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[PMID]:29381940
[Au] Autor:Moraes BRM; Nascimento MVDD; Neto EDDS; Santo RM
[Ti] Título:Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.
[So] Source:Medicine (Baltimore);96(47):e8656, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Evidence is scarce regarding appropriate treatment of conjunctival RLH. We report a case treated with topical corticosteroid. PATIENT CONCERNS: A 40 year-old female presented with a 7-month history of a slow growth tumor in the superior conjunctiva of the right eye. Slit-lamp examination demonstrated salmon colored lesion in the upper conjunctiva, with little conjunctival injection, but no significant neovascularization. There was no eyelid involvement. DIAGNOSES: Ultrasound biomicroscopy showed lesion depth (1.53 mm) and larger diameter (10.73 mm). Pathological examination revealed a chronic inflammatory process with conjunctival folicular hyperplasia. The immunohistochemistry examination showed predominance of CD20, CD23, and CD 3 e CD 5. INTERVENTION: We started topic prednisolone 1% 6 times daily. OUTCOMES: Six months after starting treatment, the lesion completely resolved, without any side-effects or recurrence during three-year follow-up period. LESSONS: Conjunctival RLH can be managed in various ways, depending on patient symptonm, comorbities, and disease distribution. Surgical resection with cryotherapy, radiotherapy, systemic corticosteroids, subconjunctival triamcinolone, and rituximab are some options. There is no strong evidence in the literature of conjunctival RLH successfully treated with topical eye drops corticosteroid. In this report, we obtained completely resolution of conjunctival RLH with topical corticosteroid. CONCLUSION: Topical eye drops corticosteroids are an alternative treatment for selected cases of conjuncitval RLH with no orbital or eyelid involvement.
[Mh] Termos MeSH primário: Túnica Conjuntiva/patologia
Neoplasias da Túnica Conjuntiva/diagnóstico
Prednisolona/administração & dosagem
Pseudolinfoma
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Diagnóstico Diferencial
Feminino
Glucocorticoides/administração & dosagem
Seres Humanos
Imuno-Histoquímica
Microscopia Acústica/métodos
Soluções Oftálmicas
Pseudolinfoma/diagnóstico
Pseudolinfoma/tratamento farmacológico
Pseudolinfoma/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Ophthalmic Solutions); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008656


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[PMID]:29325249
[Au] Autor:Liu C; Li X; Li H; Gong QX; Li Y; Wang Z; Zhang ZH
[Ad] Endereço:Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
[Ti] Título:[Clinicopathologic features of primary hepatic marginal zone lymphoma of mucosa-associated lymphoid tissue and hepatic pseudolymphoma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(1):39-44, 2018 Jan 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To study the clinicopathological features of primary hepatic extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) and hepatic pseudolymphoma, and to discuss their differential diagnosis, treatment and prognosis. Three primary hepatic MALT lymphomas and two hepatic pseudolymphomas collected from January 2012 to March 2017 in the First Affiliated Hospital of Nanjing Medical University were evaluated by HE and immunohistochemistry(IHC), in-situ hybridization and immunoglobulin (Ig) gene rearrangement detection, and the relevant literature reviewed. In the three MALT lymphomas, tumor cells infiltrated the portal areas with nodular pattern, and invaded the surrounding normal liver with serpiginous configuration and formation of confluent sheets. A number of bile ducts were entrapped within the lesions, and showed lymphoepithelial lesion. Reactive lymphoid follicles were present and surrounded by tumor cells, consisting of predominantly centrocyte-like cells and monocytoid B cells. There were clusters of epithelioid histiocytes in one case. The tumor cells were positive for CD20, PAX5 and negative for CD5, CD23, CD10, bcl-6, and cyclin D1. In the two hepatic pseudolymphomas, the lesions presented as solitary nodules well-demarcated from the surrounding liver tissue; one case was partially encapsulated with fibrous tissue. Entrapped bile ducts were only found at the edge of the lesions without lymphoepithelial lesion. The lesions comprised of massive lymphoid proliferation consisting predominantly of reactive lymphoid follicles, but not monocytoid B-cells or atypical cells. By IHC, a mixture of B- and T-cell population was identified. A monoclonal rearrangement of the Ig gene was detected in all three MALT lymphomas but not in two pseudolymphomas. Interphase fluorescence in situ hybridiazation test for MALT1 break-apart gene was positive in two cases of MALT lymphomas and EBER was negative in all studied cases. Primary heptic MALT lymphoma and pseudolymphoma are both rare lymphoid proliferative lesions of liver. These two lesions have overlapping histological and IHC features and are top differential diagnosis to each other. A combination analysis of morphology, immunophenotype and Ig gene rearrangement is helpful to distinguish between them.
[Mh] Termos MeSH primário: Neoplasias Hepáticas/patologia
Tecido Linfoide/patologia
Linfoma de Zona Marginal Tipo Células B/patologia
Pseudolinfoma/patologia
[Mh] Termos MeSH secundário: Antígenos CD20
Linfócitos B/patologia
Diagnóstico Diferencial
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Hibridização In Situ
Interfase
Neoplasias Hepáticas/química
Neoplasias Hepáticas/genética
Linfócitos/patologia
Tecido Linfoide/química
Linfoma de Zona Marginal Tipo Células B/química
Linfoma de Zona Marginal Tipo Células B/genética
Pseudolinfoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD20)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.01.008


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[PMID]:28783138
[Au] Autor:Jiang N; Chen C; Gong Q; Shields K; Li Y; Chen Y; Song J; McKeithan TW; Chan WC
[Ad] Endereço:Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Título:Flow cytometric sorting coupled with exon capture sequencing identifies somatic mutations in archival lymphoma tissues.
[So] Source:Lab Invest;97(11):1364-1374, 2017 Nov.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The enormous number of archived formalin-fixed paraffin-embedded (FFPE) tissues available are a valuable resource of material for research. However, the use of such tissues poses many challenges, among which is the difficulty of isolating different cell populations within the tissue. In this study, we used tissue from two types of non-Hodgkin lymphoma as a model to demonstrate a method we have established and optimized to separate FFPE samples into distinct tumor and nonmalignant populations. Using FFPE reactive tonsil sections, various approaches for antigen retrieval and labeling, and the effectiveness of flow cytometric sorting were tested. We found that, among the 11 cell surface or intracellular antigen markers investigated, CD3É›, CD79A, LAT, PD-1, and PAX5 could be successfully labeled after antigen retrieval in Tris-EDTA buffer (pH 8.0) at 65 °C for 60 min, and 1.8-2.7 µg DNA per million cells could be extracted after sorting with DNA quality similar to that of tissue without staining or sorting. To test whether we could perform next-generation sequencing using a custom capture platform on sorted cells, we used three lymphoma cases with FFPE tissues which had been stored for 1 to 4 years. We demonstrated that the DNA from sorted cells was adequate for exon capture sequencing. By comparing the sequencing results between neoplastic and normal populations, somatic mutations could be clearly identified in the tumor population with variant frequencies as low as 11.7%.The corresponding normal fraction clearly helps in the analysis of somatic mutations and the exclusion of artifacts. This study provides an approach using flow cytometric sorting to separate different cellular populations in paraffin-embedded tissues and to unambiguously distinguish somatic mutations from germline variants or artifacts. This approach is also useful in enriching the tumor component in samples with heterogeneous components and low tumor content.
[Mh] Termos MeSH primário: Linfócitos B/metabolismo
DNA de Neoplasias/isolamento & purificação
Linfonodos/patologia
Linfoma Folicular/genética
Linfoma de Células T/genética
Mutação
Linfócitos T/metabolismo
[Mh] Termos MeSH secundário: Linfócitos B/patologia
Bancos de Espécimes Biológicos
Biomarcadores/metabolismo
Análise Mutacional de DNA
DNA de Neoplasias/química
Éxons
Citometria de Fluxo
Sequenciamento de Nucleotídeos em Larga Escala
Temperatura Alta
Seres Humanos
Concentração de Íons de Hidrogênio
Hiperplasia
Linfonodos/metabolismo
Linfoma Folicular/metabolismo
Linfoma Folicular/patologia
Linfoma de Células T/metabolismo
Linfoma de Células T/patologia
Tonsila Palatina/metabolismo
Tonsila Palatina/patologia
Pseudolinfoma/genética
Pseudolinfoma/metabolismo
Pseudolinfoma/patologia
Análise de Célula Única
Linfócitos T/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Biomarkers); 0 (DNA, Neoplasm)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2017.73


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[PMID]:27917669
[Au] Autor:Allin D; David S; Jacob A; Mir N; Giles A; Gibbins N
[Ad] Endereço:ENT Surgery, Guy's and Saint Thomas' NHS Foundation Trust , London , UK.
[Ti] Título:Use of core biopsy in diagnosing cervical lymphadenopathy: a viable alternative to surgical excisional biopsy of lymph nodes?
[So] Source:Ann R Coll Surg Engl;99(3):242-244, 2017 Mar.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES Lymphoma often presents with a neck mass and while fine-needle aspiration cytology may be suggestive, tissue biopsy is required for reliable diagnosis and classification of a lymphoma that is sufficient to deliver the correct treatment for the patient. Traditionally, excisional biopsy of a lymph node has been the standard method of tissue sampling, providing ample tissue for assessment. However, this requires theatre time, and preceding fine-needle aspiration cytology, which may incur a delay. With careful use of tissue, coupled with advances in immunohistochemical and molecular investigative techniques, core biopsy provides a possible alternative to traditional fine-needle aspiration and excisional biopsy. In this study, we aimed to determine the efficacy of diagnosing neck masses. METHOD A retrospective analysis was performed of patients being investigated for a neck mass who were undergoing ultrasound-guided core biopsies of cervical lymph nodes over a 17-month period. The final histology report was scrutinised to assess whether adequate tissue was obtained to allow for full tissue diagnosis. RESULTS Over the 17-month period analysed, 70 patients with cervical lymphadenopathy underwent core biopsy. Of these, 63 (90%) were diagnostic for either lymphoma or other pathology and did not require further tissue sampling. Overall, 19 patients were diagnosed with lymphoma, of which only 1 required further biopsy due to inconclusive initial core biopsy. CONCLUSIONS Current guidelines for investigating lymphomas require that excisional biopsy be performed to obtain ample tissue to allow full nodal architecture assessment and ancillary investigation to reach an accurate histological classification. Within our head and neck multidisciplinary team, however, it is considered that results from core biopsies can be obtained in a more timely fashion and with histological accuracy equal to those of open biopsy. The results obtained demonstrate that core biopsy is an effective tool for investigation. We believe this should be the first-line investigation of choice, as it reduces the need for patients to undergo surgery, is more cost effective and offers a faster diagnosis.
[Mh] Termos MeSH primário: Biópsia com Agulha de Grande Calibre
Carcinoma de Células Escamosas/patologia
Linfonodos/patologia
Linfadenite/patologia
Linfadenopatia/patologia
Linfoma/patologia
Pseudolinfoma/patologia
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/diagnóstico por imagem
Carcinoma de Células Escamosas/secundário
Seres Humanos
Biópsia Guiada por Imagem
Linfonodos/diagnóstico por imagem
Linfonodos/cirurgia
Linfadenite/diagnóstico por imagem
Linfadenopatia/diagnóstico por imagem
Metástase Linfática
Linfoma/diagnóstico por imagem
Pescoço
Pseudolinfoma/diagnóstico por imagem
Estudos Retrospectivos
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2016.0353


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[PMID]:27899370
[Au] Autor:AlAkeely AG; Alkatan HM; Alsuhaibani AH; AlKhalidi H; Safieh LA; Coupland SE; Edward DP
[Ad] Endereço:King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
[Ti] Título:Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
[So] Source:Br J Ophthalmol;101(7):933-939, 2017 Jul.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Our aim is to the report the clinical and histopathological features of benign reactive lymphoid hyperplasia (BRLH) of the conjunctiva in children and the outcomes of treatment. METHODS: A retrospective chart review was performed for children aged 0-18 years, diagnosed with conjunctival BRLH from January 2000 to December 2013 at two large ophthalmology hospitals in the Middle East. Data were collected on patient demographics, features of the lesions, the site of the lesion, location, adnexal involvement, lymph nodes involvement, local spread, histopathology and molecular genetic studies of the cases (if available), outcomes of treatment and recurrence. RESULTS: There were 24 patients with lymphoid lesions classified as conjunctival BRLH during the 12-year period evaluated in this study. The mean age at diagnosis was 11.6 years. Twenty-three patients were males (96%). Systemic medical history included three patients with bronchial asthma, one patient with Down's syndrome, one patient with generalised skeletal malformation and one patient with gastritis. The initial uncorrected visual acuity was 20/30 or better in 93.5% of the eyes. At presentation, the tumour was unilateral in 12 cases (50%). The conjunctival mass was located on the bulbar conjunctiva in all cases. The mass was present nasally in 96% of lesions. No cases (that were tested) had an infectious aetiology. PCR demonstrated monoclonality suggestive of lymphoma in two cases; however, this did not alter the final diagnosis as BRLH per histopathological criteria and clinical course, CONCLUSIONS: All investigated cases of paediatric conjunctival BRLH had a benign clinical course with no local or systemic dissemination and a male predominance. Recurrence was rare, and in our cohort, it was not associated with malignant transformation.
[Mh] Termos MeSH primário: Túnica Conjuntiva/patologia
Doenças da Túnica Conjuntiva/diagnóstico
Pseudolinfoma/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Doenças da Túnica Conjuntiva/epidemiologia
Feminino
Seguimentos
Seres Humanos
Incidência
Lactente
Recém-Nascido
Masculino
Pseudolinfoma/epidemiologia
Estudos Retrospectivos
Arábia Saudita/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309030


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[PMID]:27852687
[Au] Autor:King RL; Paessler ME; Howard MT; Wertheim GB
[Ad] Endereço:Division of Hematopathology, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:Incidental EBV-positivity in paediatric post-transplant specimens demonstrates the need for stringent criteria for diagnosing post-transplant lymphoproliferative disorders.
[So] Source:J Clin Pathol;70(3):270-273, 2017 Mar.
[Is] ISSN:1472-4146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To examine the need for minimal diagnostic criteria for post-transplant lymphoproliferative disorders (PTLD) in children, we sought to determine the rate of incidental Epstein-Barr virus (EBV)-positivity in tissues from organ transplant recipients (OTR). METHODS: EBV in situ hybridisation (ISH) was done retrospectively on tissue from 34 paediatric autopsies of OTR and paediatric tonsillectomy specimens from non-OTR (96) and OTR (6). Patients with a history of PTLD were excluded from both data sets. RESULTS: EBV-positivity was found incidentally in 2/34 autopsy cases (5.9%). Median time from transplant to death for all patients was 12.8 months (range 0.1-153 months). Median time between transplant and death in EBV-positive cases was 34 months. EBV was positive in 26/102 tonsils (25%). Among tonsils from OTR, 4/6 (67%) were EBV-positive. CONCLUSIONS: These findings reinforce the need for strict morphological and clinical criteria, other than EBV-positivity, when diagnosing PTLD in the paediatric population.
[Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/epidemiologia
Transtornos Linfoproliferativos/diagnóstico
Transplante de Órgãos
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Achados Incidentais
Lactente
Transtornos Linfoproliferativos/virologia
Masculino
Tonsila Palatina/patologia
Tonsila Palatina/virologia
Complicações Pós-Operatórias/virologia
Pseudolinfoma/diagnóstico
Pseudolinfoma/patologia
Pseudolinfoma/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1136/jclinpath-2016-203924


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[PMID]:27720730
[Au] Autor:Bois MC; Sekiguchi H; Ryu JH; Yi ES
[Ad] Endereço:Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905.
[Ti] Título:No definite clinical features of immunoglobulin G4-related disease in patients with pulmonary nodular lymphoid hyperplasia.
[So] Source:Hum Pathol;59:80-86, 2017 Jan.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary nodular lymphoid hyperplasia (PNLH) may show heavy lymphoplasmacytic infiltrates with increased immunoglobulin G4 (IgG4)-positive plasma cells as in IgG4-related disease (IgG4-RD). However, it is unclear whether PNLH could be a manifestation of IgG4-RD. A recent study reported the presence of Epstein-Barr virus (EBV) in IgG4-related lymphadenopathy. We postulated that a subset of PNLH might represent IgG4-related lung disease with EBV-positive lymphocytes as has been reported in IgG4-related lymphadenopathy. IgG and IgG4 immunohistochemistries were performed on 26 PNLH cases in our files (1994-2014) and on 9 controls including diffuse lymphoid hyperplasia of the lung without nodularity (n=2), usual interstitial pneumonia with increased lymphoplasmacytic infiltrates (n=5), and thoracic lymphadenopathy (n=2). EBV in situ hybridization was performed in the cases with the highest IgG4+ count (n=15). Median IgG4+ plasma cell count in PNLH was 36 cells per high-power field (interquartile range, 7-65) with median IgG4+/IgG+ ratio of 0.24 (interquartile range, 0.12-0.37). Three of 26 cases had a markedly increased IgG4+ count (range, 55-139) and IgG4+/IgG+ ratio (>0.4). Serum IgG4 level available in 1 of these cases was not elevated, and all 3 patients had alternate medical diagnoses. Absolute counts of IgG4+ plasma cells in PNLH did not significantly differ from the other control groups. Result of EBV in situ hybridization was negative in all cases tested. In conclusion, most PNLH cases had low IgG4+ cells, and there was no clinical evidence of IgG4-RD or EBV among those with increased IgG4+ cells.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Imunoglobulina G/análise
Pneumopatias/imunologia
Pulmão/imunologia
Plasmócitos/imunologia
Pseudolinfoma/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Doenças Autoimunes/sangue
Doenças Autoimunes/patologia
Biomarcadores/análise
Biomarcadores/sangue
Biópsia
Estudos de Casos e Controles
Infecções por Vírus Epstein-Barr/imunologia
Infecções por Vírus Epstein-Barr/patologia
Feminino
Seres Humanos
Imunoglobulina G/sangue
Imuno-Histoquímica
Pulmão/patologia
Pneumopatias/sangue
Pneumopatias/patologia
Masculino
Meia-Idade
Minnesota
Plasmócitos/patologia
Pseudolinfoma/sangue
Pseudolinfoma/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27097342
[Au] Autor:Magro CM; Momtahen S
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
[Ti] Título:Differential NFATc1 Expression in Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma.
[So] Source:Am J Dermatopathol;39(2):95-103, 2017 Feb.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma (PCSTCL) has recently emerged as a distinct clinicopathological entity. Because of a considerable degree of overlap with pseudolymphoma, the diagnosis is often challenging. Preliminary studies suggest that nuclear upregulation of calcineurin/nuclear factor of activated T cells (NFAT) may play a role in lymphomagenesis. DESIGN: 137 cases (70 males and 67 female, mean age = 55) of various forms of cutaneous T-cell and B-cell infiltration were evaluated for NFATc1 expression. The study comprised 18 cases of PCSTCL, 45 cases of mycosis fungoides (MF), 5 cases of lymphomatoid papulosis (LyP), 5 cases of anaplastic large-cell lymphoma (ALCL), 8 cases of other forms of peripheral T-cell lymphoma, not otherwise specified, 12 precursor lesions of MF (ie, cutaneous T-cell dyscrasias), 35 cases of pseudolymphomas, 8 primary cutaneous B-cell lymphoma, and 1 chronic lymphocytic leukemia. The number of cells exhibiting a nuclear stain was counted per 10 high-power field and 2-tailed statistical analysis was used for comparison of nuclear NFATc1 expression between primary PCSTCL and all other groups. A P-value <0.05 was considered to indicate statistical significance. RESULTS: All cases of PCSTCL showed nuclear staining for NFATc1 (mean = 296 ± 236) with no cases in which an exclusive cytoplasmic stain was observed. The cells exhibiting this staining pattern were oftentimes larger manifesting other features of a follicular helper T-cell phenotype, such as variable positivity for PD1, ICOS, CXCL13, and BCL6. In comparison, an exclusively cytoplasmic stain was observed in 29 cases of MF; in few cases, rare nuclear staining cells were observed averaging less than 10 per high-power field (P = 0.0001). These positive staining cases were not only limited to tumor-stage MF but also encompassed patch- and plaque-stage lesions and follicular variants of MF. The same pattern was observed in cases of T-cell dyscrasia (mean = 3 ± 3, P = 0.0001) and pseudolymphoma (mean = 2 ± 3, P = 0.0001), both revealing a dominant cytoplasmic staining pattern. In pseudolymphomatous folliculitis, a greater extent of nuclear staining for NFATc1 was observed compared with other forms of pseudolymphoma. No significant difference was seen between MF and T-cell dyscrasia or pesudolymphomas excluding pseudolymphotous folliculitis. Anaplastic large-cell lymphoma cases showed an almost exclusive cytoplasmic staining pattern with rare nuclear staining (mean = 55 ± 102, P = 0.0001); similar results were observed in LyP (mean = 17 ± 15, P = 0.004). Cutaneous B-cell lymphomas showed a similar extent of staining as that noted for PCSTCL. The greatest extent of staining was observed in chronic lymphocytic leukemia. A significant difference was noted between the extent of nuclear staining in PCSTCL and other forms of primary cutaneous T-cell lymphoma, type unspecified (mean = 22 ± 43, P = 0.0002), although not between PCSTCL and B-cell lymphoma. CONCLUSION: NFAT signaling plays a critical role in peripheral T-cell activation after T cell receptor engagement. When assessing T-cell-rich infiltrates where the differential diagnosis is largely between a PCSTCL and pseudolymphoma, a significant degree of nuclear staining of lymphocytes would be more in keeping with a diagnosis of PCSTCL. Upregulation of the NFAT pathway is not a feature of tumor progression in the setting of MF.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Linfoma Cutâneo de Células T/diagnóstico
Fatores de Transcrição NFATC/biossíntese
Pseudolinfoma/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Linfócitos T CD4-Positivos/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Transcrição NFATC/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (NFATC Transcription Factors); 0 (NFATC1 protein, human)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000597


  9 / 838 MEDLINE  
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[PMID]:26861728
[Au] Autor:Loidi Pascual L; Larrea García M; Agulló Pérez AD; Córdoba Iturriagagoitia A; Yanguas Bayona JI
[Ad] Endereço:Dermatology, Department of Complejo Hospitalario de Navarra, Navarra, Spain.
[Ti] Título:Disseminated nodules after vaccines for hyposensitization for mites. Pseudolymphoma or lymphoma?
[So] Source:J Eur Acad Dermatol Venereol;31(1):e5-e6, 2017 Jan.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dessensibilização Imunológica
Linfoma/diagnóstico
Ácaros/imunologia
Pseudolinfoma/patologia
[Mh] Termos MeSH secundário: Adulto
Animais
Diagnóstico Diferencial
Feminino
Seres Humanos
Pseudolinfoma/diagnóstico
Pseudolinfoma/etiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.13581


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[PMID]:23978426
[Au] Autor:Yang CT; Liu KL; Lin MC; Yuan RH
[Ad] Endereço:Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Imaging, National Taiwan University, College of Medicine, Taipei, Taiwan.
[Ti] Título:Pseudolymphoma of the liver: Report of a case and review of the literature.
[So] Source:Asian J Surg;40(1):74-80, 2017 Jan.
[Is] ISSN:0219-3108
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:We report a case of pseudolymphoma of the liver in a 49-year-old woman without an underlying disease except for liver hemangioma. A 20-mm nodule was incidentally found in segment 2 of the liver by abdominal ultrasonography during a regular follow-up of the hepatic hemangioma. After a series of radiological examinations, a left lateral sectionectomy was performed because malignant hepatic tumor could not be excluded. The patient was discharged uneventfully 7 days after the operation. The pathology examination revealed a pseudolymphoma. No recurrence of the tumor was found 5½ years after the operation. To the best of our knowledge, only 46 cases of pseudolymphoma of the liver have been reported to date. A review of the literature showed that pseudolymphomas occur predominantly in females (89.4%), usually occur as a single tumor (80.4%), are no more than 20 mm in size (90.6%), and are frequently associated with either autoimmune disease or chronic liver disease. Because an accurate diagnosis is difficult to establish, vigilant follow-up is indicated, and surgical intervention is the choice of treatment once the suspiciousness of malignancy has been raised.
[Mh] Termos MeSH primário: Hepatopatias/diagnóstico
Pseudolinfoma/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Hepatopatias/patologia
Hepatopatias/cirurgia
Meia-Idade
Pseudolinfoma/patologia
Pseudolinfoma/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130828
[St] Status:MEDLINE



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