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[PMID]:29480854
[Au] Autor:Gebreselassie A; Mehari A; Dagne R; Berhane F; Kibreab A
[Ad] Endereço:Department of Internal Medicine.
[Ti] Título:Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report.
[So] Source:Medicine (Baltimore);97(2):e9580, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The usual presentation of sarcoidosis is hilar adenopathy, pulmonary reticular opacities, skin, joint, or eye lesions. Pancreatic involvement is unusual and hypercalcemic pancreatitis as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with 1-day history of vomiting, diffuse abdominal pain, and altered mental status. DIAGNOSES: Initial investigations showed highly elevated calcium levels, acute pancreatitis, and kidney failure. Possible causes entertained were malignancy, hyperparathyroidism, hypervitaminosis D, and granulomatous diseases. Full work-up including a hilar lymph node biopsy revealed noncaseating granuloma. After excluding other diseases capable of producing a similar picture, a diagnosis of sarcoidosis was made. INTERVENTIONS AND OUTCOMES: The patient was started on aggressive intravenous fluid hydration and intravenous calcitonin, after which her altered mental status resolved and both kidney function and hypercalcemia improved. The patient was discharged on oral prednisone and serum calcium level normalized with progressive improvement of kidney function at follow-up. LESSONS: The current case highlights the need for a high index of suspicion for this condition in patients who present with acute pancreatitis, as steroids are the treatment of choice. Thus, prompt recognition of this entity is of therapeutic significance.
[Mh] Termos MeSH primário: Hipercalcemia/diagnóstico
Pancreatite/diagnóstico
Sarcoidose/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Hipercalcemia/complicações
Hipercalcemia/tratamento farmacológico
Hipercalcemia/fisiopatologia
Meia-Idade
Pancreatite/complicações
Pancreatite/tratamento farmacológico
Pancreatite/fisiopatologia
Sarcoidose/complicações
Sarcoidose/tratamento farmacológico
Sarcoidose/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009580


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[PMID]:29406038
[Au] Autor:Yatsynovich Y; Dittoe N; Petrov M; Maroz N
[Ti] Título:Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment.
[So] Source:Am J Med Sci;355(2):113-125, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sarcoidosis is a systemic disease characterized by noncaseating granulomas and is often a diagnosis of exclusion. The actual prevalence of cardiac sarcoidosis (CS) is unknown, as studies have demonstrated mixed data. CS may be asymptomatic and is likely more frequently encountered than previously thought. Sudden death may often be the presenting feature of CS. Most deaths attributed to CS are caused by arrhythmias or conduction system disease, and congestive heart failure may occur. Current expert consensus on diagnosis of CS continues to rely on endomyocardial biopsy, in the absence of which, histologic proof of extracardiac sarcoid involvement is necessitated. Emergence of newer noninvasive imaging modalities such as cardiac magnetic resonance imaging and positron emission tomography, have become increasingly popular tools utilized in patients with both clinical and asymptomatic CS, and have demonstrated good diagnostic capability. The main therapeutic approaches in patients with CS can be broadly divided into the following 2 categories: pharmacological management and invasive or device oriented. However, much remains unknown about the optimal screening protocols of asymptomatic patients with extracardiac sarcoidosis and treatment of biopsy-proven CS. Our knowledge about CS has amplified significantly over the last 30 years and the growing realization that this process is often asymptomatic is paving the way for better screening protocols and earlier detection of this serious condition.
[Mh] Termos MeSH primário: Cardiomiopatias
Imagem por Ressonância Magnética
Miocárdio/patologia
Tomografia por Emissão de Pósitrons
Sarcoidose
[Mh] Termos MeSH secundário: Biópsia
Cardiomiopatias/diagnóstico por imagem
Cardiomiopatias/patologia
Cardiomiopatias/terapia
Seres Humanos
Sarcoidose/diagnóstico por imagem
Sarcoidose/patologia
Sarcoidose/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28449695
[Au] Autor:Ness T; Boehringer D; Heinzelmann S
[Ad] Endereço:Eye Center, Medical Center, University of Freiburg, Faculty of Medicine, Killianstr. 5, 79106, Freiburg, Germany. thomas.ness@uniklinik-freiburg.de.
[Ti] Título:Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center.
[So] Source:Orphanet J Rare Dis;12(1):81, 2017 Apr 27.
[Is] ISSN:1750-1172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with intermediate uveitis (IU) represent a heterogenous group characterized by a wide spectrum of etiologies and regional differences. Aim of the study was to analyze the characteristics of patients with IU examined in an academic center in Germany. METHODS: We conducted a retrospective analysis of the clinical records of all patients with intermediate uveitis referred to the Eye Center, University of Freiburg from 2007 to 2014. Diagnosis followed the Standardization in Uveitis Nomenclature (SUN) criteria. Data analysis included: etiology of IU, demographics, complications, treatment and visual acuity. RESULTS: We identified 159 patients with intermediate uveitis during that period. Mean age at diagnosis was 35 years. Most are female (64%), and the mean duration of IU was 6.1 years (range 1 month - 35 years). Etiology of IU was idiopathic in 59%. Multiple sclerosis (MS) (20%) and sarcoidosis (10%) were frequent systemic causes of IU. Other etiologies including infectious diseases (tuberculosis, borreliosis) or immune-mediated conditions (eg, after vaccination) were present in 11%. The pattern of complications included macular edema (CME) (36%), cataract (24%), secondary glaucoma (7%), and epiretinal membrane formation (19%). Periphlebitis and optic neuritis were more frequent in conjunction with MS. Treatment comprised local and systemic steroids, immunosuppressive agents, biologics, and surgery. Best corrected visual acuity was better than 20/25 in 60% of the eyes after more than 10 years of follow-up. CONCLUSIONS: In our German academic center, most IU cases were idiopathic or associated with MS or sarcoidosis. In contrast to other countries, infectious cases were rare. Patients' overall visual prognosis is favorable even when the duration of IU has been long and and despite numerous complications.
[Mh] Termos MeSH primário: Catarata/etiologia
Glaucoma/etiologia
Imunossupressores/uso terapêutico
Esclerose Múltipla/complicações
Sarcoidose/complicações
Uveíte Intermediária
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Catarata/fisiopatologia
Criança
Pré-Escolar
Feminino
Glaucoma/fisiopatologia
Seres Humanos
Edema Macular/etiologia
Edema Macular/fisiopatologia
Masculino
Meia-Idade
Esclerose Múltipla/fisiopatologia
Estudos Retrospectivos
Sarcoidose/fisiopatologia
Esteroides/uso terapêutico
Resultado do Tratamento
Uveíte Intermediária/complicações
Uveíte Intermediária/tratamento farmacológico
Uveíte Intermediária/etiologia
Uveíte Intermediária/fisiopatologia
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Steroids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s13023-017-0638-9


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[PMID]:29172980
[Au] Autor:Rice JB; White A; Lopez A; Nelson WW
[Ad] Endereço:1 Analysis Group, Boston, Massachusetts.
[Ti] Título:High-Cost Sarcoidosis Patients in the United States: Patient Characteristics and Patterns of Health Care Resource Utilization.
[So] Source:J Manag Care Spec Pharm;23(12):1261-1269, 2017 Dec.
[Is] ISSN:2376-1032
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sarcoidosis is a multisystem inflammatory disorder characterized by the presence of noncaseating granulomas in involved organs. Prior research has found that sarcoidosis imposes a significant economic burden to U.S. payers. However, the drivers of high health care costs among sarcoidosis patients are unknown. OBJECTIVE: To characterize sarcoidosis patients who were among the top 20% of total health care costs. METHODS: Patients with a first diagnosis of sarcoidosis between January 1, 1998, and March 31, 2015 (index date) were selected from a deidentified privately insured administrative claims database. Study patients must have at least 12 months of continuous health plan enrollment prior to the index date. High-cost patients were those in the top 20% of total health care costs during the 12 months following the index date (follow-up period), and the remaining patients were classified as lower-cost patients. Patient characteristics, comorbidities, health care resource use, and health care costs in the study period were compared between the high-cost and lower-cost patients. Multiple logistic regression was used to assess the relationship between patient characteristics and being a high-cost sarcoidosis patient. RESULTS: A total of 7,173 sarcoidosis patients met the selection criteria. The 20% of patients classified as high-cost patients accounted for approximately 72% of the total health care costs in the 12-month follow-up period. Compared with lower-cost patients, high-cost patients were slightly older (50.6 vs. 49.1 years) and had a higher comorbidity burden at baseline (Charlson Comorbidity Index = 1.8 vs. 0.7). Mean annual total health care cost for high-cost sarcoidosis patients was 10 times that of their lower-cost counterparts ($73,345 vs. $7,073). Mean annual health care cost was $119,878 for patients in the 95th-99th percentile and $375,436 for patients in the top 1% of spend. High-cost patients had greater medical resource use and costs across all places of service (i.e., inpatient, emergency department, outpatient, and other) compared with lower-cost patients. Findings showed that higher total health care cost resulted in a larger proportion of inpatient spend and a smaller proportion of outpatient and pharmacy spend. Adjusting for baseline characteristics, high-cost patients were associated with a number of factors with high ORs: the presence of comorbidities such as deficiency anemia (OR = 1.606; P < 0.001), depression (OR = 1.504; P < 0.001), or cardiac arrhythmia (OR = 1.493; P < 0.001); having an inpatient admission (OR = 9.771; P < 0.001); and use of biologic therapies adalimumab and/or infliximab (OR = 31.821; P < 0.001). CONCLUSIONS: This study described the characteristics of high-cost sarcoidosis patients and identified several high-cost indicators using contemporary administrative data. The health care cost distribution for sarcoidosis patients is highly skewed, making it a worthwhile endeavor to focus improvement efforts on patients in the top quintile. The study findings can help population health decision makers identify a subset of patients for targeted interventions aimed at improving quality of care and reducing overall costs. DISCLOSURES: This study was funded by Mallinckrodt Pharmaceuticals. Rice, White, and Lopez are employees of Analysis Group, which received funding from Mallinckrodt Pharmaceuticals to conduct this research. Nelson is an employee of Mallinckrodt Pharmaceuticals. Study concept and design were contributed by Rice, White, and Nelson, along with Lopez. Lopez took the lead in data collection, with assistance from Rice and White. Data interpretation was performed by all of the authors. The manuscript was written by Rice, Lopez, White, and Nelson and revised by Rice, along with White and Nelson.
[Mh] Termos MeSH primário: Efeitos Psicossociais da Doença
Custos de Cuidados de Saúde/estatística & dados numéricos
Recursos em Saúde/utilização
Sarcoidose/terapia
[Mh] Termos MeSH secundário: Adalimumab/administração & dosagem
Adalimumab/economia
Adulto
Comorbidade
Bases de Dados Factuais
Feminino
Seguimentos
Seres Humanos
Infliximab/administração & dosagem
Infliximab/economia
Modelos Logísticos
Masculino
Meia-Idade
Estudos Retrospectivos
Sarcoidose/economia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
B72HH48FLU (Infliximab); FYS6T7F842 (Adalimumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.18553/jmcp.2017.17203


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[PMID]:29186261
[Au] Autor:Deng Q; Ding S; Yang S; Huang J
[Ad] Endereço:Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
[Ti] Título:Cutaneous sarcoidosis and secondary open-angle glaucoma in a patient: case report and literature review.
[So] Source:An Bras Dermatol;92(3):407-409, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The current report presents the case of a 41-year-old male patient with a two-month history of asthenopia and plaques in the frontotemporal region. Computed tomography revealed bilateral hilar and mediastinal lymphadenopathy. Ophthalmological examination showed elevated intraocular pressure. Skin biopsy demonstrated aa dermal inflammatory infiltrate composed mainly of epithelioid cells and a few multinucleated giant cells, but no obvious lymphocytes. Findings of thorough physical examinations and auxiliary examinations suggested the presence of cutaneous sarcoidosis and secondary open-angle glaucoma. Treatment consisted mainly of oral methylprednisolone. Skin lesions, bilateral hilar, and mediastinal lymphadenopathy resolved completely. Cutaneous sarcoidosis is often accompanied by extracutaneous organ involvement. Dermatologists must be aware of the disease's extracutaneous manifestations to ensure accurate diagnosis for further treatments.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/etiologia
Sarcoidose/complicações
Dermatopatias/complicações
[Mh] Termos MeSH secundário: Adulto
Glaucoma de Ângulo Aberto/diagnóstico
Glucocorticoides/uso terapêutico
Seres Humanos
Masculino
Metilprednisolona/uso terapêutico
Sarcoidose/diagnóstico
Dermatopatias/diagnóstico
Dermatopatias/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:29245251
[Au] Autor:Duréault A; Chapelon C; Biard L; Domont F; Savey L; Bodaghi B; Pourcher V; Rigon MR; Cacoub P; Saadoun D
[Ad] Endereço:aDépartement de Médecine Interne et d'Immunologie Clinique, Hôpital Pitié Salpétrière, Paris, France. Centre de Référence Maladies Auto-Immunes et Systémiques Rares, Université Pierre et Marie Curie, Paris, France. DHU Inflammation, Immunopathology, Biotherapy UPMC, Paris VIbDepartment of Biostatistics and Medical Information (SBIM)cDepartment of Ophtalmology, Université Pierre et Marie CuriedDepartment of Infectious disease, Hôpital Pitié Salpétrière, Paris, France.
[Ti] Título:Severe infections in sarcoidosis: Incidence, predictors and long-term outcome in a cohort of 585 patients.
[So] Source:Medicine (Baltimore);96(49):e8846, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sarcoidosis is associated with cell-mediated immunodeficiency and treatment of symptomatic sarcoidosis usually includes systemic immunosuppressants. Data relative to incidence, prognosis factors, and outcome of infections are scarce.Retrospective cohort study of 585 patients with biopsy proven sarcoidosis in a tertiary referral specialist clinic, with a nested case-control analysis. Twenty nine patients (4.9%) with severe infections were compared to 116 controls subjects with sarcoidosis, matched according to their gender, ethnicity, age at diagnosis, and treatment with corticosteroids.After a median follow-up of 8 years [range; 1-46], 38 severe infections [mycobacterial infections (n = 14), fungal infections (n = 10), bacterial (n = 8), viral (n = 3) and parasitic (n = 1)] were observed in 30 patients. The incidence of severe infections was 0.71% persons-year (CI 95% 0.5-0.98) and 0.43% persons-year (CI 95% 0.27-0.66). Patients with severe infection were more frequently of male gender (60% vs 46%) and were more likely treated by ≥ 3 immunosuppressive agents (OR = 3.8, IC 95% [1.5-9.64], P = .005) and by cyclophosphamide (OR = 5.55, IC 95% [1.9-16.1], P = .002), and with neurological (OR = 3.36 CI 95% [1.37-8.25], P = .008), or cardiac (OR = 2.65 CI 95% [1.09-6.43], P = .031) involvement of the sarcoidosis, compared to the controls. Two patients died within the 6 months following infection, due to progressive multifocal leucoencephalopathy (n = 1), and of peritonitis (n = 1).Severe infections are observed in 5.1% of our patients with sarcoidosis after a median follow-up of 8 years. Risk factors for severe infections included neurological or cardiac involvement of sarcoidosis, the use of immunosuppressive agents and mainly cyclophosphamide.
[Mh] Termos MeSH primário: Imunossupressores/efeitos adversos
Infecções Oportunistas/epidemiologia
Sarcoidose/tratamento farmacológico
[Mh] Termos MeSH secundário: Corticosteroides/efeitos adversos
Adulto
Estudos de Casos e Controles
Ciclofosfamida/efeitos adversos
Feminino
Seguimentos
Seres Humanos
Incidência
Masculino
Meia-Idade
Infecções Oportunistas/microbiologia
Estudos Retrospectivos
Fatores de Risco
Sarcoidose/microbiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Immunosuppressive Agents); 8N3DW7272P (Cyclophosphamide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008846


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[PMID]:29208596
[Au] Autor:Ishiguchi H; Kobayashi S; Myoren T; Kohno M; Nanno T; Murakami W; Oda S; Oishi K; Okuda S; Okada M; Suga K; Yano M
[Ad] Endereço:From the Division of Cardiology, Department of Medicine and Clinical Science (H.I., S.K., T.M., M.K., T.N., W.M., S. Oda, K.O., S. Okuda, M.Y.) and Department of Radiology (M.O.), Yamaguchi University Graduate School of Medicine, Ube, Japan; and Department of Radiology, St Hill Hospital, Ube, Japan
[Ti] Título:Urinary 8-Hydroxy-2'-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis.
[So] Source:Circ Cardiovasc Imaging;10(12), 2017 Dec.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recently, we reported that urinary 8-hydroxy-2'-deoxyguanosine (U-8-OHdG), an oxidative stress marker, reflected inflammatory activity in cardiac sarcoidosis (CS). Here, we investigated whether U-8-OHdG levels were associated with ventricular tachycardia (VT) in patients with CS. METHODS AND RESULTS: This prospective cohort study enrolled 62 consecutive patients with CS, of whom 36 were diagnosed as having active CS based on abnormal F-flurodeoxyglucose accumulation in the heart on positron-emission tomography/computed tomography. The 36 patients with active CS were subdivided as having CS with sustained VT (CS-VT group; n=18) or CS without sustained VT (CS-nVT group; n=18). Twenty-seven patients diagnosed with idiopathic dilated cardiomyopathy served as heart failure controls. U-8-OHdG, brain natriuretic peptide, cardiac function indices, and immunohistological data from subendomyocardial biopsy samples were compared across groups. Immunohistochemical examination of ventricle biopsy samples revealed that the anti-8-OHdG antibody-positive area of cardiac tissue was significantly greater in CS-VT than in CS-nVT or dilated cardiomyopathy and significantly correlated with U-8-OHdG levels (n=58; =0.61; <0.00001), which were significantly higher in CS-VT than in CS-nVT (24.6±7.1 versus 15.2±3.8 ng/mg·Cr; <0.0001). Other baseline characteristics did not differ between the groups. Multivariate analysis indicated that U-8-OHdG was an independent determinant factor for VT. Receiver operating characteristic curve analysis to identify patients with VT resulted in a U-8-OHdG cutoff value of 17.5 ng/mg·Cr (sensitivity, 89%; specificity, 83%; area under the curve, 0.90). CONCLUSIONS: U-8-OHdG levels are associated with VT in patients with active CS diagnosed by F-flurodeoxyglucose positron-emission tomography, providing additive and relevant information about the arrhythmia substrate.
[Mh] Termos MeSH primário: Biomarcadores/urina
Cardiomiopatias/diagnóstico por imagem
Cardiomiopatias/urina
Desoxiguanosina/análogos & derivados
Estresse Oxidativo
Sarcoidose/diagnóstico por imagem
Sarcoidose/urina
Taquicardia Ventricular/diagnóstico por imagem
Taquicardia Ventricular/urina
[Mh] Termos MeSH secundário: Idoso
Cardiomiopatias/fisiopatologia
Desoxiguanosina/urina
Ecocardiografia
Eletrocardiografia
Feminino
Fluordesoxiglucose F18
Seres Humanos
Masculino
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Estudos Prospectivos
Compostos Radiofarmacêuticos
Sarcoidose/fisiopatologia
Taquicardia Ventricular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); G9481N71RO (Deoxyguanosine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28745675
[Au] Autor:Yakovlev AA; Yakovlev SA; Smochilin AG; Yakovleva MV
[Ad] Endereço:Federal State Budgetary Educational Institution of Higher Education 'Academician I.P. Pavlov First St. Petersburg State Medical University' of the Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia; Federal State Budgetary Educational Institution of Higher Education 'St. Peters
[Ti] Título:[A rare case of rapidly progressing primary diffuse meningeal sarcomatosis of the brain and spinal cord].
[Ti] Título:Redkii sluchai bystroprogressiruiushchego pervichnogo diffuznogo meningeal'nogo sarkomatoza golovnogo i spinnogo mozga..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):73-78, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Currently the differential diagnosis of anaplastic meningiomas often is quite complex. An interpretation of the data of radiological studies does not allow the exclusion of diseases with similar clinical course and character of a lesion, such as primary lymphoma and tuberculosis of the central nervous system, neurosarcoidosis and others. The article presents a clinical case, representing a rare and difficult to diagnose variant of anaplastic meningioma with extremely aggressive nature of the current and widespread involvement of the brain and spinal cord.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso Central/diagnóstico
Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
Sarcoidose/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Doenças do Sistema Nervoso Central/diagnóstico por imagem
Diagnóstico Diferencial
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neoplasias Meníngeas/diagnóstico por imagem
Meningioma/diagnóstico por imagem
Sarcoidose/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176173-78


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[PMID]:28984765
[Au] Autor:Liu KL; Tsai WC; Lee CH
[Ad] Endereço:Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
[Ti] Título:Cutaneous sarcoidosis: A retrospective case series and a hospital-based case-control study in Taiwan.
[So] Source:Medicine (Baltimore);96(40):e8158, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sarcoidosis is a systemic granulomatous disorder of unknown etiology often involving skin. Studies on cutaneous sarcoidosis and comorbidities are limited. This study is aimed to describe the clinical features of cutaneous sarcoidosis diagnosed in our hospital and to determine the relationships between cutaneous sarcoidosis and comorbidities.This retrospective study evaluates patients with cutaneous sarcoidosis in a tertiary center in Taiwan from 1996 to 2015. The records of 38 patients with cutaneous sarcoidosis were reviewed for clinical characteristics and evaluated by analysis of variance. A 1:4 case-control analysis was conducted with 152 age- and sex-matched controls who underwent biopsy for other benign skin tumors.The male to female ratio was 1:4.4. The average age at diagnosis was 51.7 years. Female patients were on average 13.9 years older than male patients. The correlation of age with gender was statistically significant (P = .037). The most common cutaneous lesions were plaques (47.4%) and confined to the face (71.1%). Of the 38 patients, 26.3% had diabetes mellitus. Age over 40 (P = .014) and female (P = .014) were associated with facial involvement. In the case-control study, a higher percentage of patients with cutaneous sarcoidosis than of control subjects had diabetes mellitus (P = .001), hearing loss (P = .031) and eye diseases (P = .047).The present study demonstrates a striking female predominance and high proportions of facial involvement. Diabetes mellitus, hearing loss, and eye diseases may be associated with Taiwanese patients with cutaneous sarcoidosis.
[Mh] Termos MeSH primário: Sarcoidose/complicações
Dermatopatias/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Fatores Etários
Idade de Início
Biópsia
Estudos de Casos e Controles
Face/patologia
Dermatoses Faciais/etiologia
Dermatoses Faciais/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Sarcoidose/patologia
Fatores Sexuais
Pele/patologia
Dermatopatias/etiologia
Neoplasias Cutâneas/etiologia
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008158


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[PMID]:28970261
[Au] Autor:Saltman AP; Kuriya B
[Ad] Endereço:Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ont. alexandra.saltman@gmail.com.
[Ti] Título:Löfgren syndrome in acute sarcoidosis.
[So] Source:CMAJ;189(39):E1230, 2017 10 02.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Artrite/etiologia
Eritema Nodoso/etiologia
Sarcoidose/complicações
[Mh] Termos MeSH secundário: Doença Aguda
Artrite/diagnóstico
Diagnóstico Diferencial
Eritema Nodoso/diagnóstico
Feminino
Seres Humanos
Meia-Idade
Sarcoidose/diagnóstico
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170547



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