[PMID]: | 27309418 |
[Au] Autor: | Komen L; Vrijman C; Prinsen CA; van der Veen JP; Luiten RM; Wolkerstorfer A |
[Ad] Endereço: | a Department of Dermatology and The Netherlands Institute for Pigment Disorders (SNIP) , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands. |
[Ti] Título: | Optimising size and depth of punch grafts in autologous transplantation of vitiligo and piebaldism: a randomised controlled trial. |
[So] Source: | J Dermatolog Treat;28(1):86-91, 2017 Feb. |
[Is] ISSN: | 1471-1753 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: To date, autologous punch grafting appears to be the easiest and least expensive surgical technique for stable vitiligo and piebaldism. Punch grafting is available worldwide, with no need for specialised instruments. However, no reliable data on efficacy and safety of different punch depths and punch sizes are available. OBJECTIVE/METHODS: To compare the efficacy and safety of different punch depths and punch sizes in autologous punch grafting, a randomised controlled trial was performed in 33 patients with vitiligo or piebaldism. In each patient, four depigmented regions were allocated to: 1.5 mm deep grafts, 1.5 mm superficial grafts, 1.0 mm deep grafts, and 1.0 mm superficial grafts. Primary outcome was the total pigmented surface area. Secondary outcomes were Patients' Global Assessment (PGA) and side effects. RESULTS: Six months after grafting, 1.5 mm grafts showed a significantly larger pigmented surface area compared to 1.0-mm grafts (p < 0.001), though more side effects as well. No significant differences in the total pigmented surface between different punch depths were found. Deep grafts showed more erythema compared to superficial grafts. CONCLUSION: We recommend 1.5 mm superficial grafts in autologous punch grafting for trunk and proximal extremities in patients with stable vitiligo and piebaldism. |
[Mh] Termos MeSH primário: |
Piebaldismo/cirurgia Transplante de Pele/métodos Vitiligo/cirurgia
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[Mh] Termos MeSH secundário: |
Adolescente Adulto Extremidades Feminino Seguimentos Seres Humanos Masculino Meia-Idade Tronco Transplante Autólogo/métodos Resultado do Tratamento Adulto Jovem
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[Pt] Tipo de publicação: | COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL |
[Em] Mês de entrada: | 1704 |
[Cu] Atualização por classe: | 170404 |
[Lr] Data última revisão:
| 170404 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160617 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1080/09546634.2016.1179251 |
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