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[PMID]:29277817
[Au] Autor:Tomioka K; Murakami M; Watanabe M; Fujimori A; Koizumi T; Goto S; Otsuka K; Aoki T
[Ad] Endereço:Division of Gastroenterological and General Surgery, Department of Surgery, Showa University, Tokyo, Japan tomioka@med.showa-u.ac.jp.
[Ti] Título:Evaluation of a Transumbilical Incision as an Approach for Organ Removal in Laparoscopy-assisted Colectomy.
[So] Source:Anticancer Res;38(1):513-517, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate the risk factors of transumbilical incision for organ removal in laparoscopy-assisted colectomy (LAC). PATIENTS AND METHODS: We enrolled 348 consecutive patients who underwent LAC at our hospital between 2010 and 2013. The occurrence of superficial surgical site infection (SSI) and hernia at the transumbilical port site were recorded. RESULTS: SSI was observed in 15 patients (4.31%); there were no obvious associated risk factors. Hernia occurred in 23 patients (6.61%); multivariate analysis revealed that female sex [odds ratio (OR)=4.736, 95% confidence interval (CI)=1.058 to 24.362; p=0.042] and diabetes mellitus (OR=4.655, 95% CI=1.520 to 13.585; p=0.004) were significantly associated with the risk of hernia. Anastomotic method and the anastomotic site (inside and outside the body) did not contribute to the occurrence of complications. CONCLUSION: Female sex and diabetes mellitus are independent risk factors for hernia formation in patients undergoing transumbilical incision for organ removal in laparoscopy-assisted colectomy.
[Mh] Termos MeSH primário: Colectomia/efeitos adversos
Hérnia Umbilical/epidemiologia
Laparoscopia/efeitos adversos
Infecção da Ferida Cirúrgica/epidemiologia
Umbigo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Colectomia/métodos
Colo/cirurgia
Diabetes Mellitus/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  2 / 3066 MEDLINE  
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[PMID]:29047350
[Au] Autor:Bedeschi MF; Calvello M; Paganini L; Pezzani L; Baccarin M; Fontana L; Sirchia SM; Guerneri S; Canazza L; Leva E; Colombo L; Lalatta F; Mosca F; Tabano S; Miozzo M
[Ad] Endereço:Clinical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. mariafrancesca.bedeschi@policlinico.mi.it.
[Ti] Título:Sequence variants identification at the KCNQ1OT1:TSS differentially Methylated region in isolated omphalocele cases.
[So] Source:BMC Med Genet;18(1):115, 2017 Oct 18.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Omphalocele is a congenital midline ventral body wall defect that can exist as isolated malformation or as part of a syndrome. It can be considered one of the major and most frequent clinical manifestation of Beckwith-Wiedemann Syndrome (BWS) in case of loss of methylation at KCNQ1OT1: Transcription Star Site-Differentially Methylated Region (TSS-DMR) or in presence of CDKN1C mutations. The isolated form of the omphalocele accounts approximately for about the 14% of the total cases and its molecular etiology has never been fully elucidated. METHODS: Given the tight relationship with BWS, we hypothesized that the isolated form of the omphalocele could belong to the heterogeneous spectrum of the BWS associated features, representing an endophenotype with a clear genetic connection. We therefore investigated genetic and epigenetic changes affecting BWS imprinted locus at 11p15.5 imprinted region, focusing in particular on the KCNQ1OT1:TSS DMR. RESULTS: We studied 21 cases of isolated omphalocele detected during pregnancy or at birth and identified the following rare maternally inherited variants: i) the non-coding variant G > A at nucleotide 687 (NR_002728.3) at KCNQ1OT1:TSS-DMR, which alters the methylation pattern of the imprinted allele, in one patient; ii) the deletion c.624-629delGGCCCC at exon 1 of CDKN1C, with unknown clinical significance, in two unrelated cases. CONCLUSIONS: Taken together, these findings suggest that KCNQ1OT1:TSS-DMR could be a susceptibility locus for the isolated omphalocele.
[Mh] Termos MeSH primário: Metilação de DNA
Variação Genética
Hérnia Umbilical/genética
Sítio de Iniciação de Transcrição
[Mh] Termos MeSH secundário: Sequência de Bases
Síndrome de Beckwith-Wiedemann/genética
Síndrome de Beckwith-Wiedemann/patologia
Pré-Escolar
Cromossomos Humanos Par 11/genética
Consanguinidade
Inibidor de Quinase Dependente de Ciclina p57/genética
Análise Mutacional de DNA/métodos
Feminino
Predisposição Genética para Doença/genética
Impressão Genômica
Seres Humanos
Lactente
Recém-Nascido
Masculino
Mutação
Linhagem
Polimorfismo de Nucleotídeo Único
Canais de Potássio de Abertura Dependente da Tensão da Membrana/genética
Deleção de Sequência
Homologia de Sequência do Ácido Nucleico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CDKN1C protein, human); 0 (Cyclin-Dependent Kinase Inhibitor p57); 0 (KCNQ1OT1 protein, human); 0 (Potassium Channels, Voltage-Gated)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0470-z


  3 / 3066 MEDLINE  
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[PMID]:28934221
[Au] Autor:Qian C; Wong CWY; Wu Z; He Q; Xia H; Tam PKH; Wong KKY; Lui VCH
[Ad] Endereço:Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
[Ti] Título:Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development.
[So] Source:PLoS One;12(9):e0184473, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused developmental defects of multiple endoderm and mesoderm derived structures, resulting in a complex phenotypes including orofacial cleft, spina bifida, rib deformities, and omphalocele in mice. However, it is not clear if deletion of Pdgfra at different embryonic stages differentially affects these structures. PURPOSE: To address the temporal requirement of Pdgfra in embryonic development. METHODS: We have deleted the Pdgfra in Pdgfra-expressing tissues at different embryonic stages in mice, examined and quantified the developmental anomalies. RESULTS: Current study showed that (i) conditional deletion of Pdgfra at different embryonic days (between E7.5 and E10.5) resulted in orofacial cleft, spina bifida, rib cage deformities, and omphalocele, and (ii) the day of Pdgfra deletion influenced the combinations, incidence and severities of these anomalies. Deletion of Pdgfra caused apoptosis of Pdgfra-expressing tissues, and developmental defects of their derivatives. CONCLUSION: Orofacial cleft, spina bifida and omphalocele are among the commonest skeletal and abdominal wall defects of newborns, but their genetic etiologies are largely unknown. The remarkable resemblance of our conditional Pdgfra knockout embryos to theses human congenital anomalies, suggesting that dysregulated PDGFRA expression could cause these anomalies in human. Future work should aim at defining (a) the regulatory elements for the expression of the human PDGFRA during embryonic development, and (b) if mutations / sequence variations of these regulatory elements cause these anomalies.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário/fisiologia
Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo
[Mh] Termos MeSH secundário: Parede Abdominal/anormalidades
Parede Abdominal/embriologia
Anormalidades Múltiplas/embriologia
Anormalidades Múltiplas/genética
Anormalidades Múltiplas/metabolismo
Animais
Apoptose/fisiologia
Fenda Labial/embriologia
Fenda Labial/genética
Fenda Labial/metabolismo
Fissura Palatina/embriologia
Fissura Palatina/genética
Fissura Palatina/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Técnicas de Inativação de Genes
Hérnia Umbilical/embriologia
Hérnia Umbilical/genética
Hérnia Umbilical/metabolismo
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Receptor alfa de Fator de Crescimento Derivado de Plaquetas/genética
Esqueleto/anormalidades
Esqueleto/embriologia
Esqueleto/metabolismo
Disrafismo Espinal/embriologia
Disrafismo Espinal/genética
Disrafismo Espinal/metabolismo
Tamoxifeno
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
094ZI81Y45 (Tamoxifen); EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184473


  4 / 3066 MEDLINE  
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[PMID]:28904658
[Au] Autor:Bouchahda H; El Mhabrech H; Hamouda HB; Ghanmi S; Bouchahda R; Soua H
[Ad] Endereço:Department of Gynecology Obstetric, University of Monastir, Tahar Sfar University Hospital, 5111 Mahdia, Tunisia.
[Ti] Título:Prenatal diagnosis of caudal regression syndrome and omphalocele in a fetus of a diabetic mother.
[So] Source:Pan Afr Med J;27:128, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:The caudal regression syndrome is defined as total or partial agenesis of the sacrum and lumbar spine, frequently associated with other developmental malformations (orthopedic, neurological, genito-urinary, gastrointestinal…). Prenatal diagnosis is possible through fetal ultrasound (US) and magnetic resonance imaging (MRI). A case of fetal caudal regression syndrome with omphalocele from a diabetic mother is presented, demonstrating the sonographic, MRI, CT and X-Ray features diagnostic. We will also discuss neonatal findings, risk factors and prognosis of this condition.
[Mh] Termos MeSH primário: Hérnia Umbilical/diagnóstico por imagem
Vértebras Lombares/diagnóstico por imagem
Diagnóstico Pré-Natal/métodos
Sacro/anormalidades
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Vértebras Lombares/anormalidades
Imagem por Ressonância Magnética/métodos
Gravidez
Gravidez em Diabéticas
Prognóstico
Fatores de Risco
Sacro/diagnóstico por imagem
Doenças da Medula Espinal/diagnóstico por imagem
Síndrome
Ultrassonografia Pré-Natal/métodos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.128.12041


  5 / 3066 MEDLINE  
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[PMID]:28586889
[Au] Autor:Blay E; Stulberg JJ
[Ti] Título:Umbilical Hernia.
[So] Source:JAMA;317(21):2248, 2017 06 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hérnia Umbilical
[Mh] Termos MeSH secundário: Hérnia Umbilical/cirurgia
Seres Humanos
Telas Cirúrgicas
[Pt] Tipo de publicação:PATIENT EDUCATION HANDOUT
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.3982


  6 / 3066 MEDLINE  
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[PMID]:28397950
[Au] Autor:Aljahdali AH; Al-Buainain HM; Skarsgard ED
[Ad] Endereço:Department of Pediatric Surgery, King Fahad Hospital of the University, University of Dammam, Al Khobar, Kingdom of Saudi Arabia. E-mail. akramjahdali@gmail.com.
[Ti] Título:Staged closure of a giant omphalocele with amnion preservation, modified technique.
[So] Source:Saudi Med J;38(4):422-424, 2017 Apr.
[Is] ISSN:0379-5284
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:Closure of a giant omphalocele can be challenging. Preservation of the amnion in staged closure is not commonly practiced. Here, we describe 2 cases of giant omphalocele treated with a modified amnion preservation, staged closure technique. This paper demonstrates the feasibility and safety of this technique, and the versatility of amnion to adapt to an escharization strategy if closure is not achievable.
[Mh] Termos MeSH primário: Hérnia Umbilical/cirurgia
[Mh] Termos MeSH secundário: Âmnio/cirurgia
Fasciotomia
Evolução Fatal
Seres Humanos
Hipertensão Pulmonar/complicações
Hipertensão Pulmonar/diagnóstico por imagem
Lactente
Masculino
Sulfadiazina/administração & dosagem
Sulfassalazina/administração & dosagem
Telas Cirúrgicas
Ventiladores Mecânicos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0N7609K889 (Sulfadiazine); 3XC8GUZ6CB (Sulfasalazine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.15537/smj.2017.4.16240


  7 / 3066 MEDLINE  
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[PMID]:28249618
[Au] Autor:Tenreiro N; Ferreira C; Silva S; Marques R; Ribeiro A; Sousa PJ; Luís FP
[Ad] Endereço:Department of General Surgery, Centro Hospitalar Trás-os-Montes e Alto Douro, Avenida da Noruega, Lordelo, 5000-508, Vila Real, Portugal. ntalmeida@chtmad.min-saude.pt.
[Ti] Título:Locally advanced colon cancer with cutaneous invasion: case report.
[So] Source:BMC Res Notes;10(1):113, 2017 Mar 01.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Locally advanced colon cancer with direct abdominal wall and skin invasion is an extremely rare finding with most data being derived from case reports, historical autopsy-based or single-center retrospective studies. We present a unique case of a colon cancer with direct cutaneous invasion and colocutaneous fistulization. CASE PRESENTATION: Eighty-six year old Caucasian female with multiple comorbidities, referred to Surgical Consultation due to ulcerated skin lesion in the abdomen. She had a long-standing large umbilical hernia but with no previous episodes of incarceration or occlusive symptoms. She denied any digestive or constitutional symptoms. Physical examination showed a large non-reducible umbilical hernia, with an associated painless firm mass within the hernia sac and cutaneous ulcerated growth. Colonoscopy revealed transverse colon cancer (endoscopic biopsy of the tumor and skin punch biopsy confirmed adenocarcinoma of the colon). Computed tomography showed a tumoral mass within the umbilical hernia, with cutaneous infiltration and enlarged regional lymph nodes. Rapid local progression led to colocutaneous fistula with total fecal diversion. We performed an extended right hemicolectomy with en bloc excision of the hernia sac and infiltrating cutaneous mass. CONCLUSIONS: In the current era of widespread use of screening colonoscopies, initial diagnosis of locally advanced colon cancer is decreasing. However, this unique case presented an opportunity to recall the advantages of multivisceral resections.
[Mh] Termos MeSH primário: Parede Abdominal/patologia
Colo/patologia
Neoplasias do Colo/patologia
Pele/patologia
[Mh] Termos MeSH secundário: Parede Abdominal/diagnóstico por imagem
Idoso de 80 Anos ou mais
Colo/diagnóstico por imagem
Neoplasias do Colo/complicações
Neoplasias do Colo/diagnóstico por imagem
Colonoscopia
Feminino
Hérnia Umbilical/complicações
Hérnia Umbilical/diagnóstico por imagem
Hérnia Umbilical/patologia
Seres Humanos
Fístula Intestinal/complicações
Fístula Intestinal/diagnóstico por imagem
Fístula Intestinal/patologia
Invasividade Neoplásica
Pele/diagnóstico por imagem
Tomógrafos Computadorizados
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2440-0


  8 / 3066 MEDLINE  
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[PMID]:28219116
[Au] Autor:Fleurke-Rozema H; van de Kamp K; Bakker M; Pajkrt E; Bilardo C; Snijders R
[Ad] Endereço:Department of Obstetrics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
[Ti] Título:Prevalence, timing of diagnosis and pregnancy outcome of abdominal wall defects after the introduction of a national prenatal screening program.
[So] Source:Prenat Diagn;37(4):383-388, 2017 Apr.
[Is] ISSN:1097-0223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To examine prevalence, time of diagnosis and outcome of fetuses with an exomphalos or gastroschisis, diagnosed since the introduction of a national prenatal screening program in 2007. METHODS: A prospective cohort study was undertaken in two fetal medicine units in the Netherlands. Cases were included if the estimated due date was between 2009 and 2013. Outcome measures were gestational age at diagnosis, presence of additional anomalies and pregnancy outcome. RESULTS: A total of 141 exomphalos and 44 gastroschisis cases were included in the study, of which, respectively, 96 and 95% were diagnosed prenatally. The majority of the cases are visualized prior to the 20-week scan. In the exomphalos group, 83% had additional anomalies of which 57% had a chromosomal anomaly. Additional anomalies were present in 11% of the gastroschisis cases of which 40% had a chromosomal anomaly. The pregnancy termination rate was 61% (exomphalos) and 14% (gastroschisis). CONCLUSION: Almost all exomphalos and gastroschisis cases are diagnosed prenatally, the majority in the first trimester. Associated anomalies are far more common in exomphalos with a fourfold lower survival rate than gastroschisis. In the exomphalos group, the pregnancy termination rate doubled, while in the gastroschisis group the rate remained low. © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Parede Abdominal/anormalidades
Doenças Fetais/epidemiologia
Resultado da Gravidez/epidemiologia
Diagnóstico Pré-Natal
[Mh] Termos MeSH secundário: Aborto Induzido/estatística & dados numéricos
Adulto
Feminino
Morte Fetal
Doenças Fetais/diagnóstico
Gastrosquise/diagnóstico
Gastrosquise/epidemiologia
Idade Gestacional
Implementação de Plano de Saúde
Hérnia Umbilical/diagnóstico
Hérnia Umbilical/epidemiologia
Seres Humanos
Lactente
Morte do Lactente
Recém-Nascido
Países Baixos/epidemiologia
Gravidez
Diagnóstico Pré-Natal/métodos
Prevalência
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1002/pd.5023


  9 / 3066 MEDLINE  
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[PMID]:28208152
[Au] Autor:Montalbano MJ; Loukas M; Oakes WJ; Tubbs RS
[Ad] Endereço:Department of Anatomical Sciences, St. George's University, St. George's, Grenada.
[Ti] Título:Simultaneous Umbilical Hernia Repair with Transumbilical Ventriculoperitoneal Shunt Placement.
[So] Source:Pediatr Neurosurg;52(2):127-129, 2017.
[Is] ISSN:1423-0305
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Recently, placement of a ventriculoperitoneal shunt via a transumbilical approach has been reported. PATIENTS AND METHODS: Herein, we report the repair of an umbilical hernia via the same incision and introduction of the distal end of a ventricultoperitoneal shunt into the peritoneal cavity in 3 patients. A case illustration is included. RESULTS: Both hernia repair and placement of the distal end of the ventriculoperitoneal shunt were uncomplicated in our small case series. CONCLUSIONS: To our knowledge, simultaneous repair of an umbilical hernia followed by transumbilical shunt placement has not been reported. As umbilical hernias are so common in infants, this finding, based on our experience, should not exclude placement of peritoneal tubing in the same setting.
[Mh] Termos MeSH primário: Hérnia Umbilical/cirurgia
Cavidade Peritoneal/cirurgia
Derivação Ventriculoperitoneal/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Hidrocefalia/cirurgia
Lactente
Laparoscopia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1159/000455922


  10 / 3066 MEDLINE  
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[PMID]:28199379
[Au] Autor:Yun J; Olkkola S; Hänninen ML; Oliviero C; Heinonen M
[Ad] Endereço:Research Centre for Animal Welfare, Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
[Ti] Título:The effects of amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses, growth and ampicillin resistance of intestinal coliform bacteria in weaned pigs.
[So] Source:PLoS One;12(2):e0172150, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of a single amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses until the age of nine weeks. We also studied whether the treatment was associated with growth and mortality, the need for treatment of other diseases, the proportions of ampicillin resistant coliforms and antimicrobial resistance patterns of intestinal Escherichia coli (E. coli). A total of 7156 piglets, from approximately 480 litters, were divided into two treatment groups: ANT (N = 3661) and CON (N = 3495), where piglets were treated with or without a single intramuscular injection of 75 mg amoxicillin one day after birth, respectively. The umbilical and inguinal areas of weaned pigs were palpated at four and nine weeks of age. At the same time, altogether 124 pigs with hernias or abscesses and 820 non-defective pigs from three pens per batch were weighed individually. Mortality and the need to treat piglets for other diseases were recorded. Piglet faecal samples were collected from three areas of the floors of each pen at four weeks of age. The prevalence of umbilical hernias or abscesses did not differ between the groups at four weeks of age, but it was higher in the CON group than in the ANT group at nine weeks of age (2.3% vs. 0.7%, P < 0.05). Numbers of inguinal hernias and abscesses did not differ between the groups at four or nine weeks of age. The ANT group, when it compared with the CON group, increased the weight gain between four and nine weeks of age (LS means ± SE; 497.5 g/d ± 5.0 vs. 475.3 g/d ± 4.9, P < 0.01), and decreased piglet mortality (19.5% ± 1.0 vs. 6.9% ± 1.0, P < 0.05) and the need to treat the piglets for leg problems (3.4% ± 0.3 vs. 1.9% ± 0.3%, P < 0.01) but not for other diseases by the age of four weeks. The proportion of ampicillin resistant intestinal coliform bacteria and the resistance patterns of the E. coli isolates were not different between the ANT and CON groups. In conclusion, our results showed that the amoxicillin treatment of new-born piglets produced statistically significant effect in some of the parameters studied. However, as these effects were only minor, we did not find grounds to recommend preventive antibiotic treatment. Further, continuous antimicrobial treatment of newborn piglets could negatively influence the development of the normal microbiota of the piglet and promote selection of antimicrobial resistance genes in herds. Therefore we suggest rejection of the use of routine administration of antimicrobial agents at birth.
[Mh] Termos MeSH primário: Amoxicilina/farmacologia
Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
[Mh] Termos MeSH secundário: Abscesso/diagnóstico
Abscesso/epidemiologia
Abscesso/microbiologia
Abscesso/mortalidade
Resistência a Ampicilina
Animais
Animais Recém-Nascidos
Escherichia coli/genética
Escherichia coli/isolamento & purificação
Fezes/microbiologia
Hérnia Umbilical/diagnóstico
Hérnia Umbilical/epidemiologia
Hérnia Umbilical/microbiologia
Hérnia Umbilical/mortalidade
Testes de Sensibilidade Microbiana
Prevalência
Suínos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172150



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