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Pesquisa : C16.131.831.812 [Categoria DeCS]
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  1 / 94 MEDLINE  
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[PMID]:27001336
[Au] Autor:Spohn GP; Pietras TA; Stone MS
[Ad] Endereço:Division of Dermatology, Department of Internal Medicine, Ohio State University, Columbus, Ohio.
[Ti] Título:Delayed-Onset Sclerema Neonatorum in a Critically Ill Premature Infant.
[So] Source:Pediatr Dermatol;33(2):e168-9, 2016 Mar-Apr.
[Is] ISSN:1525-1470
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sclerema neonatorum is extremely rare in the 21st century. We report a premature infant managed in a neonatal intensive care unit with delayed development of sclerema neonatorum.
[Mh] Termos MeSH primário: Esclerema Neonatal/patologia
[Mh] Termos MeSH secundário: Estado Terminal
Feminino
Seres Humanos
Lactente
Recém-Nascido
Doenças do Prematuro
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1111/pde.12814


  2 / 94 MEDLINE  
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[PMID]:24758207
[Au] Autor:Darragh CT; Eichel Y; Lewis FJ; Radack KP; Redfern ME; Hays K; Thiers BH
[Ad] Endereço:College of Medicine, Medical University of South Carolina, Charleston, South Carolina.
[Ti] Título:Sclerodermatous skin changes in an infant.
[So] Source:Pediatr Dermatol;31(3):387-8, 2014 May-Jun.
[Is] ISSN:1525-1470
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Progéria/diagnóstico
Esclerema Neonatal/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Recém-Nascido
Masculino
Progéria/patologia
Esclerema Neonatal/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140424
[Lr] Data última revisão:
140424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140425
[St] Status:MEDLINE
[do] DOI:10.1111/pde.12100


  3 / 94 MEDLINE  
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[PMID]:24592596
[Au] Autor:Afroze F; Pietroni MA; Chisti MJ
[Ad] Endereço:Clinical Services Centre, icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
[Ti] Título:Recurrent sclerema in a young infant presenting with severe sepsis and severe pneumonia: an uncommon but extremely life-threatening condition.
[So] Source:J Health Popul Nutr;31(4):538-42, 2013 Dec.
[Is] ISSN:1606-0997
[Cp] País de publicação:Bangladesh
[La] Idioma:eng
[Ab] Resumo:A one month and twenty-five days old baby girl with problems of acute watery diarrhoea, severe dehydration, severe malnutrition, and reduced activity was admitted to the gastrointestinal unit of Dhaka Hospital of icddr,b. The differentials included dehydration, dyselectrolytaemia and severe sepsis. She was treated following the protocolized management guidelines of the hospital. However, within the next 24 hours, the patient deteriorated with additional problems of severe sepsis, severe pneumonia, hypoxaemia, ileus, and sclerema. She was transferred to the Intensive Care Unit (ICU). In the ICU, she was managed with oxygen supplementation, intravenous antibiotics, intravenous fluid, including a number of blood transfusions, vitamins, minerals, and diet. One month prior to this admission, she had been admitted to the ICU also with sclerema, septic shock, and urinary tract infection due to Escherichia coli and was discharged after full recovery. On both the occasions, she required repeated blood transfusions and aggressive antibiotic therapy in addition to appropriate fluid therapy and oxygen supplementation. She fully recovered from severe sepsis, severe malnutrition, ileus, sclerema, and pneumonia, both clinically and radiologically and was discharged two weeks after admission. Consecutive episodes of sclerema, resulting in two successive hospitalizations in a severely-malnourished young septic infant, have never been reported. However, this was managed successfully with blood transfusion, broad-spectrum antibiotics, and correction of electrolyte imbalance.
[Mh] Termos MeSH primário: Pneumonia/complicações
Esclerema Neonatal/complicações
Sepse/complicações
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Bangladesh
Transfusão de Sangue/métodos
Desidratação/complicações
Desidratação/terapia
Diagnóstico Diferencial
Diarreia/complicações
Diarreia/terapia
Dieta/métodos
Feminino
Hidratação/métodos
Seres Humanos
Lactente
Transtornos da Nutrição do Lactente/complicações
Transtornos da Nutrição do Lactente/terapia
Oxigênio/administração & dosagem
Recidiva
Esclerema Neonatal/terapia
Sepse/terapia
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); S88TT14065 (Oxygen)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:150515
[Lr] Data última revisão:
150515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140306
[St] Status:MEDLINE


  4 / 94 MEDLINE  
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[PMID]:24087781
[Au] Autor:Buster KJ; Burford HN; Stewart FA; Sellheyer K; Hughey LC
[Ad] Endereço:Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Ave S, EFH Set 414, Birmingham, AL 35294-0009, USA. lchughey@uab.edu.
[Ti] Título:Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments.
[So] Source:Cutis;92(2):83-7, 2013 Aug.
[Is] ISSN:2326-6929
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sclerema neonatorum (SN) is a rare neonatal panniculitis that typically develops in severely ill, preterm newborns within the first week of life and often is fatal. It usually occurs in preterm newborns with delivery complications such as respiratory distress or maternal complications such as eclampsia. Few clinical trials have been performed to address potential treatments. Successful treatment has been achieved via exchange transfusion (ET), but its use in neonates is declining. Similar to ET, intravenous immunoglobulin (IVIG) enhances both humoral and cellular immunity and thus may decrease mortality associated with SN. We report a case of SN in a term newborn who subsequently developed septicemia. Biopsy showed subcutaneous, needle-shaped clefts without associated necrosis, inflammation, or calcifications. Treatment with IVIG led to notable but short-term clinical improvement. Sclerema neonatorum remains a poorly understood and difficult to treat neonatal disorder. Although IVIG did not prevent our patient's death, further studies are needed to determine its clinical utility in the treatment of this rare disorder.
[Mh] Termos MeSH primário: Imunoglobulinas Intravenosas/uso terapêutico
Fatores Imunológicos/uso terapêutico
Esclerema Neonatal/tratamento farmacológico
[Mh] Termos MeSH secundário: Biópsia
Evolução Fatal
Feminino
Seres Humanos
Recém-Nascido
Esclerema Neonatal/patologia
Sepse/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:131002
[Lr] Data última revisão:
131002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131003
[St] Status:MEDLINE


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[PMID]:23900159
[Au] Autor:Grassi S; Borroni RG; Brazzelli V
[Ad] Endereço:Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Sezione di Dermatologia Università di Pavia, Fondazione IRCCS Policlinico "San Matteo", Pavia, Italia - sara.grassi03@gmail.com.
[Ti] Título:Panniculitis in children.
[So] Source:G Ital Dermatol Venereol;148(4):371-85, 2013 Aug.
[Is] ISSN:0392-0488
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:This paper will give a comprehensive view of the most frequent panniculitides seen in childhood, with emphasis on the types exclusively found in infancy, and for all other types of panniculitides also found in adults. Aim of this paper is also to analyze the clinical differences between panniculitis in childhood and in adulthood, and to give reliable histopathologic criteria for a specific diagnosis. A review of the literature is here integrated by authors' personal contribution. Panniculitides in children is a heterogeneous group of diseases, as well as in adult life, characterized by inflammation of the subcutaneous fat. Only very few types of panniculitis are exclusively found in childhood, such as Sclerema neonatorum and subcutaneous fat necrosis of the newborn, while the vast majority of the other types may be found both in paediatric age and in adults. Furthermore, this paper will consider in detail panniculitis according to their frequency, such as Erythema nodosum, Lupus panniculitis, Cold panniculitis, panniculitis in Behçet disease, and poststeroid panniculitis. It will also describe rare forms of panniculitis, such as Eosinophilic panniculitis (a pathological entity debated by many authors), Subcutaneous panniculitis T-cell lymphoma, and the different forms of the so call "Lipophagic panniculitis", encompassing respectively the febrile relapsing panniculitis of Weber-Christian disease and the non-relapsing form of Rothmann-Makai disease. For each type of panniculitis considered concise information will be given about epidemiology, etiology, clinical findings, laboratory data, prognosis and therapy, while histopathologic findings will be described in detail.
[Mh] Termos MeSH primário: Paniculite/patologia
[Mh] Termos MeSH secundário: Corticosteroides/efeitos adversos
Idade de Início
Síndrome de Behçet/complicações
Celulite (Flegmão)/sangue
Celulite (Flegmão)/epidemiologia
Celulite (Flegmão)/patologia
Celulite (Flegmão)/terapia
Criança
Pré-Escolar
Temperatura Baixa/efeitos adversos
Diagnóstico Diferencial
Eosinofilia/sangue
Eosinofilia/epidemiologia
Eosinofilia/patologia
Eosinofilia/terapia
Eritema Nodoso/sangue
Eritema Nodoso/diagnóstico
Eritema Nodoso/epidemiologia
Eritema Nodoso/patologia
Eritema Nodoso/terapia
Necrose Gordurosa/sangue
Necrose Gordurosa/epidemiologia
Necrose Gordurosa/patologia
Necrose Gordurosa/terapia
Granuloma Anular/sangue
Granuloma Anular/epidemiologia
Granuloma Anular/patologia
Granuloma Anular/terapia
Seres Humanos
Lactente
Recém-Nascido
Linfoma Cutâneo de Células T/sangue
Linfoma Cutâneo de Células T/epidemiologia
Linfoma Cutâneo de Células T/patologia
Linfoma Cutâneo de Células T/terapia
Paniculite/classificação
Paniculite/diagnóstico
Paniculite/epidemiologia
Paniculite/etiologia
Paniculite/terapia
Paniculite Nodular não Supurativa/sangue
Paniculite Nodular não Supurativa/epidemiologia
Paniculite Nodular não Supurativa/patologia
Paniculite Nodular não Supurativa/terapia
Esclerema Neonatal/sangue
Esclerema Neonatal/epidemiologia
Esclerema Neonatal/patologia
Esclerema Neonatal/terapia
Gordura Subcutânea/patologia
Deficiência de alfa 1-Antitripsina/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130731
[Lr] Data última revisão:
130731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130801
[St] Status:MEDLINE


  6 / 94 MEDLINE  
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[PMID]:20178707
[Au] Autor:Zhou W; Wiesenthal A; Carr V; Allison A; Kelly B; Gibson B
[Ad] Endereço:Department of Dermatology, University of Texas Health Science Center, San Antonio, Texas, USA.
[Ti] Título:A firm plaque on the back of a newborn.
[So] Source:Dermatol Online J;16(2):11, 2010 Feb 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a case of subcutaneous fat necrosis of the newborn (SCFN), a rare disorder in term or post-term neonates. Although it is often associated with hematological abnormalities such as anemia and hypercalcemia, SCFN in this patient presented with hyperbilirubinemia. The course of SCFN is generally benign and self-limiting, though may be associated with complications secondary to hypercalcemia.
[Mh] Termos MeSH primário: Necrose Gordurosa/complicações
Necrose Gordurosa/patologia
Hiperbilirrubinemia Neonatal/etiologia
Hiperbilirrubinemia Neonatal/patologia
Gordura Subcutânea/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Recém-Nascido
Remissão Espontânea
Esclerema Neonatal/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1005
[Cu] Atualização por classe:100224
[Lr] Data última revisão:
100224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100225
[St] Status:MEDLINE


  7 / 94 MEDLINE  
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[PMID]:19319014
[Au] Autor:Zeb A; Rosenberg RE; Ahmed NU; Saha SK; Chowdhury A; Ahmed S; Darmstadt GL
[Ad] Endereço:Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.
[Ti] Título:Risk factors for sclerema neonatorum in preterm neonates in Bangladesh.
[So] Source:Pediatr Infect Dis J;28(5):435-8, 2009 May.
[Is] ISSN:0891-3668
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study presents a retrospective analysis of risk factors for sclerema neonatorum in preterm neonates in Bangladesh. METHODS: Preterm neonates admitted to Dhaka Shishu Hospital in Bangladesh were enrolled in a clinical trial to evaluate the effects of topical treatment with skin barrier-enhancing emollients on prevention of sepsis and mortality. Four hundred ninety-seven neonates were enrolled in the study and 51 (10.3%) developed sclerema neonatorum. We explored risk factors for sclerema neonatorum by comparing patients with and without sclerema neonatorum. Diagnosis of sclerema neonatorum was based on the presence of uniform hardening of skin and subcutaneous tissues to the extent that the skin could not be pitted nor picked up and pinched into a fold. Cultures of blood and cerebrospinal fluid were obtained in all neonates with clinical suspicion of sepsis. RESULTS: In multivariate analysis, lower maternal education (OR: 1.94; 95% CI: 1.02-3.69; P = 0.043), and signs of jaundice (OR: 2.82; 95% CI: 1.19-6.69; P = 0.018) and poor feeding (OR: 4.71; 95% CI: 1.02-21.74; P = 0.047) on admission were risk factors for developing sclerema neonatorum. The incidence rate ratio of sepsis in neonates who developed sclerema neonatorum was 1.81 (95% CI: 1.16-2.73; P = 0.004), primarily due to Gram-negative pathogens, and risk of death in infants with sclerema neonatorum was 46.5-fold higher (P < 0.001, 95% CI: 6.37-339.81) than for those without sclerema neonatorum. CONCLUSIONS: Sclerema neonatorum was a relatively common, grave condition in this setting, heralded by poor feeding, jaundice, and bacteremia, and signaling the need for prompt antibiotic treatment.
[Mh] Termos MeSH primário: Esclerema Neonatal/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Apneia
Bangladesh/epidemiologia
Peso Corporal
Escolaridade
Feminino
Seres Humanos
Recém-Nascido
Icterícia
Análise Multivariada
Razão de Chances
Nascimento Prematuro
Fatores de Risco
Esclerema Neonatal/complicações
Sepse/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:0907
[Cu] Atualização por classe:090512
[Lr] Data última revisão:
090512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090326
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0b013e3181951af4


  8 / 94 MEDLINE  
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[PMID]:19222934
[Au] Autor:Chisti MJ; Saha S; Roy CN; Ahmed T; Faruque AS; Salam MA; Islam S
[Ad] Endereço:International Centre for Diarrhoeal Disease Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh. chisti@icddrb.org
[Ti] Título:Predictors of mortality in infants with sclerema presenting to the Centre for Diarrhoeal Disease, Dhaka.
[So] Source:Ann Trop Paediatr;29(1):45-50, 2009 Mar.
[Is] ISSN:1465-3281
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sclerema is an uncommon, life-threatening condition, usually of newborns, with a case-fatality rate ranging from 50 to 100%. Very little is known about factors influencing outcome. AIM: To identify clinical and biochemical predictors associated with fatal outcome of sclerema in infants with diarrhoea. METHODS: Thirty infants with sclerema admitted to the Special Care Unit of the Dhaka Hospital of ICDDR,B with diarrhoea from May 2005 to end April 2006 were studied prospectively. Nine infants who died (30%) were considered to be cases while the 21 who survived constituted the comparison group. Hypothermia, severe malnutrition, septic shock, serum ammonia and CRP levels were considered to be predictors of death. Differences in proportions were compared by the chi(2) test and mean differences were compared using Student's t-test or the Mann-Whitney test, as appropriate. RESULTS: The mean age of the 30 infants was 2.1 months (range 12 d to 8 m). Fatal cases were more likely than survivors to be associated with severe underweight, a positive blood culture and higher serum ammonia and serum CRP levels. After adjusting for possible confounders in logistic regression analysis, the likelihood of death was higher in infants admitted with septic shock or who developed it soon after admission (OR 17.96, 95% CI 1.5-0220.4, p=0.024). CONCLUSIONS: Sclerema is associated with a high fatality rate and scleremic infants with diarrhoea who present with septic shock are at a greater risk of death.
[Mh] Termos MeSH primário: Esclerema Neonatal/diagnóstico
[Mh] Termos MeSH secundário: Amônia/sangue
Proteína C-Reativa/análise
Diarreia Infantil/complicações
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Prognóstico
Estudos Prospectivos
Esclerema Neonatal/complicações
Esclerema Neonatal/mortalidade
Choque Séptico/complicações
Magreza/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7664-41-7 (Ammonia); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:090219
[Lr] Data última revisão:
090219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090219
[St] Status:MEDLINE
[do] DOI:10.1179/146532809X402024


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[PMID]:19141140
[Au] Autor:Chisti MJ; Ahmed T; Faruque AS; Saha S; Salam MA; Islam S
[Ad] Endereço:International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. chisti@icddrb.org
[Ti] Título:Factors associated with sclerema in infants with diarrhoeal disease: a matched case-control study.
[So] Source:Acta Paediatr;98(5):873-8, 2009 May.
[Is] ISSN:1651-2227
[Cp] País de publicação:Norway
[La] Idioma:eng
[Ab] Resumo:AIM: To identify clinical and biochemical factors associated with sclerema in infants with diarrhoeal illness, and their outcome. METHODS: In this case-control study, we enrolled 30 infants with clinical sepsis with sclerema (cases) and another 60, age- and sex-matched infants with clinical sepsis but without sclerema (controls) from among those admitted to the special care unit (SCU) and longer stay unit (LSU) of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) for their diarrhoeal illness from May 2005 through April 2006. Sclerema as the dependant variable while hypoxia, hypothermia, C-reactive protein (CRP) level, serum total protein and prealbumin level were the major independent variables compared in the analysis. Differences in proportions were compared by the chi-square test and differences of mean were compared by Student's t-test or Mann-Whitney test, as appropriate. RESULTS: The case-fatality was significantly higher among the cases than the controls (30% vs. 2%, CI 2.9-565.5). After adjusting for confounders, infants with sclerema were more likely to be hypothermic (OR 11.6, 95% CI 1.1-126.5), and have lower serum total protein (OR 1.12, 95% CI 1.04-1.21) and prealbumin (OR 1.5, 95% CI 1.1-2.3). CONCLUSION: Diarrhoeal infants having clinical sepsis presenting with hypothermia, lower serum protein and prealbumin are prone to be associated with sclerema.
[Mh] Termos MeSH primário: Bacteriemia/complicações
Diarreia Infantil/complicações
Esclerema Neonatal/etiologia
[Mh] Termos MeSH secundário: Bacteriemia/microbiologia
Estudos de Casos e Controles
Diarreia Infantil/sangue
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estudos Prospectivos
Esclerema Neonatal/sangue
Esclerema Neonatal/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0907
[Cu] Atualização por classe:090424
[Lr] Data última revisão:
090424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090115
[St] Status:MEDLINE
[do] DOI:10.1111/j.1651-2227.2008.01196.x


  10 / 94 MEDLINE  
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[PMID]:18368059
[Au] Autor:Zeb A; Darmstadt GL
[Ad] Endereço:Department of International Health, International Center for Advancing Neonatal Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
[Ti] Título:Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management.
[So] Source:J Perinatol;28(7):453-60, 2008 Jul.
[Is] ISSN:1476-5543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To review published literature on sclerema neonatorum (SN) in order to clarify its clinical presentation, histological features and management compared with two other diseases: subcutaneous fat necrosis of the newborn (SCFN) and scleredema. STUDY DESIGN: PubMed database was searched using the key words Sclerema neonatorum. A total of 55 articles from peer-reviewed journals were reviewed and summarized. RESULT: SN, SCFN and scleredema are diseases of the subcutaneous adipose tissue. SN is characterized by hardening of the skin that gets bound down to the underlying muscle and bone, hindering respiration and feeding and is associated with congenital anomalies, cyanosis, respiratory illnesses and sepsis. Histology of the skin biopsy shows thickening of the trabeculae supporting the subcutaneous adipose tissue and a sparse inflammatory infiltrate of lymphocytes, histiocytes and multinucleate giant cells. SCFN has circumscribed hardening of skin on bony prominences with necrosis of adipocytes in subcutaneous tissue and a dense granulomatous infiltrate on histology. Scleredema is characterized by hardening of the skin along with edema; histology shows inflammatory infiltrate and edema in skin and subcutaneous tissues. SN has a high case fatality rate whereas SCFN and scleredema are self-limiting and lesions resolve within a few weeks to months. Exchange transfusion may improve survival in SN. CONCLUSION: The histological features of skin biopsy should be used to establish diagnosis of SN, SCFN and scleredema as disease-specific treatment is imperative in SN due to high fatality.
[Mh] Termos MeSH primário: Esclerema Neonatal/diagnóstico
[Mh] Termos MeSH secundário: Necrose Gordurosa/patologia
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Esclerema Neonatal/patologia
Esclerema Neonatal/fisiopatologia
Esclerema Neonatal/terapia
Gordura Subcutânea/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:0810
[Cu] Atualização por classe:080630
[Lr] Data última revisão:
080630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080328
[St] Status:MEDLINE
[do] DOI:10.1038/jp.2008.33



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde