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[PMID]: 29390535 [Au] Autor: Gutiérrez-Castrellón P; Indrio F; Bolio-Galvis A; Jiménez-Gutiérrez C; Jimenez-Escobar I; López-Velázquez G [Ad] Endereço: Center for Translational Research on Early Programming Nutrition and Mother-Child Nutrition, Hospital General Dr Manuel Gea González & Dirección de Investigación. Universidad Tecnológica de México-Unitec México. [Ti] Título: Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis. [So] Source: Medicine (Baltimore);96(51):e9375, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: 5% to 40% of infants cry excessively, usually accompanied by fussiness and excessive of gas. There are no uniform criteria for treatment of infantile colic. Lactobacillus reuteri DSM 17938 has been used with promising results. The objective of this network-meta-analysis (NMA) is to compare the efficacy of L reuteri DSM 17938 with other interventions for infantile colic. METHODS: RCTs, published between 1960 and 2015 for the treatment of infantile colic were included. Primary outcome was duration of crying after 21 to 28 days of treatment. Different databases were searched. Information was analyzed using control group as central axis. A random effect model was used. Hedges standard mean difference (SMD) and odds ratio (OR) were calculated. A SUCRA analysis was performed to evaluate superiority for each intervention. RESULTS: 32 RCTs were analyzed, including 2242 patients. Studies with L reuteri DSM 17938 versus Ctrl., Diet versus Ctrl. and Acupuncture versus Ctrl. were the most influential studies in the NMA. L reuteri DSM 17938 [WMD -51.3 h (CI95% -72.2 to -30.5 h), P .0001] and dietetic approaches [WMD -37.4 h (CI95% -56.1 to -18.7 h), P .0001] were superior compared to the other treatments. CONCLUSIONS: L reuteri DSM 17938 and some dietetic approaches are better to other interventions for treatment of infantile colic. [Mh] Termos MeSH primário: Cólica/terapia Lactobacillus reuteri Probióticos/uso terapêutico [Mh] Termos MeSH secundário: Dietoterapia Seres Humanos Lactente Modelos Estatísticos Razão de Chances Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009375

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[PMID]: 29309786 [Au] Autor: Hijjawi N; Yang R; Hatmal M; Yassin Y; Mharib T; Mukbel R; Mahmoud SA; Al-Shudifat AE; Ryan U [Ad] Endereço: Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, PO Box 150459, Zarqa, 13115, Jordan. [Ti] Título: Comparison of ELISA, nested PCR and sequencing and a novel qPCR for detection of Giardia isolates from Jordan. [So] Source: Exp Parasitol;185:23-28, 2018 Feb. [Is] ISSN: 1090-2449 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Little is known about the prevalence of Giardia duodenalis in human patients in Jordan and all previous studies have used direct microscopy, which lacks sensitivity. The present study developed a novel quantitative PCR (qPCR) assay at the ß-giardin (bg) locus and evaluated its use as a frontline test for the diagnosis of giardiasis in comparison with a commercially available ELISA using nested PCR and sequencing of the glutamate dehydrogenase (gdh) locus (gdh nPCR) as the gold standard. A total of 96 human faecal samples were collected from 96 patients suffering from diarrhoea from 5 regions of Jordan and were screened using the ELISA and qPCR. The analytical specificity of the bg qPCR assay revealed no cross-reactions with other genera and detected all the Giardia isolates tested. Analytical sensitivity was 1 Giardia cyst per µl of DNA extract. The overall prevalence of Giardia was 64.6%. The clinical sensitivity and specificity of the bg qPCR was 89.9% and 82.9% respectively compared to 76.5 and 68.0% for the ELISA. This study is the first to compare three different methods (ELISA, bg qPCR, nested PCR and sequencing at the gdh locus) to diagnose Jordanian patients suffering from giardiasis and to analyze their demographic data. [Mh] Termos MeSH primário: Diarreia/parasitologia Giardia lamblia/isolamento & purificação Giardíase/parasitologia [Mh] Termos MeSH secundário: Adolescente Adulto Antígenos de Protozoários/análise Criança Pré-Escolar Cólica/parasitologia Proteínas do Citoesqueleto/genética DNA de Protozoário/química DNA de Protozoário/isolamento & purificação Ensaio de Imunoadsorção Enzimática Fezes/parasitologia Feminino Giardia lamblia/genética Giardia lamblia/imunologia Giardíase/epidemiologia Glutamato Desidrogenase Seres Humanos Lactente Jordânia/epidemiologia Masculino Meia-Idade Reação em Cadeia da Polimerase Prevalência Proteínas de Protozoários/genética Reação em Cadeia da Polimerase em Tempo Real Sensibilidade e Especificidade Vômito/parasitologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antigens, Protozoan); 0 (Cytoskeletal Proteins); 0 (DNA, Protozoan); 0 (Protozoan Proteins); 0 (giardin protein, Giardia lamblia); EC 1.4.1.2 (Glutamate Dehydrogenase) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180109 [St] Status: MEDLINE

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[PMID]: 28462509 [Au] Autor: Southwood LL; Lindborg S; Myers M; Aceto HW [Ad] Endereço: Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania. [Ti] Título: Influence of Salmonella status on the long-term outcome of horses after colic surgery. [So] Source: Vet Surg;46(6):780-788, 2017 Aug. [Is] ISSN: 1532-950X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To compare long-term outcome of Salmonella-positive versus Salmonella-negative horses discharged from hospital after colic surgery. STUDY DESIGN: Retrospective case-control. ANIMALS: Horses discharged from the hospital after colic surgery. For each horse with positive culture for Salmonella enterica (SAL-POS, n = 59), at least 2 horses testing negative for S. enterica (SAL-NEG, n = 119) were enrolled. METHODS: Owners were interviewed via phone at least 12 months after surgery regarding: (1) complications after discharge from the hospital; (2) duration of survival; and (3) return to prior or intended use. Association between immediate postoperative clinical variables such as Salmonella status and long-term measures of outcome was tested via ratios (odds ratio [OR]) and 95% confidence intervals. Data were analyzed for survival using a Cox proportional hazards model and for return to use using multivariable logistic regression. RESULTS: SAL-POS horses had a higher OR of surgical site infection (2.7 [1.1-6.9] P = .027) and weight loss (6.8 [1.8-26.1] P = .002). At the time of follow-up, there were 53/56 (95%) SAL-POS and 99/118 (84%) SAL-NEG horses alive. The final multivariable model for nonsurvival included postoperative colic (hazard ratio 7.6 [2.8-19.2] P = .002) and the interaction between Salmonella status and duration of rectal temperature > 103°F postoperatively (SAL-POS 1.04 [1.01-1.07] and SAL-NEG 1.16 [1.06-1.25], P = .005). The majority of horses returned to their intended use regardless of their SAL-POS (38/50, 76%) or SAL-NEG (77/96, 80%, P = .498) status. CONCLUSION: Salmonella-positive horses that survive to discharge from the hospital after colic surgery have similar risks of long-term complications (colic/diarrhea), survival, and return to function than Salmonella-negative horses. [Mh] Termos MeSH primário: Cólica/veterinária Doenças dos Cavalos/cirurgia Salmonelose Animal/epidemiologia Salmonella/fisiologia [Mh] Termos MeSH secundário: Animais Estudos de Casos e Controles Cólica/microbiologia Cólica/cirurgia Feminino Doenças dos Cavalos/microbiologia Cavalos Modelos Logísticos Masculino Razão de Chances Estudos Retrospectivos Salmonelose Animal/microbiologia Infecção da Ferida Cirúrgica/veterinária Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180104 [Lr] Data última revisão: 180104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1111/vsu.12660

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[PMID]: 29191235 [Au] Autor: Porcino A; Solomonian L; Zylich S; Gluvic B; Doucet C; Vohra S [Ad] Endereço: Department of Pediatrics, CARE Program, Faculty of Medicine, University of Alberta, Edmonton, Canada. [Ti] Título: Pediatric training and practice of Canadian chiropractic and naturopathic doctors: a 2004-2014 comparative study. [So] Source: BMC Complement Altern Med;17(1):512, 2017 Dec 01. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: To assess chiropractic (DC) and naturopathic doctors' (ND) knowledge, attitudes, and behaviour with respect to the pediatric patients in their practice. METHODS: Cross-sectional surveys were developed in collaboration with DC and ND educators. Surveys were sent to randomly selected DCs and NDs in Ontario, Canada in 2004, and a national online survey was conducted in 2014. Data were analyzed using descriptive statistics, t-tests, non-parametric tests, and linear regression. RESULTS: Response rates for DCs were n = 172 (34%) in 2004, n = 553 (15.5%) in 2014, and for NDs, n = 171 (36%) in 2004, n = 162 (7%) in 2014. In 2014, 366 (78.4%) of DCs and 83 (61%) of NDs saw one or more pediatric patients per week. Pediatric training was rated as inadequate by most respondents in both 2004 and 2014, with most respondents (n = 643, 89.9%) seeking post-graduate training by 2014. Respondents' comfort in treating children and youth is based on experience and post-graduate training. Both DCs and NDs that see children and youth in their practices address a broad array of pediatric health concerns, from well child care and preventative health, to mild and serious illness. CONCLUSIONS: Although the response rate in 2014 is low, the concerns identified a decade earlier remain. The majority of responding DCs and NDs see infants, children, and youth for a variety of health conditions and issues, but self-assess their undergraduate pediatric training as inadequate. We encourage augmented pediatric educational content be included as core curriculum for DCs and NDs and suggest collaboration with institutions/organizations with expertise in pediatric education to facilitate curriculum development, especially in areas that affect patient safety. [Mh] Termos MeSH primário: Quiroprática/estatística & dados numéricos Pessoal de Saúde/psicologia Pessoal de Saúde/estatística & dados numéricos Naturopatia/estatística & dados numéricos Pediatria/estatística & dados numéricos [Mh] Termos MeSH secundário: Adulto Atitude do Pessoal de Saúde Canadá Quiroprática/educação Cólica/terapia Estudos Transversais Feminino Febre/terapia Pessoal de Saúde/educação Seres Humanos Recém-Nascido Masculino Meia-Idade Otite Média/terapia Pediatria/educação [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171220 [Lr] Data última revisão: 171220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171202 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-2024-5

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[PMID]: 28460865 [Au] Autor: Long B; April MD [Ad] Endereço: Department of Emergency Medicine, SAUSHEC, Fort Sam Houston, TX. [Ti] Título: Are Nonsteroidal Anti-inflammatory Drugs Efficacious in Relieving Biliary Colic Pain? [So] Source: Ann Emerg Med;70(6):822-824, 2017 12. [Is] ISSN: 1097-6760 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides Cólica [Mh] Termos MeSH secundário: Seres Humanos Injeções Intramusculares Dor [Pt] Tipo de publicação: EDITORIAL; COMMENT [Nm] Nome de substância: 0 (Anti-Inflammatory Agents, Non-Steroidal) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171204 [Lr] Data última revisão: 171204 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE

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[PMID]: 27772683 [Au] Autor: Meltzer AC; Michel C [Ad] Endereço: Department of Emergency Medicine, George Washington University, Washington, DC. [Ti] Título: The Importance of an Accurate Diagnosis for Renal Colic. [So] Source: Ann Emerg Med;68(5):643-644, 2016 11. [Is] ISSN: 1097-6760 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Cólica Cólica Renal [Mh] Termos MeSH secundário: Seres Humanos [Pt] Tipo de publicação: LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; COMMENT [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171201 [Lr] Data última revisão: 171201 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 28805200 [Au] Autor: Iwanczak B; Iwanczak F [Ad] Endereço: Medical University of Wroclaw, Poland: 2nd Departmet and Clinic of Pediatrics, Gastroenterology and Nutrition. [Ti] Título: [Functional gastrointestinal disorders in neonate and toddler. The Rome IV criteria]. [Ti] Título: Zaburzenia czynnosciowe przewodu pokarmowego u niemowlat i malych dzieci. IV Kryteria Rzymskie.. [So] Source: Pol Merkur Lekarski;43(253):35-40, 2017 Jul 21. [Is] ISSN: 1426-9686 [Cp] País de publicação: Poland [La] Idioma: pol [Ab] Resumo: Functional disorders of the gastrointestinal tract in infants and children are very frequent. To the most common belong: infant colic, regurgitation and functional constipation. In the year 2016 modified IV Rome criteria of functional gastrointestinal disorders were published. In the current work the authors discuss diagnostic criteria and therapy in regurgitation, rumination syndrome in infants, cyclic vomiting syndrome, infant colic, infant dyschezia and functional constipation in children younger than four years. [Mh] Termos MeSH primário: Gastroenteropatias/diagnóstico [Mh] Termos MeSH secundário: Pré-Escolar Cólica/diagnóstico Cólica/fisiopatologia Cólica/terapia Constipação Intestinal/diagnóstico Constipação Intestinal/fisiopatologia Constipação Intestinal/terapia Gastroenteropatias/fisiopatologia Gastroenteropatias/terapia Seres Humanos Lactente Recém-Nascido Vômito/diagnóstico Vômito/fisiopatologia Vômito/terapia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170815 [St] Status: MEDLINE

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[PMID]: 28554786 [Au] Autor: Harb T; Frederiksen N; Hill RJ [Ad] Endereço: Children's Nutrition Research Centre, UQ Child Health Research Centre, The University of Queensland, Australia. Electronic address: t.harb@uq.edu.au. [Ti] Título: Is sensory processing an issue for infants with colic? [So] Source: Infant Behav Dev;48(Pt B):105-113, 2017 08. [Is] ISSN: 1934-8800 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To determine the association between sensory functioning, sleep, cry/fuss, and feeding behaviors of infants with colic younger than 4 months of age. METHODS: Dunn's Infant/Toddler Sensory Profile™ and a modified Barr Baby Day Diary were used to assess 44 breastfed infants with colic under four months of age. Colic was defined according to Wessel's criteria. RESULTS: Thirty-four of the 44 infants with colic (77%) scored as atypical for sensory processing. Of these, 56% scored atypical for sensory processing on quadrant one (Q1) (Low Registration), with 24%, 65%, and 18% scoring as atypical for sensory processing on Q2 (Sensory seeking), Q3 (Sensory sensitivity), and Q4 (Sensation avoiding), respectively. All infants demonstrating sensation avoiding also scored as Low Threshold. A moderate statistically significant correlation was found between sensation seeking and time spent sleeping (r=0.31; p=0.04). No other statistically significant associations between infant behaviors and their sensory functioning were demonstrated. Overall, infants demonstrating atypical sensory responses (in any quadrant) slept significantly more than infants demonstrating typical sensory responses (mean difference=-67.8min/day; 95% CI=-133.6 to -2.1; p=0.04). CONCLUSION: Very limited associations between infant behaviors and sensory functioning were demonstrated, suggesting that sensory functioning may not be a significant factor in the multifactorial nature of infant colic. Further well-designed studies using validated tools for infants with colic are required to determine whether associations between infant behaviors and sensory functioning exist. [Mh] Termos MeSH primário: Cólica/fisiopatologia Comportamento do Lactente/fisiologia Sensação/fisiologia [Mh] Termos MeSH secundário: Aleitamento Materno Estudos Transversais Choro/fisiologia Feminino Seres Humanos Lactente Recém-Nascido Masculino Sono/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171126 [Lr] Data última revisão: 171126 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170531 [St] Status: MEDLINE

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[PMID]: 28541149 [Au] Autor: Pihl TH; Jacobsen S; Olsen DT; Højrup P; Grosche A; Freeman DE; Andersen PH; Houen G [Ti] Título: Characterization of equine vitamin D-binding protein, development of an assay, and assessment of plasma concentrations of the protein in healthy horses and horses with gastrointestinal disease. [So] Source: Am J Vet Res;78(6):718-728, 2017 Jun. [Is] ISSN: 1943-5681 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE To purify and characterize equine vitamin D-binding protein (VDBP) from equine serum and to evaluate plasma concentrations of VDBP in healthy horses and horses with gastrointestinal injury or disease. ANIMALS 13 healthy laboratory animals (8 mice and 5 rabbits), 61 healthy horses, 12 horses with experimentally induced intestinal ischemia and reperfusion (IR), and 59 horses with acute gastrointestinal diseases. PROCEDURES VDBP was purified from serum of 2 healthy horses, and recombinant equine VDBP was obtained through a commercial service. Equine VDBP was characterized by mass spectrometry. Monoclonal and polyclonal antibodies were raised against equine VDBP, and a rocket immunoelectrophoresis assay for equine VDBP was established. Plasma samples from 61 healthy horses were used to establish working VDBP reference values for study purposes. Plasma VDBP concentrations were assessed at predetermined time points in horses with IR and in horses with naturally occurring gastrointestinal diseases. RESULTS The working reference range for plasma VDBP concentration in healthy horses was 531 to 1,382 mg/L. Plasma VDBP concentrations were significantly decreased after 1 hour of ischemia in horses with IR, compared with values prior to induction of ischemia, and were significantly lower in horses with naturally occurring gastrointestinal diseases with a colic duration of < 12 hours than in healthy horses. CONCLUSIONS AND CLINICAL RELEVANCE Plasma VDBP concentrations were significantly decreased in horses with acute gastrointestinal injury or disease. Further studies and the development of a clinically relevant assay are needed to establish the reliability of VDBP as a diagnostic and prognostic marker in horses. [Mh] Termos MeSH primário: Gastroenteropatias/veterinária Doenças dos Cavalos/sangue Proteína de Ligação a Vitamina D/sangue [Mh] Termos MeSH secundário: Animais Anticorpos Cólica/veterinária Feminino Gastroenteropatias/sangue Cavalos Intestinos/irrigação sanguínea Isquemia/sangue Isquemia/veterinária Masculino Camundongos Camundongos Endogâmicos BALB C Coelhos Valores de Referência Reprodutibilidade dos Testes [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies); 0 (Vitamin D-Binding Protein) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170526 [St] Status: MEDLINE [do] DOI: 10.2460/ajvr.78.6.718

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[PMID]: 28441833 [Au] Autor: Zhu QL; Sheng XY [Ti] Título: [Research progress of infantile colic]. [So] Source: Zhonghua Er Ke Za Zhi;55(4):314-317, 2017 Apr 02. [Is] ISSN: 0578-1310 [Cp] País de publicação: China [La] Idioma: chi [Mh] Termos MeSH primário: Cólica [Mh] Termos MeSH secundário: Feminino Seres Humanos Lactente Recém-Nascido Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170807 [Lr] Data última revisão: 170807 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170427 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0578-1310.2017.04.018

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