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[PMID]:29203744
[Au] Autor:Tkachenko PI; Dobroskok VO; Korotych NM; Kolisnyk IA
[Ad] Endereço:Higher State Educational Establishment Of Ukraine " Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
[Ti] Título:Differences in clinical manifestations of odontogenic and non-odontogenic lymphadenitis.
[So] Source:Wiad Lek;70(5):930-933, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The acute suppurative lymphadenitis and its chronic forms prevail in the structure of inflammatory processes of the maxillofacial area in children. High incidence of the acute and chronic forms of lymphadenitis of both odontogenic and nonodontogenic origin is caused by the anotomophysiological peculiarities of the structure of the teeth and soft tissues in children in different age periods. THE AIM: The paper was aimed at comparison of clinical manifestations of the acute and chronic odontogenic and non-odontogenic lymphadenitis. MATERIALS AND METHODS: The results of the checkup and 5-year-period treatment of 324 children with the acute and chronic forms of the nonspecific lymphadenitis of the maxilifacial area have been used. Four study groups have been formed. The first and the second group included 16 (38,0%) and 26 (62%) children with the acute submandibular suppurative lymphadenitis of the odontogenic and nonodontogenic origin, respectively. 12 (35,3%) and 22 (64,7) individuals with chronic hyperplastic lymphadenitis have been assigned to the third and the fourth group, respectively. RESULTS: The clinical course of the acute submandibular suppurative lymphadenitis of various etiologies is different. Rapid development of the local clinical manifestations with its dramatic progressing is specific to odontogenic lymphadenitis. Its clinical course is characterized by the more apparent overall response of the body, increase of the body temperature, and these symptoms are more manifested than in nonodontogenic lymphadenitis. The clinical course of chronic hyperplastic lymphadenitis is accompanied by the enlarged regional lymph nodes of various size and shapes and dense-elastic consistency. Clinical manifestations of nonodontogenic lymphadenitis were less apparent and the overall sate was normal in both forms of lymphadenitis. CONCLUSIONS: Nonodontogenic lymphadenitis prevailed in all nosological forms of the acute and chronic nonspecific lymphadenitis.
[Mh] Termos MeSH primário: Linfadenite/diagnóstico
Cistos não Odontogênicos/diagnóstico
Cistos Odontogênicos/diagnóstico
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Feminino
Seres Humanos
Linfadenite/complicações
Masculino
Cistos não Odontogênicos/complicações
Cistos Odontogênicos/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29390337
[Au] Autor:González Saldaña N; Galvis Trujillo DM; Borbolla Pertierra AM; Mondragón Pineda AI; Juárez Olguín H
[Ad] Endereço:Department of Infectology, National Institute of Pediatrics.
[Ti] Título:Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.
[So] Source:Medicine (Baltimore);96(50):e9200, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Neuroinfection and other central nervous system affections were discarded. An adverse effect related to treatment with linezolid was suspected, and linezolid was suspended. The symptoms subsided after discontinuation; however, the patient continued to show decreased visual acuity of the left eye, assessed by his ability to count 2 fingers. The right eye remained unaffected. CONCLUSIONS: Neurotoxicity can be decreased by reducing the total dose of linezolid or by administrating it in an intermittent form. To avoid progression and loss of vision, we suggest frequent periodic ophthalmological evaluation in patients treated with linezolid.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Linezolida/efeitos adversos
Linfadenite/tratamento farmacológico
Linfadenite/microbiologia
Infecções por Micobactéria não Tuberculosa/tratamento farmacológico
Infecções por Micobactéria não Tuberculosa/microbiologia
Doenças do Nervo Óptico/induzido quimicamente
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Micobactérias não Tuberculosas
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); ISQ9I6J12J (Linezolid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009200


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[PMID]:29177266
[Au] Autor:Lu J; Fang Q; Ma C; Su F; Chen G; Huang M; Wang W; Su X
[Ad] Endereço:Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, No.201 Hubin South Road, Xiamen 361004, China. suxinhuii@163.com.
[Ti] Título:Atypical Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis simulating lymphadenitis on F-FDG PET/CT and its differential diagnosis.
[So] Source:Hell J Nucl Med;20(3):254-257, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Diagnosis of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is challenging as its clinical presentation is atypical. Here we present a case of atypical EBV-HLH simulating lymphadenitis on fluorrine-18-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT), with a view to consider this kind of EBV-HLH as a possible differential diagnosis in lymphadenitis. A 68 years old male who had episodic fever accompanied by weight loss and weakness for two weeks was studied. Finally, biopsies in bone marrow and spleen revealed hemophagocytic cells. He was diagnosed with EBV-HLH and treated with etoposide and prednisone. His condition started improving soon, and his abnormal laboratory findings were normalized at day 15. He remained in good clinical condition at 3 months follow-up after hospital discharge.
[Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/diagnóstico por imagem
Fluordesoxiglucose F18
Linfadenite/diagnóstico por imagem
Linfo-Histiocitose Hemofagocítica/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Feminino
Seres Humanos
Linfadenite/patologia
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910612


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[PMID]:29238033
[Au] Autor:Alkourbah Y; Torabi A; Ghaith T; Nahleh Z
[Ad] Endereço:Department of Internal Medicine, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA.
[Ti] Título:Dermatopathic Lymphadenitis Mimicking Breast Cancer with Lymphatic Metastasis: A Case Report and Discussion.
[So] Source:Am J Case Rep;18:1330-1333, 2017 Dec 14.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Dermatopathic lymphadenitis is a rare benign lymphatic hyperplasia commonly associated with exfoliative or eczematoid dermatitis. Of interest, this condition can be confused with lymphatic metastasis in adults. CASE REPORT In this report, we describe the case of a 56-year-old woman diagnosed with left breast invasive ductal carcinoma in remission, who presented with dermatopathic lymphadenitis mimicking breast cancer recurrence. CONCLUSIONS Dermatopathic lymphadenitis is a benign entity that needs to be considered in the differential diagnosis of lymphadenopathy. Pursuing extensive workup in asymptomatic patients with a similar presentation and initial negative tests for malignancy recurrence is not recommended.
[Mh] Termos MeSH primário: Linfadenite/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias da Mama/diagnóstico
Diagnóstico Diferencial
Eosinófilos/patologia
Feminino
Seres Humanos
Linfadenite/patologia
Metástase Linfática/diagnóstico
Macrófagos/patologia
Meia-Idade
Recidiva Local de Neoplasia/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:29025965
[Au] Autor:Hatipoglu N; Güvenç BH; Deswarte C; Koksalan K; Boisson-Dupuis S; Casanova JL; Bustamante J
[Ad] Endereço:Pediatrics Unit and naydin9@mynet.com.
[Ti] Título:Inherited IL-12Rß1 Deficiency in a Child With BCG Adenitis and Oral Candidiasis: A Case Report.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tuberculosis is a major worldwide problem, and protection from it is achieved mainly by live attenuated bacille Calmette-Guérin vaccine, which is capable of causing disease in immunocompromised host. Oral thrush is abnormal in healthy children, which suggests an underlying immunodeficiency. Mendelian susceptibility to mycobacterial disease is a rare primary immunodeficiency characterized by a selective predisposition to weakly virulent and and also predisposition to chronic mucocutaneous candidiasis. Interleukin 12 receptor ß1 (IL-12Rß1) deficiency is the most common disease of Mendelian susceptibility to mycobacterial disease, and to date only 50 IL-12Rß1 deficient patients with clinical signs of chronic mucocutaneous candidiasis have been reported. We report a 2.5-year-old daughter of consanguineous parents with both regional bacille Calmette-Guérin lymphadenitis and recurrent oral candidiasis carrying biallelic R175W mutation in the gene, resulting in complete loss of expression of IL-12Rß1. To our knowledge, this is the first report of bacille Calmette-Guérin lymphadenitis with concurrent oral candidiasis displaying such a mutation. New mutations and wide clinical diversities are the indisputable fact of populations with a high rate of consanguineous marriages.
[Mh] Termos MeSH primário: Vacina BCG/efeitos adversos
Candidíase Bucal/diagnóstico por imagem
Linfadenite/diagnóstico por imagem
Receptores de Interleucina-12/deficiência
[Mh] Termos MeSH secundário: Candidíase Bucal/genética
Pré-Escolar
Feminino
Seres Humanos
Linfadenite/induzido quimicamente
Linfadenite/complicações
Linfadenite/genética
Linhagem
Receptores de Interleucina-12/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCG Vaccine); 0 (IL12RB1 protein, human); 0 (Receptors, Interleukin-12)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


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[PMID]:28592745
[Au] Autor:Kawamoto K; Miyoshi H; Suzuki T; Muto R; Yamada K; Yanagida E; Koshino M; Sasaki Y; Takizawa J; Sone H; Sugita Y; Seto M; Ohshima K
[Ad] Endereço:Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University.
[Ti] Título:Clinicopathological features of cryptococcal lymphadenitis and a review of literature.
[So] Source:J Clin Exp Hematop;57(1):26-30, 2017 Jul 05.
[Is] ISSN:1880-9952
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Cryptococcosis is an invasive fungal infection in immunocompromised patients. The clinicopathological characteristics of cryptococcal lymphadenitis are not well known. We analyzed three cases of cryptococcal lymphadenitis and compared their characteristics with those in previous reports. Two patients were human immunodeficiency virus (HIV) carriers, and one patient was a human T-cell leukemia virus type-1 (HTLV-1) carrier. The age of the HTLV-1 carrier with cryptococcosis was much higher than that of the HIV-1 carriers. CD4-positive cell counts in peripheral blood were 5.8/µL (Case 1) and 79.9/µL (Case 2) in the HIV carriers and 3285/µL in the HTLV-1 carrier (Case 3). According to flow cytometric analysis of the lymph nodes of Cases 1, 2, and 3, 50.0%, 87.1%, and 85.9%, respectively, of the T-cells were CD3; 9.8%, 16.3%, and 75.8%, respectively, were CD4; and 35.5%, 77.3%, and 10.2%, respectively, were CD8. Cryptococcus neoformans was detected in tissue culture in all patients. Although gelatinous lesions and numerous fungal cocci were observed in the two HIV patients, the granuloma formation was small. Gelatinous formation and granuloma formation were observed in the HTLV-1 carrier. Necrosis was observed in all cases. In previous reports, granuloma formation, epithelioid cells, and necrotic lesions were observed in most cases. Most of the patients were also immunosuppressed. However, no HTLV-1 carrier was detected. In conclusion, lymphadenopathy in a HTLV-1 carrier may suggest the presence of cryptococcal lymphadenitis. The frequency of cryptococcosis in HTVL-1 carriers may increase with increase in the long-term survival rate of HTLV-1 carriers.
[Mh] Termos MeSH primário: Criptococose/diagnóstico
Linfadenite/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso de 80 Anos ou mais
Biomarcadores
Biópsia
Contagem de Linfócito CD4
Contagem de Colônia Microbiana
Criptococose/etiologia
Feminino
Infecções por HIV/complicações
Infecções por HTLV-I/complicações
Seres Humanos
Hospedeiro Imunocomprometido
Linfonodos/patologia
Linfadenite/etiologia
Masculino
Fenótipo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3960/jslrt.17011


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[PMID]:28516859
[Au] Autor:Brum AA; Rezende AFS; Brilhante FS; Collares T; Begnine K; Seixas FK; Collares TV; Dellagostin OA; Azevedo V; Santos A; Portela RW; Borsuk S
[Ad] Endereço:1​Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil.
[Ti] Título:Recombinant esterase from Corynebacterium pseudotuberculosis in DNA and subunit recombinant vaccines partially protects mice against challenge.
[So] Source:J Med Microbiol;66(5):635-642, 2017 May.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We tested the efficacy of the esterase encoded by cp1002_RS09720 from Corynebacteriumpseudotuberculosis in recombinant subunit and DNA caseous lymphadenitis (CLA) vaccines. This target was predicted as one of the best CLA vaccine candidates by mature epitope density analysis. METHODOLOGY: Gene cp1002_RS09720 was cloned into two different vectors (pAE for subunit vaccine and pTARGET for DNA vaccine). Four groups of 15 mice each were immunized with the recombinant esterase rCP09720 associated with aluminium hydroxide adjuvant (G1), pTARGET/cp09720 DNA vaccine (G2), a naked pTARGET (G3) or PBS as a negative control (G4). Immunization occurred in two doses intercalated by a 21 day interval. Twenty-one days after the last dose administration, animals were challenged with a virulent C. pseudotuberculosis MIC-6 strain. RESULTS: G1 showed high levels of IgG1 and IgG2a on days 21 and 42 post-immunization and a significant level of IFN-γ (P<0.05), suggesting a Th1 response. The protection levels obtained were 58.3 and 16.6 % for G1 and G2, respectively. CONCLUSION: The subunit vaccine composed of the recombinant esterase rCP09720 and Al(OH)3 is a promising antigenic formulation for use against CLA.
[Mh] Termos MeSH primário: Infecções por Corynebacterium/prevenção & controle
Corynebacterium pseudotuberculosis/enzimologia
Corynebacterium pseudotuberculosis/imunologia
Esterases/genética
Linfadenite/prevenção & controle
Vacinas de DNA/imunologia
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos
Animais
Infecções por Corynebacterium/imunologia
Corynebacterium pseudotuberculosis/genética
Corynebacterium pseudotuberculosis/patogenicidade
Citocinas/secreção
Esterases/administração & dosagem
Esterases/imunologia
Imunoglobulina G/sangue
Interferon gama/imunologia
Linfadenite/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Células Th1/imunologia
Vacinação
Vacinas de DNA/administração & dosagem
Vacinas Sintéticas/imunologia
Vacinas Sintéticas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Cytokines); 0 (Immunoglobulin G); 0 (Vaccines, DNA); 0 (Vaccines, Synthetic); 82115-62-6 (Interferon-gamma); EC 3.1.- (Esterases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000477


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[PMID]:28434105
[Au] Autor:Li K; Xu H; Liu NF; Sadigh P; Evans V; Zhang YX
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:Far-infrared ray for treating chronic lower extremity lymphedema with dermatolymphangioadenitis: a postoperative complication of gynecological tumor resection.
[So] Source:Arch Gynecol Obstet;295(6):1441-1450, 2017 Jun.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Lower extremity lymphedema is regarded as a relatively common postoperative complication and is often accompanied with dermatolymphangioadenitis (DLA). This study combines clinical assessment and laboratory investigation to explore therapeutic effects of far-infrared radiation (FIR) therapy for chronic lower extremity lymphedema accompanied with DLA, occurring after gynecological tumor resection. METHODS: Patients who met inclusion and exclusion criteria would be enrolled. They received regular sessions using the FIR therapy machine over the 4-week treatment course. Clinical and laboratory outcome measures were carried out before and after treatment. Clinical outcome measures included DLA seizure frequency (episodes/year), patients' subjective feedback for lymphedema-related symptoms and quality of life (QOL). Laboratory outcome measures included bacterial cultures and concentrations of inflammatory cytokines: IL-1ß, IL-2, IL-4, IL-10, IL-12, IL-18, TNF-α, TNF-ß, caspase-1 and INF-γ, detected in serum and local lymphedema tissue fluid samples using protein microarray and ELISA. RESULTS: Between 2012 and 2016, a total of 120 female patients were screened for study enrollment. Sixty-four recruited patients underwent clinical evaluation both before FIR radiation therapy and 1 year after a single course of FIR radiation therapy. Eleven patients (17.2%), randomly chosen from the study group, underwent additional laboratory analysis of blood and local lymphedema tissue fluid samples. The frequency of DLA decreased following treatment (p < 0.001). Fifty patients (78%) did not experience a single episode of DLA recurrence in the year subsequent to treatment. The efficiency rate calculated using DLA frequencies was greater than 50% for 63 (98%) patients following treatment. Patients reported a subjective decrease in lymphedema-related symptoms (p < 0.05). Patients' QOL scores were higher after treatment (p < 0.001). Laboratory analysis showed an elevation in serum concentration of IL-1ß after FIR therapy (p < 0.05) and reduced local tissue fluid concentrations of inflammatory cytokines IL-2, IL-10 and IL-18 (p < 0.05). Bacterial culture results before and after treatment were both negative. CONCLUSION: FIR radiation therapy provides an effective treatment modality for patients with chronic lymphedema accompanied with DLA that develops secondarily to treatment of gynecological malignancies, whose therapeutic effects may be due to reduced immune dysfunction within local lymphedema tissues.
[Mh] Termos MeSH primário: Neoplasias dos Genitais Femininos/cirurgia
Raios Infravermelhos
Extremidade Inferior/patologia
Linfadenite/radioterapia
Linfedema/radioterapia
Complicações Pós-Operatórias/radioterapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Citocinas/metabolismo
Feminino
Seres Humanos
Linfadenite/etiologia
Linfedema/etiologia
Meia-Idade
Qualidade de Vida
Recidiva
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170424
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-017-4371-3


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[PMID]:28390621
[Au] Autor:Sethia R; Mahida JB; Subbarayan RA; Deans KJ; Minneci PC; Elmaraghy CA; Essig GF
[Ad] Endereço:College of Medicine, The Ohio State University, 370 W. 9th Ave., Columbus, OH 43210, USA.
[Ti] Título:Evaluation of an imaging protocol using ultrasound as the primary diagnostic modality in pediatric patients with superficial soft tissue infections of the face and neck.
[So] Source:Int J Pediatr Otorhinolaryngol;96:89-93, 2017 May.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the clinical impact of an initiative to use ultrasound (US) as the primary diagnostic modality for children with superficial face and neck infections versus use of computed tomography (CT). METHODS: Children with a diagnosis of lymphadenitis, face or neck abscess, or face and neck cellulitis were retrospectively evaluated by the otolaryngology service. Patients were separated into two groups based on implementation of a departmental initiative to use US as the primary diagnostic modality. The pre-implementation cohort consisted of patients treated prior to the initiative (2006-2009) and the current protocol cohort consisted of patients treated after the initiative was started (2010-2013). Demographics, use of US or CT, necessity of surgical intervention, and failure of medical management were compared. RESULTS: Three hundred seventy three children were evaluated; 114 patients were included in the pre-implementation cohort and 259 patients were included in the current protocol cohort for comparison. Patients presenting during the current protocol period were more likely to undergo US (pre-implementation vs. current protocol, p-value) (12% vs. 49%, p < 0.0001) and less likely to undergo CT (66% vs. 41%, p < 0.0001) for their initial evaluation. There were no differences in the percentage of children who underwent prompt surgical drainage, prompt discharge without surgery, or trial inpatient observation. There were also no differences in the rate of treatment failure for patients undergoing prompt surgery or prompt discharge on antibiotics. For those patients who underwent repeat evaluation following trial medical management, US was used more frequently in the current protocol period (4% vs. 20%, p = 0.002) with no difference in CT use, selected treatment strategy, or treatment failure rates. CONCLUSION: Increased use of US on initial evaluation of children with superficial face and neck infections resulted in decreased CT utilization, without negatively impacting outcome. Decreasing pediatric radiation exposure and potential long-term effects is of primary importance.
[Mh] Termos MeSH primário: Infecções dos Tecidos Moles/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Face/diagnóstico por imagem
Face/patologia
Feminino
Seres Humanos
Linfadenite/diagnóstico por imagem
Masculino
Pescoço/diagnóstico por imagem
Pescoço/patologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


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[PMID]:28343210
[Au] Autor:Semianchuk VB
[Ad] Endereço:State Higher Educational Institution "Ivano-Frankivsk National Medical University", Department Of Children Diseases Of Postgraduate Medical Education Faculty, Ivano-Frankivsk, Ukraine.
[Ti] Título:Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children.
[So] Source:Wiad Lek;70(1):144-147, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. Most pediatricians and otolaryngologists do not suspect PFAPA syndrome when treating recurrent pharyngitis (according to Ukrainian classification - tonsillitis) and stomatitis. Therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late. The aim of the research was to provide pediatricians, family physicians and otolaryngologists with information on the importance of early diagnosis of PFAPA syndrome. MATERIALS AND METHODS: The analysis of the prevalence and diagnosis of PFAPA syndrome in Ukraine and worldwide has been made as well as a late diagnosis of PFAPA syndrome in a child living in Ivano-Frankivsk, Ukraine has been described (case report). RESULTS: The Сase report 7-year-old boy, who grows and develops normally. The symptoms of pharyngitis including high body temperature (>40 º С), sore throat and white spots on the tonsils appeared for the first time at the age of two years. The boy received antibacterial drugs about 10 times a year. During a four-year period of recurrent episodes of the disease antimicrobial susceptibility testing to determine susceptibility of the oropharyngeal flora to the antibiotics were continuously performed, different blood tests for herpes viruses, Epstein-Barr virus infection and cytomegalovirus in particular were made using the enzyme immunoassay (EIA) and polymerase chain reaction (PCR) in addition to long-term treatment. CONCLUSIONS: An example of late diagnosing PFAPA syndrome (four years after the onset of first symptoms) resulting in regular examinations, medical manoeuvres, outpatient and inpatient treatment, use of antibiotic therapy including intravenous injections on a monthly basis has been studied.
[Mh] Termos MeSH primário: Febre/diagnóstico
Linfadenite/diagnóstico
Faringite/diagnóstico
Estomatite Aftosa/diagnóstico
[Mh] Termos MeSH secundário: Criança
Diagnóstico Tardio
Febre/tratamento farmacológico
Seres Humanos
Linfadenite/tratamento farmacológico
Masculino
Faringite/tratamento farmacológico
Estomatite Aftosa/tratamento farmacológico
Síndrome
Ucrânia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE



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