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[PMID]:29216916
[Au] Autor:Baxter GD; Liu L; Petrich S; Gisselman AS; Chapple C; Anders JJ; Tumilty S
[Ad] Endereço:Centre for Health, Activity and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, New Zealand. david.baxter@otago.ac.nz.
[Ti] Título:Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review.
[So] Source:BMC Cancer;17(1):833, 2017 12 07.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous research shows increasing use of low level laser therapy (LLLT), now commonly referred to as photobiomodulation (PBM) therapy, for BCRL. This systematic review evaluated the effectiveness of LLLT (PBM) in the management of BCRL. METHODS: Clinical trials were searched in PubMed, AMED, Web of Science, and China National Knowledge Infrastructure up to November 2016. Two reviewers independently assessed the methodological quality and adequacy of LLLT (PBM) in these clinical trials. Primary outcome measures were limb circumference/volume, and secondary outcomes included pain intensity and range of motion. Because data were clinically heterogeneous, best evidence synthesis was performed. RESULTS: Eleven clinical trials were identified, of which seven randomized controlled trials (RCTs) were chosen for analysis. Overall, the methodological quality of included RCTs was high, whereas the reporting of treatment parameters was poor. Results indicated that there is strong evidence (three high quality trials) showing LLLT (PBM) was more effective than sham treatment for limb circumference/volume reduction at a short-term follow-up. There is moderate evidence (one high quality trial) indicating that LLLT (PBM) was more effective than sham laser for short-term pain relief, and limited evidence (one low quality trial) that LLLT (PBM) was more effective than no treatment for decreasing limb swelling at short-term follow-up. CONCLUSIONS: Based upon the current systematic review, LLLT (PBM) may be considered an effective treatment approach for women with BCRL. Due to the limited numbers of published trials available, there is a clear need for well-designed high-quality trials in this area. The optimal treatment parameters for clinical application have yet to be elucidated.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/terapia
Terapia com Luz de Baixa Intensidade
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3852-x


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[PMID]:29283534
[Au] Autor:Bryant JR; Hajjar RT; Lumley C; Chaiyasate K
[Ti] Título:Clinical Question: In women who have undergone breast cancer surgery, including lymph node removal, do blood pressure measurements taken in the ipsilateral arm increase the risk of lymphedema?
[So] Source:J Okla State Med Assoc;109(10):474-9, 2016 10.
[Is] ISSN:0030-1876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Throughout the healthcare industry fears of taking blood pressure in arm of patients who have undergone breast cancer surgery have been propagated for decades and continue to be recommended by multiple medical societies and healthcare organizations. However, these precautions are not well based on evidence-based medicine and may have a more historical and traditional basis. The purpose of this study was to review current evidence-based research as well as current guidelines regarding ipsilateral arm blood pressure measurements in women who have undergone breast surgery for cancer including lymph node removal.
[Mh] Termos MeSH primário: Determinação da Pressão Arterial/estatística & dados numéricos
Linfedema Relacionado a Câncer de Mama/epidemiologia
Neoplasias da Mama/cirurgia
Excisão de Linfonodo
Mastectomia
[Mh] Termos MeSH secundário: Axila
Feminino
Seres Humanos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:28934950
[Au] Autor:Zhu H; Li J; Peng Z; Huang Y; Lv X; Song L; Zhou G; Lin S; Chen J; He B; Qin F; Liu X; Dai M; Zou Y; Dai S
[Ad] Endereço:Department of Galactophore, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, Guangxi, China.
[Ti] Título:Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial.
[So] Source:BMC Complement Altern Med;17(1):467, 2017 Sep 21.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupuncture may be a potential option. This study aims to verify the effectiveness of acupuncture on BCRL and evaluate its safety using a rigorously designed trial. METHODS/DESIGN: Women who are clinically diagnosed as unilateral BCRL, with a 10% to 40% increase in volume compared to the unaffected arm, will be recruited. Following baseline assessment, participants will be randomized to either the real acupuncture group or sham-acupuncture group at a ratio of 1:1, and given a standard real acupuncture or sham-acupuncture treatment accordingly on both arms followed by the same usual care of decongestive therapy. Volume measurements of both arms will be performed for every participant after each treatment. Data collected at baseline and the last session will be used to calculate the primary outcome and secondary outcomes. Other data will be exploited for interim analyses and trial monitoring. The primary outcome is the absolute reduced limb volume ratio. Secondary outcomes are incidence of adverse events and change in quality of life. A t test or non-parameter test will be used to compare the difference between two groups, and assess the overall effectiveness of acupuncture using the SPSS software (version 12). DISCUSSION: This study will help expand our knowledge about the effectiveness of acupuncture on BCRL, and how acupuncture might be used in the management of this condition. Acupuncture may be a promising complement or alternative to conventional lymphedema treatment methods, if its effectiveness is confirmed. TRIAL REGISTRATION: ClinicalTrials.gov NCT02803736 (Registered on October 31, 2016).
[Mh] Termos MeSH primário: Terapia por Acupuntura
Linfedema Relacionado a Câncer de Mama/terapia
[Mh] Termos MeSH secundário: Pontos de Acupuntura
Feminino
Seres Humanos
Estudos Multicêntricos como Assunto
Qualidade de Vida
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1980-0


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[PMID]:28535427
[Au] Autor:Li K; Xia L; Liu NF; Nicoli F; Constantinides J; D'Ambrosia C; Lazzeri D; Tremp M; Zhang JF; Zhang YX
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
[Ti] Título:Far infrared ray (FIR) therapy: An effective and oncological safe treatment modality for breast cancer related lymphedema.
[So] Source:J Photochem Photobiol B;172:95-101, 2017 Jul.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of breast cancer related lymphedema is approximately 5%. Far infrared ray (FIR) treatment can potentially reduce fluid volume and extremity circumference as well as the frequency of dermato-lymphangitis (DLA). However, there is no published data on the oncological safety of FIR and the potential for activation of any residual breast cancer cells. The aim of this study is to investigate the safety of far infrared ray (FIR) treatment of postmastectomy lymphedema, clinically and in vitro. METHODS: Patients who underwent mastectomy more than 5years ago complicated by upper extremity lymphedema for more than 1year were included. The enrolled patients were divided into an FIR treatment group and a control group (conservative treatment using bandage compression). Outcome measures included tumor markers (CA153, CA125), ultrasonography of relevant structures and monitoring for adverse reactions 1year after treatment. For the in vitro part of the study, the effects of FIR on human breast adenocarcinoma cell lines (MCF7, MDA-MB231) compared to the effects of FIR on human dermal fibroblasts as a control were considered. The viability, proliferation, cell cycle and apoptotic statistics of the adenocarcinoma and human dermal fibroblast cell lines were analyzed and compared. RESULTS: Results demonstrated that after treatment with FIR, tumor marker (CA153, CA125) concentrations in both the FIR and control groups were not elevated. There was no statistically significant difference between FIR and control group marker expression (p>0.05). Furthermore, no patients were diagnosed with lymphadenectasis or newly enlarged lymph nodes in these two groups. Importantly, there were no adverse events in either group. The in vitro experiment indicated that FIR radiation does not affect viability, proliferation, cell cycle and apoptosis of fibroblasts, MCF-7 and MDA-MB-231 cells. CONCLUSIONS: FIR should be considered as feasible and safe for the treatment of breast cancer related lymphedema patients 5years after mastectomy. FIR does not promote recurrence or metastasis of breast cancer and is a well-tolerated therapy with no adverse reactions.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/terapia
Raios Infravermelhos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/metabolismo
Mama/diagnóstico por imagem
Mama/efeitos da radiação
Linfedema Relacionado a Câncer de Mama/diagnóstico por imagem
Linfedema Relacionado a Câncer de Mama/cirurgia
Antígeno Ca-125/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos da radiação
Linhagem Celular
Proliferação Celular/efeitos da radiação
Sobrevivência Celular/efeitos da radiação
Feminino
Seres Humanos
Células MCF-7
Mastectomia
Meia-Idade
Fototerapia
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CA-125 Antigen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28323572
[Au] Autor:Donahue PM; Crescenzi R; Scott AO; Braxton V; Desai A; Smith SA; Jordi J; Meszoely IM; Grau AM; Kauffmann RM; Sweeting RS; Spotanski K; Ridner SH; Donahue MJ
[Ad] Endereço:1 Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center , Nashville, Tennessee.
[Ti] Título:Bilateral Changes in Deep Tissue Environment After Manual Lymphatic Drainage in Patients with Breast Cancer Treatment-Related Lymphedema.
[So] Source:Lymphat Res Biol;15(1):45-56, 2017 Mar.
[Is] ISSN:1557-8585
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD). METHODS AND RESULTS: Measurements to identify lymphatic dysfunction in healthy volunteers (n = 29) and patients with BCRL (n = 16) consisted of (1) limb volume, tissue dielectric constant, and bioelectrical impedance (i.e., non-MRI measures); (2) qualitative 3 Tesla diffusion-weighted, T -weighted and T -weighted MRI; and (3) quantitative multi-echo T MRI of the axilla. Measurements were repeated in patients immediately following MLD. Normative control and BCRL T values were quantified and a signed Wilcoxon Rank-Sum test was applied (significance: two-sided p < 0.05). Non-MRI measures yielded significant capacity for discriminating between arms with versus without clinical signs of BCRL, yet yielded no change in response to MLD. Alternatively, a significant increase in deep tissue T on the involved (pre T = 0.0371 ± 0.003 seconds; post T = 0.0389 ± 0.003; p = 0.029) and contralateral (pre T = 0.0365 ± 0.002; post T = 0.0395 ± 0.002; p < 0.01) arms was observed. Trends for larger T increases on the involved side after MLD in patients with stage 2 BCRL relative to earlier stages 0 and 1 BCRL were observed, consistent with tissue composition changes in later stages of BCRL manifesting as breakdown of fibrotic tissue after MLD in the involved arm. Contrast consistent with relocation of fluid to the contralateral quadrant was observed in all stages. CONCLUSION: Quantitative deep tissue T MRI values yielded significant changes following MLD treatment, whereas non-MRI measurements did not vary. These findings highlight that internal imaging measures of tissue composition may be useful for evaluating how current and emerging therapies impact tissue function.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/fisiopatologia
Linfedema Relacionado a Câncer de Mama/terapia
Vasos Linfáticos/fisiopatologia
Massagem/métodos
[Mh] Termos MeSH secundário: Adulto
Axila
Linfedema Relacionado a Câncer de Mama/diagnóstico
Linfedema Relacionado a Câncer de Mama/etiologia
Neoplasias da Mama/complicações
Neoplasias da Mama/terapia
Estudos de Casos e Controles
Feminino
Seres Humanos
Excisão de Linfonodo/efeitos adversos
Imagem por Ressonância Magnética
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1089/lrb.2016.0020


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[PMID]:28135120
[Au] Autor:Hoffner M; Bagheri S; Hansson E; Manjer J; Troëng T; Brorson H
[Ad] Endereço:1 Department of Clinical Sciences in Malmö, Lund University , Malmö, Sweden .
[Ti] Título:SF-36 Shows Increased Quality of Life Following Complete Reduction of Postmastectomy Lymphedema with Liposuction.
[So] Source:Lymphat Res Biol;15(1):87-98, 2017 Mar.
[Is] ISSN:1557-8585
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abstracts Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. METHODS AND RESULTS: Sixty female patients with arm lymphedema were followed for a 1-year period after surgery. The 36-item short-form health survey (SF-36) was used to assess health-related quality of life (HRQoL). Patients completed the SF-36 questionnaire before liposuction, and after 1, 3, 6, and 12 months. Preoperative excess arm volume was 1365 ± 73 mL. Complete reduction was achieved after 3 months and was sustained during follow-up. The adipose tissue volume removed at surgery was 1373 ± 56 mL. One month after liposuction, better scores were found in mental health. After 3 months, an increase in physical functioning, bodily pain, and vitality was detected. After 1 year, an increase was also seen for social functioning. The physical component score was higher at 3 months and thereafter, while the mental component score was improved at 3 and 12 months. Compared with SF-36 norm data for the Swedish population, only physical functioning showed lower values than the norm at baseline. After liposuction, general health, bodily pain, vitality, mental health, and social functioning showed higher values at various time points. CONCLUSIONS: Liposuction of arm lymphedema in combination with CCT improves patients HRQoL as measured with SF-36. The treatment seems to target and improve both the physical and mental health domains.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/epidemiologia
Linfedema Relacionado a Câncer de Mama/etiologia
Neoplasias da Mama/complicações
Inquéritos Epidemiológicos
Lipectomia
Mastectomia/efeitos adversos
Qualidade de Vida
[Mh] Termos MeSH secundário: Idoso
Braço/patologia
Linfedema Relacionado a Câncer de Mama/diagnóstico
Linfedema Relacionado a Câncer de Mama/terapia
Neoplasias da Mama/cirurgia
Estudos de Coortes
Exercício
Feminino
Seres Humanos
Lipectomia/métodos
Saúde Mental
Meia-Idade
Índice de Gravidade de Doença
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1089/lrb.2016.0035


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[PMID]:28129628
[Au] Autor:Toyserkani NM; Jørgensen MG; Haugaard K; Sørensen JA
[Ad] Endereço:Department of Plastic Surgery, Odense University Hospital, Denmark. Electronic address: Navid.m.toyserkani@rsyd.dk.
[Ti] Título:Seroma indicates increased risk of lymphedema following breast cancer treatment: A retrospective cohort study.
[So] Source:Breast;32:102-104, 2017 Apr.
[Is] ISSN:1532-3080
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Lymphedema is one of the most serious complications following breast cancer treatment. While many risk factors are well described the role of seroma formation has recently produced mixed results. Therefore, we aimed to evaluate if seroma is a risk factor for development of lymphedema in one of the largest retrospective cohort studies. MATERIAL AND METHODS: We included all patients with unilateral breast cancer treated in the period of 2008-2014. Data regarding treatment and breast cancer characteristics were retrieved from the national breast cancer registry. Data regarding lymphedema treatment and seroma aspirations were retrieved from local treatment codes. RESULTS: In total 1822 patients were included of which 291 developed lymphedema. Multivariate cox regression analysis showed that seroma was an independent risk factor (HR 1.92 CI 1.30-2.85, p= 0.001). Other independent risk factors were lymphadenectomy, radiation therapy, chemotherapy, BMI above 30, total lymph nodes removed above 15 and higher number of metastatic lymph nodes. CONCLUSIONS: Postoperative seroma doubles the risk of developing lymphedema. Future studies should examine if seroma reducing measures will lead to lower risk of lymphedema.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/etiologia
Neoplasias da Mama/cirurgia
Mastectomia/efeitos adversos
Complicações Pós-Operatórias
Seroma/etiologia
[Mh] Termos MeSH secundário: Neoplasias da Mama/patologia
Feminino
Seguimentos
Seres Humanos
Modelos Logísticos
Excisão de Linfonodo/efeitos adversos
Linfonodos/patologia
Linfonodos/cirurgia
Meia-Idade
Análise Multivariada
Modelos de Riscos Proporcionais
Estudos Prospectivos
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:28117779
[Au] Autor:Jeon Y; Beom J; Ahn S; Bok SK
[Ad] Endereço:Department of Rehabilitation Medicine, Chungnam National University Hospital (CNUH).
[Ti] Título:Ultrasonographic Evaluation of Breast Cancer-related Lymphedema.
[So] Source:J Vis Exp;(119), 2017 Jan 12.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphedema is one of the most common complications after breast cancer surgery. There are many diagnostic tools for lymphedema, but no standard method yet exists. Progressive Resistance Exercise (PRE) is expected to improve lymphedema without additional swelling. This study showed the therapeutic effects of PRE on lymphedema by using ultrasonography to measure the change in thickness of the muscle and subcutaneous tissue. The thickness of subcutaneous tissue decreased more in the PRE group than in the non-PRE group. Ultrasonography is widely used in many clinics because of its easy accessibility, safety, and inexpensiveness. Ultrasound is one of the best tools for diagnosing and determining treatment efficacy on breast cancer-related lymphedema (BCRL).
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/diagnóstico por imagem
Neoplasias da Mama/patologia
Terapia por Exercício
Treinamento de Resistência
[Mh] Termos MeSH secundário: Mama/diagnóstico por imagem
Neoplasias da Mama/cirurgia
Feminino
Seres Humanos
Mastectomia
Resultado do Tratamento
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.3791/54996


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[PMID]:28101567
[Au] Autor:Schmidt T; Berner J; Jonat W; Weisser B; Röcken C; van Mackelenbergh M; Mundhenke C
[Ad] Endereço:Breast Unit, Comprehensive Cancer Center North, University of Kiel, Arnold-Heller-Str. 3, DE- 24105 Kiel, Germany. E-mail: thorsten.schmidt@uksh.de.
[Ti] Título:Influence of arm crank ergometry on development of lymphedema in breast cancer patients after axillary dissection: A randomized controlled trail.
[So] Source:J Rehabil Med;49(1):78-83, 2017 Jan 19.
[Is] ISSN:1651-2081
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the safety and efficacy of arm crank ergometry in breast cancer patients after axillary lymph node dissection, with regard to changes in bioelectrical impedance analysis, arm circumference, muscular strength, quality of life and fatigue. DESIGN: Randomized controlled clinical intervention trial. SUBJECTS: Forty-nine patients with breast cancer after axillary lymph node dissection. METHODS: Arm crank ergometer training twice-weekly was compared with usual care over 12 weeks. RESULTS: The arm crank ergometer group improved significantly in terms of lean body mass and skeletal muscle mass, and showed a significant decrease in body fat. In the arm crank ergometer group, as well as the usual care group, a significant increase in armpit circumference was detected during the training period. The magnitude of the gain was higher in the usual care group. For all other measured regions of the arm a significant decrease in circumference was seen in both groups. Muscular strength of the upper extremity increased significantly in both groups, with a greater improvement in the arm crank ergometer group. In both groups a non-significant trend towards improvement in quality of life was observed. The arm crank ergometer group showed significant improvements in physical functioning, general fatigue and physical fatigue. CONCLUSION: These results confirm the feasibility of arm crank ergometer training after axillary lymph node dissection and highlight improvements in strength, quality of life and reduced arm symptoms with this training.
[Mh] Termos MeSH primário: Axila/patologia
Linfedema Relacionado a Câncer de Mama/terapia
Ergometria/métodos
Excisão de Linfonodo/métodos
Força Muscular/fisiologia
[Mh] Termos MeSH secundário: Braço
Feminino
Seres Humanos
Meia-Idade
Estudos Prospectivos
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.2340/16501977-2167


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[PMID]:28084150
[Au] Autor:Ammitzbøll G; Lanng C; Kroman N; Zerahn B; Hyldegaard O; Kaae Andersen K; Johansen C; Dalton SO
[Ad] Endereço:a Survivorship Unit , Danish Cancer Society Research Center , Copenhagen , Denmark.
[Ti] Título:Progressive strength training to prevent LYmphoedema in the first year after breast CAncer - the LYCA feasibility study.
[So] Source:Acta Oncol;56(2):360-366, 2017 Feb.
[Is] ISSN:1651-226X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lymphoedema is a common late effect after breast cancer (BC) that has no effective cure once chronic. Accumulating evidence supports progressive strength training (PRT) as a safe exercise modality in relation to the onset and exacerbation of lymphoedema. In the 'preventive intervention against LYmphoedema after breast CAncer' (LYCA) feasibility study we examined the feasibility of a program of PRT in the first year after BC to inform a planned randomised controlled trial (RCT). MATERIAL AND METHODS: LYCA was a one-group prospective pilot trial inviting women operated with axillary lymph node dissection for unilateral primary BC. Participants exercised three times a week for 50 weeks (20 weeks supervised followed by 30 weeks home-based exercise). The program ensured slow individualised progression during the exercise program. The primary outcome was feasibility measured by eligibility and recruitment rates, as well as questionnaire-assessed satisfaction and adherence to exercise. Furthermore, we assessed arm interlimb volume difference by water displacement, muscle strength by dynamic and isometric muscle testing and range of movement in the shoulder by goniometry. RESULTS: In August 2015, eight of 11 eligible patients accepted participation. Two of them dropped out early due to other health issues. The remaining six participants had high exercise adherence through the supervised period, but only three maintained this through the home exercise period. Program satisfaction was high and no serious adverse events from testing or exercising were reported. One participant presented with lymphoedema at 50-week follow-up. Muscle strength markedly increased with supervised exercise, but was not fully maintained through the home exercise period. Range of shoulder movement was not negatively affected by the program. CONCLUSION: Recruitment, testing, and exercise in LYCA was safe and feasible. At the 50-week follow-up, there was one case of lymphoedema. The LYCA program will be further tested in a full-scale RCT.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/prevenção & controle
Neoplasias da Mama/cirurgia
Treinamento de Resistência
[Mh] Termos MeSH secundário: Idoso
Composição Corporal
Neoplasias da Mama/fisiopatologia
Estudos de Viabilidade
Feminino
Seres Humanos
Meia-Idade
Força Muscular
Projetos Piloto
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1080/0284186X.2016.1268266



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