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[PMID]: 29318368 [Au] Autor: Mirlohi MS; Yaghooti H; Shirali S; Aminasnafi A; Olapour S [Ad] Endereço: Hyperlipidemia Research Center, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [Ti] Título: Increased levels of advanced glycation end products positively correlate with iron overload and oxidative stress markers in patients with ß-thalassemia major. [So] Source: Ann Hematol;97(4):679-684, 2018 Apr. [Is] ISSN: 1432-0584 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The impaired biosynthesis of the ß-globin chain in ß-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major ß-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects. Metabolic parameters including glycemic and iron indices, hepatic and renal functions tests, oxidative stress markers, and AGEs (carboxymethyl-lysine and pentosidine) levels were measured. All parameters were significantly increased in ß-thalassemia compared to the control except for glutathione levels. Blood glucose, iron, serum ferritin, non-transferrin-bound iron (NTBI), MDA, soluble form of low-density lipoprotein receptor, glutathione peroxidase, total reactive oxygen species (ROS), and AGE levels were significantly higher in the ß-thalassemia patients. Iron and ferritin showed a significant positive correlation with pentosidine (P < 0.01) but not with carboxymethyl-lysine. The NTBI was markedly increased in the ß-thalassemia patients, and its levels correlated significantly with both carboxymethyl-lysine and pentosidine (P < 0.05). Our findings confirm the oxidative status generated by the iron overload in ß-thalassemia major patients and highlight the enhanced formation of AGEs, which may play an important role in the pathogenesis of ß-thalassemia major. [Mh] Termos MeSH primário: Transfusão de Sangue Produtos Finais de Glicação Avançada/sangue Sobrecarga de Ferro/etiologia Estresse Oxidativo Reação Transfusional/fisiopatologia Talassemia beta/sangue [Mh] Termos MeSH secundário: Adolescente Adulto Biomarcadores/sangue Terapia por Quelação/efeitos adversos Terapia Combinada/efeitos adversos Estudos Transversais Desferroxamina/uso terapêutico Feminino Seres Humanos Irã (Geográfico) Sobrecarga de Ferro/prevenção & controle Masculino Piridonas/uso terapêutico Receptores Depuradores Classe E/sangue Adulto Jovem Talassemia beta/terapia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Glycation End Products, Advanced); 0 (OLR1 protein, human); 0 (Pyridones); 0 (Scavenger Receptors, Class E); 2BTY8KH53L (deferiprone); J06Y7MXW4D (Deferoxamine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180111 [St] Status: MEDLINE [do] DOI: 10.1007/s00277-017-3223-3

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[PMID]: 29293197 [Au] Autor: DeLisle J [Ad] Endereço: BloodCenter of Wisconsin, Milwaukee, Wisconsin. Julie DeLisle, MSN, RN, is the transfusion safety and blood management officer for BloodCenter of Wisconsin, where she works with health care organizations on blood management initiatives. [Ti] Título: Is This a Blood Transfusion Reaction? Don't Hesitate; Check It Out. [So] Source: J Infus Nurs;41(1):43-51, 2018 Jan/Feb. [Is] ISSN: 1539-0667 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Blood transfusions can be lifesaving. The majority are completed without incident. However, every transfusion recipient runs the risk of developing a transfusion reaction or adverse event. These reactions can be acute, occurring during or soon after transfusion, or delayed, occurring days to weeks later. Nurses need to be able to recognize and respond to these reactions appropriately. [Mh] Termos MeSH primário: Transfusão de Sangue Reação Transfusional/enfermagem [Mh] Termos MeSH secundário: Transfusão de Sangue/enfermagem Seres Humanos Recursos Humanos de Enfermagem no Hospital [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE [do] DOI: 10.1097/NAN.0000000000000261

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[PMID]: 28470756 [Au] Autor: Roubinian NH; Looney MR; Keating S; Kor DJ; Lowell CA; Gajic O; Hubmayr R; Gropper M; Koenigsberg M; Wilson GA; A Matthay M; Toy P; Murphy EL; TRALI Study Group [Ad] Endereço: Blood Systems Research Institute. [Ti] Título: Differentiating pulmonary transfusion reactions using recipient and transfusion factors. [So] Source: Transfusion;57(7):1684-1690, 2017 07. [Is] ISSN: 1537-2995 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: It is increasingly recognized that recipient risk factors play a prominent role in possible transfusion-related acute lung injury (pTRALI) and transfusion-associated circulatory overload (TACO). We hypothesized that both transfusion and recipient factors including natriuretic peptides could be used to distinguish TRALI from TACO and pTRALI. STUDY DESIGN AND METHODS: We performed a post hoc analysis of a case-control study of pulmonary transfusion reactions conducted at the University of California at San Francisco and Mayo Clinic, Rochester. We evaluated clinical data and brain natriuretic peptides (BNP) levels drawn after transfusion in patients with TRALI (n = 21), pTRALI (n = 26), TACO (n = 22), and controls (n = 24). Logistic regression and receiver operating characteristics curve analyses were used to determine the accuracy of clinical and biomarker predictors in differentiating TRALI from TACO and pTRALI. RESULTS: We found that pTRALI and TACO were associated with older age, higher fluid balance, and elevated BNP levels relative to those of controls and TRALI. The following variables were useful in distinguishing cases of pTRALI and TACO from TRALI: age more than 70 years, BNP levels more than 1000 pg/mL, 24-hour fluid balance of more than 3 L, and a lower number of transfused blood components. Using the above variables, our logistic model had a 91% negative predictive value in the differential diagnosis of TRALI. CONCLUSIONS: Models incorporating readily available clinical and biomarker data can be used to differentiate transfusion-related respiratory complications. Additional studies examining recipient risk factors and the likelihood of TRALI may be useful in decision making regarding donor white blood cell antibody testing. [Mh] Termos MeSH primário: Lesão Pulmonar Aguda/etiologia Reação Transfusional/etiologia [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seres Humanos Modelos Logísticos Masculino Meia-Idade Peptídeo Natriurético Encefálico/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 114471-18-0 (Natriuretic Peptide, Brain) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1111/trf.14118

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[PMID]: 28470742 [Au] Autor: Lee DD; Muskaj I; Savage W [Ad] Endereço: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts. [Ti] Título: Platelet proteins cause basophil histamine release through an immunoglobulin-dependent mechanism. [So] Source: Transfusion;57(7):1709-1716, 2017 07. [Is] ISSN: 1537-2995 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: A general understanding of allergic transfusion reaction mechanisms remains elusive. Multiple mechanisms have been proposed, but none have been compared experimentally. STUDY DESIGN AND METHODS: We used histamine release (HR) from healthy human donor basophils to model allergic transfusion reactions. Platelet component supernatant (plasma), platelet lysate, and manipulated platelet lysates (dialyzed, delipidated, trypsinized, mild heat-inactivated, and ultracentrifuged) were used to characterize allergic stimuli. Immunoglobulin-dependent mechanisms were investigated through cell surface immunoglobulin depletion and ibrutinib signaling inhibition. HR induced by platelet mitochondria was compared with HR by platelet lysate with or without DNase treatment. RESULTS: Robust, dose-responsive HR to platelet lysate was observed in two of eight nulliparous, never-transfused, healthy donors. No HR was observed with plasma. Among manipulated platelet lysates, only trypsin treatment significantly reduced HR (39% reduction; p = 0.008). HR in response to platelet lysate significantly decreased with either cell surface immunoglobulin depletion or ibrutinib pretreatment. Platelet mitochondria induced minimal basophil HR, and DNase treatment did not inhibit platelet lysate-induced HR. CONCLUSION: Type I immediate hypersensitivity to platelet proteins may be an allergic transfusion reaction mechanism. Prior sensitization to human proteins is not required for basophil responses to platelet proteins. Further study into the relative contributions of hypersensitivity to platelet versus plasma proteins in transfusion is warranted. [Mh] Termos MeSH primário: Basófilos/fisiologia Plaquetas/imunologia Proteínas Sanguíneas/imunologia Liberação de Histamina Hipersensibilidade Imediata/etiologia Imunoglobulina E/imunologia Reação Transfusional/etiologia [Mh] Termos MeSH secundário: Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Blood Proteins); 37341-29-0 (Immunoglobulin E) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1111/trf.14126

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[PMID]: 27774649 [Au] Autor: Tezuka K; Kuramitsu M; Okuma K; Nojima K; Araki K; Shinohara N; Matsumoto C; Satake M; Takasaki T; Saijo M; Kurane I; Hamaguchi I [Ad] Endereço: Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan. [Ti] Título: Development of a novel dengue virus serotype-specific multiplex real-time reverse transcription-polymerase chain reaction assay for blood screening. [So] Source: Transfusion;56(12):3094-3100, 2016 12. [Is] ISSN: 1537-2995 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Dengue fever is caused by four related RNA viruses of the genus Flavivirus, dengue virus (DENV)-1, -2, -3, and -4, which are transmitted to humans by mosquitoes. Although DENV is not endemic in Japan, an autochthonous dengue outbreak occurred in 2014. Several transfusion-transmitted cases have also been reported after the use of blood and plasma products in DENV-endemic countries. The aim of this study was to develop a novel multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for DENV blood screening. STUDY DESIGN AND METHODS: Large-scale oligonucleotide screening was performed to obtain DENV-specific primers and probes using a variety of DENV clinical isolates. A multiplex RT-PCR assay was then developed using the identified oligonucleotides and the ability of this assay to detect DENV RNA was evaluated. RESULTS: A number of oligonucleotides suitable for DENV RNA detection were identified and a novel DENV serotype-specific multiplex RT-PCR assay was successfully established. Comparative analysis revealed that the multiplex assay could detect levels of viral contamination as low as 100 viral copies/mL. CONCLUSION: This established serotype-specific multiplex RT-PCR assay provides a simple, sensitive, and quantitative detection method for DENV, which could be applied in the screening of blood samples to prevent transfusion-transmitted DENV infection. [Mh] Termos MeSH primário: Vírus da Dengue/genética Dengue/diagnóstico Reação em Cadeia da Polimerase/métodos Sorogrupo Reação Transfusional [Mh] Termos MeSH secundário: Segurança do Sangue Dengue/prevenção & controle Dengue/transmissão Seres Humanos Reação em Cadeia da Polimerase Multiplex RNA Viral/análise RNA Viral/sangue Reação em Cadeia da Polimerase em Tempo Real [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (RNA, Viral) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161028 [St] Status: MEDLINE [do] DOI: 10.1111/trf.13875

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[PMID]: 27774621 [Au] Autor: Schulz U; Reil A; Kiefel V; Bux J; Moog R [Ad] Endereço: DRK Blood Service North-East, Cottbus, Germany. [Ti] Título: Evaluation of a new microbeads assay for granulocyte antibody detection. [So] Source: Transfusion;57(1):70-81, 2017 01. [Is] ISSN: 1537-2995 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: To reduce the risk of transfusion-associated acute lung injury (TRALI), a high number of plasma donors were tested for human leukocyte antigen (HLA) and human neutrophil antigen (HNA) antibodies. For HNA antibody detection, the gold standard is a combination of the granulocyte immunofluorescence test (GIFT) and the granulocyte agglutination test (GAT). However, these tests are not suitable for a high-throughput of samples. STUDY DESIGN AND METHODS: To evaluate the new generation of the LABScreen MULTI assay (One Lambda, Inc.), which has special new beads for all the known HNA specificities, including HNA-3a, 97 sera samples containing well-defined HNA antibodies were used. For background testing, we used 91 samples from plasma donors previously identified by GAT, GIFT, and the monoclonal antibody-specific immobilization of granulocyte antigens (MAIGA) assay. RESULTS: Compared with previous tests, the new LABScreen MULTI assay was highly specific for the HNA-1a, HNA-1b, HNA-2, and HNA-3a antibody specificities required to prevent TRALI. Ninety-eight percent of the HNA-1a, HNA-1b, and HNA-2 antibodies could be detected as true positive; and 90% of the HNA-3a antibodies were recognized correctly as positive. False-positive reactions were identified in 5.5% of samples that previously tested negative. CONCLUSION: The detection of HNA-3a antibody specificities could be integrated into the new LABScreen MULTI assay; however, we detected only 90%. In addition, we detected further HNA antibodies, such as HNA-1c, HNA-1d, and some HNA-3b and HNA-4a antibodies. The new generation of LABScreen MULTI is a great step toward feasible high-throughput testing for HNA antibodies. Nevertheless, GIFT and GAT remain the gold-standard methods for the differentiation of rare and currently unknown HNA specificities. [Mh] Termos MeSH primário: Autoanticorpos/sangue Isoantígenos/sangue Microesferas [Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/sangue Lesão Pulmonar Aguda/etiologia Lesão Pulmonar Aguda/prevenção & controle Testes de Aglutinação/métodos Anticorpos Monoclonais/química Feminino Técnica Direta de Fluorescência para Anticorpo/métodos Seres Humanos Masculino Reação Transfusional [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Monoclonal); 0 (Autoantibodies); 0 (Isoantigens) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE [do] DOI: 10.1111/trf.13878

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[PMID]: 29377071 [Au] Autor: Rees DC; Robinson S; Howard J [Ad] Endereço: Department of Haematological Medicine, King's College Hospital, King's College London, London, UK. [Ti] Título: How I manage red cell transfusions in patients with sickle cell disease. [So] Source: Br J Haematol;180(4):607-617, 2018 02. [Is] ISSN: 1365-2141 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Sickle cell disease is one of the commonest serious inherited diseases in the world, and red cell transfusion is still one of the few effective treatments for acute and chronic complications. Transfusion corrects anaemia and dilutes out the number of red cells able to cause vaso-occlusion and vascular damage. Urgent red cell transfusions are used to correct acute anaemia, treat acute chest syndrome and patients with acute neurological symptoms. We use elective transfusions preoperatively for moderate risk surgery, and in some pregnant women. There is good evidence for the use of long-term regular transfusions in primary stroke prevention, with the aim of keeping the percentage of sickle haemoglobin below 30%. Long-term transfusions are also used in secondary stroke prevention, and the management of progressive organ damage, including renal impairment and pulmonary hypertension. Blood needs to be matched for ABO, RH and Kell, although alloantibodies may still develop and require more careful, extended cross-matching. Delayed haemolytic transfusion reactions are relatively common, difficult to diagnose and manage, and potentially fatal. [Mh] Termos MeSH primário: Anemia Falciforme/terapia Transfusão de Eritrócitos [Mh] Termos MeSH secundário: Fatores Etários Anemia Falciforme/complicações Anemia Falciforme/diagnóstico Anemia Falciforme/etiologia Doadores de Sangue Gerenciamento Clínico Transfusão de Eritrócitos/efeitos adversos Transfusão de Eritrócitos/métodos Genótipo Seres Humanos Disseminação de Informação Isoanticorpos/sangue Isoanticorpos/imunologia Fenótipo Fatores de Tempo Reação Transfusional Conduta Expectante [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Isoantibodies) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180130 [St] Status: MEDLINE [do] DOI: 10.1111/bjh.15115

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[PMID]: 28449225 [Au] Autor: Bates I; Hassall O; Mapako T [Ad] Endereço: Capacity Research Unit, Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK. [Ti] Título: Transfusion research priorities for blood services in sub-Saharan Africa. [So] Source: Br J Haematol;177(6):855-863, 2017 06. [Is] ISSN: 1365-2141 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Evidence to support many blood transfusion policies and practices in sub-Saharan Africa (SSA) is weak or lacking. SSA cannot extrapolate from wealthy countries' research findings because its environment, users and structures are very different and SSA has critical blood shortages. SSA needs to generate its own evidence but research funds are very scarce and need to be carefully targeted to match need. This study aimed to define this need by determining research priorities for blood services in SSA. Thirty-five stakeholders representing diverse blood services' interests and expertise participated in a workshop. An adapted 'consensus development method' was used to identify, agree and justify research priorities under five themes through small group and plenary discussion, and cumulative voting. Research priorities covered traditional research areas, such as clinical use of blood and infection screening, but also highlighted many new, under-researched topics, mostly concerning blood service 'systems', such as economics, blood components and regulation. Lack of electronic information management systems was an important hindrance to the blood services' ability to generate robust research data. This study has identified and prioritised novel research that will help blood services in SSA to address their own needs including their most urgent problem: the lack of access to adequate blood supplies. To catalyse this research blood services in SSA need to enhance their capacity to conduct, commission and manage research and to strengthen their collaborations within and beyond Africa. [Mh] Termos MeSH primário: Pesquisa Biomédica/métodos Transfusão de Sangue/normas [Mh] Termos MeSH secundário: África ao Sul do Saara Doadores de Sangue/provisão & distribuição Assistência à Saúde/organização & administração Medicina Baseada em Evidências/métodos Seres Humanos Reação Transfusional [Pt] Tipo de publicação: CONSENSUS DEVELOPMENT CONFERENCE; JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 180209 [Lr] Data última revisão: 180209 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170428 [St] Status: MEDLINE [do] DOI: 10.1111/bjh.14577

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[PMID]: 29095312 [Au] Autor: Kang FB; Wang L; Sun DX [Ad] Endereço: aLiver Disease Diagnosis and Treatment Center, Bethune International Peace Hospital bOrthopedic Research Institute, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. [Ti] Título: Hepatitis B virus infection in an HBsAb-positive lymphoma patient who received chemotherapy: A case report. [So] Source: Medicine (Baltimore);96(44):e8518, 2017 Nov. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Tumor chemotherapy could weaken the immune system of patients, which might enhance the body sensitivities to the exogenous pathogens, among which the hepatitis B virus (HBV) infection should be concerned because of the higher chances of infection and the severe outcomes, especially in East Asia. The titer level of hepatitis B surface antibody (HBsAb) higher than 10 IU/L is considered to offer immunocompetent individuals adequate protection. However, whether this level is enough to the tumor patients during chemotherapy remains unclear. PATIENT CONCERNS: A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. The patient just finished a course of chemotherapy with CHOP regimen and had recent record (78.61 IU/L) of HBsAb positive. The only risk of infection we could found was that the patient had received blood transfusion shortly after chemotherapy from a donor who was recovering from an asymptomatic acute HBV infection. INTERVENTION: The patient was administered with entecavir and glycyrrhizic acid agent, and then the disease was resolved successfully with hepatitis B surface antigen serological conversion. LESSONS: Tumor chemotherapy might have weakened the immune system of the patient and enhanced the body sensitivities to hepatitis B virus, then led to the infection. We concluded that HBsAb-positive status, at least "weakly positive," might not enough to provide protection for tumor patients on chemotherapy though this level was enough for health individuals and donors recuperating from subclinical acute hepatitis B might be another potential risk of HBV infection. [Mh] Termos MeSH primário: Anticorpos Anti-Hepatite B/sangue Antígenos de Superfície da Hepatite B/imunologia Vírus da Hepatite B/imunologia Hepatite B/imunologia Linfoma/imunologia [Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Antivirais/uso terapêutico Ciclofosfamida/uso terapêutico Doxorrubicina/uso terapêutico Feminino Guanina/análogos & derivados Guanina/uso terapêutico Hepatite B/etiologia Hepatite B/virologia Seres Humanos Linfoma/tratamento farmacológico Linfoma/virologia Meia-Idade Prednisolona/uso terapêutico Reação Transfusional Vincristina/uso terapêutico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiviral Agents); 0 (Hepatitis B Antibodies); 0 (Hepatitis B Surface Antigens); 5968Y6H45M (entecavir); 5J49Q6B70F (Vincristine); 5Z93L87A1R (Guanine); 80168379AG (Doxorubicin); 8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171103 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008518

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[PMID]: 28953438 [Au] Autor: Carson JL; Triulzi DJ; Ness PM [Ad] Endereço: From the Department of Medicine, Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ ( J.L.C.); the Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh (D.J.T.); and the Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore (P.M.N.). [Ti] Título: Indications for and Adverse Effects of Red-Cell Transfusion. [So] Source: N Engl J Med;377(13):1261-1272, 2017 09 28. [Is] ISSN: 1533-4406 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Transfusão de Eritrócitos Reação Transfusional [Mh] Termos MeSH secundário: Adulto Doenças Cardiovasculares/terapia Criança Transfusão de Eritrócitos/efeitos adversos Transfusão de Eritrócitos/normas Transfusão de Eritrócitos/estatística & dados numéricos Hemorragia Gastrointestinal/terapia Hemoglobinas/análise Seres Humanos Guias de Prática Clínica como Assunto [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Nm] Nome de substância: 0 (Hemoglobins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE [do] DOI: 10.1056/NEJMra1612789

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