Citocromo-B(5) Redutase/metabolismo Metemoglobinemia/diagnóstico Metemoglobinemia/enzimologia [Mh] Termos MeSH secundário: Adolescente Adulto Criança Feminino Seres Humanos Masculino Meia-Idade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: EC 1.6.2.2 (Cytochrome-B(5) Reductase) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170512 [Lr] Data última revisão: 170512 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161120 [St] Status: MEDLINE [do] DOI: 10.1080/10245332.2016.1252873

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[PMID]: 27693073 [Au] Autor: Allister LM; Torres C; Schnall J; Bhatia K; Miller ES [Ad] Endereço: Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts. [Ti] Título: Jaundice, Anemia, and Hypoxemia. [So] Source: J Emerg Med;52(1):93-97, 2017 01. [Is] ISSN: 0736-4679 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Anemia/etiologia Deficiência de Glucosefosfato Desidrogenase/complicações Deficiência de Glucosefosfato Desidrogenase/diagnóstico Hipóxia/etiologia Icterícia/etiologia [Mh] Termos MeSH secundário: Dor Abdominal/etiologia Antioxidantes/farmacologia Antioxidantes/uso terapêutico Ácido Ascórbico/farmacologia Ácido Ascórbico/uso terapêutico Pré-Escolar Tosse/etiologia Citocromo-B(5) Redutase/farmacologia Citocromo-B(5) Redutase/uso terapêutico Diagnóstico Diferencial Serviço Hospitalar de Emergência/organização & administração Cefaleia/etiologia Seres Humanos Unidades de Terapia Intensiva/organização & administração Masculino Metemoglobinemia/etiologia Azul de Metileno/farmacologia Azul de Metileno/uso terapêutico Marrocos/etnologia Oxigenoterapia/métodos Estados Unidos Vicia faba/efeitos adversos [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); EC 1.6.2.2 (Cytochrome-B(5) Reductase); PQ6CK8PD0R (Ascorbic Acid); T42P99266K (Methylene Blue) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161004 [St] Status: MEDLINE

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[PMID]: 27624601 [Au] Autor: Smith PA; Lodwick J; Dartt J; Amani JR; Fagan KM [Ad] Endereço: a U.S. Department of Labor - OSHA , Health Response Team , Sandy , Utah. [Ti] Título: Methemoglobinemia resulting from exposure in a confined space: Exothermic self-polymerization of 4,4'-methylene diphenyl diisocyanate (MDI) material. [So] Source: J Occup Environ Hyg;14(1):D13-D21, 2017 01. [Is] ISSN: 1545-9632 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A worker attempting to remove solidified material inside a confined space (storage tank) suffered severe methemoglobinemia and almost died. The tank contained liquid 4,4'-methylene diphenyl diisocyanate monomer that had solidified after an equipment power failure caused excessive heating. Wearing a full-face elastomeric air-purifying respirator and Tyvek® coveralls, the worker used pneumatic air hammers to break up the solid material. After two tank entries totaling slightly less than one hour, the worker complained of headache and dizziness and within two hours of exiting the tank, he was admitted to the hospital in severe respiratory distress. During his eight-week hospital course, he suffered a cardiac arrest among other complications. An investigation into the cause of the worker's illness used onsite gas chromatography-mass spectrometry which identified aniline and p-toluidine vapor within the tank, attributable to overheating that led to formation of the solid material. Both are well-known causes of methemoglobinemia, and had the initial characterization of the confined space atmosphere adequately identified the hazards present appropriate engineering controls and personal protective equipment could have allowed the tank entrant to work safely in the space. [Mh] Termos MeSH primário: Espaços Confinados Isocianatos/toxicidade Metemoglobinemia/induzido quimicamente Doenças Profissionais/induzido quimicamente Exposição Ocupacional/análise [Mh] Termos MeSH secundário: Adulto Seres Humanos Isocianatos/análise Isocianatos/química Masculino Estados Unidos United States Occupational Safety and Health Administration [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Isocyanates); 101-68-8 (4,4'-diphenylmethane diisocyanate) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171120 [Lr] Data última revisão: 171120 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160915 [St] Status: MEDLINE

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